UniProtKB - Q4AC99 (1A1L2_HUMAN)
Protein
Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
Gene
ACCSL
Organism
Homo sapiens (Human)
Status
Functioni
Caution
While belonging to the class-I pyridoxal-phosphate-dependent aminotransferase family, it lacks a number of residues which are necessary for activity thus suggesting that it lacks enzymatic activity.Curated
GO - Molecular functioni
- catalytic activity Source: InterPro
- pyridoxal phosphate binding Source: InterPro
GO - Biological processi
- biosynthetic process Source: InterPro
Keywordsi
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
PathwayCommonsi | Q4AC99 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2Short name: ACC synthase-like protein 2 |
Gene namesi | Name:ACCSL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:34391, ACCSL |
neXtProti | NX_Q4AC99 |
VEuPathDBi | HostDB:ENSG00000205126.2 |
Pathology & Biotechi
Organism-specific databases
PharmGKBi | PA164714805 |
Miscellaneous databases
Pharosi | Q4AC99, Tdark |
Genetic variation databases
BioMutai | ACCSL |
DMDMi | 296439453 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000337057 | 1 – 568 | Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2Add BLAST | 568 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 395 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Proteomic databases
PaxDbi | Q4AC99 |
PeptideAtlasi | Q4AC99 |
PRIDEi | Q4AC99 |
ProteomicsDBi | 62089 |
PTM databases
iPTMneti | Q4AC99 |
PhosphoSitePlusi | Q4AC99 |
Expressioni
Gene expression databases
Bgeei | ENSG00000205126, Expressed in monocyte and 18 other tissues |
ExpressionAtlasi | Q4AC99, baseline and differential |
Organism-specific databases
HPAi | ENSG00000205126, Tissue enhanced (skin, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 133403, 1 interactor |
STRINGi | 9606.ENSP00000368109 |
Miscellaneous databases
RNActi | Q4AC99, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.Curated
Phylogenomic databases
eggNOGi | KOG0256, Eukaryota |
GeneTreei | ENSGT00940000162841 |
HOGENOMi | CLU_017584_1_3_1 |
InParanoidi | Q4AC99 |
OMAi | CDVLQEQ |
OrthoDBi | 1156861at2759 |
PhylomeDBi | Q4AC99 |
TreeFami | TF354218 |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q4AC99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHRSDTLPV PSGQRRGRVP RDHSIYTQLL EITLHLQQAM TEHFVQLTSR
60 70 80 90 100
QGLSLEERRH TEAICEHEAL LSRLICRMIN LLQSGAASGL ELQVPLPSED
110 120 130 140 150
SRGDVRYGQR AQLSGQPDPV PQLSDCEAAF VNRDLSIRGI DISVFYQSSF
160 170 180 190 200
QDYNAYQKDK YHKDKNTLGF INLGTSENKL CMDLMTERLQ ESDMNCIEDT
210 220 230 240 250
LLQYPDWRGQ PFLREEVARF LTYYCRAPTR LDPENVVVLN GCCSVFCALA
260 270 280 290 300
MVLCDPGEAF LVPAPFYGGF AFSSRLYAKV ELIPVHLESE VTVTNTHPFQ
310 320 330 340 350
LTVDKLEEAL LEARLEGKKV RGLVLINPQN PLGDIYSPDS LMKYLEFAKR
360 370 380 390 400
YNLHVIIDEI YMLSVFDESI TFHSILSMKS LPDSNRTHVI WGTSKDFGIS
410 420 430 440 450
GFRFGALYTH NKEVASAVSA FGYLHSISGI TQHKLCQLLQ NTEWIDKVYL
460 470 480 490 500
PTNCYRLREA HKYITAELKA LEIPFHNRSS GLYVWINLKK YLDPCTFEEE
510 520 530 540 550
RLLYCRFLDN KLLLSRGKTY MCKEPGWFCL IFADELPRLK LAMRRFCDVL
560
QEQKEALIVK QLEDAMRE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PI59 | E9PI59_HUMAN | Probable inactive 1-aminocyclopropa... | ACCSL | 175 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 192 | S → R in BAE17132 (Ref. 1) Curated | 1 | |
Sequence conflicti | 272 | F → S in BAE17132 (Ref. 1) Curated | 1 | |
Sequence conflicti | 276 | L → P in BAE17132 (Ref. 1) Curated | 1 | |
Sequence conflicti | 311 | L → P in BAE17132 (Ref. 1) Curated | 1 | |
Sequence conflicti | 434 | K → E in BAE17132 (Ref. 1) Curated | 1 | |
Sequence conflicti | 454 | C → R in BAE17132 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060626 | 529 | C → R1 PublicationCorresponds to variant dbSNP:rs2074051Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB231734 mRNA Translation: BAE17132.1 AC134775 Genomic DNA No translation available. |
CCDSi | CCDS41636.1 |
RefSeqi | NP_001027025.2, NM_001031854.2 |
Genome annotation databases
Ensembli | ENST00000378832; ENSP00000368109; ENSG00000205126 |
GeneIDi | 390110 |
KEGGi | hsa:390110 |
UCSCi | uc001mxw.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB231734 mRNA Translation: BAE17132.1 AC134775 Genomic DNA No translation available. |
CCDSi | CCDS41636.1 |
RefSeqi | NP_001027025.2, NM_001031854.2 |
3D structure databases
SMRi | Q4AC99 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 133403, 1 interactor |
STRINGi | 9606.ENSP00000368109 |
PTM databases
iPTMneti | Q4AC99 |
PhosphoSitePlusi | Q4AC99 |
Genetic variation databases
BioMutai | ACCSL |
DMDMi | 296439453 |
Proteomic databases
PaxDbi | Q4AC99 |
PeptideAtlasi | Q4AC99 |
PRIDEi | Q4AC99 |
ProteomicsDBi | 62089 |
Protocols and materials databases
Antibodypediai | 26088, 49 antibodies |
Genome annotation databases
Ensembli | ENST00000378832; ENSP00000368109; ENSG00000205126 |
GeneIDi | 390110 |
KEGGi | hsa:390110 |
UCSCi | uc001mxw.1, human |
Organism-specific databases
CTDi | 390110 |
GeneCardsi | ACCSL |
HGNCi | HGNC:34391, ACCSL |
HPAi | ENSG00000205126, Tissue enhanced (skin, testis) |
neXtProti | NX_Q4AC99 |
PharmGKBi | PA164714805 |
VEuPathDBi | HostDB:ENSG00000205126.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0256, Eukaryota |
GeneTreei | ENSGT00940000162841 |
HOGENOMi | CLU_017584_1_3_1 |
InParanoidi | Q4AC99 |
OMAi | CDVLQEQ |
OrthoDBi | 1156861at2759 |
PhylomeDBi | Q4AC99 |
TreeFami | TF354218 |
Enzyme and pathway databases
PathwayCommonsi | Q4AC99 |
Miscellaneous databases
BioGRID-ORCSi | 390110, 4 hits in 866 CRISPR screens |
ChiTaRSi | ACCSL, human |
GenomeRNAii | 390110 |
Pharosi | Q4AC99, Tdark |
PROi | PR:Q4AC99 |
RNActi | Q4AC99, protein |
Gene expression databases
Bgeei | ENSG00000205126, Expressed in monocyte and 18 other tissues |
ExpressionAtlasi | Q4AC99, baseline and differential |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 1A1L2_HUMAN | |
Accessioni | Q4AC99Primary (citable) accession number: Q4AC99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 115 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families