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Entry version 67 (31 Jul 2019)
Sequence version 1 (30 Aug 2005)
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Protein
Submitted name:

Abnormal spindle-like microcephaly associated splice variant 2

Gene

ASPM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Abnormal spindle-like microcephaly associated splice variant 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASPMImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q4G1H0

PRoteomics IDEntifications database

More...
PRIDEi
Q4G1H0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 134ASHInterPro annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0165 Eukaryota
ENOG410XSAR LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000134527

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR031549 ASH
IPR029955 ASPM
IPR013783 Ig-like_fold
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR22590:SF4 PTHR22590:SF4, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15780 ASH, 1 hit
PF00612 IQ, 24 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015 IQ, 29 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4G1H0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANRRVGRGC WEVSPTERRP PAGLRGPAAE EEASSPPVLS LSHFCRSPFL
60 70 80 90 100
CFGDVLLGAS RTLSLALDNP NEEVAEVKIS HFPAADLGFS VSQRCFVLQP
110 120 130 140 150
KEKIVISVNW TPLKEGRVRE IMTFLVNDVL KHQAILLGNA EEQKKKKRSL
160 170 180 190 200
WDTIKKKKIS ASTSHNRRVS NIQNVNKTFS VSQKVDRRYR QQTYFNKLKK
210 220 230 240 250
ITKTVQQRYW AMKERNIQFQ RYNKLRHSVI YIQAIFRGKK ARRHLKMMHI
260 270 280 290 300
AATLIQRRFR TLMMRRRFLS LKKTAILIQR KYRAHLCTKH HLQFLQVQNA
310 320 330 340 350
VIKIQSSYRR WMIRKRMREM HRAATFIQST FRMHRLHMRY RALKQASVVI
360 370 380 390 400
QQQYQANRAA KLQRQHYLRQ RHSAVILQAA FRGMKTRRHL KSMHSSATLI
410 420 430 440 450
QSRFRSLLVR RRFISLKKAT IFVQRKYRAT ICAKHKLYQF LHLRKAAITI
460 470 480 490 500
QSSYRRLMVK KKLQEMQRAA VLIQATFRMH RTYITFQTWK HASILIQQHY
510 520 530 540 550
RTYRAAKLQR ENYIRQWHSA VVIQAAYKGM KARQLLREKH KASIVIQSTY
560 570 580 590 600
RMYRQYCFYQ KLQWATKIIQ EKYRANKKKQ KVFQHNELKK ETCVQAGFQD
610 620 630 640 650
MNIKKQIQEQ HQAAIIIQKH CKAFKIRKHY LHLRATVVSI QRRYRKLTAV
660 670 680 690 700
RTQAVICIQS YYRGFKVRKD IQNMHRAATL IQSFYRMHRA KVDYETKKTA
710 720 730 740 750
IVVIQNYYRL YVRVKTERKN FLAVQKSVRT IQAAFRGMKV RQKLKNVSEE
760 770 780 790 800
KMAAIVNQSA LCCYRSKTQY EAVQSEGVMI QEWYKASGLA CSQEAEYHSQ
810 820 830 840 850
SRAAVTIQKA FCRMVTRKLE TQKCAALRIQ FFLQMAVYRR RFVQQKRAAI
860 870 880 890 900
TLQHYFRTWQ TRKQFLLYRK AAVVLQNHYR AFLSAKHQRQ VYLQIRSSVI
910 920 930 940 950
IIQARSKGFI QKRKFQEIKN STIKIQAMWR RYRAKKYLCK VKAACKIQAW
960 970 980 990 1000
YRCWRAHKEY LAILKAVKII QGCFYTKLER TRFLNVRASA IIIQRKWRAI
1010 1020 1030 1040 1050
LPAKIAHEHF LMIKRHRAAC LIQAHYRGYK GRQVFLRQKS AALIIQKYIR
1060 1070 1080 1090 1100
AREAGKHERI KYIEFKKSTV ILQALVRGWL VRKRFLEQRA KIRLLHFTAA
1110 1120 1130 1140 1150
AYYHLNAVRI QRAYKLYLAV KNANKQVNSV ICIQRWFRAR LQEKRFIQKY
1160 1170 1180 1190 1200
HSIKKIEHEG QECLSQRNRA ASVIQKAVRH FLLRKKQEKF TSGIIKIQAL
1210 1220 1230 1240 1250
WRGYSWRKKN DCTKIKAIRL SLQVVNREIR EENKLYKRTA LALHYLLTYK
1260 1270 1280 1290 1300
HLSAILEALK HLEVVTRLSP LCCENMAQSG AISKIFVLIR SCNRSIPCME
1310 1320 1330 1340 1350
VIRYAVQVLL NVSKYEKTTS AVYDVENCID ILLELLQIYR EKPGNKVADK
1360 1370 1380
GGSIFTKTCC LLAILLKTTN RASVSISQLP FFKIIFLWS
Length:1,389
Mass (Da):164,948
Last modified:August 30, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC85A88407F64B9B6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY971957 mRNA Translation: AAY46815.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY971957 mRNA Translation: AAY46815.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ4G1H0
PRIDEiQ4G1H0

Phylogenomic databases

eggNOGiKOG0165 Eukaryota
ENOG410XSAR LUCA
HOGENOMiHOG000134527

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ASPM human

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR031549 ASH
IPR029955 ASPM
IPR013783 Ig-like_fold
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
PANTHERiPTHR22590:SF4 PTHR22590:SF4, 3 hits
PfamiView protein in Pfam
PF15780 ASH, 1 hit
PF00612 IQ, 24 hits
SMARTiView protein in SMART
SM00015 IQ, 29 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 10 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4G1H0_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4G1H0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: July 31, 2019
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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