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UniProtKB - Q4ADG7 (MX1_OTABY)
Protein
Interferon-induced GTP-binding protein Mx1
Gene
MX1
Organism
Otaria byronia (South American sea lion)
Status
Functioni
Interferon-induced dynamin-like GTPase with antiviral activity.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 75 – 82 | GTPSequence analysis | 8 | |
Nucleotide bindingi | 176 – 180 | GTPSequence analysis | 5 | |
Nucleotide bindingi | 245 – 248 | GTPSequence analysis | 4 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- defense response to virus Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
Keywordsi
Biological process | Antiviral defense, Immunity, Innate immunity |
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon-induced GTP-binding protein Mx1Alternative name(s): Myxoma resistance protein 1 Myxovirus resistance protein 1 |
Gene namesi | Name:MX1 Synonyms:MX |
Organismi | Otaria byronia (South American sea lion) |
Taxonomic identifieri | 161932 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Otariidae › Otaria |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- perinuclear region By similarity
Note: Binds preferentially to negatively charged phospholipids.By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000319954 | 1 – 658 | Interferon-induced GTP-binding protein Mx1Add BLAST | 658 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 |
Post-translational modificationi
ISGylated.By similarity
Keywords - PTMi
Acetylation, Ubl conjugationExpressioni
Inductioni
By type I and type III interferons.1 Publication
Interactioni
Subunit structurei
Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity).
Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity).
Interacts with HSPA5 (By similarity).
Interacts with TUBB/TUBB5 (By similarity).
Interacts with DDX39A and DDX39B (By similarity).
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 338 | Dynamin-type GPROSITE-ProRule annotationAdd BLAST | 274 | |
Domaini | 570 – 658 | GEDPROSITE-ProRule annotationAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 75 – 82 | G1 motifPROSITE-ProRule annotation | 8 | |
Regioni | 100 – 102 | G2 motifPROSITE-ProRule annotation | 3 | |
Regioni | 176 – 179 | G3 motifPROSITE-ProRule annotation | 4 | |
Regioni | 245 – 248 | G4 motifPROSITE-ProRule annotation | 4 | |
Regioni | 277 – 280 | G5 motifPROSITE-ProRule annotation | 4 | |
Regioni | 339 – 364 | Bundle signaling element (BSE)By similarityAdd BLAST | 26 | |
Regioni | 364 – 531 | Middle domainBy similarityAdd BLAST | 168 | |
Regioni | 365 – 628 | StalkBy similarityAdd BLAST | 264 | |
Regioni | 551 – 554 | Critical for lipid-bindingBy similarity | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | Polar residuesSequence analysisAdd BLAST | 16 |
Domaini
The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.By similarity
The middle domain mediates self-assembly and oligomerization.By similarity
Sequence similaritiesi
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR022812, Dynamin IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR045063, Dynamin_N IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11566, PTHR11566, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4ADG7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVNSKGKITD SDPGSSHLLL NGLADKAGKN QDTEPENSLC SQYEEKVRPC
60 70 80 90 100
IDLIDSLRAL GVEQDLALPA IAVIGDQSSG KSSVLEALSG VALPRGSGIV
110 120 130 140 150
TRCPLVLKLK KLLNKDEWRG KVSYQDFEME ISDPSEVEVE INKAQNAIAG
160 170 180 190 200
EGQGISHELI SLEVSSPHVP DLTLIDLPGI TRVAVGNQPA DIGHQTKKLI
210 220 230 240 250
KKYILKQETI NLVVVPCNVD IATTEALSMA QEVDPDGDRT IGILTKPDLV
260 270 280 290 300
DRGTESKVVD VAQNLVCHLK KGYMIVKCRG QQDIQDQVTL TEALQKERDF
310 320 330 340 350
FEDHPHFRVL LEEGRATVPC LADRLTSELI THICKTLPLL EKQIKENYEK
360 370 380 390 400
ITEELQKYGS DVPEEEHEKM FFLIEKINAF NHDITSLTEG EEFVGEDECR
410 420 430 440 450
LFTKIRNEFH KWSLVIEKRF QQGYKAICKQ IERFENRYRG RELPGFVNYK
460 470 480 490 500
TFEIIIKQQI KELEEPAVYM LHTITDMVQA AFTDISEANF AEFFNLYRTT
510 520 530 540 550
KSKIEDIKFE LEKEAEKSIR LHFQMEQIVY CQDQVYQCAL QRVREESDKE
560 570 580 590 600
KDKKINSMCS KEVSSVNISL SDIFEHLLAY RQEATNRISS HIPLIIQYFI
610 620 630 640 650
LQVYGQKLQK DMLLLLHDKD THNWLLKERS DTRDKRKLLK ERLARLAQAR
RRLAKFPG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB222180 mRNA Translation: BAE16331.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB222180 mRNA Translation: BAE16331.1 |
3D structure databases
SMRi | Q4ADG7 |
ModBasei | Search... |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR022812, Dynamin IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR045063, Dynamin_N IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11566, PTHR11566, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MX1_OTABY | |
Accessioni | Q4ADG7Primary (citable) accession number: Q4ADG7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | September 13, 2005 | |
Last modified: | February 23, 2022 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |