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Entry version 98 (07 Apr 2021)
Sequence version 2 (02 Sep 2008)
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Protein

Nischarin

Gene

Nisch

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis (By similarity). Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3 (By similarity). When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures (By similarity).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processApoptosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nischarin
Alternative name(s):
Imidazoline receptor 1
Short name:
I-1
Short name:
IR1
Imidazoline-1 receptor
Short name:
I1R
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nisch
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Rat genome database

More...
RGDi
1306950, Nisch

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5221

DrugCentral

More...
DrugCentrali
Q4G017

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003482671 – 1502NischarinAdd BLAST1502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei542PhosphoserineBy similarity1
Modified residuei544PhosphoserineBy similarity1
Modified residuei547PhosphoserineBy similarity1
Modified residuei1280PhosphothreonineBy similarity1
Modified residuei1282PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q4G017

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4G017

PRoteomics IDEntifications database

More...
PRIDEi
Q4G017

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4G017

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4G017

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000018823, Expressed in frontal cortex and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4G017, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer.

Interacts with GRB2.

Interacts with PIK3R1; probably associates with the PI3-kinase complex.

Interacts with IRS4.

Found in a complex with ITGA5 and PAK1.

Found in a complex with LIMK1 and PAK1.

Interacts with ITGA5 (via cytoplasmic domain); this interaction is direct.

Interacts with PAK1 (via kinase domain); this interaction is direct and is increased upon activation of PAK1.

Interacts with LIMK1 (via PDZ and kinase domain); this interaction is direct.

Interacts with LIMK2; this interaction depends on LIMK2 activity.

Interacts with RAC1 (activated state) (By similarity).

Interacts with STK11; this interaction may increase STK11 activity (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q4G017, 3 interactors

Molecular INTeraction database

More...
MINTi
Q4G017

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000032758

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q4G017

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 122PXPROSITE-ProRule annotationAdd BLAST111
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati289 – 310LRR 1Add BLAST22
Repeati312 – 333LRR 2Add BLAST22
Repeati334 – 355LRR 3Add BLAST22
Repeati357 – 378LRR 4Add BLAST22
Repeati379 – 400LRR 5Add BLAST22
Repeati404 – 425LRR 6Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 134Necessary for binding to phosphoinositide-3-P; not sufficient for targeting to endosomesBy similarityAdd BLAST134
Regioni121 – 693Necessary for homooligomerization and targeting to endosomesBy similarityAdd BLAST573
Regioni246 – 867Interaction with PAK1By similarityAdd BLAST622
Regioni659 – 867Interaction with LIMKBy similarityAdd BLAST209
Regioni707 – 805Interaction with ITGA5By similarityAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili623 – 692Sequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi630 – 689Glu-richAdd BLAST60
Compositional biasi1046 – 1102Ala/Pro-richAdd BLAST57

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Both the presence of the PX domain and the coiled coil region are necessary for its endosomal targeting.By similarity

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1259, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156494

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_252294_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4G017

Identification of Orthologs from Complete Genome Data

More...
OMAi
LDEDYVH

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06875, PX_IRAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1520.10, 1 hit
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR025875, Leu-rich_rpt_4
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR037904, Nischarin_PX
IPR001683, PX_dom
IPR036871, PX_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12799, LRR_4, 1 hit
PF00787, PX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 4 hits
SM00312, PX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 6 hits
PS50195, PX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4G017-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAATLSFGP EREAEPAKEA RVVGSELVDT YTVYVIQVTD GNHEWTIKHR
60 70 80 90 100
YSDFHDLHEK LVAERKIDKT LLPPKKIIGK NSRSLVEKRE KDLEVYLQTL
110 120 130 140 150
LKTFPDVAPR VLAHFLHFHL YEINGVTAAL AEELFEKGEQ LLGAGEVFAI
160 170 180 190 200
RPLQLYAITE QLQQGKPTCA SGDAKTDLGH ILDFTCRLKY LKVSGTEGPF
210 220 230 240 250
GTSNIREQLL PFDLSIFKSL HQVEMSHCDA KHVRGLVTSK PTLATMSVRF
260 270 280 290 300
SAASMKEVLV PEASEFDEWE PEGTTLGGPV TAVIPTWQAL TTLDLSHNSI
310 320 330 340 350
SEIDESVKLI PKIEYLDLSH NGVLVVDNLQ HLYNLVHLDL SYNKLSSLEG
360 370 380 390 400
VHTKLGNVKT LNLAGNFLER LSGLHKLYSL VNLDLRDNRI EQLDEVKSIG
410 420 430 440 450
NLPCLEHVAL LNNPLSIIPD YRTKVLSQFG ERASEICLDD VATTEKELDT
460 470 480 490 500
VEVLKAIQKA KDVKSKLSST EKKVGEDFRL PTAPCIRPSS SPPTAVPTSA
510 520 530 540 550
SLPQPILSNQ GIMFVQEEAL ASSLSSTDSL PPDDRPIAQA CSNSMGSLPT
560 570 580 590 600
GQVAAEDLRD LPGAVGGVSP DHAEPEVQVV PGSGQIIFLP FTCIGYTATN
610 620 630 640 650
QDFIQRLSTL IRQAIERQLP AWIEAANQRE EAHGEQGEEE EEEEEEDVAE
660 670 680 690 700
SRYFEMGPPD AEEEEGSGQG EEDEEDEDEE AEEERLALEW ALGADEDFLL
710 720 730 740 750
EHIRILKVLW CFLIHVQGSI RQFAACLVLT DFGIAVFEIP HQESRGSSQH
760 770 780 790 800
ILSSLRFVFC FPHGDLTEFG FLMPELCLVL KVRHSENTLF IISDAANLHE
810 820 830 840 850
FHADLRSCFA PQHMAMLCSP ILYGSHTSLQ EFLRQLLTFY KVAGGSQERS
860 870 880 890 900
QGCFPVYLVY SDKRMVQTAA GDYSGNIEWA SCTLCSAVRR SCCAPSEAVK
910 920 930 940 950
SAAIPYWLLL TSQHLNVIKA DFNPMPSRGT HNCRNRNSFK LSRVPLSTVL
960 970 980 990 1000
LDPTRSCTQP RGAFADGHVL ELLVGYRFVT AIFVLPHEKF HFLRVYNQLR
1010 1020 1030 1040 1050
ASLKDLKTVV IAKNPSARPR TQGPLAGGQP AKSRVSAEQR LQETPAEAPA
1060 1070 1080 1090 1100
PAPAAAESAA EAPAAAEASA PAGAPAPAGA PAPAGAPAGA QAPAPAQAEV
1110 1120 1130 1140 1150
PAQYPSERLI QSTSEENQIP SHLPVCPSLQ HIARLRGRAI IDLFHSSIAE
1160 1170 1180 1190 1200
VENEELRHLL WSSVVFYQTP GLEVTACVLL STKAVYFILH DGLRRYFSEP
1210 1220 1230 1240 1250
LQDFWHQKNT DYNNSPFHIS QCFVLKLSDL QSVNVGLFDQ YFRLTGSSPT
1260 1270 1280 1290 1300
QVVTCLTRDS YLTHCFLQHL MLVLSSLERT PSPEPIDKDF YSEFGDKNTG
1310 1320 1330 1340 1350
KMENYELIHS SRVKFTYPSE EEVGDLTYVV AQKMADPAKN PALSILLYIQ
1360 1370 1380 1390 1400
AFQVITPQLG RGRGPLRPKT LLLTSAEIFL LDEDYIHYPL PEFAKEPPQR
1410 1420 1430 1440 1450
DRYRLDDGRR VRDLDRVLMG YNPYPQALTL VFDDTQGHDL MGSVTLDHFG
1460 1470 1480 1490 1500
EMPGGPGRAG QGREVQWQVF VPSAESREKL ISLLARQWEA LCGRELPVEL

TG
Length:1,502
Mass (Da):166,503
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE89025E32450ECF8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR03100261 Genomic DNA No translation available.
BC098837 mRNA Translation: AAH98837.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000036910; ENSRNOP00000032758; ENSRNOG00000018823

UCSC genome browser

More...
UCSCi
RGD:1306950, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03100261 Genomic DNA No translation available.
BC098837 mRNA Translation: AAH98837.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ4G017, 3 interactors
MINTiQ4G017
STRINGi10116.ENSRNOP00000032758

Chemistry databases

BindingDBiQ4G017
ChEMBLiCHEMBL5221
DrugCentraliQ4G017

PTM databases

iPTMnetiQ4G017
PhosphoSitePlusiQ4G017

Proteomic databases

jPOSTiQ4G017
PaxDbiQ4G017
PRIDEiQ4G017

Genome annotation databases

EnsembliENSRNOT00000036910; ENSRNOP00000032758; ENSRNOG00000018823
UCSCiRGD:1306950, rat

Organism-specific databases

RGDi1306950, Nisch

Phylogenomic databases

eggNOGiKOG1259, Eukaryota
GeneTreeiENSGT00940000156494
HOGENOMiCLU_252294_0_0_1
InParanoidiQ4G017
OMAiLDEDYVH

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q4G017

Gene expression databases

BgeeiENSRNOG00000018823, Expressed in frontal cortex and 21 other tissues
GenevisibleiQ4G017, RN

Family and domain databases

CDDicd06875, PX_IRAS, 1 hit
Gene3Di3.30.1520.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR025875, Leu-rich_rpt_4
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR037904, Nischarin_PX
IPR001683, PX_dom
IPR036871, PX_dom_sf
PfamiView protein in Pfam
PF12799, LRR_4, 1 hit
PF00787, PX, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 4 hits
SM00312, PX, 1 hit
SUPFAMiSSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 6 hits
PS50195, PX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNISCH_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4G017
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: April 7, 2021
This is version 98 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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