UniProtKB - Q4G0P3 (HYDIN_HUMAN)
Hydrocephalus-inducing protein homolog
HYDIN
Functioni
Required for ciliary motility.
By similarityGO - Biological processi
- axonemal central apparatus assembly Source: GO_Central
- cilium movement Source: GO_Central
- epithelial cell development Source: Ensembl
- trachea development Source: Ensembl
- ventricular system development Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q4G0P3 |
SignaLinki | Q4G0P3 |
SIGNORi | Q4G0P3 |
Names & Taxonomyi
Protein namesi | Recommended name: Hydrocephalus-inducing protein homolog |
Gene namesi | Name:HYDIN Synonyms:HYDIN1, KIAA1864 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19368, HYDIN |
MIMi | 610812, gene |
neXtProti | NX_Q4G0P3 |
VEuPathDBi | HostDB:ENSG00000157423 |
Subcellular locationi
Cytoskeleton
- cilium axoneme By similarity
Other locations
- cilium Curated
Note: Localizes in the cilium axoneme in a SPEF1-dependent manner.By similarity
Cytoskeleton
- axonemal central apparatus Source: UniProtKB
- axonemal central pair projection Source: Ensembl
- axoneme Source: GO_Central
Keywords - Cellular componenti
Cell projection, Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
Ciliary dyskinesia, primary, 5 (CILD5)2 Publications
Keywords - Diseasei
Ciliopathy, Kartagener syndrome, Primary ciliary dyskinesiaOrganism-specific databases
DisGeNETi | 54768 |
GeneReviewsi | HYDIN |
MalaCardsi | HYDIN |
MIMi | 608647, phenotype |
OpenTargetsi | ENSG00000157423 |
Orphaneti | 244, Primary ciliary dyskinesia |
PharmGKBi | PA134866950 |
Miscellaneous databases
Pharosi | Q4G0P3, Tbio |
Genetic variation databases
BioMutai | HYDIN |
DMDMi | 327478578 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284844 | 1 – 5121 | Hydrocephalus-inducing protein homologAdd BLAST | 5121 |
Proteomic databases
EPDi | Q4G0P3 |
MassIVEi | Q4G0P3 |
MaxQBi | Q4G0P3 |
PaxDbi | Q4G0P3 |
PeptideAtlasi | Q4G0P3 |
PRIDEi | Q4G0P3 |
ProteomicsDBi | 27301 62119 [Q4G0P3-1] 62120 [Q4G0P3-2] 62121 [Q4G0P3-5] 62122 [Q4G0P3-6] 62123 [Q4G0P3-8] |
PTM databases
iPTMneti | Q4G0P3 |
PhosphoSitePlusi | Q4G0P3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000157423, Expressed in bronchial epithelial cell and 149 other tissues |
ExpressionAtlasi | Q4G0P3, baseline and differential |
Genevisiblei | Q4G0P3, HS |
Organism-specific databases
HPAi | ENSG00000157423, Tissue enhanced (brain, choroid plexus) |
Interactioni
Subunit structurei
Interacts with KIF9.
By similarityBinary interactionsi
Isoform 5 [Q4G0P3-6]
With | #Exp. | IntAct |
---|---|---|
PEF1 [Q9UBV8] | 3 | EBI-14748124,EBI-724639 |
Protein-protein interaction databases
BioGRIDi | 120142, 10 interactors |
IntActi | Q4G0P3, 5 interactors |
STRINGi | 9606.ENSP00000377197 |
Miscellaneous databases
RNActi | Q4G0P3, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q4G0P3 |
SMRi | Q4G0P3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q4G0P3 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 363 – 754 | Interaction with KIF9By similarityAdd BLAST | 392 | |
Regioni | 956 – 987 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1925 – 1951 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 2155 – 2186 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 2333 – 2459 | DisorderedSequence analysisAdd BLAST | 127 | |
Regioni | 2482 – 2534 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 2664 – 2684 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 3852 – 3874 | DisorderedSequence analysisAdd BLAST | 23 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1908 – 1933 | Sequence analysisAdd BLAST | 26 | |
Coiled coili | 2267 – 2365 | Sequence analysisAdd BLAST | 99 | |
Coiled coili | 2504 – 2549 | Sequence analysisAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1936 – 1951 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 2333 – 2374 | Basic and acidic residuesSequence analysisAdd BLAST | 42 | |
Compositional biasi | 2395 – 2426 | Basic and acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 2440 – 2455 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 2489 – 2534 | Basic and acidic residuesSequence analysisAdd BLAST | 46 | |
Compositional biasi | 3856 – 3874 | Polar residuesSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QQ4F, Eukaryota |
GeneTreei | ENSGT00610000086095 |
HOGENOMi | CLU_000116_1_0_1 |
InParanoidi | Q4G0P3 |
OMAi | AHLQMEV |
OrthoDBi | 3322at2759 |
PhylomeDBi | Q4G0P3 |
TreeFami | TF340616 |
Family and domain databases
Gene3Di | 2.60.40.10, 22 hits 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR031549, ASH IPR033305, Hydin-like IPR033768, Hydin_ADK IPR013783, Ig-like_fold IPR027417, P-loop_NTPase |
PANTHERi | PTHR23053, PTHR23053, 1 hit |
Pfami | View protein in Pfam PF15780, ASH, 1 hit PF17213, Hydin_ADK, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTSRRLEESM GAVQMGLVNM FKGFQSKVLP PLSPKVVTEE EVNRMLTPSE
60 70 80 90 100
FLKEMSLTTE QRLAKTRLMC RPQIIELLDM GETTHQKFSG IDLDQALFQP
110 120 130 140 150
FPSEIIFQNY TPCEVYEVPL ILRNNDKIPR LVKVVEESSP YFKVISPKDI
160 170 180 190 200
GHKVAPGVPS IFRILFTPEE NKDYAHTLTC VTEREKFIVP IKARGARAIL
210 220 230 240 250
DFPDKLNFST CPVKYSTQKI LLVRNIGNKN AVFHIKTCRP FSIEPAIGTL
260 270 280 290 300
NVGESMQLEV EFEPQSVGDH SGRLIVCYDT GEKVFVSLYG AAIDMNIRLD
310 320 330 340 350
KNSLTIEKTY ISLANQRTIT IHNRSNIIAH FLWKVFATQQ EEDREKYRAC
360 370 380 390 400
DDLIKEEKDE TDEFFEECIT DPLLREHLSV LSRTFANQRR LVQGDSKLFF
410 420 430 440 450
NNVFTVEPLE GDVWPNSSAE ITVYFNPLEA KLYQQTIYCD ILGREIRLPL
460 470 480 490 500
RIKGEGMGPK IHFNFELLDI GKVFTGSAHC YEAILYNKGS IDALFNMTPP
510 520 530 540 550
TSALGACFVF SPKEGIIEPS GVQAIQISFS STILGNFEEE FLVNVNGSPE
560 570 580 590 600
PVKLTIRGCV IGPTFHFNVP ALHFGDVSFG FPHTLICSLN NTSLIPMTYK
610 620 630 640 650
LRIPGDGLGH KSISYCEQHV DYKRPSWTKE EISSMKPKEF TISPDCGTIR
660 670 680 690 700
PQGFAAIRVT LCSNTVQKYE LALVVDVEGI GEEVLALLIT ARCVVPALHL
710 720 730 740 750
VNTEVDFGHC FLKYPYEKTL QLANQDDLPG FYEVQPQVCE EVPTVLFSSP
760 770 780 790 800
TPSGVISPSS TIHIPLVLET QVTGEHRSTV YISIFGSQDP PLVCHLKSAG
810 820 830 840 850
EGPVIYVHPN QVDFGNIYVL KDSSRILNLC NQSFIPAFFQ AHMAHKKSLW
860 870 880 890 900
TIEPNEGMVP PETDVQLALT ANLNDTLTFK DCVILDIENS STYRIPVQAS
910 920 930 940 950
GTGSTIVSDK PFAPELNLGA HFSLDTHYYH FKLINKGRRI QQLFWMNDSF
960 970 980 990 1000
RPQAKLSKKG RVKKGHAHVQ PQPSGSQEPR DPQSPVFHLH PASMELYPGQ
1010 1020 1030 1040 1050
AIDVILEGYS ATPRIVKEKL VCHAIIGAQK GKSLVMAVNI TCEFVAPLIQ
1060 1070 1080 1090 1100
LSTKQLIYRL EKKPNSILKP DYQPLAIKNI STLPVNLLLS TSGPFFICET
1110 1120 1130 1140 1150
DKSLLPATPE PIKLEIDEEK NLLIKFDPSY RNDLNNWVAE EILAIKYVEH
1160 1170 1180 1190 1200
PQIDSLDLRG EVHYPNLSFE TKELDFGCIL NDTELIRYVT ITNCSPLVVK
1210 1220 1230 1240 1250
FRWFFLVNDE ENQIRFVTLP KKPYSAPVSQ MESIPATSEA ASPPAILVTV
1260 1270 1280 1290 1300
ESPEMDLNDF VKTVLVDEDA RPEEKELRKT KASSVISDEI KISSTEIERI
1310 1320 1330 1340 1350
YSSQSQVEDQ ESLQTCEQNE MLSIGIEEVF DILPLFGVLQ PHSSHQISFT
1360 1370 1380 1390 1400
FYGHANIIAQ AKALCEVEEG PTYEITLKGE ASLVNYSFDT KDIHYGLQLF
1410 1420 1430 1440 1450
DHVTEREITL TNMGKVGFEF KVLTDHQSSP DNLLPGVPLI LPVSGFISSH
1460 1470 1480 1490 1500
QEQVLKVYYL PGVPEVFKRS FQIQIAHLDP ENITLSGEGI FPQICLDLPR
1510 1520 1530 1540 1550
NLTANEKYEM FLNQARKNTD KEYNKCEMLD HFDIITEEVP EDEPAEVSAH
1560 1570 1580 1590 1600
LQMEVERLIV QSYVLEHQKT TTPDPMDDPC FSHRSRRKLA KIQLPEYILD
1610 1620 1630 1640 1650
FGYIILGEVR THIIKIINTS HFPVSFHADK RVLHETGFST ELDRVKNLPH
1660 1670 1680 1690 1700
CETEIFEVRF DPQGANLPVG SKEVILPIKV VGGPTVHICL QAKVTIPTMT
1710 1720 1730 1740 1750
LSRGKVDFAT IQCGQCLVET IQLSNHLQVP CEWFVQSQKP VDKLEKHMPK
1760 1770 1780 1790 1800
YLRQKLRAEL KPKTRIFEIQ PISGVLDPGE KSNVQVKFMP KEEKFYSQTL
1810 1820 1830 1840 1850
VFQIAQSAQK LTLLARGQGL EPRLEFSPSV LDLGPLLLCA PGDEAEVIVK
1860 1870 1880 1890 1900
NPCNFPIEFY SLEFDQQYLI EEKILRKLKG YDSYNTLLLP PRNPGEKLPP
1910 1920 1930 1940 1950
ELYEYFKEIK KSKEEQMRAK YLENLAQENE EEDITSSDQG TSNSTKRTSL
1960 1970 1980 1990 2000
SRGISVTSNL EEWHALLVES KTYLEEEEDE ESLEKIIFQT DKLQSIDSHS
2010 2020 2030 2040 2050
MEEVGEVENN PVSKAIARHL GIDISAEGRL AKNRKGIAII IHGTPLSGKS
2060 2070 2080 2090 2100
ANAVSVAKYY NAACLSIDSI VLEAVANSNN IPGIRARELC IRAAIEQSVK
2110 2120 2130 2140 2150
EGEEAAQEAA VGQNVIGQGR LSTDTLGKLA SEMTLVAPEI KPGKSVRGSV
2160 2170 2180 2190 2200
VITKSKADSH GSGSQKQHHS HQSETPQISS SPLPPGPIHR WLSVSPSVGG
2210 2220 2230 2240 2250
ETGLMSCVLP DELLVQILAE RIQLSDCYRG VVFDGLDTLF AQNAAAALLC
2260 2270 2280 2290 2300
LLKAIGSREH IYILNMAQDY AAMKAQEKAK KEQEERKHKG ALEKEKERLQ
2310 2320 2330 2340 2350
NMDEEEYDAL TEEEKLTFDR GIQQALRERK KREQERLAKE MQEKKLQQEL
2360 2370 2380 2390 2400
ERQKEEDELK RRVKKGKQGP IKEEPPMKKS QAANKQVPPL TKVDVKMETI
2410 2420 2430 2440 2450
ERKISVREQT MSEKEELNKK KRNMGDVSMH GLPLVQDQED SEGDNSKDPD
2460 2470 2480 2490 2500
KQLAPKFKTY ELTLKDVQNI LMYWDRKQGV QLPPAGMEEA PHEPDDQRQV
2510 2520 2530 2540 2550
PLGGRRGRKD RERERLEKER TEKERLEREK AERERLEKLR ALEERSDWEG
2560 2570 2580 2590 2600
EGEEDHEGKK EKDLGVPFLD IQTPDFEGLS WKQALESDKL PKGEQILDIL
2610 2620 2630 2640 2650
GLGASGPPIP PPALFSIVSY PVKRPPLTMT DDLEHFVFVI PPSEDISLDE
2660 2670 2680 2690 2700
KKEMEIESDF LATTNTTKAQ EEQTSSSKGG KQKMKEKIDQ VFEIQKDKRH
2710 2720 2730 2740 2750
MALNRKVLSG EPAGTISQLS DTDLDNFNGQ HSQEKFTRLN HFRWIVPANG
2760 2770 2780 2790 2800
EVTLQVHFSS DEFGNFDQTF NFEILGTCCQ YQLYCRGICT YPYICQDPKV
2810 2820 2830 2840 2850
VFPQRKMDMK TNEVIFKKYV MSTETYYFGP LLCGKSRDKY KSSLFPGNME
2860 2870 2880 2890 2900
TLTILNTSLM VVEASFYFQN DVKANTYFLE PNTMVLKPNE KQILNVWAYP
2910 2920 2930 2940 2950
TSVGVFEDSI VCCINDNPEP AIFQLSCQGI RPELELEPRQ LHFDRLLLHR
2960 2970 2980 2990 3000
QESRVVLLRN VTLLPVAWRI TSLEHLGDDF TVSLMQGTIP PEAEYGLHLY
3010 3020 3030 3040 3050
FQPTKPVNIK KAIRLEVLDA ENLLGVVQIE NIMVFAEAYD IALDITFPKG
3060 3070 3080 3090 3100
AEGGLDFGIV RVTEEAKQPL QLKNRGKYEI AFSFSVDSVG ISTPNINSMI
3110 3120 3130 3140 3150
SVQPKKGSLT PTEKPTNVQV FFHAKKEVKI EHQPVLRCQI IEPNISEGGE
3160 3170 3180 3190 3200
IIASIPIKFS ANAVYSKYNI TPSSVINFGA LICGTRKSTT FTIENQGVTD
3210 3220 3230 3240 3250
FKFALYKLTG ESPIHQKKAA SHVRHARSRE SESFYKTGSS RAAKFSDTIQ
3260 3270 3280 3290 3300
KEVTTTGQAR FAHGMFTVYP GFGSIPSGGQ QVINVDCVAD AMGKCEEFIA
3310 3320 3330 3340 3350
IDISGRDPAV HPAGILYTLL AEACLPAFVT ENNALIFEEH QICTSANLHH
3360 3370 3380 3390 3400
ILQTIESGGL FVEDENKFIF CNVLVGRQAK ARFKISNVGK ITCDVNIVVR
3410 3420 3430 3440 3450
PISNKPFARI VDIFEVEPSK MCIASHSHAF ATVSFTPQIM QNYQCIFEAT
3460 3470 3480 3490 3500
LDGLPSTLAK SRGLVFDIAG EGNLPRVTVV RPVLHNQYGN PLLLFKRLLL
3510 3520 3530 3540 3550
GHSEKLPLIL KNNGVLPAQL HVDLQDELGV FSLKGRPTTA YIYITEENKP
3560 3570 3580 3590 3600
HVKAKKAHTA SLVVSPGDTA EFDVVFHSQK VGRMRGIIHL SVINNQYEET
3610 3620 3630 3640 3650
SIHMVGEGYE DDITLDNIHG LVAPTSQEDI SISEFTEIIE DNDMEDLVAA
3660 3670 3680 3690 3700
ALVDHIQFGD CHIGHSYNAS FTVTNHSQVN LIRFEWPVSA TIAFSPQMGH
3710 3720 3730 3740 3750
LHPGCAKDIV VTMKSDVPIN LKNMRIRCKL SRIMFQLPAD QVPDWDDRMH
3760 3770 3780 3790 3800
TVKWVDVPRN MPGTFTTKRK VIETDPEPAH SVLEENYQEL QLQISANVDF
3810 3820 3830 3840 3850
ASYHCQARDV RFKETLVYQT RVFEFDVINS GRVQLEFSWV SEDTSKAVSF
3860 3870 3880 3890 3900
AKPDHQGSAQ KDQLSQGTMH TGSTLDSTMD HWAEGSPQPF SVEPSSGIVP
3910 3920 3930 3940 3950
VGKIQKFKVK FSPLDIGDFE SNLFCQIPNL PPGEQGPVLV AKGRSTLPIC
3960 3970 3980 3990 4000
HFDLKDSDYI SGHQRNPELR GSSGGALDPN TRVIEFTTVG IGGKNLRTFT
4010 4020 4030 4040 4050
ILNPTNSTYS FCWISEEIES LQNPAAFTCL TEKGFIHPEK KAEIVFQFTP
4060 4070 4080 4090 4100
FHLGITESSW TFLIPEHNIT VPFLLVGKTT EPLISLNKSH LNFSSLLIGR
4110 4120 4130 4140 4150
EARETVQIIN KEEQGFDFSF QDNSRYSEGF SNSLLVCPME GWIPPLSRFP
4160 4170 4180 4190 4200
IDIFFTPKQE GDVNFNLICN VEKKVHPVTL NVKAEGYTMN VEIKCKDRTG
4210 4220 4230 4240 4250
SITLLTPNQT NIINFYEVEL NECVQCEFNF INTGKFTFSF QAQLCGSKTL
4260 4270 4280 4290 4300
LQYLEFSPID STVDVGQSVH ATLSFQPLKK CVLTDLELII KISHGPTFMC
4310 4320 4330 4340 4350
NISGCAVSPA IHFSFTSYNF GTCFIYQAGM PPYKQTLVIT NKEETPMSID
4360 4370 4380 4390 4400
CLYTNTTHLE VNSRVDVVKP GNTLEIPITF YPRESINYQE LIPFEINGLS
4410 4420 4430 4440 4450
QQTVEIKGKG TKMKILVLDP ANRIVKLGAV LPGQVVKRTV SIMNNSLAQL
4460 4470 4480 4490 4500
TFNQSILFTI PELQEPKVLT LAPFHNITLK PKEVCKLEVI FAPKKRVPPF
4510 4520 4530 4540 4550
SEEVFMECMG LLRPLFLLSG CCQALEISLD QEHIPFGPVV YQTQATRRIL
4560 4570 4580 4590 4600
MMNTGDVGAR FKWDIKKFEP HFSISPEEGY ITSGMEVSFE VTYHPTEVGK
4610 4620 4630 4640 4650
ESLCKNILCY IQGGSPLSLT LSGVCVGPPA VKEVVNFTCQ VRSKHTQTIL
4660 4670 4680 4690 4700
LSNRTNQTWN LHPIFEGEHW EGPEFITLEA HQQNKPYEIT YRPRTMNLEN
4710 4720 4730 4740 4750
RKHQGTLFFP LPDGTGWLYA LHGTSELPKA VANIYREVPC KTPYTELLPI
4760 4770 4780 4790 4800
TNWLNKPQRF RVIVEILKPE KPDLSITMKG LDYIDVLSGS KKDYKLNFFS
4810 4820 4830 4840 4850
HKEGTYAAKV IFRNEVTNEF LYYNVSFRVI PSGIIKTIEM VTPVRQVASA
4860 4870 4880 4890 4900
SIKLENPLPY SVTFSTECRM PDIALPSQFV VPANSEGTFS FEFQPLKAGE
4910 4920 4930 4940 4950
TFGRLTLHNT DLGYYQYELY LKATPALPEK PVHFQTVLGS SQIILVKFIN
4960 4970 4980 4990 5000
YTRQRTEYYC RTDCTDFHAE KLINAAPGGQ GGTEASVEVL FEPSHLGETK
5010 5020 5030 5040 5050
GILILSSLAG GEYIIPLFGM ALPPKPQGPF SIRAGYSIII PFKNVFYHMV
5060 5070 5080 5090 5100
TFSIIVDNPA FTIRAGESVR PKKINNITVS FEGNPSGSKT PITTKLTVSC
5110 5120
PPGEGSETGV KWVYYLKGIT L
The sequence of this isoform differs from the canonical sequence as follows:
1-3823: Missing.
3824-3824: E → M
4887-5121: GTFSFEFQPL...WVYYLKGITL → RWGLTASSRLECSGMIIAPCSLKLLQSRPPPASAS
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QQJ7 | J3QQJ7_HUMAN | Hydrocephalus-inducing protein homo... | HYDIN | 833 | Annotation score: | ||
F8WD03 | F8WD03_HUMAN | Hydrocephalus-inducing protein homo... | HYDIN | 725 | Annotation score: | ||
J3QL79 | J3QL79_HUMAN | Hydrocephalus-inducing protein homo... | HYDIN | 528 | Annotation score: | ||
H0YF91 | H0YF91_HUMAN | Hydrocephalus-inducing protein homo... | HYDIN | 204 | Annotation score: | ||
H0YH52 | H0YH52_HUMAN | Hydrocephalus-inducing protein homo... | HYDIN | 127 | Annotation score: | ||
F5H8I6 | F5H8I6_HUMAN | Hydrocephalus-inducing protein homo... | HYDIN | 39 | Annotation score: | ||
J3KRJ6 | J3KRJ6_HUMAN | Hydrocephalus-inducing protein homo... | HYDIN | 113 | Annotation score: | ||
J3KTP9 | J3KTP9_HUMAN | Hydrocephalus-inducing protein homo... | HYDIN | 151 | Annotation score: | ||
A0A087WVK9 | A0A087WVK9_HUMAN | Hydrocephalus-inducing protein homo... | HYDIN | 82 | Annotation score: | ||
F5GXK3 | F5GXK3_HUMAN | Hydrocephalus-inducing protein homo... | HYDIN | 36 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 299 | L → P in BAB14314 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 313 | L → M in AAH28351 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 460 | K → T in BAB14314 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 532 | T → I in AAH28351 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 584 | T → I in BAG61096 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 881 | D → N in BAG61096 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 3945 | S → N in AAH43273 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 4663 | P → T in AAH43273 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 4667 | G → V in BAB15527 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031837 | 451 | R → P. Corresponds to variant dbSNP:rs7200485Ensembl. | 1 | |
Natural variantiVAR_031838 | 584 | T → N. Corresponds to variant dbSNP:rs7200126Ensembl. | 1 | |
Natural variantiVAR_031839 | 690 | T → A. Corresponds to variant dbSNP:rs10744982Ensembl. | 1 | |
Natural variantiVAR_031840 | 724 | N → D. Corresponds to variant dbSNP:rs3817211Ensembl. | 1 | |
Natural variantiVAR_059667 | 1077 | I → V. Corresponds to variant dbSNP:rs6416709Ensembl. | 1 | |
Natural variantiVAR_059668 | 1228 | V → L. Corresponds to variant dbSNP:rs1774513Ensembl. | 1 | |
Natural variantiVAR_059669 | 1534 | I → V. Corresponds to variant dbSNP:rs1774303Ensembl. | 1 | |
Natural variantiVAR_051036 | 1718 | V → M. Corresponds to variant dbSNP:rs783762Ensembl. | 1 | |
Natural variantiVAR_051037 | 1892 | R → H. Corresponds to variant dbSNP:rs783732Ensembl. | 1 | |
Natural variantiVAR_051038 | 1952 | R → Q. Corresponds to variant dbSNP:rs17321570Ensembl. | 1 | |
Natural variantiVAR_059670 | 2087 | R → C. Corresponds to variant dbSNP:rs1774541Ensembl. | 1 | |
Natural variantiVAR_051039 | 2099 | V → M. Corresponds to variant dbSNP:rs1798337Ensembl. | 1 | |
Natural variantiVAR_059671 | 2242 | Q → R. Corresponds to variant dbSNP:rs2258307Ensembl. | 1 | |
Natural variantiVAR_051040 | 2276 | Q → R. Corresponds to variant dbSNP:rs1815707Ensembl. | 1 | |
Natural variantiVAR_059672 | 2298 | R → G. Corresponds to variant dbSNP:rs1774360Ensembl. | 1 | |
Natural variantiVAR_051041 | 2306 | E → G. Corresponds to variant dbSNP:rs2502726EnsemblClinVar. | 1 | |
Natural variantiVAR_051042 | 2445 | N → I. Corresponds to variant dbSNP:rs1798532Ensembl. | 1 | |
Natural variantiVAR_061666 | 2455 | P → Q. Corresponds to variant dbSNP:rs1798531EnsemblClinVar. | 1 | |
Natural variantiVAR_051043 | 2502 | L → S. Corresponds to variant dbSNP:rs1798529Ensembl. | 1 | |
Natural variantiVAR_059673 | 2530 | K → E. Corresponds to variant dbSNP:rs1798528Ensembl. | 1 | |
Natural variantiVAR_051044 | 2558 | G → E. Corresponds to variant dbSNP:rs8044142Ensembl. | 1 | |
Natural variantiVAR_059674 | 2570 | D → N. Corresponds to variant dbSNP:rs8044001Ensembl. | 1 | |
Natural variantiVAR_051045 | 2589 | K → R. Corresponds to variant dbSNP:rs1774395Ensembl. | 1 | |
Natural variantiVAR_059675 | 2694 | I → S. Corresponds to variant dbSNP:rs1774449Ensembl. | 1 | |
Natural variantiVAR_051046 | 2932 | P → L. Corresponds to variant dbSNP:rs11075812Ensembl. | 1 | |
Natural variantiVAR_051047 | 2937 | E → K. Corresponds to variant dbSNP:rs8047935Ensembl. | 1 | |
Natural variantiVAR_051048 | 2939 | R → K. Corresponds to variant dbSNP:rs7188837Ensembl. | 1 | |
Natural variantiVAR_051049 | 2994 | E → G. Corresponds to variant dbSNP:rs12102425Ensembl. | 1 | |
Natural variantiVAR_051050 | 3116 | T → R. Corresponds to variant dbSNP:rs1774423Ensembl. | 1 | |
Natural variantiVAR_051051 | 3269 | Y → D. Corresponds to variant dbSNP:rs7197263Ensembl. | 1 | |
Natural variantiVAR_059676 | 3291 | A → P. Corresponds to variant dbSNP:rs1798440Ensembl. | 1 | |
Natural variantiVAR_059677 | 3316 | L → P. Corresponds to variant dbSNP:rs1774331Ensembl. | 1 | |
Natural variantiVAR_059678 | 3739 | A → T. Corresponds to variant dbSNP:rs1774504Ensembl. | 1 | |
Natural variantiVAR_059679 | 3742 | V → I. Corresponds to variant dbSNP:rs1798413Ensembl. | 1 | |
Natural variantiVAR_051052 | 3811 | R → H. Corresponds to variant dbSNP:rs13338821Ensembl. | 1 | |
Natural variantiVAR_059680 | 3840 | V → L. Corresponds to variant dbSNP:rs1798325Ensembl. | 1 | |
Natural variantiVAR_059681 | 3869 | M → R. Corresponds to variant dbSNP:rs7192347Ensembl. | 1 | |
Natural variantiVAR_051053 | 3899 | V → M. Corresponds to variant dbSNP:rs1626593Ensembl. | 1 | |
Natural variantiVAR_059682 | 4005 | T → A. Corresponds to variant dbSNP:rs1539302Ensembl. | 1 | |
Natural variantiVAR_051054 | 4026 | A → T. Corresponds to variant dbSNP:rs11075798Ensembl. | 1 | |
Natural variantiVAR_051055 | 4088 | K → R. Corresponds to variant dbSNP:rs1774416Ensembl. | 1 | |
Natural variantiVAR_059683 | 4160 | E → Q. Corresponds to variant dbSNP:rs1798314Ensembl. | 1 | |
Natural variantiVAR_051056 | 4270 | H → Y. Corresponds to variant dbSNP:rs1891343Ensembl. | 1 | |
Natural variantiVAR_059684 | 4363 | S → C. Corresponds to variant dbSNP:rs1770434Ensembl. | 1 | |
Natural variantiVAR_059685 | 4412 | K → E. Corresponds to variant dbSNP:rs1774480Ensembl. | 1 | |
Natural variantiVAR_059686 | 4552 | M → L. Corresponds to variant dbSNP:rs1770442Ensembl. | 1 | |
Natural variantiVAR_051058 | 4606 | N → K. Corresponds to variant dbSNP:rs783898Ensembl. | 1 | |
Natural variantiVAR_059687 | 4869 | R → Q. Corresponds to variant dbSNP:rs2795652Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024684 | 1 – 3823 | Missing in isoform 2. 1 PublicationAdd BLAST | 3823 | |
Alternative sequenceiVSP_042692 | 1 | M → MESAGGFKLGMEPLSGGGVC EKKKLLKM in isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_046818 | 1 | M → MESAGGFKLGEKKKLLKM in isoform 7. 1 Publication | 1 | |
Alternative sequenceiVSP_024687 | 693 – 708 | CVVPA…EVDFG → YCSPACSSPESPPSLQ in isoform 5. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_024688 | 709 – 5121 | Missing in isoform 5. 1 PublicationAdd BLAST | 4413 | |
Alternative sequenceiVSP_042693 | 923 | S → R in isoform 6 and isoform 7. 1 Publication | 1 | |
Alternative sequenceiVSP_042694 | 924 – 5121 | Missing in isoform 6 and isoform 7. 1 PublicationAdd BLAST | 4198 | |
Alternative sequenceiVSP_024691 | 1015 – 1017 | IVK → VRG in isoform 4. 2 Publications | 3 | |
Alternative sequenceiVSP_024692 | 1018 – 5121 | Missing in isoform 4. 2 PublicationsAdd BLAST | 4104 | |
Alternative sequenceiVSP_024697 | 3824 | E → M in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_024698 | 4887 – 5121 | GTFSF…KGITL → RWGLTASSRLECSGMIIAPC SLKLLQSRPPPASAS in isoform 2. 1 PublicationAdd BLAST | 235 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022933 mRNA Translation: BAB14314.1 AK026688 mRNA Translation: BAB15527.1 Frameshift. AK299016 mRNA Translation: BAG61096.1 AK299348 mRNA Translation: BAG61346.1 AC027281 Genomic DNA No translation available. AC099495 Genomic DNA No translation available. AC138625 Genomic DNA No translation available. BC028351 mRNA Translation: AAH28351.2 Different initiation. BC043273 mRNA Translation: AAH43273.1 AL122038 mRNA Translation: CAB59178.1 AL133042 mRNA Translation: CAB61370.1 AL137259 mRNA Translation: CAB70660.1 |
CCDSi | CCDS10897.1 [Q4G0P3-5] CCDS56004.1 [Q4G0P3-8] CCDS56005.1 [Q4G0P3-10] CCDS59269.1 [Q4G0P3-1] |
PIRi | T42699 T46330 |
RefSeqi | NP_001185471.1, NM_001198542.1 [Q4G0P3-8] NP_001185472.1, NM_001198543.1 [Q4G0P3-10] NP_001257903.1, NM_001270974.2 [Q4G0P3-1] NP_060028.2, NM_017558.4 [Q4G0P3-5] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022933 mRNA Translation: BAB14314.1 AK026688 mRNA Translation: BAB15527.1 Frameshift. AK299016 mRNA Translation: BAG61096.1 AK299348 mRNA Translation: BAG61346.1 AC027281 Genomic DNA No translation available. AC099495 Genomic DNA No translation available. AC138625 Genomic DNA No translation available. BC028351 mRNA Translation: AAH28351.2 Different initiation. BC043273 mRNA Translation: AAH43273.1 AL122038 mRNA Translation: CAB59178.1 AL133042 mRNA Translation: CAB61370.1 AL137259 mRNA Translation: CAB70660.1 |
CCDSi | CCDS10897.1 [Q4G0P3-5] CCDS56004.1 [Q4G0P3-8] CCDS56005.1 [Q4G0P3-10] CCDS59269.1 [Q4G0P3-1] |
PIRi | T42699 T46330 |
RefSeqi | NP_001185471.1, NM_001198542.1 [Q4G0P3-8] NP_001185472.1, NM_001198543.1 [Q4G0P3-10] NP_001257903.1, NM_001270974.2 [Q4G0P3-1] NP_060028.2, NM_017558.4 [Q4G0P3-5] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2E6J | NMR | - | A | 459-563 | [»] | |
2YS4 | NMR | - | A | 182-296 | [»] | |
BMRBi | Q4G0P3 | |||||
SMRi | Q4G0P3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120142, 10 interactors |
IntActi | Q4G0P3, 5 interactors |
STRINGi | 9606.ENSP00000377197 |
PTM databases
iPTMneti | Q4G0P3 |
PhosphoSitePlusi | Q4G0P3 |
Genetic variation databases
BioMutai | HYDIN |
DMDMi | 327478578 |
Proteomic databases
EPDi | Q4G0P3 |
MassIVEi | Q4G0P3 |
MaxQBi | Q4G0P3 |
PaxDbi | Q4G0P3 |
PeptideAtlasi | Q4G0P3 |
PRIDEi | Q4G0P3 |
ProteomicsDBi | 27301 62119 [Q4G0P3-1] 62120 [Q4G0P3-2] 62121 [Q4G0P3-5] 62122 [Q4G0P3-6] 62123 [Q4G0P3-8] |
Protocols and materials databases
Antibodypediai | 66504, 47 antibodies from 12 providers |
DNASUi | 54768 |
Genome annotation databases
Organism-specific databases
CTDi | 54768 |
DisGeNETi | 54768 |
GeneCardsi | HYDIN |
GeneReviewsi | HYDIN |
HGNCi | HGNC:19368, HYDIN |
HPAi | ENSG00000157423, Tissue enhanced (brain, choroid plexus) |
MalaCardsi | HYDIN |
MIMi | 608647, phenotype 610812, gene |
neXtProti | NX_Q4G0P3 |
OpenTargetsi | ENSG00000157423 |
Orphaneti | 244, Primary ciliary dyskinesia |
PharmGKBi | PA134866950 |
VEuPathDBi | HostDB:ENSG00000157423 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ4F, Eukaryota |
GeneTreei | ENSGT00610000086095 |
HOGENOMi | CLU_000116_1_0_1 |
InParanoidi | Q4G0P3 |
OMAi | AHLQMEV |
OrthoDBi | 3322at2759 |
PhylomeDBi | Q4G0P3 |
TreeFami | TF340616 |
Enzyme and pathway databases
PathwayCommonsi | Q4G0P3 |
SignaLinki | Q4G0P3 |
SIGNORi | Q4G0P3 |
Miscellaneous databases
BioGRID-ORCSi | 54768, 46 hits in 1056 CRISPR screens |
ChiTaRSi | HYDIN, human |
EvolutionaryTracei | Q4G0P3 |
GenomeRNAii | 54768 |
Pharosi | Q4G0P3, Tbio |
PROi | PR:Q4G0P3 |
RNActi | Q4G0P3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157423, Expressed in bronchial epithelial cell and 149 other tissues |
ExpressionAtlasi | Q4G0P3, baseline and differential |
Genevisiblei | Q4G0P3, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 22 hits 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR031549, ASH IPR033305, Hydin-like IPR033768, Hydin_ADK IPR013783, Ig-like_fold IPR027417, P-loop_NTPase |
PANTHERi | PTHR23053, PTHR23053, 1 hit |
Pfami | View protein in Pfam PF15780, ASH, 1 hit PF17213, Hydin_ADK, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HYDIN_HUMAN | |
Accessioni | Q4G0P3Primary (citable) accession number: Q4G0P3 Secondary accession number(s): A6NC70 Q9UBE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | April 5, 2011 | |
Last modified: | May 25, 2022 | |
This is version 148 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references