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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei59Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciSSAP342451:G1G2H-2139-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:SSP2134
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006371 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000099481 – 218Uracil-DNA glycosylaseAdd BLAST218

Proteomic databases

PRIDEiQ49VD1

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP2134

Structurei

3D structure databases

ProteinModelPortaliQ49VD1
SMRiQ49VD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF
OrthoDBiPOG091H03VL

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q49VD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWSDVFHEI TTRHDFAAMH DFLEKEYTTE IVYPDRKNIY QAFDLTPFEQ
60 70 80 90 100
VKVVILGQDP YHGPNQAHGL AFSVQPDAKF PPSLRNMYKE LQDDVGCIRK
110 120 130 140 150
SPHLQDWARE GVLLLNTVLT VRQGEAHSHK NIGWETFTDE VIQAVSEHLT
160 170 180 190 200
HVVFILWGKP AQQKIKLIDT SKHHIIQSPH PSPLSAYRGF FGSKPYSQAN
210
TYLQANGKQP VNWCESEV
Length:218
Mass (Da):25,050
Last modified:September 13, 2005 - v1
Checksum:iD04687AA950224AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA Translation: BAE19279.1
RefSeqiWP_011303771.1, NZ_MTGA01000039.1

Genome annotation databases

EnsemblBacteriaiBAE19279; BAE19279; SSP2134
GeneIDi3616342
KEGGissp:SSP2134
PATRICifig|342451.11.peg.2126

Similar proteinsi

Entry informationi

Entry nameiUNG_STAS1
AccessioniPrimary (citable) accession number: Q49VD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: July 18, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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