UniProtKB - Q4GWZ2 (RSSA_PIG)
40S ribosomal protein SA
RPSA
Functioni
Miscellaneous
GO - Molecular functioni
- laminin binding Source: UniProtKB-UniRule
- laminin receptor activity Source: UniProtKB-UniRule
- structural constituent of ribosome Source: GO_Central
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- cytoplasmic translation Source: GO_Central
- ribosomal small subunit assembly Source: GO_Central
- translation Source: GO_Central
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor, Ribonucleoprotein, Ribosomal protein |
Names & Taxonomyi
Protein namesi | Recommended name: 40S ribosomal protein SAUniRule annotationAlternative name(s): 37 kDa laminin receptor precursorUniRule annotation Short name: 37LRPUniRule annotation 37/67 kDa laminin receptorUniRule annotation Short name: LRP/LRUniRule annotation 67 kDa laminin receptorUniRule annotation Short name: 67LRUniRule annotation Laminin receptor 1UniRule annotation Short name: LamRUniRule annotation Laminin-binding protein precursor p40UniRule annotation Short name: LBP/p40UniRule annotation |
Gene namesi | Name:RPSAUniRule annotation Synonyms:LAMR1 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Plasma membrane
- Cell membrane UniRule annotation
Other locations
- Cytoplasm UniRule annotation
Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane.UniRule annotation
Cytosol
- cytosolic small ribosomal subunit Source: UniProtKB
Endoplasmic reticulum
- cytoplasmic side of rough endoplasmic reticulum membrane Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- glutamatergic synapse Source: Ensembl
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedUniRule annotation | |||
ChainiPRO_0000271751 | 2 – 295 | 40S ribosomal protein SAAdd BLAST | 294 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineUniRule annotationBy similarity | 1 | |
Modified residuei | 43 | PhosphoserineBy similarity | 1 | |
Modified residuei | 52 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 89 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 89 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 97 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 115 – 116 | Cleavage; by ST3; site 1UniRule annotation | 2 | |
Sitei | 133 – 134 | Cleavage; by ST3; site 2UniRule annotation | 2 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q4GWZ2 |
PeptideAtlasi | Q4GWZ2 |
PRIDEi | Q4GWZ2 |
Interactioni
Subunit structurei
Monomer (37LRP) and homodimer (67LR).
Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
Interacts with RPS21.
Interacts with several laminins including at least LAMB1.
Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat).
Interacts with PPP1CA only in the presence of PPP1R16B.
UniRule annotationGO - Molecular functioni
- laminin binding Source: UniProtKB-UniRule
- laminin receptor activity Source: UniProtKB-UniRule
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000021621 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 230 – 232 | [DE]-W-[ST] 1 | 3 | |
Repeati | 247 – 249 | [DE]-W-[ST] 2 | 3 | |
Repeati | 266 – 268 | [DE]-W-[ST] 3 | 3 | |
Repeati | 275 – 277 | [DE]-W-[ST] 4 | 3 | |
Repeati | 293 – 295 | [DE]-W-[ST] 5 | 3 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 54 – 113 | Interaction with PPP1R16BUniRule annotationAdd BLAST | 60 | |
Regioni | 161 – 180 | Laminin-bindingUniRule annotationAdd BLAST | 20 | |
Regioni | 205 – 229 | Laminin-bindingUniRule annotationAdd BLAST | 25 | |
Regioni | 242 – 295 | Laminin-bindingUniRule annotationAdd BLAST | 54 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0830, Eukaryota |
GeneTreei | ENSGT00950000183099 |
InParanoidi | Q4GWZ2 |
OrthoDBi | 1129610at2759 |
Family and domain databases
CDDi | cd01425, RPS2, 1 hit |
HAMAPi | MF_03015, Ribosomal_S2_euk, 1 hit MF_03016, Ribosomal_S2_laminin_receptor, 1 hit |
InterProi | View protein in InterPro IPR027504, 40S_ribosomal_SA IPR032281, 40S_SA_C IPR001865, Ribosomal_S2 IPR018130, Ribosomal_S2_CS IPR027498, Ribosomal_S2_euk IPR005707, Ribosomal_S2_euk/arc IPR023591, Ribosomal_S2_flav_dom_sf |
PANTHERi | PTHR11489, PTHR11489, 1 hit |
Pfami | View protein in Pfam PF16122, 40S_SA_C, 1 hit PF00318, Ribosomal_S2, 2 hits |
PRINTSi | PR00395, RIBOSOMALS2 |
SUPFAMi | SSF52313, SSF52313, 1 hit |
TIGRFAMsi | TIGR01012, uS2_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00962, RIBOSOMAL_S2_1, 1 hit PS00963, RIBOSOMAL_S2_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN
60 70 80 90 100
LKRTWEKLLL AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA
110 120 130 140 150
GRFTPGTFTN QIQAAFREPR LLVVTDPRAD HQPLTEASYV NLPTIALCNT
160 170 180 190 200
DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR EVLRMRGTIS REHPWEVMPD
210 220 230 240 250
LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA TQPEVADWSE
260 270 280 290
GVQVPSVPIQ QFPTEDWSAQ PTTEDWSAAP TAQATEWVGT TTEWS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A287B2M3 | A0A287B2M3_PIG | 40S ribosomal protein SA | RPSA | 275 | Annotation score: | ||
A0A5S8KR21 | A0A5S8KR21_PIG | 40S ribosomal protein SA | RPSA | 288 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM050292 mRNA Translation: CAJ18354.1 |
RefSeqi | NP_001032223.1, NM_001037146.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM050292 mRNA Translation: CAJ18354.1 |
RefSeqi | NP_001032223.1, NM_001037146.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J7P | electron microscopy | 3.50 | SA | 1-295 | [»] | |
3J7R | electron microscopy | 3.90 | SA | 1-295 | [»] | |
SMRi | Q4GWZ2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000021621 |
Proteomic databases
PaxDbi | Q4GWZ2 |
PeptideAtlasi | Q4GWZ2 |
PRIDEi | Q4GWZ2 |
Genome annotation databases
Organism-specific databases
CTDi | 3921 |
Phylogenomic databases
eggNOGi | KOG0830, Eukaryota |
GeneTreei | ENSGT00950000183099 |
InParanoidi | Q4GWZ2 |
OrthoDBi | 1129610at2759 |
Gene expression databases
ExpressionAtlasi | Q4GWZ2, baseline and differential |
Family and domain databases
CDDi | cd01425, RPS2, 1 hit |
HAMAPi | MF_03015, Ribosomal_S2_euk, 1 hit MF_03016, Ribosomal_S2_laminin_receptor, 1 hit |
InterProi | View protein in InterPro IPR027504, 40S_ribosomal_SA IPR032281, 40S_SA_C IPR001865, Ribosomal_S2 IPR018130, Ribosomal_S2_CS IPR027498, Ribosomal_S2_euk IPR005707, Ribosomal_S2_euk/arc IPR023591, Ribosomal_S2_flav_dom_sf |
PANTHERi | PTHR11489, PTHR11489, 1 hit |
Pfami | View protein in Pfam PF16122, 40S_SA_C, 1 hit PF00318, Ribosomal_S2, 2 hits |
PRINTSi | PR00395, RIBOSOMALS2 |
SUPFAMi | SSF52313, SSF52313, 1 hit |
TIGRFAMsi | TIGR01012, uS2_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00962, RIBOSOMAL_S2_1, 1 hit PS00963, RIBOSOMAL_S2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RSSA_PIG | |
Accessioni | Q4GWZ2Primary (citable) accession number: Q4GWZ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Ribosomal proteins
Ribosomal proteins families and list of entries