UniProtKB - Q49XV0 (P5CR_STAS1)
Protein
Pyrroline-5-carboxylate reductase
Gene
proC
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)
Status
Functioni
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.UniRule annotation
Catalytic activityi
: L-proline biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde.UniRule annotationProteins known to be involved in this subpathway in this organism are:
- Pyrroline-5-carboxylate reductase (proC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- pyrroline-5-carboxylate reductase activity Source: UniProtKB-UniRule
GO - Biological processi
- L-proline biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Amino-acid biosynthesis, Proline biosynthesis |
Ligand | NADP |
Enzyme and pathway databases
BioCyci | SSAP342451:G1G2H-1267-MONOMER |
UniPathwayi | UPA00098;UER00361 |
Names & Taxonomyi
Protein namesi | Recommended name: Pyrroline-5-carboxylate reductaseUniRule annotation (EC:1.5.1.2UniRule annotation)Short name: P5C reductaseUniRule annotation Short name: P5CRUniRule annotation Alternative name(s): PCA reductaseUniRule annotation |
Gene namesi | Name:proCUniRule annotation Ordered Locus Names:SSP1250 |
Organismi | Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) |
Taxonomic identifieri | 342451 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000187307 | 1 – 271 | Pyrroline-5-carboxylate reductaseAdd BLAST | 271 |
Family & Domainsi
Sequence similaritiesi
Belongs to the pyrroline-5-carboxylate reductase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0345, Bacteria |
HOGENOMi | CLU_042344_0_1_9 |
OMAi | RLATQTC |
OrthoDBi | 1349288at2 |
Family and domain databases
HAMAPi | MF_01925, P5C_reductase, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR036291, NAD(P)-bd_dom_sf IPR028939, P5C_Rdtase_cat_N IPR029036, P5CR_dimer IPR000304, Pyrroline-COOH_reductase |
Pfami | View protein in Pfam PF03807, F420_oxidored, 1 hit PF14748, P5CR_dimer, 1 hit |
PIRSFi | PIRSF000193, Pyrrol-5-carb_rd, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00112, proC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q49XV0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLVFYGAGN MAHAIFTGIV NSKVIDSNDI YLTNRSNEVA LKEYAEKLGV
60 70 80 90 100
NYSYDDEALL KAADYVFLGT KPYDFESLAE RIKPFITDKN KFISIMAGLP
110 120 130 140 150
ISYIREKLEA DNPIARIMPN TNAHVGHSVT GISFSSNFGP NSKDEVDELI
160 170 180 190 200
NAFGSAIEVP EDNLHQVTAI TGSGPAFLYH VFEQYVTAGT RLGLEKAQVE
210 220 230 240 250
ESIRNLIIGT SKMIERSELS MEQLRKNITS KGGTTQAGLN ALSQHDLESV
260 270
FEDCLRAAVD RSVELSSQDE D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP008934 Genomic DNA Translation: BAE18395.1 |
RefSeqi | WP_011303054.1, NZ_MTGA01000038.1 |
Genome annotation databases
EnsemblBacteriai | BAE18395; BAE18395; SSP1250 |
KEGGi | ssp:SSP1250 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP008934 Genomic DNA Translation: BAE18395.1 |
RefSeqi | WP_011303054.1, NZ_MTGA01000038.1 |
3D structure databases
SMRi | Q49XV0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 342451.SSP1250 |
Protocols and materials databases
DNASUi | 3616880 |
Genome annotation databases
EnsemblBacteriai | BAE18395; BAE18395; SSP1250 |
KEGGi | ssp:SSP1250 |
Phylogenomic databases
eggNOGi | COG0345, Bacteria |
HOGENOMi | CLU_042344_0_1_9 |
OMAi | RLATQTC |
OrthoDBi | 1349288at2 |
Enzyme and pathway databases
UniPathwayi | UPA00098;UER00361 |
BioCyci | SSAP342451:G1G2H-1267-MONOMER |
Family and domain databases
HAMAPi | MF_01925, P5C_reductase, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR036291, NAD(P)-bd_dom_sf IPR028939, P5C_Rdtase_cat_N IPR029036, P5CR_dimer IPR000304, Pyrroline-COOH_reductase |
Pfami | View protein in Pfam PF03807, F420_oxidored, 1 hit PF14748, P5CR_dimer, 1 hit |
PIRSFi | PIRSF000193, Pyrrol-5-carb_rd, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00112, proC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P5CR_STAS1 | |
Accessioni | Q49XV0Primary (citable) accession number: Q49XV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | September 13, 2005 | |
Last modified: | February 10, 2021 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families