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Protein

Macrolide export ATP-binding/permease protein MacB

Gene

macB

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi53 – 60ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPARC259536:PSYC_RS03010-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Macrolide export ATP-binding/permease protein MacBUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:macBUniRule annotation
Ordered Locus Names:Psyc_0572
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
Proteomesi
  • UP000000546 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei287 – 307HelicalUniRule annotationAdd BLAST21
Transmembranei544 – 564HelicalUniRule annotationAdd BLAST21
Transmembranei588 – 608HelicalUniRule annotationAdd BLAST21
Transmembranei630 – 650HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002699671 – 665Macrolide export ATP-binding/permease protein MacBAdd BLAST665

Proteomic databases

PRIDEiQ4FU75

Interactioni

Subunit structurei

Homodimer. Part of the tripartite efflux system MacAB-TolC, which is composed of an inner membrane transporter, MacB, a periplasmic membrane fusion protein, MacA, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. Interacts with MacA.UniRule annotation

Protein-protein interaction databases

STRINGi259536.Psyc_0572

Structurei

3D structure databases

ProteinModelPortaliQ4FU75
SMRiQ4FU75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 255ABC transporterUniRule annotationAdd BLAST239

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D6C Bacteria
COG0577 LUCA
COG1136 LUCA
HOGENOMiHOG000208217
KOiK05685
OMAiLNTDDIR
OrthoDBiPOG091H023H

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003838 ABC_permease_dom
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR017911 ABC_transptr_macrolide_ATP-bd
IPR025857 MacB_PCD
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
PF02687 FtsX, 1 hit
PF12704 MacB_PCD, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51267 MACB, 1 hit

Sequencei

Sequence statusi: Complete.

Q4FU75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSQDLYANA ATDKPLMQVK GLIREFKAGE QTIRVLHDIN LTIHQGEMVA
60 70 80 90 100
IIGQSGSGKS TLMNILGCLD QATAGDYQVF GQSVNRLAPD ELAKLRREHF
110 120 130 140 150
GFIFQRYHLL GDISARDNVS VPAVYAGMDG QARNERAEQL LSDLGLADKV
160 170 180 190 200
NNRPSQLSGG QQQRVSIARA LMNGGDIILA DEPTGALDSK SGKDVVQILK
210 220 230 240 250
NLNAQGHTII MVTHDPGLAA QAERVIEIKD GYIIADYKNE DYQRPVAQFS
260 270 280 290 300
SIIDKHRKSA FGSFIDRLLE SFKMSLLAMR AHKMRTLLTM LGIIIGIASV
310 320 330 340 350
VSVVGLGKGS QEQILSNISS LGTNTITITD GYPYGDPRRQ YNDDNLTPQD
360 370 380 390 400
AQAVADQPYV LSVSPQLNSN MSVRYRNVQE AASISGVGKD YLDVSGETLA
410 420 430 440 450
MGQGFDEQSI LRRTQDIIID SNAHKTFFPT TANPIGEVLL IGSVPGRVIG
460 470 480 490 500
VLEPNEGGFS RSVDSPTLYM PYTTMMSRLI GSAYIESFVA LIDNNISSSA
510 520 530 540 550
AESAISNLMK SRHGTDDFRI RNSDSIRQTI ESTTAAMTLL ISSIAIISLI
560 570 580 590 600
VGGIGVMNIM LVSVTERTNE IGVRMAVGAR QSDIMQQFLI EAVLVCILGG
610 620 630 640 650
LLGIGMAFAI GELINRVGGD SFKVIYSSTS IIAAFVCSTL IGVVFGFLPA
660
RNAAKLDPVE ALSRD
Length:665
Mass (Da):71,792
Last modified:August 30, 2005 - v1
Checksum:i56EA210BA90DA3EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA Translation: AAZ18433.1
RefSeqiWP_011279862.1, NC_007204.1

Genome annotation databases

EnsemblBacteriaiAAZ18433; AAZ18433; Psyc_0572
KEGGipar:Psyc_0572

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA Translation: AAZ18433.1
RefSeqiWP_011279862.1, NC_007204.1

3D structure databases

ProteinModelPortaliQ4FU75
SMRiQ4FU75
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi259536.Psyc_0572

Proteomic databases

PRIDEiQ4FU75

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ18433; AAZ18433; Psyc_0572
KEGGipar:Psyc_0572

Phylogenomic databases

eggNOGiENOG4105D6C Bacteria
COG0577 LUCA
COG1136 LUCA
HOGENOMiHOG000208217
KOiK05685
OMAiLNTDDIR
OrthoDBiPOG091H023H

Enzyme and pathway databases

BioCyciPARC259536:PSYC_RS03010-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003838 ABC_permease_dom
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR017911 ABC_transptr_macrolide_ATP-bd
IPR025857 MacB_PCD
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
PF02687 FtsX, 1 hit
PF12704 MacB_PCD, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51267 MACB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMACB_PSYA2
AccessioniPrimary (citable) accession number: Q4FU75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 30, 2005
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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