UniProtKB - Q4G0E8 (Q4G0E8_HUMAN)
Protein
Acetyl-coenzyme A synthetase
Gene
ACSS2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:6.2.1.1UniRule annotation
GO - Molecular functioni
- acetate-CoA ligase activity Source: UniProtKB-UniRule
- AMP binding Source: InterPro
- ATP binding Source: UniProtKB-UniRule
GO - Biological processi
- acetyl-CoA biosynthetic process from acetate Source: InterPro
Keywordsi
Molecular function | LigaseUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ACSS2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 479 | AMP-bindingInterPro annotationAdd BLAST | 460 | |
Domaini | 488 – 566 | AMP-binding_CInterPro annotationAdd BLAST | 79 |
Sequence similaritiesi
Phylogenomic databases
OrthoDBi | 288915at2759 |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR011904, Ac_CoA_lig IPR025110, AMP-bd_C IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
TIGRFAMsi | TIGR02188, Ac_CoA_lig_AcsA, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4G0E8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKGATTNICY NVLDRNVHEK KLGDKVAFYW EGNEPGETTQ ITYHQLLVQV
60 70 80 90 100
CQFSNVLRKQ GIQKGDRVAI YMPMIPELVV AMLACARIGA LHSIVFAGFS
110 120 130 140 150
SESLCERILD SSCSLLITTD AFYRGEKLVN LKELADEALQ KCQEKGFPVR
160 170 180 190 200
CCIVVKHLGR AELGMGDSTS QSPPIKRSCP DVQISWNQGI DLWWHELMQE
210 220 230 240 250
AGDECEPEWC DAEDPLFILY TSGSTGKPKG VVHTVGGYML YVATTFKYVF
260 270 280 290 300
DFHAEDVFWC TADIGWITGH SYVTYGPLAN GATSVLFEGI PTYPDVNRLW
310 320 330 340 350
SIVDKYKVTK FYTAPTAIRL LMKFGDEPVT KHSRASLQVL GTVGEPINPE
360 370 380 390 400
AWLWYHRVVG AQRCPIVDTF WQTETGGHML TPLPGATPMK PGSATFPFFG
410 420 430 440 450
VAPAILNESG EELEGEAEGY LVFKQPWPGI MRTVYGNHER FETTYFKKFP
460 470 480 490 500
GYYVTGDGCQ RDQDGYYWIT GRIDDMLNVS GHLLSTAEVE SALVEHEAVA
510 520 530 540 550
EAAVVGHPHP VKGECLYCFV TLCDGHTFSP KLTEELKKQI REKIGPIATP
560 570 580 590 600
DYIQNAPGLP KTRSGKIMRR VLRKIAQNDH DLGDMSTVAD PSVISHLFSH
RCLTIQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC098422 mRNA Translation: AAH98422.1 |
RefSeqi | NP_001229322.1, NM_001242393.1 |
Genome annotation databases
GeneIDi | 55902 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC098422 mRNA Translation: AAH98422.1 |
RefSeqi | NP_001229322.1, NM_001242393.1 |
3D structure databases
SMRi | Q4G0E8 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | Q4G0E8 |
Genome annotation databases
GeneIDi | 55902 |
Organism-specific databases
CTDi | 55902 |
Phylogenomic databases
OrthoDBi | 288915at2759 |
Miscellaneous databases
BioGRID-ORCSi | 55902, 6 hits in 879 CRISPR screens |
ChiTaRSi | ACSS2, human |
GenomeRNAii | 55902 |
Gene expression databases
Genevisiblei | Q4G0E8, HS |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR011904, Ac_CoA_lig IPR025110, AMP-bd_C IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
TIGRFAMsi | TIGR02188, Ac_CoA_lig_AcsA, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q4G0E8_HUMAN | |
Accessioni | Q4G0E8Primary (citable) accession number: Q4G0E8 Secondary accession number(s): A6NLR6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 10, 2021 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |