Prnp

Functionⁱ

GO - Molecular functionⁱ

ATP-dependent protein binding Source: Ensembl
chaperone binding Source: Ensembl
ion channel binding Source: Ensembl
lamin binding Source: Ensembl
type 5 metabotropic glutamate receptor binding Source: Ensembl

GO - Biological processⁱ

learning or memory Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of catalytic activity Source: Ensembl
negative regulation of long-term synaptic potentiation Source: Ensembl
positive regulation of protein localization to plasma membrane Source: Ensembl
protein homooligomerization Source: InterPro
response to cadmium ion Source: Ensembl
response to copper ion Source: Ensembl

Keywordsⁱ

Molecular function	PrionUniRule annotationARBA annotation
Ligand	CopperARBA annotation, ZincARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Major prion proteinUniRule annotationARBA annotation
Gene namesⁱ	Name:PrnpImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:97769, Prnp

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	111 – 130	HelicalSequence analysisAdd BLAST		20
Transmembraneⁱ	234 – 253	HelicalSequence analysisAdd BLAST		20

Keywords - Cellular componentⁱ

Amyloid, Cell membraneUniRule annotation, Golgi apparatusARBA annotation, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_5014309351	23 – 254	Major prion proteinSequence analysisAdd BLAST		232

Keywords - PTMⁱ

Glycoprotein, GPI-anchorARBA annotation, Lipoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q4FJQ7

MaxQBⁱ

Q4FJQ7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000079037, Expressed in Ammon's horn and 353 other tissues
ExpressionAtlasⁱ	Q4FJQ7, baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

ATP-dependent protein binding Source: Ensembl
chaperone binding Source: Ensembl
ion channel binding Source: Ensembl
lamin binding Source: Ensembl
type 5 metabotropic glutamate receptor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Chemistry databases

BindingDBⁱ	Q4FJQ7

BindingDBⁱ

Q4FJQ7

Structureⁱ

3D structure databases

SMRⁱ	Q4FJQ7
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	112 – 127	Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST		16
Domainⁱ	199 – 217	Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST		19

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	25 – 104	DisorderedSequence analysisAdd BLAST		80

Sequence similaritiesⁱ

Belongs to the prion family.UniRule annotationARBA annotation

Keywords - Domainⁱ

RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOGENOMⁱ	CLU_094631_0_0_1
OMAⁱ	HNPGYPH
Database of Orthologous Groups More...OrthoDBⁱ	1403854at2759

Family and domain databases

Gene3Dⁱ	1.10.790.10, 1 hit
InterProⁱ	View protein in InterPro IPR000817, Prion IPR036924, Prion/Doppel_b-ribbon_dom_sf IPR022416, Prion/Doppel_prot_b-ribbon_dom IPR025860, Prion_N_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00377, Prion, 1 hit PF11587, Prion_bPrPp, 1 hit
PRINTSⁱ	PR00341, PRION
SMARTⁱ	View protein in SMART SM00157, PRP, 1 hit
SUPFAMⁱ	SSF54098, SSF54098, 1 hit
PROSITEⁱ	View protein in PROSITE PS00291, PRION_1, 1 hit PS00706, PRION_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q4FJQ7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MANLGYWLLA LFVTMWTDVG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP 
        60         70         80         90        100
PQGGTWGQPH GGGWGQPHGG SWGQPHGGSW GQPHGGGWGQ GGGTHNQWNK 
       110        120        130        140        150
PSKPKTNLKH VAGAAAAGAV VGGLGGYMLG SAMSRPMIHF GNDWEDRYYR 
       160        170        180        190        200
ENMYRYPNQV YYRPVDQYSN QNNFVHDCVN ITIKQHTVTT TTKGENFTET 
       210        220        230        240        250
DVKMMERVVE QMCVTQYQKE SQAYYDGRRS SSTVLFSSPP VILLISFLIF 

LIVG

Length:254

Mass (Da):27,977

Last modified:August 30, 2005 - v1

Checksum:ⁱD5331E6321826CC0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK158908 mRNA Translation: BAE34724.1 AK159056 mRNA Translation: BAE34788.1 AK159224 mRNA Translation: BAE34911.1 AK160091 mRNA Translation: BAE35622.1 AK162504 mRNA Translation: BAE36950.1 CT010345 mRNA Translation: CAJ18553.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001265185.1, NM_001278256.1 NP_035300.1, NM_011170.3

Genome annotation databases

GeneIDⁱ	19122
KEGGⁱ	mmu:19122

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q4FJQ7	Major prion protein	)	MOUSE		254	UniRef100_P04925
+6

Protein	Similar proteins		Species	Score	Length	Source
Q4FJQ7	Major prion protein	)	MOUSE		254	UniRef90_P04925
Major prion protein		SIGHI		254
Major prion protein		RAT		254
Major prion protein		CRISP		257
Major prion protein		MYOGP		255
+53

Protein	Similar proteins		Species	Score	Length	Source
Q4FJQ7	Major prion protein	)	MOUSE		254	UniRef50_P04925
Major prion protein		RAT		254
Major prion protein		SIGHI		254
Major prion protein		TRIVU		259
Major prion protein		VULLA		257
+860

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK158908 mRNA Translation: BAE34724.1 AK159056 mRNA Translation: BAE34788.1 AK159224 mRNA Translation: BAE34911.1 AK160091 mRNA Translation: BAE35622.1 AK162504 mRNA Translation: BAE36950.1 CT010345 mRNA Translation: CAJ18553.1
RefSeqⁱ	NP_001265185.1, NM_001278256.1 NP_035300.1, NM_011170.3

3D structure databases

SMRⁱ	Q4FJQ7
ModBaseⁱ	Search...

Chemistry databases

BindingDBⁱ	Q4FJQ7

BindingDBⁱ

Q4FJQ7

Proteomic databases

MaxQBⁱ	Q4FJQ7

MaxQBⁱ

Q4FJQ7

Protocols and materials databases

Antibodypediaⁱ	3351, 835 antibodies
The DNASU plasmid repository More...DNASUⁱ	19122

Genome annotation databases

GeneIDⁱ	19122
KEGGⁱ	mmu:19122

Organism-specific databases

CTDⁱ	5621
MGIⁱ	MGI:97769, Prnp

Phylogenomic databases

HOGENOMⁱ	CLU_094631_0_0_1
OMAⁱ	HNPGYPH
OrthoDBⁱ	1403854at2759

Miscellaneous databases

BioGRID-ORCSⁱ	19122, 0 hits in 52 CRISPR screens
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000079037, Expressed in Ammon's horn and 353 other tissues
ExpressionAtlasⁱ	Q4FJQ7, baseline and differential

Family and domain databases

Gene3Dⁱ	1.10.790.10, 1 hit
InterProⁱ	View protein in InterPro IPR000817, Prion IPR036924, Prion/Doppel_b-ribbon_dom_sf IPR022416, Prion/Doppel_prot_b-ribbon_dom IPR025860, Prion_N_dom
Pfamⁱ	View protein in Pfam PF00377, Prion, 1 hit PF11587, Prion_bPrPp, 1 hit
PRINTSⁱ	PR00341, PRION
SMARTⁱ	View protein in SMART SM00157, PRP, 1 hit
SUPFAMⁱ	SSF54098, SSF54098, 1 hit
PROSITEⁱ	View protein in PROSITE PS00291, PRION_1, 1 hit PS00706, PRION_2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q4FJQ7_MOUSE
Accessionⁱ	Q4FJQ7Primary (citable) accession number: Q4FJQ7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	August 30, 2005
	Last sequence update:	August 30, 2005
	Last modified:	June 2, 2021
	This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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UniParc

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Supporting data

UniProtKB - Q4FJQ7 (Q4FJQ7_MOUSE)

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Major prion protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Plasma membrane

Other locations

Cytosol

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ