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Entry version 114 (17 Jun 2020)
Sequence version 3 (20 Apr 2010)
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Protein

Minichromosome maintenance domain-containing protein 2

Gene

MCMDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in meiotic recombination and associated DNA double-strand break repair.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair, Meiosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Minichromosome maintenance domain-containing protein 2
Short name:
MCM domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MCMDC2
Synonyms:C8orf45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000178460.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26368 MCMDC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617545 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q4G0Z9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000178460

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672364

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q4G0Z9 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MCMDC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
294862519

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002552581 – 681Minichromosome maintenance domain-containing protein 2Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei292PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4G0Z9

PeptideAtlas

More...
PeptideAtlasi
Q4G0Z9

PRoteomics IDEntifications database

More...
PRIDEi
Q4G0Z9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62145 [Q4G0Z9-1]
62146 [Q4G0Z9-2]
62147 [Q4G0Z9-3]
62148 [Q4G0Z9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4G0Z9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4G0Z9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178460 Expressed in left testis and 91 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q4G0Z9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4G0Z9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000178460 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127624, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q4G0Z9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000413632

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q4G0Z9 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini533 – 621MCMAdd BLAST89

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0480 Eukaryota
COG1241 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00980000198511

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4G0Z9

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFLAIKT

Database of Orthologous Groups

More...
OrthoDBi
736394at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4G0Z9

TreeFam database of animal gene trees

More...
TreeFami
TF332272

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031327 MCM
IPR001208 MCM_dom
IPR041562 MCM_lid

The PANTHER Classification System

More...
PANTHERi
PTHR11630 PTHR11630, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00493 MCM, 1 hit
PF17855 MCM_lid, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00350 MCM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4G0Z9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNLKMKEAA LIYLDRSGGL QKFIDDCKYY NDSKQSYAVY RFKILINPSD
60 70 80 90 100
VVELDAELGN HILHQPLKAA EVFQSVCFIA VKTLSLIGQL QTETQINIVL
110 120 130 140 150
KLTHLPPLPS YGLDLCEFPL DYTSQRFYMM QGIVIAMTTI TKYTQGARFL
160 170 180 190 200
CSDEACPLSK GFQYIRVHVP GATESATIRN DFLCNLCASS LQEDRKFRVL
210 220 230 240 250
GDKQIVEIIA TKALRAFQGY SNNQPFRFQS LTIFLRDESV NKMNIGNEYK
260 270 280 290 300
IIGIPTCVKT SQTAVCIEAN SITFCNSKVP SGISDNFRCL LSLTSSSCWK
310 320 330 340 350
FTAILANIFA SQITPPGTYN LLKLCLLMSL VQTTDRNKEL EDCLDILIIT
360 370 380 390 400
SDTLLIDRLL NFSINLVPRG IRHLVSTEIF PTLSRNKYGT GAVSIQAGSA
410 420 430 440 450
LLAKGGICFI GDLASHKKDK LEQLQTVLES RSITVYIPGK KFGEDIDQQM
460 470 480 490 500
TFPVQCSFWS FVDVDSSSRR NAQKINTLIG QMDCSLIPAN LVEAFGLLIN
510 520 530 540 550
CNESSPCHPF LPTVQHTLNK AINPEGLFYA ASRQFTTEDF EKLLAFAKNL
560 570 580 590 600
NVEFSLEAER MTHGYYLASR RIRTGSVCGS KLSASALKYL VFLSEAHARL
610 620 630 640 650
NLRNKVLKED VLIAALLFET SLTLKYGATV FCVAPNAVFP FELYNEEYLE
660 670 680
QRDLYLTQCQ QQLEQFIATY GPGTTIFSSD E
Length:681
Mass (Da):76,219
Last modified:April 20, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21FFAC8E243005BA
GO
Isoform 2 (identifier: Q4G0Z9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     591-681: Missing.

Show »
Length:590
Mass (Da):65,838
Checksum:i9EECC189AAEE1C48
GO
Isoform 3 (identifier: Q4G0Z9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-242: Missing.

Show »
Length:439
Mass (Da):48,761
Checksum:i7654BFE4316C3914
GO
Isoform 4 (identifier: Q4G0Z9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.
     64-75: HQPLKAAEVFQS → MIASTTMVRSAK

Show »
Length:618
Mass (Da):68,919
Checksum:iC53B8ABF3869E76D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DXX4B4DXX4_HUMAN
Chromosome 8 open reading frame 45,...
MCMDC2 C8orf45, hCG_2039391
632Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3XAN3G3XAN3_HUMAN
Chromosome 8 open reading frame 45,...
MCMDC2 C8orf45, hCG_2039391
368Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCM6F8WCM6_HUMAN
Minichromosome maintenance domain-c...
MCMDC2
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDR8F8WDR8_HUMAN
Minichromosome maintenance domain-c...
MCMDC2
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34576 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH63108 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94T → M in BAG63905 (PubMed:14702039).Curated1
Sequence conflicti164Y → H in BAG65055 (PubMed:14702039).Curated1
Sequence conflicti168H → Q in CAD97790 (PubMed:17974005).Curated1
Sequence conflicti258V → I in CAD97790 (PubMed:17974005).Curated1
Sequence conflicti366L → F in BAG65055 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028861137M → K. Corresponds to variant dbSNP:rs16933088Ensembl.1
Natural variantiVAR_028862322L → V. Corresponds to variant dbSNP:rs17332410Ensembl.1
Natural variantiVAR_028863583S → A. Corresponds to variant dbSNP:rs11778562Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0389981 – 242Missing in isoform 3. 1 PublicationAdd BLAST242
Alternative sequenceiVSP_0389991 – 63Missing in isoform 4. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_03900064 – 75HQPLK…EVFQS → MIASTTMVRSAK in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_039001591 – 681Missing in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK302672 mRNA Translation: BAG63905.1
AK303003 mRNA Translation: BAG64136.1
AK304170 mRNA Translation: BAG65055.1
AC011031 Genomic DNA No translation available.
BC034576 mRNA Translation: AAH34576.2 Different initiation.
BC063108 mRNA Translation: AAH63108.1 Different initiation.
BX537587 mRNA Translation: CAD97790.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47869.1 [Q4G0Z9-2]
CCDS6197.2 [Q4G0Z9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001129633.1, NM_001136161.1 [Q4G0Z9-2]
NP_775789.3, NM_173518.4 [Q4G0Z9-1]
XP_005251231.1, XM_005251174.2 [Q4G0Z9-4]
XP_006716496.1, XM_006716433.3 [Q4G0Z9-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000396592; ENSP00000379837; ENSG00000178460 [Q4G0Z9-2]
ENST00000422365; ENSP00000413632; ENSG00000178460 [Q4G0Z9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
157777

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:157777

UCSC genome browser

More...
UCSCi
uc003xwz.4 human [Q4G0Z9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302672 mRNA Translation: BAG63905.1
AK303003 mRNA Translation: BAG64136.1
AK304170 mRNA Translation: BAG65055.1
AC011031 Genomic DNA No translation available.
BC034576 mRNA Translation: AAH34576.2 Different initiation.
BC063108 mRNA Translation: AAH63108.1 Different initiation.
BX537587 mRNA Translation: CAD97790.2
CCDSiCCDS47869.1 [Q4G0Z9-2]
CCDS6197.2 [Q4G0Z9-1]
RefSeqiNP_001129633.1, NM_001136161.1 [Q4G0Z9-2]
NP_775789.3, NM_173518.4 [Q4G0Z9-1]
XP_005251231.1, XM_005251174.2 [Q4G0Z9-4]
XP_006716496.1, XM_006716433.3 [Q4G0Z9-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127624, 1 interactor
IntActiQ4G0Z9, 1 interactor
STRINGi9606.ENSP00000413632

PTM databases

iPTMnetiQ4G0Z9
PhosphoSitePlusiQ4G0Z9

Polymorphism and mutation databases

BioMutaiMCMDC2
DMDMi294862519

Proteomic databases

PaxDbiQ4G0Z9
PeptideAtlasiQ4G0Z9
PRIDEiQ4G0Z9
ProteomicsDBi62145 [Q4G0Z9-1]
62146 [Q4G0Z9-2]
62147 [Q4G0Z9-3]
62148 [Q4G0Z9-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24923 78 antibodies

Genome annotation databases

EnsembliENST00000396592; ENSP00000379837; ENSG00000178460 [Q4G0Z9-2]
ENST00000422365; ENSP00000413632; ENSG00000178460 [Q4G0Z9-1]
GeneIDi157777
KEGGihsa:157777
UCSCiuc003xwz.4 human [Q4G0Z9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
157777
EuPathDBiHostDB:ENSG00000178460.17

GeneCards: human genes, protein and diseases

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GeneCardsi
MCMDC2
HGNCiHGNC:26368 MCMDC2
HPAiENSG00000178460 Tissue enriched (testis)
MIMi617545 gene
neXtProtiNX_Q4G0Z9
OpenTargetsiENSG00000178460
PharmGKBiPA142672364

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0480 Eukaryota
COG1241 LUCA
GeneTreeiENSGT00980000198511
InParanoidiQ4G0Z9
OMAiCFLAIKT
OrthoDBi736394at2759
PhylomeDBiQ4G0Z9
TreeFamiTF332272

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
157777 28 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MCMDC2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
157777
PharosiQ4G0Z9 Tdark

Protein Ontology

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PROi
PR:Q4G0Z9
RNActiQ4G0Z9 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000178460 Expressed in left testis and 91 other tissues
ExpressionAtlasiQ4G0Z9 baseline and differential
GenevisibleiQ4G0Z9 HS

Family and domain databases

InterProiView protein in InterPro
IPR031327 MCM
IPR001208 MCM_dom
IPR041562 MCM_lid
PANTHERiPTHR11630 PTHR11630, 1 hit
PfamiView protein in Pfam
PF00493 MCM, 1 hit
PF17855 MCM_lid, 1 hit
SMARTiView protein in SMART
SM00350 MCM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCMD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4G0Z9
Secondary accession number(s): B4DYZ3
, B4DZM4, B4E293, Q6P533, Q7Z3P4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 20, 2010
Last modified: June 17, 2020
This is version 114 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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