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Protein

Microtubule-associated protein 9

Gene

MAP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.1 Publication

GO - Molecular functioni

  • microtubule binding Source: UniProtKB

GO - Biological processi

  • cytokinesis Source: InterPro
  • mitotic spindle assembly Source: UniProtKB
  • regulation of mitotic centrosome separation Source: UniProtKB
  • regulation of mitotic cytokinesis Source: UniProtKB
  • regulation of mitotic spindle organization Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

SIGNORiQ49MG5

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 9
Alternative name(s):
Aster-associated protein
Gene namesi
Name:MAP9
Synonyms:ASAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164114.18
HGNCiHGNC:26118 MAP9
MIMi610070 gene
neXtProtiNX_Q49MG5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi79884
OpenTargetsiENSG00000164114
PharmGKBiPA145148442

Polymorphism and mutation databases

BioMutaiMAP9
DMDMi116242626

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002477532 – 647Microtubule-associated protein 9Add BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei12PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ49MG5
MaxQBiQ49MG5
PaxDbiQ49MG5
PeptideAtlasiQ49MG5
PRIDEiQ49MG5
ProteomicsDBi62073
62074 [Q49MG5-2]

PTM databases

iPTMnetiQ49MG5
PhosphoSitePlusiQ49MG5

Expressioni

Developmental stagei

Constitutively expressed during the cell cycle.1 Publication

Gene expression databases

BgeeiENSG00000164114
CleanExiHS_MAP9
ExpressionAtlasiQ49MG5 baseline and differential
GenevisibleiQ49MG5 HS

Interactioni

Subunit structurei

Binds to purified microtubules via its C-terminus.

GO - Molecular functioni

  • microtubule binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122969, 7 interactors
IntActiQ49MG5, 4 interactors
STRINGi9606.ENSP00000310593

Structurei

3D structure databases

ProteinModelPortaliQ49MG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili184 – 210Sequence analysisAdd BLAST27
Coiled coili298 – 328Sequence analysisAdd BLAST31
Coiled coili443 – 628Sequence analysisAdd BLAST186

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGGW Eukaryota
ENOG4111X21 LUCA
GeneTreeiENSGT00730000111184
HOGENOMiHOG000113480
HOVERGENiHBG081953
InParanoidiQ49MG5
KOiK10434
OMAiEDRNMKN
OrthoDBiEOG091G07GL
PhylomeDBiQ49MG5
TreeFamiTF328794

Family and domain databases

InterProiView protein in InterPro
IPR026106 MAP9
PANTHERiPTHR14739 PTHR14739, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q49MG5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDEVFSTTL AYTKSPKVTK RTTFQDELIR AITARSARQR SSEYSDDFDS
60 70 80 90 100
DEIVSLGDFS DTSADENSVN KKMNDFHISD DEEKNPSKLL FLKTNKSNGN
110 120 130 140 150
ITKDEPVCAI KNEEEMAPDG CEDIVVKSFS ESQNKDEEFE KDKIKMKPKP
160 170 180 190 200
RILSIKSTSS AENNSLDTDD HFKPSPRPRS MLKKKSHMEE KDGLEDKETA
210 220 230 240 250
LSEELELHSA PSSLPTPNGI QLEAEKKAFS ENLDPEDSCL TSLASSSLKQ
260 270 280 290 300
ILGDSFSPGS EGNASGKDPN EEITENHNSL KSDENKENSF SADHVTTAVE
310 320 330 340 350
KSKESQVTAD DLEEEKAKAE LIMDDDRTVD PLLSKSQSIL ISTSATASSK
360 370 380 390 400
KTIEDRNIKN KKSTNNRASS ASARLMTSEF LKKSSSKRRT PSTTTSSHYL
410 420 430 440 450
GTLKVLDQKP SQKQSIEPDR ADNIRAAVYQ EWLEKKNVYL HEMHRIKRIE
460 470 480 490 500
SENLRIQNEQ KKAAKREEAL ASFEAWKAMK EKEAKKIAAK KRLEEKNKKK
510 520 530 540 550
TEEENAARKG EALQAFEKWK EKKMEYLKEK NRKEREYERA KKQKEEETVA
560 570 580 590 600
EKKKDNLTAV EKWNEKKEAF FKQKEKEKIN EKRKEELKRA EKKDKDKQAI
610 620 630 640
NEYEKWLENK EKQERIERKQ KKRHSFLESE ALPPWSPPSR TVFAKVF
Length:647
Mass (Da):74,234
Last modified:October 17, 2006 - v3
Checksum:i1F0BDE2986845B39
GO
Isoform 2 (identifier: Q49MG5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     374-377: RLMT → ARSG
     378-647: Missing.

Note: No experimental confirmation available.
Show »
Length:377
Mass (Da):41,582
Checksum:iB76E5EBED1224B79
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116M → L in BAB14978 (PubMed:14702039).Curated1
Sequence conflicti450E → G in BAB14978 (PubMed:14702039).Curated1
Sequence conflicti575E → K in AAW02921 (PubMed:16049101).Curated1
Sequence conflicti631A → T in CAH18129 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051152146M → V. Corresponds to variant dbSNP:rs34082815Ensembl.1
Natural variantiVAR_027151177R → W2 PublicationsCorresponds to variant dbSNP:rs3733391Ensembl.1
Natural variantiVAR_051153499K → R. Corresponds to variant dbSNP:rs1058992Ensembl.1
Natural variantiVAR_051154601N → D1 PublicationCorresponds to variant dbSNP:rs2305050Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020037374 – 377RLMT → ARSG in isoform 2. 1 Publication4
Alternative sequenceiVSP_020038378 – 647Missing in isoform 2. 1 PublicationAdd BLAST270

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY690636 mRNA Translation: AAW02921.1
AK024730 mRNA Translation: BAB14978.1 Sequence problems.
AK024812 mRNA Translation: BAB15017.1
AC097467 Genomic DNA Translation: AAY40981.1
CR749274 mRNA Translation: CAH18129.1
CCDSiCCDS35493.1 [Q49MG5-1]
RefSeqiNP_001034669.1, NM_001039580.1 [Q49MG5-1]
XP_011530555.1, XM_011532253.1 [Q49MG5-1]
XP_011530556.1, XM_011532254.2 [Q49MG5-1]
UniGeneiHs.61271

Genome annotation databases

EnsembliENST00000311277; ENSP00000310593; ENSG00000164114 [Q49MG5-1]
GeneIDi79884
KEGGihsa:79884
UCSCiuc003ios.4 human [Q49MG5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMAP9_HUMAN
AccessioniPrimary (citable) accession number: Q49MG5
Secondary accession number(s): Q4W5I7
, Q68DU1, Q9H781, Q9H7B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 98 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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