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UniProtKB - Q49SP3 (TPSPS_POGCB)
Protein
Patchoulol synthase
Gene
N/A
Organism
Pogostemon cablin (Patchouli) (Mentha cablin)
Status
Functioni
Involved in the biosynthesis of patchoulol. Produces also at least 13 additional sesquiterpene products, including alpha- and beta-patchoulene, alpha-bulnesene, seychellene, pogostol and alpha-guiaene.
4 PublicationsCatalytic activityi
Cofactori
Kineticsi
- KM=4.45 µM for farnesyl diphosphate2 Publications
pH dependencei
Optimum pH is 7.0-7.5.2 Publications
Temperature dependencei
Optimum temperature is 40 degrees Celsius.2 Publications
: terpenoid biosynthesis Pathwayi
This protein is involved in the pathway terpenoid biosynthesis, which is part of Secondary metabolite biosynthesis.View all proteins of this organism that are known to be involved in the pathway terpenoid biosynthesis and in Secondary metabolite biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 304 | Magnesium 1By similarity | 1 | |
Metal bindingi | 304 | Magnesium 2By similarity | 1 | |
Metal bindingi | 308 | Magnesium 1By similarity | 1 | |
Metal bindingi | 308 | Magnesium 2By similarity | 1 | |
Metal bindingi | 457 | Magnesium 3By similarity | 1 |
GO - Molecular functioni
- magnesium ion binding Source: InterPro
- terpene synthase activity Source: InterPro
GO - Biological processi
- diterpenoid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Lyase |
Ligand | Magnesium, Manganese, Metal-binding |
Enzyme and pathway databases
BRENDAi | 4.2.3.70, 9724 4.2.3.87, 9724 |
UniPathwayi | UPA00213 |
Names & Taxonomyi
Protein namesi | |
Organismi | Pogostemon cablin (Patchouli) (Mentha cablin) |
Taxonomic identifieri | 28511 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › lamiids › Lamiales › Lamiaceae › Lamioideae › Pogostemoneae › Pogostemon |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000412251 | 1 – 552 | Patchoulol synthaseAdd BLAST | 552 |
Proteomic databases
PRIDEi | Q49SP3 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationFamily & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 304 – 308 | DDXXD motif | 5 |
Domaini
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.By similarity
Sequence similaritiesi
Belongs to the terpene synthase family.Curated
Family and domain databases
CDDi | cd00684, Terpene_cyclase_plant_C1, 1 hit |
Gene3Di | 1.10.600.10, 1 hit 1.50.10.130, 1 hit |
InterProi | View protein in InterPro IPR008949, Isoprenoid_synthase_dom_sf IPR034741, Terpene_cyclase-like_1_C IPR044814, Terpene_cyclase_plant_C1 IPR001906, Terpene_synth_N IPR036965, Terpene_synth_N_sf IPR005630, Terpene_synthase_metal-bd IPR008930, Terpenoid_cyclase/PrenylTrfase |
Pfami | View protein in Pfam PF01397, Terpene_synth, 1 hit PF03936, Terpene_synth_C, 1 hit |
SFLDi | SFLDG01019, Terpene_Cyclase_Like_1_C_Termi, 1 hit |
SUPFAMi | SSF48239, SSF48239, 1 hit SSF48576, SSF48576, 1 hit |
i Sequence
Sequence statusi: Complete.
Q49SP3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELYAQSVGV GAASRPLANF HPCVWGDKFI VYNPQSCQAG EREEAEELKV
60 70 80 90 100
ELKRELKEAS DNYMRQLKMV DAIQRLGIDY LFVEDVDEAL KNLFEMFDAF
110 120 130 140 150
CKNNHDMHAT ALSFRLLRQH GYRVSCEVFE KFKDGKDGFK VPNEDGAVAV
160 170 180 190 200
LEFFEATHLR VHGEDVLDNA FDFTRNYLES VYATLNDPTA KQVHNALNEF
210 220 230 240 250
SFRRGLPRVE ARKYISIYEQ YASHHKGLLK LAKLDFNLVQ ALHRRELSED
260 270 280 290 300
SRWWKTLQVP TKLSFVRDRL VESYFWASGS YFEPNYSVAR MILAKGLAVL
310 320 330 340 350
SLMDDVYDAY GTFEELQMFT DAIERWDASC LDKLPDYMKI VYKALLDVFE
360 370 380 390 400
EVDEELIKLG APYRAYYGKE AMKYAARAYM EEAQWREQKH KPTTKEYMKL
410 420 430 440 450
ATKTCGYITL IILSCLGVEE GIVTKEAFDW VFSRPPFIEA TLIIARLVND
460 470 480 490 500
ITGHEFEKKR EHVRTAVECY MEEHKVGKQE VVSEFYNQME SAWKDINEGF
510 520 530 540 550
LRPVEFPIPL LYLILNSVRT LEVIYKEGDS YTHVGPAMQN IIKQLYLHPV
PY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY508730 mRNA Translation: AAS86323.1 DQ355151 Genomic DNA Translation: ABC87816.1 |
Genome annotation databases
KEGGi | ag:AAS86323 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY508730 mRNA Translation: AAS86323.1 DQ355151 Genomic DNA Translation: ABC87816.1 |
3D structure databases
AlphaFoldDBi | Q49SP3 |
SMRi | Q49SP3 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q49SP3 |
Genome annotation databases
KEGGi | ag:AAS86323 |
Enzyme and pathway databases
UniPathwayi | UPA00213 |
BRENDAi | 4.2.3.70, 9724 4.2.3.87, 9724 |
Family and domain databases
CDDi | cd00684, Terpene_cyclase_plant_C1, 1 hit |
Gene3Di | 1.10.600.10, 1 hit 1.50.10.130, 1 hit |
InterProi | View protein in InterPro IPR008949, Isoprenoid_synthase_dom_sf IPR034741, Terpene_cyclase-like_1_C IPR044814, Terpene_cyclase_plant_C1 IPR001906, Terpene_synth_N IPR036965, Terpene_synth_N_sf IPR005630, Terpene_synthase_metal-bd IPR008930, Terpenoid_cyclase/PrenylTrfase |
Pfami | View protein in Pfam PF01397, Terpene_synth, 1 hit PF03936, Terpene_synth_C, 1 hit |
SFLDi | SFLDG01019, Terpene_Cyclase_Like_1_C_Termi, 1 hit |
SUPFAMi | SSF48239, SSF48239, 1 hit SSF48576, SSF48576, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TPSPS_POGCB | |
Accessioni | Q49SP3Primary (citable) accession number: Q49SP3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 21, 2011 |
Last sequence update: | September 13, 2005 | |
Last modified: | May 25, 2022 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families