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Entry version 66 (11 Dec 2019)
Sequence version 2 (03 Apr 2007)
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Protein
Submitted name:

Non-ribosomal peptide synthetase B

Gene

pstB

Organism
Actinoplanes friuliensis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Non-ribosomal peptide synthetase BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pstBImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiActinoplanes friuliensisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri196914 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeActinoplanes

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei972O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1524O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2594O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini937 – 1012CarrierInterPro annotationAdd BLAST76
Domaini1489 – 1564CarrierInterPro annotationAdd BLAST76
Domaini2559 – 2633CarrierInterPro annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1778 – 1799DisorderedSequence analysisAdd BLAST22

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 2 hits
3.30.559.10, 4 hits
3.40.50.12780, 2 hits
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR029058 AB_hydrolase
IPR036736 ACP-like_sf
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR010060 NRPS_synth
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 2 hits
PF13193 AMP-binding_C, 2 hits
PF00668 Condensation, 4 hits
PF00550 PP-binding, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823 PKS_PP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 3 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733 AA-adenyl-dom, 2 hits
TIGR01720 NRPS-para261, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 2 hits
PS50075 CARRIER, 3 hits
PS00012 PHOSPHOPANTETHEINE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4H1C8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDVSVDRRP VSAAQLGIWV AQQVLPDSPL YNCGCYYEIG AADPVLLDRA
60 70 80 90 100
VRHAVAETEA LRSRFETIDD ELWQLVGPAE PEPLEVVDLS AEADPQEAAQ
110 120 130 140 150
SWMRAAMAGV RPLGRGPLSR QAVLLLGADR RLWFHGYHHA VLDGFGQSVY
160 170 180 190 200
ASRVAEVYAA LAAGQAPPPR VFTTLDEVHA DAAVDPSTRR YAADRDYWLN
210 220 230 240 250
TFADRPEPAG LAGRSAGAVP TQLRRIRALT PETATRFAAA AGAVGSTWPA
260 270 280 290 300
AVIAAVAAYY HRLTGREDIV FALPLAGRRG RTSLTTPGAL VNVLPIRLTV
310 320 330 340 350
SSRDTFAELA GQAARRLADV LRHQRFRGEQ LFQELGLTGE RAFWGPTVNV
360 370 380 390 400
MGFGGDLALG ELTAVPHPLA TGPVQDLKIN FYGTPATGVR LEFDADPALY
410 420 430 440 450
DAAAVEAHQT RLVRLLTALG DDPATRIGAV DLLDGTERHH LLHTWNETAP
460 470 480 490 500
LHTGHYLPEL FAEQVARTPD AVAVRQAGTA LTYAELDERA NRFARYLIGR
510 520 530 540 550
GAGPERLVGV HLPRSADLMV VLLGVLKAGA GYLPIDASYP PDRIAAVLDD
560 570 580 590 600
ARPVLLVDDT AVLAASAGLP GTPVTDAERR TPLLPQHPAY VIYTSGSTGR
610 620 630 640 650
PKGVLIDHRA LGEFLTTCRD RYPQAAGTAL LHSSISFDLT VTVLFTPLVA
660 670 680 690 700
GGCVDVADLP NDGRPPAFVK ATPSHLALLE GPGDNASPTG ALVLGGEQLL
710 720 730 740 750
GEALAPWRAR HPQAAVFNDY GPTETTVNCA DYLLEPGDDT PAGAVPIGRP
760 770 780 790 800
LPGNRLYVLD PALQPVPAGA TGELYIGGTG LARGYVNRPG LTGQRFVADP
810 820 830 840 850
YAGPGARMYR SGDLARLRAD GNLEYLGRID DQVKIRGYRV EPGEIEAVLA
860 870 880 890 900
SADQVARCAV VVREDRPGDQ RLVAYVVAAD GTVDPSALTA HLAARLPAYM
910 920 930 940 950
VPSAIVGLDE LPWTANGKVD RRALPVPPQQ APVAGRAPAS PRQEILAGLF
960 970 980 990 1000
AETLGVPRVG ADDDFFALGG HSLLATRLVS RVRSVFGAEL TIGQVFRSPT
1010 1020 1030 1040 1050
VAGLAAGLDR AGAGRSPITA RPRPGRVPLS FAQQRLRFLD LLEQDSTAYH
1060 1070 1080 1090 1100
APGALRLTGP LDRTALAAAL NDLVVRHESL RTVFAADDEG FHQVILTPEQ
1110 1120 1130 1140 1150
APVPLPVAEL DEAALPDRLA AEAAQPFDLA GEPAIRARLF VLGPQDHVLL
1160 1170 1180 1190 1200
LVLHHITGDG WSMRPLARDL AAAYRARLTG GEPSWPALPV QYADYTLWQH
1210 1220 1230 1240 1250
EVLDTEGEQL GYWRQNLAGL PAELALPVDR ARHDDMPAHA ERASADLPAE
1260 1270 1280 1290 1300
LHESLHAVAR EHGASLFMVV QSALAALLTR LGAGEDIPLG TPIAGRSDAA
1310 1320 1330 1340 1350
VEDLVGFFAN TLVIRADTTG DPTFGELLGR VRETSLSAYA HQDVPFERLV
1360 1370 1380 1390 1400
EELNPPRSLA RHPLFQVCLT LHHADPATVV AEVTDLPGVA VRMLPVPGAD
1410 1420 1430 1440 1450
AMFDLNLELT ERFTPDGRPA GVRVDLDAAA GLFDPATVRA LTDGFAAVLT
1460 1470 1480 1490 1500
SVAADARQRL SEVDVPALGT RPGLTPAEPV VVPAVRSRAP RTPQEQILCT
1510 1520 1530 1540 1550
LFAETLDTDA IGVDDDFFAR GGHSLSAVRL LSRIRTELGA EVSIRTLFAH
1560 1570 1580 1590 1600
PTVTGLLPHL STATRPAIET AARPARLPLS YAQQRLWFLH HLEGPSATYN
1610 1620 1630 1640 1650
IPVALRLTGD LDRSALTAAL SDLVLRHESL RTVFAQDESG SYQVVLPGER
1660 1670 1680 1690 1700
ARPELIVRAL PSAGREEAVR EAAAEPFDLG RELPVRVTLF EGTGEHVLLV
1710 1720 1730 1740 1750
VLHHIAGDGQ SMGPLARDLT TAYAARAAGS APAWAPLPVQ YADYTLWQRT
1760 1770 1780 1790 1800
MLGAEDNPGS EFGRQLGYWR ETLAGLPGEL QLPTDRPRPP RQSYRGDRVS
1810 1820 1830 1840 1850
RGVPAELHRA LRELARETRS SLVMVVQAAL ATTLSRLGAG TDVPIGMPIA
1860 1870 1880 1890 1900
GRTDAALEDL VGFFVNTLVL RNDVSGEPSF RDLVARVRET NLGAYAHQDV
1910 1920 1930 1940 1950
PFERLVDVLS PARSLARHPL FQVLLGFDDN TEALSALRLP GLAVEAGAPE
1960 1970 1980 1990 2000
TGRAKFDLSF FFDEAYAPDG TPQSLTAALE YSTDLYDRST AEAMLATLLR
2010 2020 2030 2040 2050
VCAGVTADPD VPVSRVDVLD DADRDRVLRH WNRAPHPVAA DLVPDRLARQ
2060 2070 2080 2090 2100
AAARPGELAV LADSAELTYG ELDAAANRLA RHLIGLGAGP EQVVAIALPR
2110 2120 2130 2140 2150
TPGMVVAMVA ALKTGAAYLT LDPAVPDQRL RAVVADCGAV AVVTDTAIAP
2160 2170 2180 2190 2200
RLDGTSRAVV LDDPATAAAV TGQPGTAITD ADRRGPLDPR HPAYVVYTSG
2210 2220 2230 2240 2250
STGTPKGVVM PMGSLTNLLA WHTGTYPAAP GTRTAQFLAV SFDFAVQEIL
2260 2270 2280 2290 2300
QALVAGKTLV LPAEHVRHDA YELAAWIDRY AVNELFAPRL VIDAVLAAAA
2310 2320 2330 2340 2350
DRGSDLRTLT DVFQGGEAFQ LGDELRAWAA GGNRRAHNVY GPAETHAVTT
2360 2370 2380 2390 2400
ATMPADPAAW PATAPIGRPL WNATVFVLDA RLQPVPLGAP GELYVGGAQL
2410 2420 2430 2440 2450
ARGYLNRPGR TAERFVASPF GAPGDRLYRT GDLVRWTRDG ELQFLGRGDH
2460 2470 2480 2490 2500
QVKIGGFRVE PGEVEGVLAA HPGVTTAVVV PRDDLPGGTR LVAYAVPDPQ
2510 2520 2530 2540 2550
HDLGPDGGRR LRAHLEEHLP SYLVPAAVVL LDVLPLTPNG KLDRAALPAP
2560 2570 2580 2590 2600
EFGGSTGRGP RDDREKLLAA LFAEVLGVAE VGVDEGFFDL GGDSIMSIQL
2610 2620 2630 2640 2650
VSRARRAGLE LSVREVFEHR TVEALAPVVR EVGTAPAEAP GEAYGDVPAT
2660 2670 2680 2690 2700
PIMHWLADRV TTAAVVDTFN MSIVLQVPAT LAVAPLTTAV QAVVDRHDAL
2710 2720 2730 2740 2750
RARLHTEGTW SLTVPEPGSV DATTLVSRVD ATDLDEPALN TLVRQHGHAA
2760 2770 2780 2790 2800
RSRLDPARGV QLQLVWFDRG PSTAGLLLVL VHHIVMDGVS WRVLLPDLME
2810 2820 2830 2840 2850
AYSAAEAGTE VRLQPVGTSL RRWAHGLVAA AGDPLRAAEA GWWRDVLRHS
2860 2870 2880 2890 2900
DPLLGARPLD PAVDTYGTAG SLTRHLDPVV TEAVLTRVPA LFHAEINDVL
2910 2920 2930 2940 2950
LTAFVLAWSR WRGDRTTGLL LDLEGHGREE HLVPGADLSR TIGWFTAIFP
2960 2970 2980 2990 3000
VRLDAGPVDL ADAFAGGPAA GAVLKRVKEQ LRAIPDKGLG HGLARHLDPG
3010 3020 3030 3040 3050
AAPGFAGTAA PQAGFNYLGR FAAPAPGSAG WTPVFGLEAV PGEEDGLPLA
3060 3070 3080 3090 3100
HTVDLNARTE ETADGPSLTA MWTWAGELLT TAQVDELAGL WFEALEALVA
3110 3120 3130 3140
HADGPGAGGL TPSDVPLAVT QDEIDAFEDE FQDEFDAEEE DEL
Length:3,143
Mass (Da):334,995
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7F7A9357FC73A3A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ488769 Genomic DNA Translation: CAJ18237.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ488769 Genomic DNA Translation: CAJ18237.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.1200.10, 2 hits
3.30.559.10, 4 hits
3.40.50.12780, 2 hits
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR029058 AB_hydrolase
IPR036736 ACP-like_sf
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR010060 NRPS_synth
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501 AMP-binding, 2 hits
PF13193 AMP-binding_C, 2 hits
PF00668 Condensation, 4 hits
PF00550 PP-binding, 3 hits
SMARTiView protein in SMART
SM00823 PKS_PP, 3 hits
SUPFAMiSSF47336 SSF47336, 3 hits
TIGRFAMsiTIGR01733 AA-adenyl-dom, 2 hits
TIGR01720 NRPS-para261, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 2 hits
PS50075 CARRIER, 3 hits
PS00012 PHOSPHOPANTETHEINE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4H1C8_9ACTN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4H1C8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: April 3, 2007
Last modified: December 11, 2019
This is version 66 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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