UniProtKB - Q4FJQ7 (Q4FJQ7_MOUSE)
Protein
Major prion protein
Gene
Prnp
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- amyloid-beta binding Source: Ensembl
- ATP-dependent protein binding Source: Ensembl
- chaperone binding Source: Ensembl
- cuprous ion binding Source: Ensembl
- identical protein binding Source: Ensembl
- ion channel binding Source: Ensembl
- lamin binding Source: Ensembl
- microtubule binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- type 5 metabotropic glutamate receptor binding Source: Ensembl
GO - Biological processi
- calcium-mediated signaling using intracellular calcium source Source: Ensembl
- cellular response to amyloid-beta Source: Ensembl
- cellular response to copper ion Source: Ensembl
- learning or memory Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of catalytic activity Source: Ensembl
- negative regulation of long-term synaptic potentiation Source: Ensembl
- positive regulation of neuron apoptotic process Source: Ensembl
- positive regulation of protein localization to plasma membrane Source: Ensembl
- positive regulation of protein tyrosine kinase activity Source: Ensembl
- protein destabilization Source: Ensembl
- protein homooligomerization Source: InterPro
- regulation of intracellular calcium activated chloride channel activity Source: Ensembl
- response to cadmium ion Source: Ensembl
Keywordsi
Molecular function | PrionUniRule annotationARBA annotation |
Ligand | CopperARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Major prion proteinUniRule annotationARBA annotation |
Gene namesi | Name:PrnpImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:97769, Prnp |
Subcellular locationi
Golgi apparatus
- Golgi apparatus ARBA annotation
Plasma membrane
- Cell membrane ARBA annotation; GPI-anchor ARBA annotation
Other locations
- Membrane ARBA annotation; GPI-anchor ARBA annotation
Cytosol
- cytosol Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Nucleus
- nuclear membrane Source: Ensembl
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- anchored component of membrane Source: UniProtKB-KW
- cell surface Source: Ensembl
- dendrite Source: Ensembl
- inclusion body Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: Ensembl
- postsynaptic density Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 111 – 130 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 234 – 253 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Amyloid, Cell membraneUniRule annotation, Golgi apparatusARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5014309351 | 23 – 254 | Major prion proteinSequence analysisAdd BLAST | 232 |
Keywords - PTMi
Glycoprotein, GPI-anchorARBA annotation, LipoproteinProteomic databases
MaxQBi | Q4FJQ7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000079037, Expressed in Ammon's horn and 347 other tissues |
ExpressionAtlasi | Q4FJQ7, baseline and differential |
Interactioni
GO - Molecular functioni
- ATP-dependent protein binding Source: Ensembl
- chaperone binding Source: Ensembl
- identical protein binding Source: Ensembl
- ion channel binding Source: Ensembl
- lamin binding Source: Ensembl
- microtubule binding Source: Ensembl
- type 5 metabotropic glutamate receptor binding Source: Ensembl
Chemistry databases
BindingDBi | Q4FJQ7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 112 – 127 | Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST | 16 | |
Domaini | 199 – 217 | Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST | 19 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 104 | DisorderedSequence analysisAdd BLAST | 80 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_094631_0_0_1 |
OMAi | HNPGYPH |
OrthoDBi | 1403854at2759 |
Family and domain databases
Gene3Di | 1.10.790.10, 1 hit |
InterProi | View protein in InterPro IPR000817, Prion IPR036924, Prion/Doppel_b-ribbon_dom_sf IPR022416, Prion/Doppel_prot_b-ribbon_dom IPR025860, Prion_N_dom |
Pfami | View protein in Pfam PF00377, Prion, 1 hit PF11587, Prion_bPrPp, 1 hit |
PRINTSi | PR00341, PRION |
SMARTi | View protein in SMART SM00157, PRP, 1 hit |
SUPFAMi | SSF54098, SSF54098, 1 hit |
PROSITEi | View protein in PROSITE PS00291, PRION_1, 1 hit PS00706, PRION_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4FJQ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANLGYWLLA LFVTMWTDVG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP
60 70 80 90 100
PQGGTWGQPH GGGWGQPHGG SWGQPHGGSW GQPHGGGWGQ GGGTHNQWNK
110 120 130 140 150
PSKPKTNLKH VAGAAAAGAV VGGLGGYMLG SAMSRPMIHF GNDWEDRYYR
160 170 180 190 200
ENMYRYPNQV YYRPVDQYSN QNNFVHDCVN ITIKQHTVTT TTKGENFTET
210 220 230 240 250
DVKMMERVVE QMCVTQYQKE SQAYYDGRRS SSTVLFSSPP VILLISFLIF
LIVG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK158908 mRNA Translation: BAE34724.1 AK159056 mRNA Translation: BAE34788.1 AK159224 mRNA Translation: BAE34911.1 AK160091 mRNA Translation: BAE35622.1 AK162504 mRNA Translation: BAE36950.1 CT010345 mRNA Translation: CAJ18553.1 |
RefSeqi | NP_001265185.1, NM_001278256.1 NP_035300.1, NM_011170.3 |
Genome annotation databases
GeneIDi | 19122 |
KEGGi | mmu:19122 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK158908 mRNA Translation: BAE34724.1 AK159056 mRNA Translation: BAE34788.1 AK159224 mRNA Translation: BAE34911.1 AK160091 mRNA Translation: BAE35622.1 AK162504 mRNA Translation: BAE36950.1 CT010345 mRNA Translation: CAJ18553.1 |
RefSeqi | NP_001265185.1, NM_001278256.1 NP_035300.1, NM_011170.3 |
3D structure databases
SMRi | Q4FJQ7 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q4FJQ7 |
Proteomic databases
MaxQBi | Q4FJQ7 |
Protocols and materials databases
Antibodypediai | 3351, 814 antibodies |
Genome annotation databases
GeneIDi | 19122 |
KEGGi | mmu:19122 |
Organism-specific databases
CTDi | 5621 |
MGIi | MGI:97769, Prnp |
Phylogenomic databases
HOGENOMi | CLU_094631_0_0_1 |
OMAi | HNPGYPH |
OrthoDBi | 1403854at2759 |
Miscellaneous databases
BioGRID-ORCSi | 19122, 0 hits in 17 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000079037, Expressed in Ammon's horn and 347 other tissues |
ExpressionAtlasi | Q4FJQ7, baseline and differential |
Family and domain databases
Gene3Di | 1.10.790.10, 1 hit |
InterProi | View protein in InterPro IPR000817, Prion IPR036924, Prion/Doppel_b-ribbon_dom_sf IPR022416, Prion/Doppel_prot_b-ribbon_dom IPR025860, Prion_N_dom |
Pfami | View protein in Pfam PF00377, Prion, 1 hit PF11587, Prion_bPrPp, 1 hit |
PRINTSi | PR00341, PRION |
SMARTi | View protein in SMART SM00157, PRP, 1 hit |
SUPFAMi | SSF54098, SSF54098, 1 hit |
PROSITEi | View protein in PROSITE PS00291, PRION_1, 1 hit PS00706, PRION_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q4FJQ7_MOUSE | |
Accessioni | Q4FJQ7Primary (citable) accession number: Q4FJQ7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 30, 2005 |
Last sequence update: | August 30, 2005 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |