UniProtKB - Q4G0X4 (KCD21_HUMAN)
Protein
BTB/POZ domain-containing protein KCTD21
Gene
KCTD21
Organism
Homo sapiens (Human)
Status
Functioni
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).1 Publication
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- cullin family protein binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- identical protein binding Source: IntAct
GO - Biological processi
- negative regulation of smoothened signaling pathway Source: UniProtKB
- protein homooligomerization Source: InterPro
- protein ubiquitination Source: UniProtKB-UniPathway
- regulation of growth Source: UniProtKB-KW
- ubiquitin-dependent protein catabolic process Source: UniProtKB
Keywordsi
Biological process | Growth regulation, Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q4G0X4 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: BTB/POZ domain-containing protein KCTD21Alternative name(s): KCASH2 protein1 Publication Potassium channel tetramerization domain-containing protein 21 |
Gene namesi | Name:KCTD21 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000188997.7 |
HGNCi | HGNC:27452, KCTD21 |
MIMi | 618790, gene |
neXtProti | NX_Q4G0X4 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 85 – 87 | DFY → KKK: Abolishes interaction with CUL3. 1 Publication | 3 |
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 283219 |
OpenTargetsi | ENSG00000188997 |
PharmGKBi | PA145148689 |
Miscellaneous databases
Pharosi | Q4G0X4, Tbio |
Polymorphism and mutation databases
BioMutai | KCTD21 |
DMDMi | 121943921 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000281151 | 1 – 260 | BTB/POZ domain-containing protein KCTD21Add BLAST | 260 |
Proteomic databases
EPDi | Q4G0X4 |
jPOSTi | Q4G0X4 |
MassIVEi | Q4G0X4 |
MaxQBi | Q4G0X4 |
PaxDbi | Q4G0X4 |
PeptideAtlasi | Q4G0X4 |
PRIDEi | Q4G0X4 |
ProteomicsDBi | 62137 |
PTM databases
iPTMneti | Q4G0X4 |
PhosphoSitePlusi | Q4G0X4 |
Expressioni
Tissue specificityi
Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma.1 Publication
Gene expression databases
Bgeei | ENSG00000188997, Expressed in substantia nigra and 205 other tissues |
ExpressionAtlasi | Q4G0X4, baseline and differential |
Genevisiblei | Q4G0X4, HS |
Organism-specific databases
HPAi | ENSG00000188997, Low tissue specificity |
Interactioni
Subunit structurei
Homopentamer (By similarity).
Interacts with KCTD11; KCTD21 and KCTD11 may associate in pentameric assemblies.
Interacts (via BTB domain) with CUL3; indicative for a participation in a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:21472142).
By similarityCurated1 PublicationBinary interactionsi
Hide detailsQ4G0X4
GO - Molecular functioni
- cullin family protein binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 129500, 24 interactors |
IntActi | Q4G0X4, 20 interactors |
STRINGi | 9606.ENSP00000339340 |
Miscellaneous databases
RNActi | Q4G0X4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 72 | BTBPROSITE-ProRule annotationAdd BLAST | 70 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 88 – 112 | Sequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 135 – 140 | Poly-Ser | 6 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2723, Eukaryota |
GeneTreei | ENSGT00940000160906 |
HOGENOMi | CLU_088122_0_0_1 |
InParanoidi | Q4G0X4 |
OMAi | QNIHFTV |
OrthoDBi | 1426852at2759 |
PhylomeDBi | Q4G0X4 |
TreeFami | TF315332 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q4G0X4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDPITLNVG GKLYTTSLAT LTSFPDSMLG AMFSGKMPTK RDSQGNCFID
60 70 80 90 100
RDGKVFRYIL NFLRTSHLDL PEDFQEMGLL RREADFYQVQ PLIEALQEKE
110 120 130 140 150
VELSKAEKNA MLNITLNQRV QTVHFTVREA PQIYSLSSSS MEVFNANIFS
160 170 180 190 200
TSCLFLKLLG SKLFYCSNGN LSSITSHLQD PNHLTLDWVA NVEGLPEEEY
210 220 230 240 250
TKQNLKRLWV VPANKQINSF QVFVEEVLKI ALSDGFCIDS SHPHALDFMN
260
NKIIRLIRYR
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PRT1 | E9PRT1_HUMAN | BTB/POZ domain-containing protein K... | KCTD21 | 140 | Annotation score: | ||
E9PMS5 | E9PMS5_HUMAN | BTB/POZ domain-containing protein K... | KCTD21 | 115 | Annotation score: | ||
E9PJJ5 | E9PJJ5_HUMAN | BTB/POZ domain-containing protein K... | KCTD21 | 165 | Annotation score: | ||
E9PK99 | E9PK99_HUMAN | BTB/POZ domain-containing protein K... | KCTD21 | 71 | Annotation score: | ||
E9PM10 | E9PM10_HUMAN | BTB/POZ domain-containing protein K... | KCTD21 | 37 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 152 | S → P in BAG62072 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK300320 mRNA Translation: BAG62072.1 BC036058 mRNA Translation: AAH36058.1 |
CCDSi | CCDS31645.1 |
RefSeqi | NP_001025030.1, NM_001029859.2 XP_005273985.1, XM_005273928.1 XP_006718580.1, XM_006718517.2 XP_006718581.1, XM_006718518.3 XP_011543257.1, XM_011544955.2 |
Genome annotation databases
Ensembli | ENST00000340067; ENSP00000339340; ENSG00000188997 |
GeneIDi | 283219 |
KEGGi | hsa:283219 |
UCSCi | uc001ozb.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK300320 mRNA Translation: BAG62072.1 BC036058 mRNA Translation: AAH36058.1 |
CCDSi | CCDS31645.1 |
RefSeqi | NP_001025030.1, NM_001029859.2 XP_005273985.1, XM_005273928.1 XP_006718580.1, XM_006718517.2 XP_006718581.1, XM_006718518.3 XP_011543257.1, XM_011544955.2 |
3D structure databases
SMRi | Q4G0X4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129500, 24 interactors |
IntActi | Q4G0X4, 20 interactors |
STRINGi | 9606.ENSP00000339340 |
PTM databases
iPTMneti | Q4G0X4 |
PhosphoSitePlusi | Q4G0X4 |
Polymorphism and mutation databases
BioMutai | KCTD21 |
DMDMi | 121943921 |
Proteomic databases
EPDi | Q4G0X4 |
jPOSTi | Q4G0X4 |
MassIVEi | Q4G0X4 |
MaxQBi | Q4G0X4 |
PaxDbi | Q4G0X4 |
PeptideAtlasi | Q4G0X4 |
PRIDEi | Q4G0X4 |
ProteomicsDBi | 62137 |
Protocols and materials databases
Antibodypediai | 31300, 100 antibodies |
Genome annotation databases
Ensembli | ENST00000340067; ENSP00000339340; ENSG00000188997 |
GeneIDi | 283219 |
KEGGi | hsa:283219 |
UCSCi | uc001ozb.4, human |
Organism-specific databases
CTDi | 283219 |
DisGeNETi | 283219 |
EuPathDBi | HostDB:ENSG00000188997.7 |
GeneCardsi | KCTD21 |
HGNCi | HGNC:27452, KCTD21 |
HPAi | ENSG00000188997, Low tissue specificity |
MIMi | 618790, gene |
neXtProti | NX_Q4G0X4 |
OpenTargetsi | ENSG00000188997 |
PharmGKBi | PA145148689 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2723, Eukaryota |
GeneTreei | ENSGT00940000160906 |
HOGENOMi | CLU_088122_0_0_1 |
InParanoidi | Q4G0X4 |
OMAi | QNIHFTV |
OrthoDBi | 1426852at2759 |
PhylomeDBi | Q4G0X4 |
TreeFami | TF315332 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q4G0X4 |
Miscellaneous databases
BioGRID-ORCSi | 283219, 7 hits in 842 CRISPR screens |
ChiTaRSi | KCTD21, human |
GenomeRNAii | 283219 |
Pharosi | Q4G0X4, Tbio |
PROi | PR:Q4G0X4 |
RNActi | Q4G0X4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188997, Expressed in substantia nigra and 205 other tissues |
ExpressionAtlasi | Q4G0X4, baseline and differential |
Genevisiblei | Q4G0X4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCD21_HUMAN | |
Accessioni | Q4G0X4Primary (citable) accession number: Q4G0X4 Secondary accession number(s): B4DTR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | August 30, 2005 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM