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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Binding sitei206ATPUniRule annotation1
Binding sitei325ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi352 – 355ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:SSP1915
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006371 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000096521 – 396Phosphoglycerate kinaseAdd BLAST396

Proteomic databases

PRIDEiQ49W00

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi342451.SSP1915

Structurei

3D structure databases

SMRiQ49W00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227108
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q49W00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKIVTDLE LKGKTVLVRA DFNVPMKDGE ITDDNRIVQA LPTIKYIIEQ
60 70 80 90 100
GGKVVLFSHL GKVKEESDKA ALTLKPVANA LTEKLGEEVT FVPETRGETL
110 120 130 140 150
EQSVKDLNEG DVLLVENTRF EDVDGKKESK NDPELGKYWA SLGDVFVNDA
160 170 180 190 200
FGTAHREHAS NVGIASNLET VAGFLMEKEI KYIGGVVENP DKPVVAILGG
210 220 230 240 250
AKVSDKIGVI TNLLKIADKV LIGGGMSYTF FKAQGKEIGL SLLEKDKVDF
260 270 280 290 300
AKELLDRAGD QIVLPVDCKV AKEFSNDAEI TEVSVDDIPA DQEAMDIGPK
310 320 330 340 350
SVELFKEQLQ GAHTVVWNGP MGVFELSNFA KGTIGVCEAI AELKDANTII
360 370 380 390
GGGDSAAAAI SLGYGDDFSH ISTGGGASLE YLEGKELPGV VAIANK
Length:396
Mass (Da):42,337
Last modified:September 13, 2005 - v1
Checksum:i38BCFC3ADFB66148
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA Translation: BAE19060.1
RefSeqiWP_011303588.1, NZ_MTGA01000039.1

Genome annotation databases

EnsemblBacteriaiBAE19060; BAE19060; SSP1915
GeneIDi3615269
KEGGissp:SSP1915

Similar proteinsi

Entry informationi

Entry nameiPGK_STAS1
AccessioniPrimary (citable) accession number: Q49W00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: June 20, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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