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Protein

Vacuolar protein sorting-associated protein 26B

Gene

VPS26B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).By similarity

GO - Molecular functioni

  • protein transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

TCDBi9.A.3.1.1 the sorting nexin27 (snx27)-retromer assembly apparatus for recycling integral membrane proteins (snx27-retromeraa) family

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 26B
Alternative name(s):
Vesicle protein sorting 26B
Gene namesi
Name:VPS26B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000151502.10
HGNCiHGNC:28119 VPS26B
MIMi610027 gene
neXtProtiNX_Q4G0F5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151502
PharmGKBiPA128394747

Polymorphism and mutation databases

BioMutaiVPS26B
DMDMi110816482

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002470891 – 336Vacuolar protein sorting-associated protein 26BAdd BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei302PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ4G0F5
MaxQBiQ4G0F5
PaxDbiQ4G0F5
PeptideAtlasiQ4G0F5
PRIDEiQ4G0F5
ProteomicsDBi62102

PTM databases

iPTMnetiQ4G0F5
PhosphoSitePlusiQ4G0F5
SwissPalmiQ4G0F5

Expressioni

Gene expression databases

BgeeiENSG00000151502 Expressed in 192 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_VPS26B
ExpressionAtlasiQ4G0F5 baseline and differential
GenevisibleiQ4G0F5 HS

Organism-specific databases

HPAiHPA038172

Interactioni

Subunit structurei

Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting VPS subcomplex (VPS,) formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35. The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform. The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex. Interacts with VPS29, VPS35, TBC1D5, GOLPH3, SNX27 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
VPS35Q96QK14EBI-6151831,EBI-1054634

Protein-protein interaction databases

BioGridi125215, 50 interactors
CORUMiQ4G0F5
IntActiQ4G0F5, 31 interactors
MINTiQ4G0F5
STRINGi9606.ENSP00000281187

Structurei

3D structure databases

ProteinModelPortaliQ4G0F5
SMRiQ4G0F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VPS26 family.Curated

Phylogenomic databases

eggNOGiKOG3063 Eukaryota
ENOG410XSI1 LUCA
GeneTreeiENSGT00390000002588
HOGENOMiHOG000191799
HOVERGENiHBG082914
InParanoidiQ4G0F5
KOiK18466
OMAiGEMRQAQ
OrthoDBiEOG091G09TQ
PhylomeDBiQ4G0F5
TreeFamiTF300907

Family and domain databases

Gene3Di2.60.40.640, 2 hits
InterProiView protein in InterPro
IPR014752 Arrestin_C
IPR028934 Vps26-related
PANTHERiPTHR12233 PTHR12233, 1 hit
PfamiView protein in Pfam
PF03643 Vps26, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q4G0F5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFFGFGQSV EVEILLNDAE SRKRAEHKTE DGKKEKYFLF YDGETVSGKV
60 70 80 90 100
SLALKNPNKR LEHQGIKIEF IGQIELYYDR GNHHEFVSLV KDLARPGEIT
110 120 130 140 150
QSQAFDFEFT HVEKPYESYT GQNVKLRYFL RATISRRLND VVKEMDIVVH
160 170 180 190 200
TLSTYPELNS SIKMEVGIED CLHIEFEYNK SKYHLKDVIV GKIYFLLVRI
210 220 230 240 250
KIKHMEIDII KRETTGTGPN VYHENDTIAK YEIMDGAPVR GESIPIRLFL
260 270 280 290 300
AGYELTPTMR DINKKFSVRY YLNLVLIDEE ERRYFKQQEV VLWRKGDIVR
310 320 330
KSMSHQAAIA SQRFEGTTSL GEVRTPSQLS DNNCRQ
Length:336
Mass (Da):39,155
Last modified:July 25, 2006 - v2
Checksum:i1C07D0ABA7797A12
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCI7H0YCI7_HUMAN
Vacuolar protein sorting-associated...
VPS26B
72Annotation score:
A0A0D9SFQ6A0A0D9SFQ6_HUMAN
Vacuolar protein sorting-associated...
VPS26B
48Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55K → R in AAH98386 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452718 mRNA Translation: AAP13353.1
BC009747 mRNA Translation: AAH09747.1
BC014128 mRNA Translation: AAH14128.1
BC098386 mRNA Translation: AAH98386.1
CCDSiCCDS8495.1
RefSeqiNP_443107.1, NM_052875.4
UniGeneiHs.334684

Genome annotation databases

EnsembliENST00000281187; ENSP00000281187; ENSG00000151502
ENST00000525095; ENSP00000434162; ENSG00000151502
GeneIDi112936
KEGGihsa:112936
UCSCiuc001qhe.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452718 mRNA Translation: AAP13353.1
BC009747 mRNA Translation: AAH09747.1
BC014128 mRNA Translation: AAH14128.1
BC098386 mRNA Translation: AAH98386.1
CCDSiCCDS8495.1
RefSeqiNP_443107.1, NM_052875.4
UniGeneiHs.334684

3D structure databases

ProteinModelPortaliQ4G0F5
SMRiQ4G0F5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125215, 50 interactors
CORUMiQ4G0F5
IntActiQ4G0F5, 31 interactors
MINTiQ4G0F5
STRINGi9606.ENSP00000281187

Protein family/group databases

TCDBi9.A.3.1.1 the sorting nexin27 (snx27)-retromer assembly apparatus for recycling integral membrane proteins (snx27-retromeraa) family

PTM databases

iPTMnetiQ4G0F5
PhosphoSitePlusiQ4G0F5
SwissPalmiQ4G0F5

Polymorphism and mutation databases

BioMutaiVPS26B
DMDMi110816482

Proteomic databases

EPDiQ4G0F5
MaxQBiQ4G0F5
PaxDbiQ4G0F5
PeptideAtlasiQ4G0F5
PRIDEiQ4G0F5
ProteomicsDBi62102

Protocols and materials databases

DNASUi112936
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281187; ENSP00000281187; ENSG00000151502
ENST00000525095; ENSP00000434162; ENSG00000151502
GeneIDi112936
KEGGihsa:112936
UCSCiuc001qhe.4 human

Organism-specific databases

CTDi112936
EuPathDBiHostDB:ENSG00000151502.10
GeneCardsiVPS26B
HGNCiHGNC:28119 VPS26B
HPAiHPA038172
MIMi610027 gene
neXtProtiNX_Q4G0F5
OpenTargetsiENSG00000151502
PharmGKBiPA128394747
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3063 Eukaryota
ENOG410XSI1 LUCA
GeneTreeiENSGT00390000002588
HOGENOMiHOG000191799
HOVERGENiHBG082914
InParanoidiQ4G0F5
KOiK18466
OMAiGEMRQAQ
OrthoDBiEOG091G09TQ
PhylomeDBiQ4G0F5
TreeFamiTF300907

Miscellaneous databases

ChiTaRSiVPS26B human
GeneWikiiVPS26B
GenomeRNAii112936
PROiPR:Q4G0F5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151502 Expressed in 192 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_VPS26B
ExpressionAtlasiQ4G0F5 baseline and differential
GenevisibleiQ4G0F5 HS

Family and domain databases

Gene3Di2.60.40.640, 2 hits
InterProiView protein in InterPro
IPR014752 Arrestin_C
IPR028934 Vps26-related
PANTHERiPTHR12233 PTHR12233, 1 hit
PfamiView protein in Pfam
PF03643 Vps26, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVP26B_HUMAN
AccessioniPrimary (citable) accession number: Q4G0F5
Secondary accession number(s): Q96A55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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