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Protein

Probable molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18GTPUniRule annotation1
Binding sitei65GTPUniRule annotation1
Metal bindingi97MagnesiumUniRule annotation1
Binding sitei97GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 8GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSAP342451:G1G2H-623-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:SSP0644
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006371 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000191601 – 202Probable molybdenum cofactor guanylyltransferaseAdd BLAST202

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP0644

Structurei

3D structure databases

ProteinModelPortaliQ49ZI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41082CS Bacteria
COG0746 LUCA
HOGENOMiHOG000280425
KOiK03752
OMAiSVCYVQA
OrthoDBiPOG091H05CW

Family and domain databases

CDDicd02503 MobA, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00316 MobA, 1 hit
InterProiView protein in InterPro
IPR025877 MobA-like_NTP_Trfase
IPR013482 Molybde_CF_guanTrfase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF12804 NTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Q49ZI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAIILAGGQ SERFGEPKAF AQINAQPFYK RIIDVLEGTN MFNQIIISTN
60 70 80 90 100
ETLASQFDHS DIIIDEDQNK DKGPLAGIQS VIQHYESEEL FFVVSVDTPM
110 120 130 140 150
ISQKAVSKLY QFMVEHLIED QLDIAGFKEK GRPIPTIAFY SPHTLPYIDD
160 170 180 190 200
ALNSNDYSLK SVYNKVKSDW LDVNLIESPD YWYKNINYQQ DLDSLQQDIL

NR
Length:202
Mass (Da):23,174
Last modified:September 13, 2005 - v1
Checksum:i48D803B7584B2A15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA Translation: BAE17789.1
RefSeqiWP_011302583.1, NZ_MTGA01000036.1

Genome annotation databases

EnsemblBacteriaiBAE17789; BAE17789; SSP0644
GeneIDi3616040
KEGGissp:SSP0644
PATRICifig|342451.11.peg.647

Similar proteinsi

Entry informationi

Entry nameiMOBA_STAS1
AccessioniPrimary (citable) accession number: Q49ZI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: July 18, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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