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UniProtKB - Q4G0J3 (LARP7_HUMAN)

Entry version 154 (02 Dec 2020)
Sequence version 1 (30 Aug 2005)
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Protein

La-related protein 7

Gene

LARP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18483487, PubMed:18281698). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity).By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processDifferentiation, mRNA processing, mRNA splicing, Spermatogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q4G0J3

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q4G0J3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
La-related protein 71 Publication
Alternative name(s):
La ribonucleoprotein domain family member 71 Publication
Short name:
hLARP71 Publication
P-TEFb-interaction protein for 7SK stability1 Publication
Short name:
PIP7S1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LARP71 PublicationImported
ORF Names:HDCMA18P1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000174720.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:24912, LARP7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612026, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q4G0J3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Alazami syndrome (ALAZS)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndromic form of primordial dwarfism, a condition characterized by severe growth restriction that has its onset in utero, and results in short stature and undersize. ALAZS patients manifest severe intellectual disability and distinct facial features including malar hypoplasia, deep-set eyes, broad nose, short philtrum, and macrostomia. Some patients have non-specific and inconsistent skeletal findings, for example, scoliosis and mild epiphyseal changes in the proximal phalanges, but no frank dysplasia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083351558 – 582ITKAE…FSEYD → KRLDWQRLNKRVNI in ALAZS; reduced 2'-O-methylation of U6 snRNAs and defects in mRNA splicing. 1 PublicationAdd BLAST25

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi44F → A: Reduced binding to U6 snRNA without affecting binding to 7SK RNA. Reduced 2'-O-methylation of U6 snRNAs. 1 Publication1
Mutagenesisi128Y → D: Loss of 7SK RNA-binding and marked decrease in 7SK RNP complex formation. 1 Publication1
Mutagenesisi130E → A: Decreased RNA-binding. 1 Publication1
Mutagenesisi168F → A: Does not affect RNA-binding. 1 Publication1
Mutagenesisi451F → A: Does not affect binding to the 7SK RNA. 1 Publication1
Mutagenesisi472R → A: Does not affect binding to the 7SK RNA. 1 Publication1
Mutagenesisi483Y → A: Reduced binding to the 7SK RNA. Does not affect binding to U6 snRNA. 2 Publications1
Mutagenesisi483Y → F: Does not affect binding to the 7SK RNA. 1 Publication1
Mutagenesisi496R → A: Strongly reduced binding to the stem loop 4 of 7SK RNA. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		51574

MalaCards human disease database

More...MalaCardsi		LARP7
MIMi615071, phenotype

Open Targets

More...OpenTargetsi		ENSG00000174720

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		319671, Microcephalic primordial dwarfism, Alazami type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA145148525

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q4G0J3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LARP7

Domain mapping of disease mutations (DMDM)

More...DMDMi		121945944

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002811431 – 582La-related protein 7Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei257PhosphothreonineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei338PhosphothreonineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Cross-linki410Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q4G0J3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q4G0J3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q4G0J3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q4G0J3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q4G0J3

PeptideAtlas

More...PeptideAtlasi		Q4G0J3

PRoteomics IDEntifications database

More...PRIDEi		Q4G0J3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62106 [Q4G0J3-1]
62107 [Q4G0J3-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q4G0J3

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q4G0J3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q4G0J3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000174720, Expressed in calcaneal tendon and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q4G0J3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q4G0J3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000174720, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Core component of the 7SK RNP complex, at least composed of 7SK RNA, LARP7, MEPCE, HEXIM1 (or HEXIM2) and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) (PubMed:18483487, PubMed:18281698, PubMed:19906723).

Interacts with METTL16 (PubMed:29051200).

Interacts with RBM7; upon genotoxic stress this interaction is enhanced, triggering the release of inactive P-TEFb complex from the core, yielding to P-TEFb complex activation (PubMed:30824372). Associates with box C/D small nucleolar ribonucleoprotein (snoRNP) complexes (PubMed:32017898).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119619, 1007 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q4G0J3

Database of interacting proteins

More...DIPi		DIP-47624N

Protein interaction database and analysis system

More...IntActi		Q4G0J3, 71 interactors

Molecular INTeraction database

More...MINTi		Q4G0J3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000422626

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q4G0J3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1582
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q4G0J3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 122HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST95
Domaini125 – 203RRMPROSITE-ProRule annotationAdd BLAST79
Domaini450 – 563xRRMPROSITE-ProRule annotationAdd BLAST114

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi202 – 368Lys-richAdd BLAST167

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The xRRM domain binds the 3' end of 7SK snRNA (7SK RNA) at the top of stem-loop 4.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LARP7 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1855, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154949

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020946_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4G0J3

Identification of Orthologs from Complete Genome Data

More...OMAi		RKAVHKM

Database of Orthologous Groups

More...OrthoDBi		1499213at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q4G0J3

TreeFam database of animal gene trees

More...TreeFami		TF314476

Family and domain databases

Conserved Domains Database

More...CDDi		cd08032, LARP_7, 1 hit
cd12290, RRM1_LARP7, 1 hit
cd12542, RRM2_LARP7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006630, La_HTH
IPR014886, La_RRM
IPR034946, LARP7_La
IPR034887, LARP7_RRM1
IPR034910, LARP7_RRM2
IPR002344, Lupus_La
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05383, La, 1 hit
PF00076, RRM_1, 1 hit
PF08777, RRM_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00302, LUPUSLA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00715, LA, 1 hit
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit
SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50961, HTH_LA, 1 hit
PS50102, RRM, 1 hit
PS51939, XRRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4G0J3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METESGNQEK VMEEESTEKK KEVEKKKRSR VKQVLADIAK QVDFWFGDAN 
        60         70         80         90        100
LHKDRFLREQ IEKSRDGYVD ISLLVSFNKM KKLTTDGKLI ARALRSSAVV 
       110        120        130        140        150
ELDLEGTRIR RKKPLGERPK DEDERTVYVE LLPKNVNHSW IERVFGKCGN 
       160        170        180        190        200
VVYISIPHYK STGDPKGFAF VEFETKEQAA KAIEFLNNPP EEAPRKPGIF 
       210        220        230        240        250
PKTVKNKPIP ALRVVEEKKK KKKKKGRMKK EDNIQAKEEN MDTSNTSISK 
       260        270        280        290        300
MKRSRPTSEG SDIESTEPQK QCSKKKKKRD RVEASSLPEV RTGKRKRSSS 
       310        320        330        340        350
EDAESLAPRS KVKKIIQKDI IKEASEASKE NRDIEISTEE EKDTGDLKDS 
       360        370        380        390        400
SLLKTKRKHK KKHKERHKMG EEVIPLRVLS KSEWMDLKKE YLALQKASMA 
       410        420        430        440        450
SLKKTISQIK SESEMETDSG VPQNTGMKNE KTANREECRT QEKVNATGPQ 
       460        470        480        490        500
FVSGVIVKII STEPLPGRKQ VRDTLAAISE VLYVDLLEGD TECHARFKTP 
       510        520        530        540        550
EDAQAVINAY TEINKKHCWK LEILSGDHEQ RYWQKILVDR QAKLNQPREK 
       560        570        580 
KRGTEKLITK AEKIRLAKTQ QASKHIRFSE YD
Length:582
Mass (Da):66,899
Last modified:August 30, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04209B8159A5738C
GO
Isoform 2 (identifier: Q4G0J3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-368: Missing.

Show »
Length:214
Mass (Da):24,488
Checksum:i12A03DED56668BA7
GO
Isoform 3 (identifier: Q4G0J3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MIPNIEGM

Show »
Length:589
Mass (Da):67,654
Checksum:iCD532FEBA691906E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFF0D6RFF0_HUMAN
La ribonucleoprotein domain family ...
LARP7
299Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF49D6RF49_HUMAN
La-related protein 7
LARP7
119Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAF3D6RAF3_HUMAN
La-related protein 7
LARP7
129Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA82H0YA82_HUMAN
La-related protein 7
LARP7
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9Z6D6R9Z6_HUMAN
La-related protein 7
LARP7
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF22D6RF22_HUMAN
La-related protein 7
LARP7
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBH8D6RBH8_HUMAN
La-related protein 7
LARP7
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH66945 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti295R → G in AAI07710 (PubMed:15489334).Curated1
Sequence conflicti516K → R in AAF65503 (Ref. 2) Curated1
Sequence conflicti516K → R in CAB43230 (PubMed:17974005).Curated1
Sequence conflicti560K → Q in CAB43230 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_083351558 – 582ITKAE…FSEYD → KRLDWQRLNKRVNI in ALAZS; reduced 2'-O-methylation of U6 snRNAs and defects in mRNA splicing. 1 PublicationAdd BLAST25

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0240211 – 368Missing in isoform 2. 1 PublicationAdd BLAST368
Alternative sequenceiVSP_0473901M → MIPNIEGM in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
EU667388 mRNA Translation: ACD13786.1
AF068284 mRNA Translation: AAF65503.1
AC106864 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06284.1
BC066945 mRNA Translation: AAH66945.1 Different initiation.
BC107709 mRNA Translation: AAI07710.2
AL049996 mRNA Translation: CAB43230.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3701.2 [Q4G0J3-1]
CCDS58924.1 [Q4G0J3-3]

Protein sequence database of the Protein Information Resource

More...PIRi		T08692

NCBI Reference Sequences

More...RefSeqi		NP_001253968.1, NM_001267039.1 [Q4G0J3-3]
NP_056269.1, NM_015454.2 [Q4G0J3-1]
NP_057732.2, NM_016648.3 [Q4G0J3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000324052; ENSP00000314311; ENSG00000174720 [Q4G0J3-1]
ENST00000344442; ENSP00000344950; ENSG00000174720 [Q4G0J3-1]
ENST00000509061; ENSP00000422626; ENSG00000174720 [Q4G0J3-3]
ENST00000651579; ENSP00000499190; ENSG00000174720 [Q4G0J3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51574

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51574

UCSC genome browser

More...UCSCi		uc003iay.5, human [Q4G0J3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU667388 mRNA Translation: ACD13786.1
AF068284 mRNA Translation: AAF65503.1
AC106864 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06284.1
BC066945 mRNA Translation: AAH66945.1 Different initiation.
BC107709 mRNA Translation: AAI07710.2
AL049996 mRNA Translation: CAB43230.1
CCDSiCCDS3701.2 [Q4G0J3-1]
CCDS58924.1 [Q4G0J3-3]
PIRiT08692
RefSeqiNP_001253968.1, NM_001267039.1 [Q4G0J3-3]
NP_056269.1, NM_015454.2 [Q4G0J3-1]
NP_057732.2, NM_016648.3 [Q4G0J3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WKRX-ray3.20A/B1-208[»]
5KNWNMR-A445-561[»]
6D12X-ray2.21A/B445-556[»]
SMRiQ4G0J3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119619, 1007 interactors
CORUMiQ4G0J3
DIPiDIP-47624N
IntActiQ4G0J3, 71 interactors
MINTiQ4G0J3
STRINGi9606.ENSP00000422626

PTM databases

CarbonylDBiQ4G0J3
iPTMnetiQ4G0J3
PhosphoSitePlusiQ4G0J3

Polymorphism and mutation databases

BioMutaiLARP7
DMDMi121945944

Proteomic databases

EPDiQ4G0J3
jPOSTiQ4G0J3
MassIVEiQ4G0J3
MaxQBiQ4G0J3
PaxDbiQ4G0J3
PeptideAtlasiQ4G0J3
PRIDEiQ4G0J3
ProteomicsDBi62106 [Q4G0J3-1]
62107 [Q4G0J3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15535, 188 antibodies

Genome annotation databases

EnsembliENST00000324052; ENSP00000314311; ENSG00000174720 [Q4G0J3-1]
ENST00000344442; ENSP00000344950; ENSG00000174720 [Q4G0J3-1]
ENST00000509061; ENSP00000422626; ENSG00000174720 [Q4G0J3-3]
ENST00000651579; ENSP00000499190; ENSG00000174720 [Q4G0J3-1]
GeneIDi51574
KEGGihsa:51574
UCSCiuc003iay.5, human [Q4G0J3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51574
DisGeNETi51574
EuPathDBiHostDB:ENSG00000174720.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		LARP7
HGNCiHGNC:24912, LARP7
HPAiENSG00000174720, Low tissue specificity
MalaCardsiLARP7
MIMi612026, gene
615071, phenotype
neXtProtiNX_Q4G0J3
OpenTargetsiENSG00000174720
Orphaneti319671, Microcephalic primordial dwarfism, Alazami type
PharmGKBiPA145148525

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1855, Eukaryota
GeneTreeiENSGT00940000154949
HOGENOMiCLU_020946_2_0_1
InParanoidiQ4G0J3
OMAiRKAVHKM
OrthoDBi1499213at2759
PhylomeDBiQ4G0J3
TreeFamiTF314476

Enzyme and pathway databases

PathwayCommonsiQ4G0J3
SIGNORiQ4G0J3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51574, 30 hits in 849 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LARP7, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51574
PharosiQ4G0J3, Tbio

Protein Ontology

More...PROi		PR:Q4G0J3
RNActiQ4G0J3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000174720, Expressed in calcaneal tendon and 240 other tissues
ExpressionAtlasiQ4G0J3, baseline and differential
GenevisibleiQ4G0J3, HS

Family and domain databases

CDDicd08032, LARP_7, 1 hit
cd12290, RRM1_LARP7, 1 hit
cd12542, RRM2_LARP7, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR006630, La_HTH
IPR014886, La_RRM
IPR034946, LARP7_La
IPR034887, LARP7_RRM1
IPR034910, LARP7_RRM2
IPR002344, Lupus_La
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383, La, 1 hit
PF00076, RRM_1, 1 hit
PF08777, RRM_3, 1 hit
PRINTSiPR00302, LUPUSLA
SMARTiView protein in SMART
SM00715, LA, 1 hit
SM00360, RRM, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50961, HTH_LA, 1 hit
PS50102, RRM, 1 hit
PS51939, XRRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLARP7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4G0J3
Secondary accession number(s): B2ZHN6
, Q3B7A9, Q9P1S7, Q9Y3Z8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: August 30, 2005
Last modified: December 2, 2020
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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