UniProtKB - Q4FJL1 (Q4FJL1_MOUSE)
Protein
Receptor protein serine/threonine kinase
Gene
Tgfbr1
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:2.7.11.30ARBA annotation
- ATP + L-threonyl-[receptor-protein] = ADP + H+ + O-phospho-L-threonyl-[receptor-protein]ARBA annotationEC:2.7.11.30ARBA annotation
Cofactori
Protein has several cofactor binding sites:GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- I-SMAD binding Source: Ensembl
- transforming growth factor beta binding Source: Ensembl
- transforming growth factor beta receptor activity, type I Source: AgBase
- type II transforming growth factor beta receptor binding Source: Ensembl
GO - Biological processi
- activation of MAPKK activity Source: Ensembl
- activin receptor signaling pathway Source: AgBase
- cardiac epithelial to mesenchymal transition Source: AgBase
- cell motility Source: Ensembl
- endothelial cell activation Source: AgBase
- heart development Source: AgBase
- intracellular signal transduction Source: AgBase
- mesenchymal cell differentiation Source: AgBase
- negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
- pathway-restricted SMAD protein phosphorylation Source: Ensembl
- peptidyl-serine phosphorylation Source: Ensembl
- peptidyl-threonine phosphorylation Source: Ensembl
- positive regulation of apoptotic signaling pathway Source: Ensembl
- positive regulation of cell growth Source: Ensembl
- positive regulation of cell migration Source: Ensembl
- positive regulation of endothelial cell proliferation Source: AgBase
- positive regulation of gene expression Source: AgBase
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
- positive regulation of protein kinase B signaling Source: Ensembl
- positive regulation of SMAD protein signal transduction Source: Ensembl
- positive regulation of transcription, DNA-templated Source: AgBase
- regulation of epithelial to mesenchymal transition Source: AgBase
- regulation of gene expression Source: AgBase
- regulation of protein ubiquitination Source: Ensembl
- response to cholesterol Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseARBA annotation, Transferase |
Ligand | ATP-bindingARBA annotation, ManganeseARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor protein serine/threonine kinaseARBA annotation (EC:2.7.11.30ARBA annotation) |
Gene namesi | Name:Tgfbr1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:98728, Tgfbr1 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Endosome
- endosome Source: Ensembl
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- bicellular tight junction Source: Ensembl
- cell surface Source: Ensembl
- membrane Source: AgBase
- membrane raft Source: Ensembl
- receptor complex Source: Ensembl
Keywords - Cellular componenti
MembraneARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000007613, Expressed in metanephric cortical collecting duct and 327 other tissues |
ExpressionAtlasi | Q4FJL1, baseline and differential |
Interactioni
GO - Molecular functioni
- I-SMAD binding Source: Ensembl
- transforming growth factor beta binding Source: Ensembl
- type II transforming growth factor beta receptor binding Source: Ensembl
Chemistry databases
BindingDBi | Q4FJL1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.ARBA annotation
Keywords - Domaini
SignalARBA annotationPhylogenomic databases
OrthoDBi | 776697at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF00069, Pkinase, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4FJL1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAAAAAPRR PQLLIVLVAA ATLLPGAKAL QCFCHLCTKD NFTCETDGLC
60 70 80 90 100
FVSVTETTDK VIHNSMCIAE IDLIPRDRPF VCAPSSKTGA VTTTYCCNQD
110 120 130 140 150
HCNKIELPTT GPFSEKQSAG LGPVELAAVI AGPVCFVCIA LMLMVYICHN
160 170 180 190 200
RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL IYDMTTSGSG SGLPLLVQRT
210 220 230 240 250
IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ
260 270 280 290 300
TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE
310 320 330 340 350
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA
360 370 380 390 400
DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD
410 420 430 440 450
IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL
460 470 480 490 500
RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG
IKM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CT010393 mRNA Translation: CAJ18600.1 |
RefSeqi | NP_033396.1, NM_009370.3 |
Genome annotation databases
GeneIDi | 21812 |
KEGGi | mmu:21812 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CT010393 mRNA Translation: CAJ18600.1 |
RefSeqi | NP_033396.1, NM_009370.3 |
3D structure databases
SMRi | Q4FJL1 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q4FJL1 |
Protocols and materials databases
Antibodypediai | 29038, 588 antibodies |
Genome annotation databases
GeneIDi | 21812 |
KEGGi | mmu:21812 |
Organism-specific databases
CTDi | 7046 |
MGIi | MGI:98728, Tgfbr1 |
Phylogenomic databases
OrthoDBi | 776697at2759 |
Miscellaneous databases
BioGRID-ORCSi | 21812, 3 hits in 17 CRISPR screens |
ChiTaRSi | Tgfbr1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000007613, Expressed in metanephric cortical collecting duct and 327 other tissues |
ExpressionAtlasi | Q4FJL1, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF00069, Pkinase, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q4FJL1_MOUSE | |
Accessioni | Q4FJL1Primary (citable) accession number: Q4FJL1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 30, 2005 |
Last sequence update: | August 30, 2005 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |