UniProtKB - Q4FK66 (PR38A_MOUSE)
Protein
Pre-mRNA-splicing factor 38A
Gene
Prpf38a
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in pre-mRNA splicing as a component of the spliceosome.By similarity
GO - Biological processi
- mRNA splicing, via spliceosome Source: UniProtKB
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
Reactomei | R-MMU-72163, mRNA Splicing - Major Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Pre-mRNA-splicing factor 38A |
Gene namesi | Name:Prpf38a |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916962, Prpf38a |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nuclear membrane Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
- precatalytic spliceosome Source: MGI
- U2-type precatalytic spliceosome Source: UniProtKB
Keywords - Cellular componenti
Nucleus, SpliceosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287274 | 1 – 312 | Pre-mRNA-splicing factor 38AAdd BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 11 | PhosphoserineBy similarity | 1 | |
Modified residuei | 193 | PhosphoserineCombined sources | 1 | |
Modified residuei | 194 | PhosphoserineCombined sources | 1 | |
Modified residuei | 209 | PhosphoserineCombined sources | 1 | |
Modified residuei | 226 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q4FK66 |
jPOSTi | Q4FK66 |
PaxDbi | Q4FK66 |
PeptideAtlasi | Q4FK66 |
PRIDEi | Q4FK66 |
PTM databases
iPTMneti | Q4FK66 |
PhosphoSitePlusi | Q4FK66 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000063800, Expressed in vestibular organ and 309 other tissues |
ExpressionAtlasi | Q4FK66, baseline and differential |
Genevisiblei | Q4FK66, MM |
Interactioni
Subunit structurei
Component of the spliceosome B complex.
Interacts (via N-terminal interaction domain) with ZMAT2 AND MFAP1.
By similarityProtein-protein interaction databases
IntActi | Q4FK66, 2 interactors |
MINTi | Q4FK66 |
STRINGi | 10090.ENSMUSP00000078207 |
Miscellaneous databases
RNActi | Q4FK66, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 179 | N-terminal protein interaction domainBy similarityAdd BLAST | 179 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 170 – 204 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 213 – 291 | Arg-richAdd BLAST | 79 |
Sequence similaritiesi
Belongs to the PRP38 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2889, Eukaryota |
GeneTreei | ENSGT00730000111085 |
HOGENOMi | CLU_039466_1_0_1 |
InParanoidi | Q4FK66 |
OMAi | NVHGTNP |
PhylomeDBi | Q4FK66 |
TreeFami | TF105910 |
Family and domain databases
InterProi | View protein in InterPro IPR005037, PRP38 IPR024767, PRP38_C |
PANTHERi | PTHR23142, PTHR23142, 1 hit |
Pfami | View protein in Pfam PF03371, PRP38, 1 hit PF12871, PRP38_assoc, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q4FK66-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MANRTVKDAH SIHGTNPQYL VEKIIRTRIY ESKYWKEECF GLTAELVVDK
60 70 80 90 100
AMELKFVGGV YGGNIKPTPF LCLTLKMLQI QPEKDIIVEF IKNEDFKYVR
110 120 130 140 150
MLGALYMRLT GTAIDCYKYL EPLYNDYRKI KSQNRNGEFV LMHVDEFIYE
160 170 180 190 200
LLHSERVCDI ILPRLQKRYV LEEAEQLEPR VSALEEDMDD VESSEEEEEE
210 220 230 240 250
DEKLERVPSP DHRRRSYRDL DKPRRSPALR YRRSRSRSPR RRSRSPKRRS
260 270 280 290 300
PSPRRERHRS KSPRRHRSRS RDRRHRSRSK SPGHHRSHRH RSHSKSPERS
310
KKSHKKSRRG NE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 | Y → F in BAC36057 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025425 | 1 – 141 | Missing in isoform 2. 1 PublicationAdd BLAST | 141 | |
Alternative sequenceiVSP_025426 | 204 – 207 | LERV → VRHV in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_025427 | 208 – 312 | Missing in isoform 2. 1 PublicationAdd BLAST | 105 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075925 mRNA Translation: BAC36057.1 AK169741 mRNA Translation: BAE41341.1 CT010186 mRNA Translation: CAJ18394.1 AL626783 Genomic DNA No translation available. BC059875 mRNA Translation: AAH59875.1 |
CCDSi | CCDS18452.1 [Q4FK66-1] |
RefSeqi | NP_766285.2, NM_172697.3 [Q4FK66-1] |
Genome annotation databases
Ensembli | ENSMUST00000079213; ENSMUSP00000078207; ENSMUSG00000063800 [Q4FK66-1] |
GeneIDi | 230596 |
KEGGi | mmu:230596 |
UCSCi | uc008ubf.2, mouse [Q4FK66-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075925 mRNA Translation: BAC36057.1 AK169741 mRNA Translation: BAE41341.1 CT010186 mRNA Translation: CAJ18394.1 AL626783 Genomic DNA No translation available. BC059875 mRNA Translation: AAH59875.1 |
CCDSi | CCDS18452.1 [Q4FK66-1] |
RefSeqi | NP_766285.2, NM_172697.3 [Q4FK66-1] |
3D structure databases
SMRi | Q4FK66 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q4FK66, 2 interactors |
MINTi | Q4FK66 |
STRINGi | 10090.ENSMUSP00000078207 |
PTM databases
iPTMneti | Q4FK66 |
PhosphoSitePlusi | Q4FK66 |
Proteomic databases
EPDi | Q4FK66 |
jPOSTi | Q4FK66 |
PaxDbi | Q4FK66 |
PeptideAtlasi | Q4FK66 |
PRIDEi | Q4FK66 |
Protocols and materials databases
Antibodypediai | 53332, 105 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000079213; ENSMUSP00000078207; ENSMUSG00000063800 [Q4FK66-1] |
GeneIDi | 230596 |
KEGGi | mmu:230596 |
UCSCi | uc008ubf.2, mouse [Q4FK66-1] |
Organism-specific databases
CTDi | 84950 |
MGIi | MGI:1916962, Prpf38a |
Phylogenomic databases
eggNOGi | KOG2889, Eukaryota |
GeneTreei | ENSGT00730000111085 |
HOGENOMi | CLU_039466_1_0_1 |
InParanoidi | Q4FK66 |
OMAi | NVHGTNP |
PhylomeDBi | Q4FK66 |
TreeFami | TF105910 |
Enzyme and pathway databases
Reactomei | R-MMU-72163, mRNA Splicing - Major Pathway |
Miscellaneous databases
BioGRID-ORCSi | 230596, 9 hits in 18 CRISPR screens |
ChiTaRSi | Prpf38a, mouse |
PROi | PR:Q4FK66 |
RNActi | Q4FK66, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000063800, Expressed in vestibular organ and 309 other tissues |
ExpressionAtlasi | Q4FK66, baseline and differential |
Genevisiblei | Q4FK66, MM |
Family and domain databases
InterProi | View protein in InterPro IPR005037, PRP38 IPR024767, PRP38_C |
PANTHERi | PTHR23142, PTHR23142, 1 hit |
Pfami | View protein in Pfam PF03371, PRP38, 1 hit PF12871, PRP38_assoc, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PR38A_MOUSE | |
Accessioni | Q4FK66Primary (citable) accession number: Q4FK66 Secondary accession number(s): Q6PB58, Q8BVY2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | August 30, 2005 | |
Last modified: | February 10, 2021 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families