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Protein

Signal recognition particle receptor subunit beta

Gene

Srprb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei118GTP; via amide nitrogenBy similarity1
Binding sitei246GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 77GTPBy similarity9
Nucleotide bindingi90 – 93GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • ubiquitin protein ligase binding Source: RGD

Keywordsi

Molecular functionReceptor
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit beta
Short name:
SR-beta
Gene namesi
Name:Srprb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1304698 Srprb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003312451 – 269Signal recognition particle receptor subunit betaAdd BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphoserineBy similarity1
Modified residuei212PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4FZX7

PTM databases

iPTMnetiQ4FZX7
PhosphoSitePlusiQ4FZX7

Interactioni

Subunit structurei

Heterodimer with SRPRA.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi256772, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ4FZX7
SMRiQ4FZX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SRP receptor beta subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEAI Eukaryota
ENOG410XQ36 LUCA
HOVERGENiHBG054206
InParanoidiQ4FZX7
KOiK12272

Family and domain databases

CDDicd04105 SR_beta, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR019009 SRP_receptor_beta_su
PANTHERiPTHR11485:SF34 PTHR11485:SF34, 1 hit
PfamiView protein in Pfam
PF09439 SRPRB, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q4FZX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASANTRRVG DGAGGAFQPY LDSLRQELQQ RDPTLLSVAV AVLAVLLTLV
60 70 80 90 100
FWKFIWSRKS SQRAVLFVGL CDSGKTLLFV RLLTGQYRDT QTSITDSSAI
110 120 130 140 150
YKVNNNRGNS LTLIDLPGHE SLRLQFLDRF KSSARAVVFV VDSATFQREV
160 170 180 190 200
KDVAEFLYQV LIDSMALKNT PAFLVACNKQ DIAMAKSAKL IQQQLEKELN
210 220 230 240 250
TLRVTRSAAP STLDSSSTAP AQLGKKGKEF EFSQLPLKVE FLECSAKGGR
260
GDAGSADVQD LEKWLAKIA
Length:269
Mass (Da):29,569
Last modified:August 30, 2005 - v1
Checksum:iDA63194232A47386
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098951 mRNA Translation: AAH98951.1
RefSeqiNP_001013270.1, NM_001013252.1
UniGeneiRn.138078

Genome annotation databases

GeneIDi300965
KEGGirno:300965
UCSCiRGD:1304698 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098951 mRNA Translation: AAH98951.1
RefSeqiNP_001013270.1, NM_001013252.1
UniGeneiRn.138078

3D structure databases

ProteinModelPortaliQ4FZX7
SMRiQ4FZX7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi256772, 1 interactor

PTM databases

iPTMnetiQ4FZX7
PhosphoSitePlusiQ4FZX7

Proteomic databases

PRIDEiQ4FZX7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi300965
KEGGirno:300965
UCSCiRGD:1304698 rat

Organism-specific databases

CTDi58477
RGDi1304698 Srprb

Phylogenomic databases

eggNOGiENOG410IEAI Eukaryota
ENOG410XQ36 LUCA
HOVERGENiHBG054206
InParanoidiQ4FZX7
KOiK12272

Miscellaneous databases

PROiPR:Q4FZX7

Family and domain databases

CDDicd04105 SR_beta, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR019009 SRP_receptor_beta_su
PANTHERiPTHR11485:SF34 PTHR11485:SF34, 1 hit
PfamiView protein in Pfam
PF09439 SRPRB, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRPRB_RAT
AccessioniPrimary (citable) accession number: Q4FZX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 30, 2005
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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