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Protein

Pyruvate kinase

Gene

pyk

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • K+By similarity

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32SubstrateBy similarity1
Metal bindingi34PotassiumBy similarity1
Metal bindingi36PotassiumBy similarity1
Metal bindingi66PotassiumBy similarity1
Metal bindingi67Potassium; via carbonyl oxygenBy similarity1
Sitei220Transition state stabilizerBy similarity1
Metal bindingi222MagnesiumBy similarity1
Binding sitei245Substrate; via amide nitrogenBy similarity1
Metal bindingi246MagnesiumBy similarity1
Binding sitei246Substrate; via amide nitrogenBy similarity1
Binding sitei278SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

BioCyciSSAP342451:G1G2H-1086-MONOMER
UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pyk
Ordered Locus Names:SSP1069
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006371 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002941401 – 586Pyruvate kinaseAdd BLAST586

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP1069

Structurei

3D structure databases

ProteinModelPortaliQ49YC7
SMRiQ49YC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated
In the C-terminal section; belongs to the PEP-utilizing enzyme family.Curated

Phylogenomic databases

eggNOGiENOG4105CA9 Bacteria
COG0469 LUCA
COG3848 LUCA
HOGENOMiHOG000021559
KOiK00873
OMAiKHEAIEQ
OrthoDBiPOG091H02AT

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR008279 PEP-util_enz_mobile_dom
IPR036637 Phosphohistidine_dom_sf
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00391 PEP-utilizers, 1 hit
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52009 SSF52009, 1 hit
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q49YC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKTKIVCTI GPASESEEML EKLIKAGMNV ARLNFSHGDQ AEHKARIDTI
60 70 80 90 100
RKVSKRLGKT VAILLDTKGP EIRTHNMKDG LIELEKGSEV TVSMTEVEGT
110 120 130 140 150
PEKFSVTYEN LINDVEEGSY ILLDDGLIEL QVKSIDKANG EVLCDVLNTG
160 170 180 190 200
ELKNKKGVNL PGVKVSLPGI TDKDADDINF GISEGVDFIA ASFVRRPSDV
210 220 230 240 250
LDIRKLLEAK QNKNISIIPK IENQEGIDNI KEILEVSDGL MVARGDMGVE
260 270 280 290 300
IPPESVPMVQ KDLIRQCNKL GKPVITATQM LDSMQRNPRA TRAEASDVAN
310 320 330 340 350
AIYDGTDAVM LSGETAAGQY PEEAVKTMRN IAVSAEAAQD YKKLLSDRTK
360 370 380 390 400
LVETSLVNAI GVSVAHTALN LNVKAIVAAT ESGSTARTIS KYRPQSDIIA
410 420 430 440 450
VTPNAETARQ CALVWGIFPV VKEGRKTTDA LLNNAVATAV ETERVQNGDL
460 470 480 490 500
IIITAGVPTG EKGTTNMMKL HLVGDELAKG QGIGRSSVVG KTLVVKDASE
510 520 530 540 550
LEGKDLSESI IVTSSVDETL VPYIENAIGL ITEENGITSP SAIIGLEKGI
560 570 580
PTVVGVENAT SEIQSDVLIT VDANQGKIFE GYANVL
Length:586
Mass (Da):62,853
Last modified:September 13, 2005 - v1
Checksum:iFE093F0E7D948CAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA Translation: BAE18214.1
RefSeqiWP_011302911.1, NZ_MTGA01000038.1

Genome annotation databases

EnsemblBacteriaiBAE18214; BAE18214; SSP1069
GeneIDi3615437
KEGGissp:SSP1069
PATRICifig|342451.11.peg.1068

Similar proteinsi

Entry informationi

Entry nameiKPYK_STAS1
AccessioniPrimary (citable) accession number: Q49YC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 13, 2005
Last modified: July 18, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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