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UniProtKB - Q4G0P3 (HYDIN_HUMAN)

Entry version 148 (25 May 2022)
Sequence version 3 (05 Apr 2011)
Previous versions | rss
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Protein

Hydrocephalus-inducing protein homolog

Gene

HYDIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for ciliary motility.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q4G0P3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q4G0P3

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q4G0P3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hydrocephalus-inducing protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HYDIN
Synonyms:HYDIN1, KIAA1864
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19368, HYDIN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610812, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q4G0P3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000157423

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ciliary dyskinesia, primary, 5 (CILD5)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive form of primary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. CILD5 is characterized by early onset of a progressive decline in lung function due to an inability to clear mucus and particles from the airways. Affected individuals have recurrent infections of the sinuses, ears, airways, and lungs. Sperm motility is also decreased. Individuals with CILD5 do not have situs inversus.
Related information in OMIM

Keywords - Diseasei

Ciliopathy, Kartagener syndrome, Primary ciliary dyskinesia

Organism-specific databases

DisGeNET

More...DisGeNETi		54768

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		HYDIN

MalaCards human disease database

More...MalaCardsi		HYDIN
MIMi608647, phenotype

Open Targets

More...OpenTargetsi		ENSG00000157423

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		244, Primary ciliary dyskinesia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134866950

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q4G0P3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HYDIN

Domain mapping of disease mutations (DMDM)

More...DMDMi		327478578

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002848441 – 5121Hydrocephalus-inducing protein homologAdd BLAST5121

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q4G0P3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q4G0P3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q4G0P3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q4G0P3

PeptideAtlas

More...PeptideAtlasi		Q4G0P3

PRoteomics IDEntifications database

More...PRIDEi		Q4G0P3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		27301
62119 [Q4G0P3-1]
62120 [Q4G0P3-2]
62121 [Q4G0P3-5]
62122 [Q4G0P3-6]
62123 [Q4G0P3-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q4G0P3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q4G0P3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157423, Expressed in bronchial epithelial cell and 149 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q4G0P3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q4G0P3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000157423, Tissue enhanced (brain, choroid plexus)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KIF9.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120142, 10 interactors

Protein interaction database and analysis system

More...IntActi		Q4G0P3, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377197

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q4G0P3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

15121
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q4G0P3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q4G0P3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q4G0P3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni363 – 754Interaction with KIF9By similarityAdd BLAST392
Regioni956 – 987DisorderedSequence analysisAdd BLAST32
Regioni1925 – 1951DisorderedSequence analysisAdd BLAST27
Regioni2155 – 2186DisorderedSequence analysisAdd BLAST32
Regioni2333 – 2459DisorderedSequence analysisAdd BLAST127
Regioni2482 – 2534DisorderedSequence analysisAdd BLAST53
Regioni2664 – 2684DisorderedSequence analysisAdd BLAST21
Regioni3852 – 3874DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1908 – 1933Sequence analysisAdd BLAST26
Coiled coili2267 – 2365Sequence analysisAdd BLAST99
Coiled coili2504 – 2549Sequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1936 – 1951Polar residuesSequence analysisAdd BLAST16
Compositional biasi2333 – 2374Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi2395 – 2426Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi2440 – 2455Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi2489 – 2534Basic and acidic residuesSequence analysisAdd BLAST46
Compositional biasi3856 – 3874Polar residuesSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQ4F, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00610000086095

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000116_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4G0P3

Identification of Orthologs from Complete Genome Data

More...OMAi		AHLQMEV

Database of Orthologous Groups

More...OrthoDBi		3322at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q4G0P3

TreeFam database of animal gene trees

More...TreeFami		TF340616

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 22 hits
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031549, ASH
IPR033305, Hydin-like
IPR033768, Hydin_ADK
IPR013783, Ig-like_fold
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR23053, PTHR23053, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15780, ASH, 1 hit
PF17213, Hydin_ADK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4G0P3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSRRLEESM GAVQMGLVNM FKGFQSKVLP PLSPKVVTEE EVNRMLTPSE 
        60         70         80         90        100
FLKEMSLTTE QRLAKTRLMC RPQIIELLDM GETTHQKFSG IDLDQALFQP 
       110        120        130        140        150
FPSEIIFQNY TPCEVYEVPL ILRNNDKIPR LVKVVEESSP YFKVISPKDI 
       160        170        180        190        200
GHKVAPGVPS IFRILFTPEE NKDYAHTLTC VTEREKFIVP IKARGARAIL 
       210        220        230        240        250
DFPDKLNFST CPVKYSTQKI LLVRNIGNKN AVFHIKTCRP FSIEPAIGTL 
       260        270        280        290        300
NVGESMQLEV EFEPQSVGDH SGRLIVCYDT GEKVFVSLYG AAIDMNIRLD 
       310        320        330        340        350
KNSLTIEKTY ISLANQRTIT IHNRSNIIAH FLWKVFATQQ EEDREKYRAC 
       360        370        380        390        400
DDLIKEEKDE TDEFFEECIT DPLLREHLSV LSRTFANQRR LVQGDSKLFF 
       410        420        430        440        450
NNVFTVEPLE GDVWPNSSAE ITVYFNPLEA KLYQQTIYCD ILGREIRLPL 
       460        470        480        490        500
RIKGEGMGPK IHFNFELLDI GKVFTGSAHC YEAILYNKGS IDALFNMTPP 
       510        520        530        540        550
TSALGACFVF SPKEGIIEPS GVQAIQISFS STILGNFEEE FLVNVNGSPE 
       560        570        580        590        600
PVKLTIRGCV IGPTFHFNVP ALHFGDVSFG FPHTLICSLN NTSLIPMTYK 
       610        620        630        640        650
LRIPGDGLGH KSISYCEQHV DYKRPSWTKE EISSMKPKEF TISPDCGTIR 
       660        670        680        690        700
PQGFAAIRVT LCSNTVQKYE LALVVDVEGI GEEVLALLIT ARCVVPALHL 
       710        720        730        740        750
VNTEVDFGHC FLKYPYEKTL QLANQDDLPG FYEVQPQVCE EVPTVLFSSP 
       760        770        780        790        800
TPSGVISPSS TIHIPLVLET QVTGEHRSTV YISIFGSQDP PLVCHLKSAG 
       810        820        830        840        850
EGPVIYVHPN QVDFGNIYVL KDSSRILNLC NQSFIPAFFQ AHMAHKKSLW 
       860        870        880        890        900
TIEPNEGMVP PETDVQLALT ANLNDTLTFK DCVILDIENS STYRIPVQAS 
       910        920        930        940        950
GTGSTIVSDK PFAPELNLGA HFSLDTHYYH FKLINKGRRI QQLFWMNDSF 
       960        970        980        990       1000
RPQAKLSKKG RVKKGHAHVQ PQPSGSQEPR DPQSPVFHLH PASMELYPGQ 
      1010       1020       1030       1040       1050
AIDVILEGYS ATPRIVKEKL VCHAIIGAQK GKSLVMAVNI TCEFVAPLIQ 
      1060       1070       1080       1090       1100
LSTKQLIYRL EKKPNSILKP DYQPLAIKNI STLPVNLLLS TSGPFFICET 
      1110       1120       1130       1140       1150
DKSLLPATPE PIKLEIDEEK NLLIKFDPSY RNDLNNWVAE EILAIKYVEH 
      1160       1170       1180       1190       1200
PQIDSLDLRG EVHYPNLSFE TKELDFGCIL NDTELIRYVT ITNCSPLVVK 
      1210       1220       1230       1240       1250
FRWFFLVNDE ENQIRFVTLP KKPYSAPVSQ MESIPATSEA ASPPAILVTV 
      1260       1270       1280       1290       1300
ESPEMDLNDF VKTVLVDEDA RPEEKELRKT KASSVISDEI KISSTEIERI 
      1310       1320       1330       1340       1350
YSSQSQVEDQ ESLQTCEQNE MLSIGIEEVF DILPLFGVLQ PHSSHQISFT 
      1360       1370       1380       1390       1400
FYGHANIIAQ AKALCEVEEG PTYEITLKGE ASLVNYSFDT KDIHYGLQLF 
      1410       1420       1430       1440       1450
DHVTEREITL TNMGKVGFEF KVLTDHQSSP DNLLPGVPLI LPVSGFISSH 
      1460       1470       1480       1490       1500
QEQVLKVYYL PGVPEVFKRS FQIQIAHLDP ENITLSGEGI FPQICLDLPR 
      1510       1520       1530       1540       1550
NLTANEKYEM FLNQARKNTD KEYNKCEMLD HFDIITEEVP EDEPAEVSAH 
      1560       1570       1580       1590       1600
LQMEVERLIV QSYVLEHQKT TTPDPMDDPC FSHRSRRKLA KIQLPEYILD 
      1610       1620       1630       1640       1650
FGYIILGEVR THIIKIINTS HFPVSFHADK RVLHETGFST ELDRVKNLPH 
      1660       1670       1680       1690       1700
CETEIFEVRF DPQGANLPVG SKEVILPIKV VGGPTVHICL QAKVTIPTMT 
      1710       1720       1730       1740       1750
LSRGKVDFAT IQCGQCLVET IQLSNHLQVP CEWFVQSQKP VDKLEKHMPK 
      1760       1770       1780       1790       1800
YLRQKLRAEL KPKTRIFEIQ PISGVLDPGE KSNVQVKFMP KEEKFYSQTL 
      1810       1820       1830       1840       1850
VFQIAQSAQK LTLLARGQGL EPRLEFSPSV LDLGPLLLCA PGDEAEVIVK 
      1860       1870       1880       1890       1900
NPCNFPIEFY SLEFDQQYLI EEKILRKLKG YDSYNTLLLP PRNPGEKLPP 
      1910       1920       1930       1940       1950
ELYEYFKEIK KSKEEQMRAK YLENLAQENE EEDITSSDQG TSNSTKRTSL 
      1960       1970       1980       1990       2000
SRGISVTSNL EEWHALLVES KTYLEEEEDE ESLEKIIFQT DKLQSIDSHS 
      2010       2020       2030       2040       2050
MEEVGEVENN PVSKAIARHL GIDISAEGRL AKNRKGIAII IHGTPLSGKS 
      2060       2070       2080       2090       2100
ANAVSVAKYY NAACLSIDSI VLEAVANSNN IPGIRARELC IRAAIEQSVK 
      2110       2120       2130       2140       2150
EGEEAAQEAA VGQNVIGQGR LSTDTLGKLA SEMTLVAPEI KPGKSVRGSV 
      2160       2170       2180       2190       2200
VITKSKADSH GSGSQKQHHS HQSETPQISS SPLPPGPIHR WLSVSPSVGG 
      2210       2220       2230       2240       2250
ETGLMSCVLP DELLVQILAE RIQLSDCYRG VVFDGLDTLF AQNAAAALLC 
      2260       2270       2280       2290       2300
LLKAIGSREH IYILNMAQDY AAMKAQEKAK KEQEERKHKG ALEKEKERLQ 
      2310       2320       2330       2340       2350
NMDEEEYDAL TEEEKLTFDR GIQQALRERK KREQERLAKE MQEKKLQQEL 
      2360       2370       2380       2390       2400
ERQKEEDELK RRVKKGKQGP IKEEPPMKKS QAANKQVPPL TKVDVKMETI 
      2410       2420       2430       2440       2450
ERKISVREQT MSEKEELNKK KRNMGDVSMH GLPLVQDQED SEGDNSKDPD 
      2460       2470       2480       2490       2500
KQLAPKFKTY ELTLKDVQNI LMYWDRKQGV QLPPAGMEEA PHEPDDQRQV 
      2510       2520       2530       2540       2550
PLGGRRGRKD RERERLEKER TEKERLEREK AERERLEKLR ALEERSDWEG 
      2560       2570       2580       2590       2600
EGEEDHEGKK EKDLGVPFLD IQTPDFEGLS WKQALESDKL PKGEQILDIL 
      2610       2620       2630       2640       2650
GLGASGPPIP PPALFSIVSY PVKRPPLTMT DDLEHFVFVI PPSEDISLDE 
      2660       2670       2680       2690       2700
KKEMEIESDF LATTNTTKAQ EEQTSSSKGG KQKMKEKIDQ VFEIQKDKRH 
      2710       2720       2730       2740       2750
MALNRKVLSG EPAGTISQLS DTDLDNFNGQ HSQEKFTRLN HFRWIVPANG 
      2760       2770       2780       2790       2800
EVTLQVHFSS DEFGNFDQTF NFEILGTCCQ YQLYCRGICT YPYICQDPKV 
      2810       2820       2830       2840       2850
VFPQRKMDMK TNEVIFKKYV MSTETYYFGP LLCGKSRDKY KSSLFPGNME 
      2860       2870       2880       2890       2900
TLTILNTSLM VVEASFYFQN DVKANTYFLE PNTMVLKPNE KQILNVWAYP 
      2910       2920       2930       2940       2950
TSVGVFEDSI VCCINDNPEP AIFQLSCQGI RPELELEPRQ LHFDRLLLHR 
      2960       2970       2980       2990       3000
QESRVVLLRN VTLLPVAWRI TSLEHLGDDF TVSLMQGTIP PEAEYGLHLY 
      3010       3020       3030       3040       3050
FQPTKPVNIK KAIRLEVLDA ENLLGVVQIE NIMVFAEAYD IALDITFPKG 
      3060       3070       3080       3090       3100
AEGGLDFGIV RVTEEAKQPL QLKNRGKYEI AFSFSVDSVG ISTPNINSMI 
      3110       3120       3130       3140       3150
SVQPKKGSLT PTEKPTNVQV FFHAKKEVKI EHQPVLRCQI IEPNISEGGE 
      3160       3170       3180       3190       3200
IIASIPIKFS ANAVYSKYNI TPSSVINFGA LICGTRKSTT FTIENQGVTD 
      3210       3220       3230       3240       3250
FKFALYKLTG ESPIHQKKAA SHVRHARSRE SESFYKTGSS RAAKFSDTIQ 
      3260       3270       3280       3290       3300
KEVTTTGQAR FAHGMFTVYP GFGSIPSGGQ QVINVDCVAD AMGKCEEFIA 
      3310       3320       3330       3340       3350
IDISGRDPAV HPAGILYTLL AEACLPAFVT ENNALIFEEH QICTSANLHH 
      3360       3370       3380       3390       3400
ILQTIESGGL FVEDENKFIF CNVLVGRQAK ARFKISNVGK ITCDVNIVVR 
      3410       3420       3430       3440       3450
PISNKPFARI VDIFEVEPSK MCIASHSHAF ATVSFTPQIM QNYQCIFEAT 
      3460       3470       3480       3490       3500
LDGLPSTLAK SRGLVFDIAG EGNLPRVTVV RPVLHNQYGN PLLLFKRLLL 
      3510       3520       3530       3540       3550
GHSEKLPLIL KNNGVLPAQL HVDLQDELGV FSLKGRPTTA YIYITEENKP 
      3560       3570       3580       3590       3600
HVKAKKAHTA SLVVSPGDTA EFDVVFHSQK VGRMRGIIHL SVINNQYEET 
      3610       3620       3630       3640       3650
SIHMVGEGYE DDITLDNIHG LVAPTSQEDI SISEFTEIIE DNDMEDLVAA 
      3660       3670       3680       3690       3700
ALVDHIQFGD CHIGHSYNAS FTVTNHSQVN LIRFEWPVSA TIAFSPQMGH 
      3710       3720       3730       3740       3750
LHPGCAKDIV VTMKSDVPIN LKNMRIRCKL SRIMFQLPAD QVPDWDDRMH 
      3760       3770       3780       3790       3800
TVKWVDVPRN MPGTFTTKRK VIETDPEPAH SVLEENYQEL QLQISANVDF 
      3810       3820       3830       3840       3850
ASYHCQARDV RFKETLVYQT RVFEFDVINS GRVQLEFSWV SEDTSKAVSF 
      3860       3870       3880       3890       3900
AKPDHQGSAQ KDQLSQGTMH TGSTLDSTMD HWAEGSPQPF SVEPSSGIVP 
      3910       3920       3930       3940       3950
VGKIQKFKVK FSPLDIGDFE SNLFCQIPNL PPGEQGPVLV AKGRSTLPIC 
      3960       3970       3980       3990       4000
HFDLKDSDYI SGHQRNPELR GSSGGALDPN TRVIEFTTVG IGGKNLRTFT 
      4010       4020       4030       4040       4050
ILNPTNSTYS FCWISEEIES LQNPAAFTCL TEKGFIHPEK KAEIVFQFTP 
      4060       4070       4080       4090       4100
FHLGITESSW TFLIPEHNIT VPFLLVGKTT EPLISLNKSH LNFSSLLIGR 
      4110       4120       4130       4140       4150
EARETVQIIN KEEQGFDFSF QDNSRYSEGF SNSLLVCPME GWIPPLSRFP 
      4160       4170       4180       4190       4200
IDIFFTPKQE GDVNFNLICN VEKKVHPVTL NVKAEGYTMN VEIKCKDRTG 
      4210       4220       4230       4240       4250
SITLLTPNQT NIINFYEVEL NECVQCEFNF INTGKFTFSF QAQLCGSKTL 
      4260       4270       4280       4290       4300
LQYLEFSPID STVDVGQSVH ATLSFQPLKK CVLTDLELII KISHGPTFMC 
      4310       4320       4330       4340       4350
NISGCAVSPA IHFSFTSYNF GTCFIYQAGM PPYKQTLVIT NKEETPMSID 
      4360       4370       4380       4390       4400
CLYTNTTHLE VNSRVDVVKP GNTLEIPITF YPRESINYQE LIPFEINGLS 
      4410       4420       4430       4440       4450
QQTVEIKGKG TKMKILVLDP ANRIVKLGAV LPGQVVKRTV SIMNNSLAQL 
      4460       4470       4480       4490       4500
TFNQSILFTI PELQEPKVLT LAPFHNITLK PKEVCKLEVI FAPKKRVPPF 
      4510       4520       4530       4540       4550
SEEVFMECMG LLRPLFLLSG CCQALEISLD QEHIPFGPVV YQTQATRRIL 
      4560       4570       4580       4590       4600
MMNTGDVGAR FKWDIKKFEP HFSISPEEGY ITSGMEVSFE VTYHPTEVGK 
      4610       4620       4630       4640       4650
ESLCKNILCY IQGGSPLSLT LSGVCVGPPA VKEVVNFTCQ VRSKHTQTIL 
      4660       4670       4680       4690       4700
LSNRTNQTWN LHPIFEGEHW EGPEFITLEA HQQNKPYEIT YRPRTMNLEN 
      4710       4720       4730       4740       4750
RKHQGTLFFP LPDGTGWLYA LHGTSELPKA VANIYREVPC KTPYTELLPI 
      4760       4770       4780       4790       4800
TNWLNKPQRF RVIVEILKPE KPDLSITMKG LDYIDVLSGS KKDYKLNFFS 
      4810       4820       4830       4840       4850
HKEGTYAAKV IFRNEVTNEF LYYNVSFRVI PSGIIKTIEM VTPVRQVASA 
      4860       4870       4880       4890       4900
SIKLENPLPY SVTFSTECRM PDIALPSQFV VPANSEGTFS FEFQPLKAGE 
      4910       4920       4930       4940       4950
TFGRLTLHNT DLGYYQYELY LKATPALPEK PVHFQTVLGS SQIILVKFIN 
      4960       4970       4980       4990       5000
YTRQRTEYYC RTDCTDFHAE KLINAAPGGQ GGTEASVEVL FEPSHLGETK 
      5010       5020       5030       5040       5050
GILILSSLAG GEYIIPLFGM ALPPKPQGPF SIRAGYSIII PFKNVFYHMV 
      5060       5070       5080       5090       5100
TFSIIVDNPA FTIRAGESVR PKKINNITVS FEGNPSGSKT PITTKLTVSC 
      5110       5120 
PPGEGSETGV KWVYYLKGIT L
Length:5,121
Mass (Da):575,892
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47FB2A11C7E50A4F
GO
Isoform 2 (identifier: Q4G0P3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3823: Missing.
     3824-3824: E → M
     4887-5121: GTFSFEFQPL...WVYYLKGITL → RWGLTASSRLECSGMIIAPCSLKLLQSRPPPASAS

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:1,098
Mass (Da):123,076
Checksum:i253E0EF252881F8B
GO
Isoform 4 (identifier: Q4G0P3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1015-1017: IVK → VRG
     1018-5121: Missing.

Show »
Length:1,017
Mass (Da):114,208
Checksum:iB4AB03CA5302D5BB
GO
Isoform 5 (identifier: Q4G0P3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     693-708: CVVPALHLVNTEVDFG → YCSPACSSPESPPSLQ
     709-5121: Missing.

Show »
Length:708
Mass (Da):79,722
Checksum:i06C5B2713F7D7470
GO
Isoform 6 (identifier: Q4G0P3-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MESAGGFKLGMEPLSGGGVCEKKKLLKM
     923-923: S → R
     924-5121: Missing.

Show »
Length:950
Mass (Da):106,269
Checksum:i7236F8324AD317AF
GO
Isoform 7 (identifier: Q4G0P3-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MESAGGFKLGEKKKLLKM
     923-923: S → R
     924-5121: Missing.

Show »
Length:940
Mass (Da):105,338
Checksum:i5AE6895A825BACF8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQJ7J3QQJ7_HUMAN
Hydrocephalus-inducing protein homo...
HYDIN
833Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD03F8WD03_HUMAN
Hydrocephalus-inducing protein homo...
HYDIN
725Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL79J3QL79_HUMAN
Hydrocephalus-inducing protein homo...
HYDIN
528Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF91H0YF91_HUMAN
Hydrocephalus-inducing protein homo...
HYDIN
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH52H0YH52_HUMAN
Hydrocephalus-inducing protein homo...
HYDIN
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H8I6F5H8I6_HUMAN
Hydrocephalus-inducing protein homo...
HYDIN
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRJ6J3KRJ6_HUMAN
Hydrocephalus-inducing protein homo...
HYDIN
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTP9J3KTP9_HUMAN
Hydrocephalus-inducing protein homo...
HYDIN
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVK9A0A087WVK9_HUMAN
Hydrocephalus-inducing protein homo...
HYDIN
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXK3F5GXK3_HUMAN
Hydrocephalus-inducing protein homo...
HYDIN
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH28351 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB15527 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti299L → P in BAB14314 (PubMed:14702039).Curated1
Sequence conflicti313L → M in AAH28351 (PubMed:15489334).Curated1
Sequence conflicti460K → T in BAB14314 (PubMed:14702039).Curated1
Sequence conflicti532T → I in AAH28351 (PubMed:15489334).Curated1
Sequence conflicti584T → I in BAG61096 (PubMed:14702039).Curated1
Sequence conflicti881D → N in BAG61096 (PubMed:14702039).Curated1
Sequence conflicti3945S → N in AAH43273 (PubMed:15489334).Curated1
Sequence conflicti4663P → T in AAH43273 (PubMed:15489334).Curated1
Sequence conflicti4667G → V in BAB15527 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031837451R → P. Corresponds to variant dbSNP:rs7200485Ensembl.1
Natural variantiVAR_031838584T → N. Corresponds to variant dbSNP:rs7200126Ensembl.1
Natural variantiVAR_031839690T → A. Corresponds to variant dbSNP:rs10744982Ensembl.1
Natural variantiVAR_031840724N → D. Corresponds to variant dbSNP:rs3817211Ensembl.1
Natural variantiVAR_0596671077I → V. Corresponds to variant dbSNP:rs6416709Ensembl.1
Natural variantiVAR_0596681228V → L. Corresponds to variant dbSNP:rs1774513Ensembl.1
Natural variantiVAR_0596691534I → V. Corresponds to variant dbSNP:rs1774303Ensembl.1
Natural variantiVAR_0510361718V → M. Corresponds to variant dbSNP:rs783762Ensembl.1
Natural variantiVAR_0510371892R → H. Corresponds to variant dbSNP:rs783732Ensembl.1
Natural variantiVAR_0510381952R → Q. Corresponds to variant dbSNP:rs17321570Ensembl.1
Natural variantiVAR_0596702087R → C. Corresponds to variant dbSNP:rs1774541Ensembl.1
Natural variantiVAR_0510392099V → M. Corresponds to variant dbSNP:rs1798337Ensembl.1
Natural variantiVAR_0596712242Q → R. Corresponds to variant dbSNP:rs2258307Ensembl.1
Natural variantiVAR_0510402276Q → R. Corresponds to variant dbSNP:rs1815707Ensembl.1
Natural variantiVAR_0596722298R → G. Corresponds to variant dbSNP:rs1774360Ensembl.1
Natural variantiVAR_0510412306E → G. Corresponds to variant dbSNP:rs2502726EnsemblClinVar.1
Natural variantiVAR_0510422445N → I. Corresponds to variant dbSNP:rs1798532Ensembl.1
Natural variantiVAR_0616662455P → Q. Corresponds to variant dbSNP:rs1798531EnsemblClinVar.1
Natural variantiVAR_0510432502L → S. Corresponds to variant dbSNP:rs1798529Ensembl.1
Natural variantiVAR_0596732530K → E. Corresponds to variant dbSNP:rs1798528Ensembl.1
Natural variantiVAR_0510442558G → E. Corresponds to variant dbSNP:rs8044142Ensembl.1
Natural variantiVAR_0596742570D → N. Corresponds to variant dbSNP:rs8044001Ensembl.1
Natural variantiVAR_0510452589K → R. Corresponds to variant dbSNP:rs1774395Ensembl.1
Natural variantiVAR_0596752694I → S. Corresponds to variant dbSNP:rs1774449Ensembl.1
Natural variantiVAR_0510462932P → L. Corresponds to variant dbSNP:rs11075812Ensembl.1
Natural variantiVAR_0510472937E → K. Corresponds to variant dbSNP:rs8047935Ensembl.1
Natural variantiVAR_0510482939R → K. Corresponds to variant dbSNP:rs7188837Ensembl.1
Natural variantiVAR_0510492994E → G. Corresponds to variant dbSNP:rs12102425Ensembl.1
Natural variantiVAR_0510503116T → R. Corresponds to variant dbSNP:rs1774423Ensembl.1
Natural variantiVAR_0510513269Y → D. Corresponds to variant dbSNP:rs7197263Ensembl.1
Natural variantiVAR_0596763291A → P. Corresponds to variant dbSNP:rs1798440Ensembl.1
Natural variantiVAR_0596773316L → P. Corresponds to variant dbSNP:rs1774331Ensembl.1
Natural variantiVAR_0596783739A → T. Corresponds to variant dbSNP:rs1774504Ensembl.1
Natural variantiVAR_0596793742V → I. Corresponds to variant dbSNP:rs1798413Ensembl.1
Natural variantiVAR_0510523811R → H. Corresponds to variant dbSNP:rs13338821Ensembl.1
Natural variantiVAR_0596803840V → L. Corresponds to variant dbSNP:rs1798325Ensembl.1
Natural variantiVAR_0596813869M → R. Corresponds to variant dbSNP:rs7192347Ensembl.1
Natural variantiVAR_0510533899V → M. Corresponds to variant dbSNP:rs1626593Ensembl.1
Natural variantiVAR_0596824005T → A. Corresponds to variant dbSNP:rs1539302Ensembl.1
Natural variantiVAR_0510544026A → T. Corresponds to variant dbSNP:rs11075798Ensembl.1
Natural variantiVAR_0510554088K → R. Corresponds to variant dbSNP:rs1774416Ensembl.1
Natural variantiVAR_0596834160E → Q. Corresponds to variant dbSNP:rs1798314Ensembl.1
Natural variantiVAR_0510564270H → Y. Corresponds to variant dbSNP:rs1891343Ensembl.1
Natural variantiVAR_0596844363S → C. Corresponds to variant dbSNP:rs1770434Ensembl.1
Natural variantiVAR_0596854412K → E. Corresponds to variant dbSNP:rs1774480Ensembl.1
Natural variantiVAR_0596864552M → L. Corresponds to variant dbSNP:rs1770442Ensembl.1
Natural variantiVAR_0510584606N → K. Corresponds to variant dbSNP:rs783898Ensembl.1
Natural variantiVAR_0596874869R → Q. Corresponds to variant dbSNP:rs2795652Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0246841 – 3823Missing in isoform 2. 1 PublicationAdd BLAST3823
Alternative sequenceiVSP_0426921M → MESAGGFKLGMEPLSGGGVC EKKKLLKM in isoform 6. 1 Publication1
Alternative sequenceiVSP_0468181M → MESAGGFKLGEKKKLLKM in isoform 7. 1 Publication1
Alternative sequenceiVSP_024687693 – 708CVVPA…EVDFG → YCSPACSSPESPPSLQ in isoform 5. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_024688709 – 5121Missing in isoform 5. 1 PublicationAdd BLAST4413
Alternative sequenceiVSP_042693923S → R in isoform 6 and isoform 7. 1 Publication1
Alternative sequenceiVSP_042694924 – 5121Missing in isoform 6 and isoform 7. 1 PublicationAdd BLAST4198
Alternative sequenceiVSP_0246911015 – 1017IVK → VRG in isoform 4. 2 Publications3
Alternative sequenceiVSP_0246921018 – 5121Missing in isoform 4. 2 PublicationsAdd BLAST4104
Alternative sequenceiVSP_0246973824E → M in isoform 2. 1 Publication1
Alternative sequenceiVSP_0246984887 – 5121GTFSF…KGITL → RWGLTASSRLECSGMIIAPC SLKLLQSRPPPASAS in isoform 2. 1 PublicationAdd BLAST235

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK022933 mRNA Translation: BAB14314.1
AK026688 mRNA Translation: BAB15527.1 Frameshift.
AK299016 mRNA Translation: BAG61096.1
AK299348 mRNA Translation: BAG61346.1
AC027281 Genomic DNA No translation available.
AC099495 Genomic DNA No translation available.
AC138625 Genomic DNA No translation available.
BC028351 mRNA Translation: AAH28351.2 Different initiation.
BC043273 mRNA Translation: AAH43273.1
AL122038 mRNA Translation: CAB59178.1
AL133042 mRNA Translation: CAB61370.1
AL137259 mRNA Translation: CAB70660.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10897.1 [Q4G0P3-5]
CCDS56004.1 [Q4G0P3-8]
CCDS56005.1 [Q4G0P3-10]
CCDS59269.1 [Q4G0P3-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T42699
T46330

NCBI Reference Sequences

More...RefSeqi		NP_001185471.1, NM_001198542.1 [Q4G0P3-8]
NP_001185472.1, NM_001198543.1 [Q4G0P3-10]
NP_001257903.1, NM_001270974.2 [Q4G0P3-1]
NP_060028.2, NM_017558.4 [Q4G0P3-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000321489.9; ENSP00000314736.5; ENSG00000157423.18 [Q4G0P3-5]
ENST00000393567.7; ENSP00000377197.2; ENSG00000157423.18
ENST00000538248.5; ENSP00000444970.1; ENSG00000157423.18 [Q4G0P3-8]
ENST00000541601.5; ENSP00000437341.1; ENSG00000157423.18 [Q4G0P3-10]
ENST00000634268.1; ENSP00000489181.1; ENSG00000283022.2 [Q4G0P3-8]
ENST00000634392.1; ENSP00000489221.1; ENSG00000283022.2 [Q4G0P3-10]
ENST00000634745.1; ENSP00000489246.1; ENSG00000283022.2 [Q4G0P3-5]
ENST00000635381.2; ENSP00000489526.1; ENSG00000283022.2

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54768

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54768

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000393567.7; ENSP00000377197.2; NM_001270974.2; NP_001257903.1

UCSC genome browser

More...UCSCi		uc010vmc.3, human [Q4G0P3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022933 mRNA Translation: BAB14314.1
AK026688 mRNA Translation: BAB15527.1 Frameshift.
AK299016 mRNA Translation: BAG61096.1
AK299348 mRNA Translation: BAG61346.1
AC027281 Genomic DNA No translation available.
AC099495 Genomic DNA No translation available.
AC138625 Genomic DNA No translation available.
BC028351 mRNA Translation: AAH28351.2 Different initiation.
BC043273 mRNA Translation: AAH43273.1
AL122038 mRNA Translation: CAB59178.1
AL133042 mRNA Translation: CAB61370.1
AL137259 mRNA Translation: CAB70660.1
CCDSiCCDS10897.1 [Q4G0P3-5]
CCDS56004.1 [Q4G0P3-8]
CCDS56005.1 [Q4G0P3-10]
CCDS59269.1 [Q4G0P3-1]
PIRiT42699
T46330
RefSeqiNP_001185471.1, NM_001198542.1 [Q4G0P3-8]
NP_001185472.1, NM_001198543.1 [Q4G0P3-10]
NP_001257903.1, NM_001270974.2 [Q4G0P3-1]
NP_060028.2, NM_017558.4 [Q4G0P3-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E6JNMR-A459-563[»]
2YS4NMR-A182-296[»]
BMRBiQ4G0P3
SMRiQ4G0P3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120142, 10 interactors
IntActiQ4G0P3, 5 interactors
STRINGi9606.ENSP00000377197

PTM databases

iPTMnetiQ4G0P3
PhosphoSitePlusiQ4G0P3

Genetic variation databases

BioMutaiHYDIN
DMDMi327478578

Proteomic databases

EPDiQ4G0P3
MassIVEiQ4G0P3
MaxQBiQ4G0P3
PaxDbiQ4G0P3
PeptideAtlasiQ4G0P3
PRIDEiQ4G0P3
ProteomicsDBi27301
62119 [Q4G0P3-1]
62120 [Q4G0P3-2]
62121 [Q4G0P3-5]
62122 [Q4G0P3-6]
62123 [Q4G0P3-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		66504, 47 antibodies from 12 providers

The DNASU plasmid repository

More...DNASUi		54768

Genome annotation databases

EnsembliENST00000321489.9; ENSP00000314736.5; ENSG00000157423.18 [Q4G0P3-5]
ENST00000393567.7; ENSP00000377197.2; ENSG00000157423.18
ENST00000538248.5; ENSP00000444970.1; ENSG00000157423.18 [Q4G0P3-8]
ENST00000541601.5; ENSP00000437341.1; ENSG00000157423.18 [Q4G0P3-10]
ENST00000634268.1; ENSP00000489181.1; ENSG00000283022.2 [Q4G0P3-8]
ENST00000634392.1; ENSP00000489221.1; ENSG00000283022.2 [Q4G0P3-10]
ENST00000634745.1; ENSP00000489246.1; ENSG00000283022.2 [Q4G0P3-5]
ENST00000635381.2; ENSP00000489526.1; ENSG00000283022.2
GeneIDi54768
KEGGihsa:54768
MANE-SelectiENST00000393567.7; ENSP00000377197.2; NM_001270974.2; NP_001257903.1
UCSCiuc010vmc.3, human [Q4G0P3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54768
DisGeNETi54768

GeneCards: human genes, protein and diseases

More...GeneCardsi		HYDIN
GeneReviewsiHYDIN
HGNCiHGNC:19368, HYDIN
HPAiENSG00000157423, Tissue enhanced (brain, choroid plexus)
MalaCardsiHYDIN
MIMi608647, phenotype
610812, gene
neXtProtiNX_Q4G0P3
OpenTargetsiENSG00000157423
Orphaneti244, Primary ciliary dyskinesia
PharmGKBiPA134866950
VEuPathDBiHostDB:ENSG00000157423

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQ4F, Eukaryota
GeneTreeiENSGT00610000086095
HOGENOMiCLU_000116_1_0_1
InParanoidiQ4G0P3
OMAiAHLQMEV
OrthoDBi3322at2759
PhylomeDBiQ4G0P3
TreeFamiTF340616

Enzyme and pathway databases

PathwayCommonsiQ4G0P3
SignaLinkiQ4G0P3
SIGNORiQ4G0P3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54768, 46 hits in 1056 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HYDIN, human
EvolutionaryTraceiQ4G0P3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54768
PharosiQ4G0P3, Tbio

Protein Ontology

More...PROi		PR:Q4G0P3
RNActiQ4G0P3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000157423, Expressed in bronchial epithelial cell and 149 other tissues
ExpressionAtlasiQ4G0P3, baseline and differential
GenevisibleiQ4G0P3, HS

Family and domain databases

Gene3Di2.60.40.10, 22 hits
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR031549, ASH
IPR033305, Hydin-like
IPR033768, Hydin_ADK
IPR013783, Ig-like_fold
IPR027417, P-loop_NTPase
PANTHERiPTHR23053, PTHR23053, 1 hit
PfamiView protein in Pfam
PF15780, ASH, 1 hit
PF17213, Hydin_ADK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHYDIN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4G0P3
Secondary accession number(s): A6NC70
, A6NLZ0, B4DQY4, B4DRN4, F5H6V3, Q8N3H8, Q8N3P6, Q8TC08, Q96JG3, Q96SS4, Q9H5U3, Q9H9B8, Q9NTI0, Q9UBE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 5, 2011
Last modified: May 25, 2022
This is version 148 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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