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Entry version 57 (08 May 2019)
Sequence version 1 (13 Sep 2005)
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Protein
Submitted name:

Calpain cysteine peptidase, putative

Gene

Tc00.1047053510121.170

Organism
Trypanosoma cruzi (strain CL Brener)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calpain cysteine peptidase, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:Tc00.1047053510121.170Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrypanosoma cruzi (strain CL Brener)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri353153 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002296 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4DQ12

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5693.XP_816478.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini686 – 993Calpain catalyticInterPro annotationAdd BLAST308

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0045 Eukaryota
ENOG410XP0B LUCA

Database of Orthologous Groups

More...
OrthoDBi
25664at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR036213 Calpain_III_sf
IPR032675 LRR_dom_sf
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00704 CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00230 CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49758 SSF49758, 6 hits
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4DQ12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTLEDLYAS YCRRRGCRPN SFLSRYLQEE FTRHSQQRVL ESVDLSDNYV
60 70 80 90 100
GAKGIIPVLD LVKNVKTVRR LDVRKNMLEH EQLEHLVYCL ALHPSIEEVD
110 120 130 140 150
VSGNALDDGS VDIILKLLQA NESITVFRVD GNHFASSSLS LINDHLERNK
160 170 180 190 200
ERKAERQKEM TPVYTGKWFR AQVRGSLAEE TSGGHVHFST WWKNQQYIMR
210 220 230 240 250
VSRRAQVRVV MDVDDPKAAR QAGFFVFYSD GTRKVIVADA DHIAAESNVD
260 270 280 290 300
HSHCFVTLLV EEHAAYSIMP FTFHPERSMS FTLMVELCQE SLKSSEGWVT
310 320 330 340 350
LEPVDSALDW LVYVMHGEWT SASAGGSPTQ HLWCRNPMIH VQYAGSIQSY
360 370 380 390 400
RMASPATVFV QLSKSIDADE NDDRHIGFDV VTLDTTGNNK PPICCKEESR
410 420 430 440 450
KCTCPHEHRT TVTASFVIMC AALDLFIVPS TAIPGELGSY TVTVFSSVPL
460 470 480 490 500
RLTTSAFPHG WNYRAVKGVW DEDNCGGSRE RSMSWKCNPS LALHFDAHQS
510 520 530 540 550
PPDLTLFLEE SLPRPKSPVR RGSADSCGNL MDSLSAVEET QKKKELKEFL
560 570 580 590 600
HRHQLSHLEG CISLVEACPP MYRLLYSSEY SRGSVVSLVV PAVSEEFFLL
610 620 630 640 650
AATRHAGQLG NFILHIFSSR PFVTDELKTL ALREREYQLL QCAQESQARQ
660 670 680 690 700
AANSVLAKKR SGPKDSEDAV LAHNEILLRC MVTGEKYVDR DFPRGGSSLW
710 720 730 740 750
IDPAKKTPAW CGKEIYWKRP TELVEEVTFL REWKCDCPFP FSRREWFASV
760 770 780 790 800
TYAIATKPLW LQNLTAGYNV TEGLAQFRFF KSGQWTLVTI DDYLPFDSTM
810 820 830 840 850
ELCMGRPSRD NTDFFFPLLE KAYAKHHRCY EALELKVTPE LSIVDVMCHG
860 870 880 890 900
LMDLSGCAPV HFPLRGSVEM SAEQQNILWM KLKNAIQQDV LFTFLLRGDS
910 920 930 940 950
AEASERISLG ILSDHLYPAL DARFVEGQRL VKLRHWGQVG EVRWGGKWRA
960 970 980 990 1000
MSTRWTTILR DLLKFDEDDR ETFWMSLDEV FFYFTDLIMT AGTKHTSWVS
1010 1020 1030 1040 1050
ADFADCPKEC GTPVMEGAQF TLRLGDLPPD LNKTQISLGL HQPDARARVI
1060 1070 1080 1090 1100
RQKNALAAYR TAIGLAVVAT EDNTVWLKEV REAEVVKCLE PCKCRDVMCS
1110 1120 1130 1140 1150
LNIDMDNVKG SKRLTLIAFR EDQKAANVPF LLSAWSDNCE VALTPITRDI
1160 1170 1180 1190 1200
KTTVSGEWPI GYPVGSPSSS FWRDCPQYFV FPSESTEFLF VLRQDLPVGE
1210 1220 1230 1240 1250
LPKPIGFTVH REMTCRSYLE YNPDTVVLYV QAVASACVEG TVRLLGMKER
1260 1270 1280 1290 1300
RGMPYIIVPF CTEATPGGKF WIDAIANRSS RFCCIDPRLD WYRDRKSVSF
1310 1320 1330 1340 1350
TLADGSFGGS PRFSSWRSSP QLALNFPVGG QGRLFVVVRN DDLSDNRTEL
1360 1370 1380 1390 1400
GMMLLRGDNQ WENGLRRKLF ISSGDIVARS EEKIGETVID CNVDVQPECT
1410 1420 1430 1440 1450
LILVVYASMP YREAAVTVAL YSASAVEVEP VKEWAQVAVA EGSWELGYTA
1460 1470 1480 1490 1500
GGGSDQFGSW INNPFVALNT YRRTQIVALL LQYPQGPDKP LVKRAGKKKA
1510 1520 1530 1540 1550
FLPPIIINPN NRMMIALDLN VQNSELTPIA STPYTYNSEV TLVAHVPAAD
1560 1570 1580 1590
SLPFLFIPHT KLPEGNGEFK LFVYADSPIE LYTLEKKRLP YV
Length:1,592
Mass (Da):179,690
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC91EFDF9E673F277
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAHK01000263 Genomic DNA Translation: EAN94627.1

NCBI Reference Sequences

More...
RefSeqi
XP_816478.1, XM_811385.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAN94627; EAN94627; Tc00.1047053510121.170

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
TcCLB.510121.170:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3548378

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tcr:510121.170

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01000263 Genomic DNA Translation: EAN94627.1
RefSeqiXP_816478.1, XM_811385.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5693.XP_816478.1

Proteomic databases

PaxDbiQ4DQ12

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAN94627; EAN94627; Tc00.1047053510121.170
GeneDBiTcCLB.510121.170:pep
GeneIDi3548378
KEGGitcr:510121.170

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
OrthoDBi25664at2759

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR036213 Calpain_III_sf
IPR032675 LRR_dom_sf
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 6 hits
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4DQ12_TRYCC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4DQ12
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 8, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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