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Protein

Phosphatidylinositol 4-kinase beta

Gene

pi4kb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP).By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.

GO - Molecular functioni

GO - Biological processi

  • phosphatidylinositol-mediated signaling Source: GO_Central
  • semicircular canal development Source: ZFIN

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-1660514 Synthesis of PIPs at the Golgi membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-kinase beta (EC:2.7.1.67)
Short name:
PI4K-beta
Short name:
PI4Kbeta
Short name:
PtdIns 4-kinase beta
Gene namesi
Name:pi4kb
Synonyms:pik4cb
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-061013-96 pi4kb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003651691 – 835Phosphatidylinositol 4-kinase betaAdd BLAST835

Proteomic databases

PaxDbiQ49GP3
PRIDEiQ49GP3

Expressioni

Gene expression databases

BgeeiENSDARG00000040111
ExpressionAtlasiQ49GP3 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000099330

Structurei

3D structure databases

SMRiQ49GP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 262PIK helicalPROSITE-ProRule annotationAdd BLAST204
Domaini578 – 784PI3K/PI4KPROSITE-ProRule annotationAdd BLAST207

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi19 – 56Ser-richAdd BLAST38
Compositional biasi277 – 286Poly-Pro10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0903 Eukaryota
ENOG410XPH3 LUCA
GeneTreeiENSGT00550000074892
HOGENOMiHOG000008289
HOVERGENiHBG053597
InParanoidiQ49GP3
KOiK19801
OMAiESIDNSF
TreeFamiTF102042

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
PANTHERiPTHR10048 PTHR10048, 2 hits
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 2 hits
SMARTiView protein in SMART
SM00146 PI3Kc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q49GP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDTELELSP THLEELQKSP STSTTSSLSL PSSPSSGPHP LTSSSPSTSE
60 70 80 90 100
GLPTSSPPLD VISEGLGELS LVIDTEVAKK ACQEVLQKVK FLKGDGEVSS
110 120 130 140 150
ASSEPILANG TAHPEANDGG QPPKISEEEV EPIKSVRRRQ KNNSSKQSWL
160 170 180 190 200
LRLFESKLFD ISMAISYLYN SKEPGVQAYI GNRLFSFRNE DVDFYLPQLL
210 220 230 240 250
NMYIHMDEDV GDAIKPYVVY RCRQSINFSL QCAWLLGAYS SDMHISTQRH
260 270 280 290 300
SRGTKLRKLI LSDELKPSSQ RIRREVPQPP PPYPPPLHHG PGMSEHSLSP
310 320 330 340 350
SKRTHQRSKS DATVSISLSS NLKRTASNPK VETSQDEPVR LTPQREFIKS
360 370 380 390 400
LMGIGKRLAT LPTKEQKTQR LISELSLLNH KLPARVWLPT AAFDHHVVRV
410 420 430 440 450
PHTQAVVLNS KDKAPYLIYV EVLECENFET SSVPVRIPET QIRSTRSVEN
460 470 480 490 500
LPDCGITPDQ RASSFSTVPN YDNDDEAWSV DDIGELQVEL PEIHTNSCDN
510 520 530 540 550
ISQFSVDSIT SQESKEPIFI AAGDIRRRLS EQLAHTPTTF RKDPEDPSAV
560 570 580 590 600
ALKEPWQEKV RRIREGSPYG HLPNWRLLSV IVKCGDDLRQ ELLAYQVLKQ
610 620 630 640 650
LQIIWEQERV PLWIKPYKIL VISSDSGMIE PVVNAVSIHQ VKKQSQLLLL
660 670 680 690 700
DYFRQEHGNF NTEEFLTAQR NFVQSCAGYC LICYLLQVKD RHNGNILLDS
710 720 730 740 750
EGHIIHIDFG FILSSSPRNL GFETSAFKLT SEFVDVMGGL DGDMFNYYKM
760 770 780 790 800
LMLQGLIAAR KHMEKVIQIV EIMQQGSQLP CFHGSSTIRN LKERFHMNLT
810 820 830
EEQLQVLVEQ MVDGSMRSIT TKLYDGFQYL TNGIM
Length:835
Mass (Da):94,059
Last modified:March 3, 2009 - v2
Checksum:iDE044DB4C925B795
GO

Sequence cautioni

The sequence ACH92118 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100S → L in AAY16568 (Ref. 1) Curated1
Sequence conflicti370R → G in AAI24585 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY929293 mRNA Translation: AAY16568.1
FJ032032 mRNA Translation: ACH92118.1 Sequence problems.
BC124584 mRNA Translation: AAI24585.1
RefSeqiNP_001030149.2, NM_001034977.2
UniGeneiDr.48538

Genome annotation databases

EnsembliENSDART00000058666; ENSDARP00000058665; ENSDARG00000040111
ENSDART00000160332; ENSDARP00000130423; ENSDARG00000040111
ENSDART00000182202; ENSDARP00000149614; ENSDARG00000111175
GeneIDi563201
KEGGidre:563201

Similar proteinsi

Entry informationi

Entry nameiPI4KB_DANRE
AccessioniPrimary (citable) accession number: Q49GP3
Secondary accession number(s): B5TXD8, Q08BS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 20, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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