UniProtKB - Q4H132 (Q4H132_SQUAC)
Protein
Sodium/potassium-transporting ATPase subunit alpha
Gene
atn1
Organism
Squalus acanthias (Spiny dogfish)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 381 | MagnesiumCombined sources | 1 | |
Metal bindingi | 383 | Magnesium; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 722 | MagnesiumCombined sources | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- potassium transmembrane transporter activity, phosphorylative mechanism Source: InterPro
Keywordsi
Molecular function | TranslocaseARBA annotation |
Biological process | Ion transport, Potassium transportUniRule annotation, Transport |
Ligand | ATP-bindingUniRule annotationARBA annotation, MagnesiumCombined sourcesARBA annotation, Metal-bindingUniRule annotationCombined sources, Nucleotide-binding, Potassium |
Enzyme and pathway databases
BRENDAi | 3.6.3.9, 5813 |
Protein family/group databases
TCDBi | 3.A.3.1.6, the p-type atpase (p-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/potassium-transporting ATPase subunit alphaUniRule annotation |
Gene namesi | Name:atn1Imported |
Organismi | Squalus acanthias (Spiny dogfish)Imported |
Taxonomic identifieri | 7797 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Squalomorphii › Squaliformes › Squalidae › Squalus |
Subcellular locationi
Other locations
- Membrane UniRule annotation
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 101 – 123 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 135 – 154 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 296 – 320 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 326 – 349 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 854 – 877 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 918 – 937 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 958 – 975 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 990 – 1006 | HelicalUniRule annotationAdd BLAST | 17 |
Keywords - Cellular componenti
MembraneStructurei
3D structure databases
SMRi | Q4H132 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q4H132 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 121 | Cation_ATPase_NInterPro annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 221 – 240 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 39 | PolyampholyteSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]UniRule annotationARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationFamily and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4H132-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKGTASDKY EPAATSENAT KSKKKGKKDK IDKKRDLDEL KKEVSMDDHK
60 70 80 90 100
LSLDELHNKY GTDLTRGLTN ARAKEILARD GPNSLTPPPT TPEWIKFCRQ
110 120 130 140 150
LFGGFSILLW IGAILCFLAY GIQAATEDEP ANDNLYLGVV LSTVVIVTGC
160 170 180 190 200
FSYYQEAKSS RIMDSFKNMV PQQALVIRDG EKSTINAEFV VAGDLVEVKG
210 220 230 240 250
GDRIPADLRI ISAHGCKVDN SSLTGESEPQ TRSPEFSSEN PLETRNIAFF
260 270 280 290 300
STNCVEGTAR GVVVYTGDRT VMGRIATLAS GLEVGRTPIA IEIEHFIHII
310 320 330 340 350
TGVAVFLGVS FFILSLILGY SWLEAVIFLI GIIVANVPEG LLATVTVCLT
360 370 380 390 400
LTAKRMARKN CLVKNLEAVE TLGSTSTICS DKTGTLTQNR MTVAHMWFDN
410 420 430 440 450
QIHEADTTEN QSGAAFDKTS ATWSALSRIA ALCNRAVFQA GQDNVPILKR
460 470 480 490 500
SVAGDASESA LLKCIELCCG SVQGMRDRNP KIVEIPFNST NKYQLSIHEN
510 520 530 540 550
EKSSESRYLL VMKGAPERIL DRCSTILLNG AEEPLKEDMK EAFQNAYLEL
560 570 580 590 600
GGLGERVLGF CHFALPEDKY NEGYPFDADE PNFPTTDLCF VGLMAMIDPP
610 620 630 640 650
RAAVPDAVGK CRSAGIKVIM VTGDHPITAK AIAKGVGIIS EGNETIEDIA
660 670 680 690 700
ARLNIPIGQV NPRDAKACVV HGSDLKDLST EVLDDILHYH TEIVFARTSP
710 720 730 740 750
QQKLIIVEGC QRQGAIVAVT GDGVNDSPAL KKADIGVAMG ISGSDVSKQA
760 770 780 790 800
ADMILLDDNF ASIVTGVEEG RLIFDNLKKS IAYTLTSNIP EITPFLVFII
810 820 830 840 850
GNVPLPLGTV TILCIDLGTD MVPAISLAYE QAESDIMKRQ PRNPKTDKLV
860 870 880 890 900
NERLISMAYG QIGMIQALGG FFSYFVILAE NGFLPMDLIG KRVRWDDRWI
910 920 930 940 950
SDVEDSFGQQ WTYEQRKIVE FTCHTSFFIS IVVVQWADLI ICKTRRNSIF
960 970 980 990 1000
QQGMKNKILI FGLFEETALA AFLSYCPGTD VALRMYPLKP SWWFCAFPYS
1010 1020
LIIFLYDEMR RFIIRRSPGG WVEQETYY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ781093 mRNA Translation: CAG77578.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ781093 mRNA Translation: CAG77578.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ZXE | X-ray | 2.40 | A | 1-1028 | [»] | |
3A3Y | X-ray | 2.80 | A | 1-1028 | [»] | |
5AVQ | X-ray | 2.60 | A | 1-1028 | [»] | |
5AVR | X-ray | 2.70 | A | 1-1028 | [»] | |
5AVS | X-ray | 2.90 | A | 1-1028 | [»] | |
5AVT | X-ray | 2.90 | A | 1-1028 | [»] | |
5AVU | X-ray | 2.55 | A | 1-1028 | [»] | |
5AVV | X-ray | 2.90 | A | 1-1028 | [»] | |
5AVW | X-ray | 2.60 | A | 1-1028 | [»] | |
5AVX | X-ray | 3.30 | A | 1-1028 | [»] | |
5AVY | X-ray | 3.45 | A | 1-1028 | [»] | |
5AVZ | X-ray | 3.20 | A | 1-1028 | [»] | |
5AW0 | X-ray | 3.30 | A | 1-1028 | [»] | |
5AW1 | X-ray | 3.35 | A | 1-1028 | [»] | |
5AW2 | X-ray | 3.20 | A | 1-1028 | [»] | |
5AW3 | X-ray | 3.35 | A | 1-1028 | [»] | |
5AW4 | X-ray | 2.80 | A | 1-1028 | [»] | |
5AW5 | X-ray | 2.90 | A | 1-1028 | [»] | |
5AW6 | X-ray | 2.80 | A | 1-1028 | [»] | |
5AW7 | X-ray | 2.90 | A | 1-1028 | [»] | |
5AW8 | X-ray | 2.80 | A | 1-1028 | [»] | |
5AW9 | X-ray | 2.80 | A | 1-1028 | [»] | |
SMRi | Q4H132 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-59758N |
IntActi | Q4H132, 1 interactor |
Protein family/group databases
TCDBi | 3.A.3.1.6, the p-type atpase (p-atpase) superfamily |
Enzyme and pathway databases
BRENDAi | 3.6.3.9, 5813 |
Miscellaneous databases
EvolutionaryTracei | Q4H132 |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q4H132_SQUAC | |
Accessioni | Q4H132Primary (citable) accession number: Q4H132 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 30, 2005 |
Last sequence update: | August 30, 2005 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |