UniProtKB - Q4AB31 (Q4AB31_DROME)
Protein
Submitted name:
Gilgamesh, isoform G
Gene
gish
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 99 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine kinase activity Source: UniProtKB-KW
GO - Biological processi
- glial cell migration Source: FlyBase
- negative regulation of actin nucleation Source: FlyBase
- olfactory learning Source: FlyBase
- protein phosphorylation Source: FlyBase
- regulation of endocytic recycling Source: FlyBase
- sperm individualization Source: FlyBase
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Biological process | Wnt signaling pathwayARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | Q4AB31 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:gishImported Synonyms:anon-WO0118547.425Imported, CK1Imported, CK1-gammaImported, CK1[[gamma]]Imported, CK1gammaImported, CKI-relatedImported, CKIgammaImported, Dmel\CG6963Imported, GishImported, Hrr25Imported, ms(3)89BImported, NEST:bs27c08Imported, SpiderImported, spiderImported ORF Names:CG6963Imported, Dmel_CG6963Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0250823, gish |
Subcellular locationi
Nucleus
- nucleus Source: FlyBase
Plasma Membrane
- plasma membrane Source: FlyBase
Other locations
- sperm individualization complex Source: FlyBase
Expressioni
Gene expression databases
Bgeei | FBgn0250823, Expressed in saliva-secreting gland and 39 other tissues |
ExpressionAtlasi | Q4AB31, baseline and differential |
Genevisiblei | Q4AB31, DM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 70 – 360 | Protein kinaseInterPro annotationAdd BLAST | 291 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 397 – 451 | DisorderedSequence analysisAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 420 – 451 | PolarSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000156470 |
InParanoidi | Q4AB31 |
PhylomeDBi | Q4AB31 |
Family and domain databases
InterProi | View protein in InterPro IPR022247, Casein_kinase-1_gamma_C IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF12605, CK1gamma_C, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
Q4AB31-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRKYLYIQK TNIKEENGGG PQTTTAGPSA GNVANATTAL AGGKSSSNNM
60 70 80 90 100
YSTRQSVSTT TGVLMVGPNF RVGKKIGCGN FGELRLGKNL YNNEHVAIKM
110 120 130 140 150
EPMKSKAPQL HLEYRFYKLL GSHADNAPDG IPRIYHLGTC GGRYNAMVLE
160 170 180 190 200
LLGLSLEDLF NICARKFSLK TVLMIAKQLL HRIEYVHSRH LIYRDVKPEN
210 220 230 240 250
FLIGRTSTKR EKIIHIIDFG LAKEYIDLDT NRHIPYREHK SLTGTARYMS
260 270 280 290 300
INTHMGREQS RRDDLEALGH MFMYFLRGSL PWQGLKADTL KERYQKIGDT
310 320 330 340 350
KRATPIEVLC DGHPEEFATY LRYVRRLDFF ETPDYDFLRR LFQDLFDRKG
360 370 380 390 400
YTDEGEFDWT GKTMSTPVGS LQTGHEVIIS PNKDRHNVTA KTNAKGGVAA
410 420 430 440 450
WPDVPKPGAT LGNLTPADRH GSVQVVSSTN GELNPDDPTA GHSNTPITQQ
460 470
PEVEVVDETK CCCFFKRKKK KSTRQK
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KHL4 | A0A0B4KHL4_DROME | Gilgamesh, isoform L | gish anon-WO0118547.425, CK1, CK1-gamma, CK1[[gamma]], CK1gamma | 537 | Annotation score: | ||
Q59DW8 | Q59DW8_DROME | Gilgamesh, isoform E | gish anon-WO0118547.425, CK1, CK1-gamma, CK1[[gamma]], CK1gamma | 463 | Annotation score: | ||
Q8IHB0 | Q8IHB0_DROME | AT18609p | gish anon-WO0118547.425, CK1, CK1-gamma, CK1[[gamma]], CK1gamma | 358 | Annotation score: | ||
Q86NK8 | Q86NK8_DROME | Gilgamesh, isoform I | gish anon-WO0118547.425, CK1, CK1-gamma, CK1[[gamma]], CK1gamma | 474 | Annotation score: | ||
Q86BR9 | Q86BR9_DROME | Gilgamesh, isoform B | gish anon-WO0118547.425, CK1, CK1-gamma, CK1[[gamma]], CK1gamma | 468 | Annotation score: | ||
Q8INB6 | Q8INB6_DROME | Gilgamesh, isoform C | gish anon-WO0118547.425, CK1, CK1-gamma, CK1[[gamma]], CK1gamma | 427 | Annotation score: | ||
Q9VEX2 | Q9VEX2_DROME | Gilgamesh, isoform A | gish anon-WO0118547.425, CK1, CK1-gamma, CK1[[gamma]], CK1gamma | 422 | Annotation score: | ||
A0A0B4K697 | A0A0B4K697_DROME | Gilgamesh, isoform J | gish anon-WO0118547.425, CK1, CK1-gamma, CK1[[gamma]], CK1gamma | 521 | Annotation score: | ||
A0A0B4K7C4 | A0A0B4K7C4_DROME | Gilgamesh, isoform K | gish anon-WO0118547.425, CK1, CK1-gamma, CK1[[gamma]], CK1gamma | 496 | Annotation score: | ||
A0A6H2EFT7 | A0A6H2EFT7_DROME | Gilgamesh, isoform N | gish anon-WO0118547.425, CK1, CK1-gamma, CK1[[gamma]], CK1gamma | 448 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAX52958.2 |
RefSeqi | NP_001014627.2, NM_001014627.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0100332; FBpp0099737; FBgn0250823 |
GeneIDi | 49701 |
UCSCi | CG6963-RG, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAX52958.2 |
RefSeqi | NP_001014627.2, NM_001014627.2 |
3D structure databases
SMRi | Q4AB31 |
ModBasei | Search... |
PTM databases
SwissPalmi | Q4AB31 |
Proteomic databases
PRIDEi | Q4AB31 |
Protocols and materials databases
DNASUi | 49701 |
Genome annotation databases
EnsemblMetazoai | FBtr0100332; FBpp0099737; FBgn0250823 |
GeneIDi | 49701 |
UCSCi | CG6963-RG, d. melanogaster |
Organism-specific databases
CTDi | 49701 |
FlyBasei | FBgn0250823, gish |
Phylogenomic databases
GeneTreei | ENSGT00940000156470 |
InParanoidi | Q4AB31 |
PhylomeDBi | Q4AB31 |
Enzyme and pathway databases
SignaLinki | Q4AB31 |
Miscellaneous databases
BioGRID-ORCSi | 49701, 1 hit in 3 CRISPR screens |
ChiTaRSi | gish, fly |
GenomeRNAii | 49701 |
Gene expression databases
Bgeei | FBgn0250823, Expressed in saliva-secreting gland and 39 other tissues |
ExpressionAtlasi | Q4AB31, baseline and differential |
Genevisiblei | Q4AB31, DM |
Family and domain databases
InterProi | View protein in InterPro IPR022247, Casein_kinase-1_gamma_C IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF12605, CK1gamma_C, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q4AB31_DROME | |
Accessioni | Q4AB31Primary (citable) accession number: Q4AB31 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 13, 2005 |
Last sequence update: | September 13, 2005 | |
Last modified: | April 7, 2021 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |