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Protein

Annexin

Gene

Anxa1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:Anxa1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96819 Anxa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiQ4FJV4
PRIDEiQ4FJV4
TopDownProteomicsiQ4FJV4

Expressioni

Gene expression databases

BgeeiENSMUSG00000024659 Expressed in 267 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ4FJV4 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ4FJV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The full-length protein can bind eight Ca2+ ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca2+, these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
HOVERGENiHBG061815
KOiK17091
OMAiGTRHKTL
OrthoDBiEOG091G0H6H

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002388 ANX1
PANTHERiPTHR10502:SF17 PTHR10502:SF17, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00197 ANNEXINI
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 3 hits

Sequencei

Sequence statusi: Complete.

Q4FJV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMVSEFLKQ ARFLENQEQE YVQAVKSYKG GPGSAVSPYP SFNVSSDVAA
60 70 80 90 100
LHKAIMVKGV DEATIIDILT KRTNAQRQQI KAAYLQENGK PLDEVLRKAL
110 120 130 140 150
TGHLEEVVLA MLKTPAQFDA DELRGAMKGL GTDEDTLIEI LTTRSNEQIR
160 170 180 190 200
EINRVYREEL KRDLAKDITS DTSGDFRKAL LALAKGDRCQ DLSVNQDLAD
210 220 230 240 250
TDARALYEAG ERRKGTDVNV FTTILTSRSF PHLRRVFQNY GKYSQHDMNK
260 270 280 290 300
ALDLELKGDI EKCLTTIVKC ATSTPAFFAE KLYEAMKGAG TRHKALIRIM
310 320 330 340
VSRSEIDMNE IKVFYQKKYG ISLCQAILDE TKGDYEKILV ALCGGN
Length:346
Mass (Da):38,734
Last modified:August 30, 2005 - v1
Checksum:i9393A11B24191D3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150564 mRNA Translation: BAE29662.1
AK150718 mRNA Translation: BAE29796.1
AK153156 mRNA Translation: BAE31766.1
AK167612 mRNA Translation: BAE39665.1
CT010298 mRNA Translation: CAJ18506.1
RefSeqiNP_034860.2, NM_010730.2
UniGeneiMm.248360

Genome annotation databases

GeneIDi16952
KEGGimmu:16952

Similar proteinsi

Entry informationi

Entry nameiQ4FJV4_MOUSE
AccessioniPrimary (citable) accession number: Q4FJV4
Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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