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Entry version 123 (07 Apr 2021)
Sequence version 2 (24 Jul 2007)
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Protein

NAD kinase 2, mitochondrial

Gene

NADK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial NAD+ kinase that phosphorylates NAD+ to yield NADP+. Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD+ kinase activity and may not be relevant in vivo.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by NADH, NADPH and NADP+.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.022 mM for NAD+1 Publication
  2. KM=1.7 mM for ATP1 Publication
  3. KM=1.2 mM for tetrapolyphosphate1 Publication
  1. Vmax=0.091 µmol/min/mg enzyme1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q4G0N4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196807, Nicotinate metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q4G0N4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NAD kinase 2, mitochondrial (EC:2.7.1.23)
Alternative name(s):
Mitochondrial NAD kinase
NAD kinase domain-containing protein 1, mitochondrial
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NADK2
Synonyms:C5orf33, MNADK, NADKD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26404, NADK2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615787, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q4G0N4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000152620.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

2,4-dienoyl-CoA reductase deficiency (DECRD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction. Affected individuals have a severe encephalopathy with neurologic and metabolic abnormalities beginning in early infancy. Laboratory studies show increased C10:2 carnitine levels and hyperlysinemia.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
133686

MalaCards human disease database

More...
MalaCardsi
NADK2
MIMi616034, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000152620

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
431361, Progressive encephalopathy with leukodystrophy due to DECR deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162380039

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q4G0N4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NADK2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156630863

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 62MitochondrionSequence analysisAdd BLAST62
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029629263 – 442NAD kinase 2, mitochondrialAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei76N6-acetyllysine; alternateBy similarity1
Modified residuei76N6-succinyllysine; alternateBy similarity1
Modified residuei188PhosphoserineCombined sources1
Modified residuei302N6-succinyllysineBy similarity1
Modified residuei317N6-acetyllysine; alternateBy similarity1
Modified residuei317N6-succinyllysine; alternateBy similarity1
Modified residuei367PhosphoserineCombined sources1
Modified residuei397N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q4G0N4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q4G0N4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q4G0N4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q4G0N4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4G0N4

PeptideAtlas

More...
PeptideAtlasi
Q4G0N4

PRoteomics IDEntifications database

More...
PRIDEi
Q4G0N4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62113 [Q4G0N4-1]
62114 [Q4G0N4-2]
62115 [Q4G0N4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4G0N4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4G0N4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152620, Expressed in liver and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q4G0N4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4G0N4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000152620, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
126369, 29 interactors

Protein interaction database and analysis system

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IntActi
Q4G0N4, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371362

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q4G0N4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NAD kinase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4180, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006320

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039559_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4G0N4

Identification of Orthologs from Complete Genome Data

More...
OMAi
NVGCEVK

Database of Orthologous Groups

More...
OrthoDBi
1416565at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4G0N4

TreeFam database of animal gene trees

More...
TreeFami
TF314077

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.200.30, 1 hit
3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR017437, ATP-NAD_kinase_PpnK-typ_C
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002504, NADK
IPR012355, NADK2_mit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01513, NAD_kinase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017565, Kin_ATP-NAD_euk, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111331, SSF111331, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4G0N4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTCYRGFLLG SCCRVAGGRA AALRGPGAGG PAARPRLGGD GGGRRHLGQG
60 70 80 90 100
QPRELAGCGS RADGGFRPSR VVVVAKTTRY EFEQQRYRYA ELSEEDLKQL
110 120 130 140 150
LALKGSSYSG LLERHHIHTK NVEHIIDSLR NEGIEVRLVK RREYDEETVR
160 170 180 190 200
WADAVIAAGG DGTMLLAASK VLDRLKPVIG VNTDPERSEG HLCLPVRYTH
210 220 230 240 250
SFPEALQKFY RGEFRWLWRQ RIRLYLEGTG INPVPVDLHE QQLSLNQHNR
260 270 280 290 300
ALNIERAHDE RSEASGPQLL PVRALNEVFI GESLSSRASY YEISVDDGPW
310 320 330 340 350
EKQKSSGLNL CTGTGSKAWS FNINRVATQA VEDVLNIAKR QGNLSLPLNR
360 370 380 390 400
ELVEKVTNEY NESLLYSPEE PKILFSIREP IANRVFSSSR QRCFSSKVCV
410 420 430 440
RSRCWDACMV VDGGTSFEFN DGAIASMMIN KEDELRTVLL EQ
Length:442
Mass (Da):49,433
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i289EA16979AF14D8
GO
Isoform 2 (identifier: Q4G0N4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     288-319: Missing.

Show »
Length:410
Mass (Da):45,972
Checksum:iBAED88797577AAC2
GO
Isoform 3 (identifier: Q4G0N4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.

Show »
Length:279
Mass (Da):31,716
Checksum:i8A6977E19682F747
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z8V7B7Z8V7_HUMAN
NAD kinase 2, mitochondrial
NADK2
301Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9H7H0Y9H7_HUMAN
NAD kinase 2, mitochondrial
NADK2
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGV3A0A0C4DGV3_HUMAN
NAD kinase 2, mitochondrial
NADK2
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHI4D6RHI4_HUMAN
NAD kinase 2, mitochondrial
NADK2
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0271921 – 163Missing in isoform 3. 2 PublicationsAdd BLAST163
Alternative sequenceiVSP_027193288 – 319Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055158 mRNA Translation: BAB70864.1
AC008807 Genomic DNA No translation available.
AC008942 Genomic DNA No translation available.
BC045565 mRNA No translation available.
BC062567 mRNA Translation: AAH62567.1
AY360463 mRNA Translation: AAQ62967.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3917.1 [Q4G0N4-3]
CCDS47197.1 [Q4G0N4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001078880.1, NM_001085411.2 [Q4G0N4-1]
NP_001274269.1, NM_001287340.1 [Q4G0N4-3]
NP_001274270.1, NM_001287341.1
NP_694558.1, NM_153013.4 [Q4G0N4-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282512; ENSP00000282512; ENSG00000152620 [Q4G0N4-3]
ENST00000381937; ENSP00000371362; ENSG00000152620 [Q4G0N4-1]
ENST00000397338; ENSP00000380499; ENSG00000152620 [Q4G0N4-3]
ENST00000514504; ENSP00000421029; ENSG00000152620 [Q4G0N4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
133686

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:133686

UCSC genome browser

More...
UCSCi
uc003jkf.6, human [Q4G0N4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055158 mRNA Translation: BAB70864.1
AC008807 Genomic DNA No translation available.
AC008942 Genomic DNA No translation available.
BC045565 mRNA No translation available.
BC062567 mRNA Translation: AAH62567.1
AY360463 mRNA Translation: AAQ62967.1
CCDSiCCDS3917.1 [Q4G0N4-3]
CCDS47197.1 [Q4G0N4-1]
RefSeqiNP_001078880.1, NM_001085411.2 [Q4G0N4-1]
NP_001274269.1, NM_001287340.1 [Q4G0N4-3]
NP_001274270.1, NM_001287341.1
NP_694558.1, NM_153013.4 [Q4G0N4-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126369, 29 interactors
IntActiQ4G0N4, 4 interactors
STRINGi9606.ENSP00000371362

PTM databases

iPTMnetiQ4G0N4
PhosphoSitePlusiQ4G0N4

Genetic variation databases

BioMutaiNADK2
DMDMi156630863

Proteomic databases

EPDiQ4G0N4
jPOSTiQ4G0N4
MassIVEiQ4G0N4
MaxQBiQ4G0N4
PaxDbiQ4G0N4
PeptideAtlasiQ4G0N4
PRIDEiQ4G0N4
ProteomicsDBi62113 [Q4G0N4-1]
62114 [Q4G0N4-2]
62115 [Q4G0N4-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
50834, 152 antibodies

The DNASU plasmid repository

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DNASUi
133686

Genome annotation databases

EnsembliENST00000282512; ENSP00000282512; ENSG00000152620 [Q4G0N4-3]
ENST00000381937; ENSP00000371362; ENSG00000152620 [Q4G0N4-1]
ENST00000397338; ENSP00000380499; ENSG00000152620 [Q4G0N4-3]
ENST00000514504; ENSP00000421029; ENSG00000152620 [Q4G0N4-2]
GeneIDi133686
KEGGihsa:133686
UCSCiuc003jkf.6, human [Q4G0N4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
133686
DisGeNETi133686

GeneCards: human genes, protein and diseases

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GeneCardsi
NADK2
HGNCiHGNC:26404, NADK2
HPAiENSG00000152620, Tissue enriched (liver)
MalaCardsiNADK2
MIMi615787, gene
616034, phenotype
neXtProtiNX_Q4G0N4
OpenTargetsiENSG00000152620
Orphaneti431361, Progressive encephalopathy with leukodystrophy due to DECR deficiency
PharmGKBiPA162380039
VEuPathDBiHostDB:ENSG00000152620.12

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4180, Eukaryota
GeneTreeiENSGT00390000006320
HOGENOMiCLU_039559_0_0_1
InParanoidiQ4G0N4
OMAiNVGCEVK
OrthoDBi1416565at2759
PhylomeDBiQ4G0N4
TreeFamiTF314077

Enzyme and pathway databases

PathwayCommonsiQ4G0N4
ReactomeiR-HSA-196807, Nicotinate metabolism
SABIO-RKiQ4G0N4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
133686, 15 hits in 957 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NADK2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
133686
PharosiQ4G0N4, Tbio

Protein Ontology

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PROi
PR:Q4G0N4
RNActiQ4G0N4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152620, Expressed in liver and 227 other tissues
ExpressionAtlasiQ4G0N4, baseline and differential
GenevisibleiQ4G0N4, HS

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR017437, ATP-NAD_kinase_PpnK-typ_C
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002504, NADK
IPR012355, NADK2_mit
PfamiView protein in Pfam
PF01513, NAD_kinase, 1 hit
PIRSFiPIRSF017565, Kin_ATP-NAD_euk, 1 hit
SUPFAMiSSF111331, SSF111331, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAKD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4G0N4
Secondary accession number(s): B5MC93, Q6UTX5, Q96NM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 7, 2021
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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