UniProtKB - Q4FZT0 (STML2_RAT)
Stomatin-like protein 2, mitochondrial
Stoml2
Functioni
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation (By similarity).
By similarityGO - Molecular functioni
- cardiolipin binding Source: UniProtKB
- GTPase binding Source: RGD
GO - Biological processi
- CD4-positive, alpha-beta T cell activation Source: UniProtKB
- cellular calcium ion homeostasis Source: UniProtKB
- lipid localization Source: UniProtKB
- mitochondrial ATP synthesis coupled proton transport Source: UniProtKB
- mitochondrial calcium ion transmembrane transport Source: UniProtKB
- mitochondrial protein processing Source: UniProtKB
- mitochondrion organization Source: UniProtKB
- positive regulation of cardiolipin metabolic process Source: UniProtKB
- positive regulation of interleukin-2 production Source: UniProtKB
- positive regulation of mitochondrial DNA replication Source: UniProtKB
- positive regulation of mitochondrial membrane potential Source: UniProtKB
- protein complex oligomerization Source: UniProtKB
- stress-induced mitochondrial fusion Source: UniProtKB
- T cell receptor signaling pathway Source: UniProtKB
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
Reactomei | R-RNO-8949664, Processing of SMDT1 |
Names & Taxonomyi
Protein namesi | Recommended name: Stomatin-like protein 2, mitochondrialShort name: SLP-2 |
Gene namesi | Name:Stoml2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1308285, Stoml2 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
- Mitochondrion inner membrane By similarity; Lipid-anchor By similarity
- Mitochondrion intermembrane space By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Cytoskeleton
- cytoskeleton By similarity
Other locations
- Membrane raft By similarity
Note: Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain. Also associates with the actin cytoskeleton and membrane rafts in activated T-cells. A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells.By similarity
Cytoskeleton
- actin cytoskeleton Source: Ensembl
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB
- mitochondrial intermembrane space Source: UniProtKB
- mitochondrion Source: RGD
Nucleus
- COP9 signalosome Source: Ensembl
Plasma Membrane
- extrinsic component of plasma membrane Source: UniProtKB
- immunological synapse Source: Ensembl
- T cell receptor complex Source: Ensembl
Other locations
- membrane raft Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 28 | MitochondrionSequence analysisAdd BLAST | 28 | |
ChainiPRO_0000288494 | 29 – 353 | Stomatin-like protein 2, mitochondrialAdd BLAST | 325 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | Phosphoserine; by PKC/PRKCZBy similarity | 1 | |
Modified residuei | 124 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 145 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 145 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 233 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 330 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Lipoprotein, PhosphoproteinProteomic databases
jPOSTi | Q4FZT0 |
PaxDbi | Q4FZT0 |
PRIDEi | Q4FZT0 |
PTM databases
iPTMneti | Q4FZT0 |
PhosphoSitePlusi | Q4FZT0 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000009535, Expressed in female gonad and 21 other tissues |
Genevisiblei | Q4FZT0, RN |
Interactioni
Subunit structurei
Forms homooligomers.
Interacts with MFN2; may form heterooligomers.
Interacts with PHB1 and PHB2; recruits them to cardiolipin-enriched mitochondrial membranes and stabilizes them.
Interacts with CACNA2D2 (By similarity).
By similarityGO - Molecular functioni
- GTPase binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 255804, 4 interactors |
IntActi | Q4FZT0, 2 interactors |
MINTi | Q4FZT0 |
STRINGi | 10116.ENSRNOP00000013151 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 324 – 353 | DisorderedSequence analysisAdd BLAST | 30 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 215 – 252 | Sequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 338 – 353 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transit peptidePhylogenomic databases
eggNOGi | KOG2620, Eukaryota |
GeneTreei | ENSGT01030000234614 |
HOGENOMi | CLU_024949_1_0_1 |
InParanoidi | Q4FZT0 |
OMAi | TQIRAEM |
OrthoDBi | 1237942at2759 |
PhylomeDBi | Q4FZT0 |
TreeFami | TF105750 |
Family and domain databases
Gene3Di | 3.30.479.30, 1 hit |
InterProi | View protein in InterPro IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR032435, Band_7_C IPR001972, Stomatin_HflK_HflKC_fam |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit PF16200, Band_7_C, 1 hit |
PRINTSi | PR00721, STOMATIN |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MLARAARGTG ALLLRGSVQA SGRIPRRASS GLPRNTVILF VPQQEAWVVE
60 70 80 90 100
RMGRFHRILE PGLNVLIPVL DRIRYVQSLK EIVINVPEQS AVTLDNVTLQ
110 120 130 140 150
IDGVLYLRIM DPYKASYGVE DPEYAVTQLA QTTMRSELGK LSLDKVFRER
160 170 180 190 200
ESLNANIVDA INQAADCWGI RCLRYEIKDI HVPPRVKESM QMQVEAERRK
210 220 230 240 250
RATVLESEGT RESAINVAEG KKQAQILASE AEKAEQINQA AGEASAVLAK
260 270 280 290 300
AKAKAEAIRI LAGALTQHNG DAAASLTVAE QYVSAFSKLA KDSNTVLLPS
310 320 330 340 350
NPSDVTSMVA QAMGVYGALT KAPVPGAQNS SEARRDVQTT DTSIEELGRV
KLS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC099164 mRNA Translation: AAH99164.1 |
RefSeqi | NP_001026816.1, NM_001031646.1 |
Genome annotation databases
Ensembli | ENSRNOT00000013151; ENSRNOP00000013151; ENSRNOG00000009535 |
GeneIDi | 298203 |
KEGGi | rno:298203 |
UCSCi | RGD:1308285, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC099164 mRNA Translation: AAH99164.1 |
RefSeqi | NP_001026816.1, NM_001031646.1 |
3D structure databases
AlphaFoldDBi | Q4FZT0 |
SMRi | Q4FZT0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 255804, 4 interactors |
IntActi | Q4FZT0, 2 interactors |
MINTi | Q4FZT0 |
STRINGi | 10116.ENSRNOP00000013151 |
PTM databases
iPTMneti | Q4FZT0 |
PhosphoSitePlusi | Q4FZT0 |
Proteomic databases
jPOSTi | Q4FZT0 |
PaxDbi | Q4FZT0 |
PRIDEi | Q4FZT0 |
Genome annotation databases
Ensembli | ENSRNOT00000013151; ENSRNOP00000013151; ENSRNOG00000009535 |
GeneIDi | 298203 |
KEGGi | rno:298203 |
UCSCi | RGD:1308285, rat |
Organism-specific databases
CTDi | 30968 |
RGDi | 1308285, Stoml2 |
Phylogenomic databases
eggNOGi | KOG2620, Eukaryota |
GeneTreei | ENSGT01030000234614 |
HOGENOMi | CLU_024949_1_0_1 |
InParanoidi | Q4FZT0 |
OMAi | TQIRAEM |
OrthoDBi | 1237942at2759 |
PhylomeDBi | Q4FZT0 |
TreeFami | TF105750 |
Enzyme and pathway databases
Reactomei | R-RNO-8949664, Processing of SMDT1 |
Miscellaneous databases
PROi | PR:Q4FZT0 |
Gene expression databases
Bgeei | ENSRNOG00000009535, Expressed in female gonad and 21 other tissues |
Genevisiblei | Q4FZT0, RN |
Family and domain databases
Gene3Di | 3.30.479.30, 1 hit |
InterProi | View protein in InterPro IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR032435, Band_7_C IPR001972, Stomatin_HflK_HflKC_fam |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit PF16200, Band_7_C, 1 hit |
PRINTSi | PR00721, STOMATIN |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STML2_RAT | |
Accessioni | Q4FZT0Primary (citable) accession number: Q4FZT0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | August 30, 2005 | |
Last modified: | May 25, 2022 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families