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Protein

Erythroferrone

Gene

ERFE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Erythroferrone
Alternative name(s):
Complement C1q tumor necrosis factor-related protein 15
Myonectin
Gene namesi
Name:ERFE
Synonyms:C1QTNF15, CTRP15, FAM132B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000178752.15
HGNCiHGNC:26727 ERFE
MIMi615099 gene
neXtProtiNX_Q4G0M1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi151176
OpenTargetsiENSG00000178752

Polymorphism and mutation databases

DMDMi190359335

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000034025029 – 354ErythroferroneAdd BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ4G0M1
PaxDbiQ4G0M1
PRIDEiQ4G0M1
ProteomicsDBi62110

PTM databases

iPTMnetiQ4G0M1
PhosphoSitePlusiQ4G0M1

Expressioni

Gene expression databases

BgeeiENSG00000178752 Expressed in 105 organ(s), highest expression level in testis
CleanExiHS_FAM132B
ExpressionAtlasiQ4G0M1 baseline and differential

Organism-specific databases

HPAiHPA077259

Interactioni

Subunit structurei

Homodimer; disulfide-linked. May form heteromeric complexes with C1QTNF2 and C1QTNF12 and, to a lesser extent, with C1QTNF5 and C1QTNF10.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127350, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliQ4G0M1
SMRiQ4G0M1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 354C1qPROSITE-ProRule annotationAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 129Pro-richAdd BLAST19
Compositional biasi177 – 180Poly-Asp4

Sequence similaritiesi

Belongs to the adipolin/erythroferrone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ2E Eukaryota
ENOG410YGMD LUCA
GeneTreeiENSGT00390000007846
HOGENOMiHOG000112436
HOVERGENiHBG107865
InParanoidiQ4G0M1
OMAiDPRDTWM
OrthoDBiEOG091G0HNK
PhylomeDBiQ4G0M1
TreeFamiTF331282

Family and domain databases

InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008983 Tumour_necrosis_fac-like_dom
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q4G0M1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPARRPAGA RLLLVYAGLL AAAAAGLGSP EPGAPSRSRA RREPPPGNEL
60 70 80 90 100
PRGPGESRAG PAARPPEPTA ERAHSVDPRD AWMLFVRQSD KGVNGKKRSR
110 120 130 140 150
GKAKKLKFGL PGPPGPPGPQ GPPGPIIPPE ALLKEFQLLL KGAVRQRERA
160 170 180 190 200
EPEPCTCGPA GPVAASLAPV SATAGEDDDD VVGDVLALLA APLAPGPRAP
210 220 230 240 250
RVEAAFLCRL RRDALVERRA LHELGVYYLP DAEGAFRRGP GLNLTSGQYR
260 270 280 290 300
APVAGFYALA ATLHVALGEP PRRGPPRPRD HLRLLICIQS RCQRNASLEA
310 320 330 340 350
IMGLESSSEL FTISVNGVLY LQMGQWTSVF LDNASGCSLT VRSGSHFSAV

LLGV
Length:354
Mass (Da):37,279
Last modified:June 10, 2008 - v2
Checksum:iF336BBFC1068FF52
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY19H7BY19_HUMAN
Erythroferrone
ERFE
63Annotation score:
H0Y2X4H0Y2X4_HUMAN
Erythroferrone
ERFE
74Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220 – 229ALHELGVYYL → SRGDHPCPSQ in AAH47423 (PubMed:15489334).Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF984314 mRNA Translation: AHL84165.1
AC016757 Genomic DNA No translation available.
BC047423 mRNA Translation: AAH47423.1
CCDSiCCDS77548.1
RefSeqiNP_001278761.1, NM_001291832.1
UniGeneiHs.24951
Hs.742300

Genome annotation databases

EnsembliENST00000546354; ENSP00000442304; ENSG00000178752
GeneIDi151176
KEGGihsa:151176
UCSCiuc061udn.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF984314 mRNA Translation: AHL84165.1
AC016757 Genomic DNA No translation available.
BC047423 mRNA Translation: AAH47423.1
CCDSiCCDS77548.1
RefSeqiNP_001278761.1, NM_001291832.1
UniGeneiHs.24951
Hs.742300

3D structure databases

ProteinModelPortaliQ4G0M1
SMRiQ4G0M1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127350, 4 interactors

PTM databases

iPTMnetiQ4G0M1
PhosphoSitePlusiQ4G0M1

Polymorphism and mutation databases

DMDMi190359335

Proteomic databases

MaxQBiQ4G0M1
PaxDbiQ4G0M1
PRIDEiQ4G0M1
ProteomicsDBi62110

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000546354; ENSP00000442304; ENSG00000178752
GeneIDi151176
KEGGihsa:151176
UCSCiuc061udn.1 human

Organism-specific databases

CTDi151176
DisGeNETi151176
EuPathDBiHostDB:ENSG00000178752.15
GeneCardsiERFE
HGNCiHGNC:26727 ERFE
HPAiHPA077259
MIMi615099 gene
neXtProtiNX_Q4G0M1
OpenTargetsiENSG00000178752
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ2E Eukaryota
ENOG410YGMD LUCA
GeneTreeiENSGT00390000007846
HOGENOMiHOG000112436
HOVERGENiHBG107865
InParanoidiQ4G0M1
OMAiDPRDTWM
OrthoDBiEOG091G0HNK
PhylomeDBiQ4G0M1
TreeFamiTF331282

Miscellaneous databases

ChiTaRSiERFE human
GenomeRNAii151176
PROiPR:Q4G0M1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178752 Expressed in 105 organ(s), highest expression level in testis
CleanExiHS_FAM132B
ExpressionAtlasiQ4G0M1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008983 Tumour_necrosis_fac-like_dom
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERFE_HUMAN
AccessioniPrimary (citable) accession number: Q4G0M1
Secondary accession number(s): W8S2M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 7, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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