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Entry version 81 (07 Apr 2021)
Sequence version 1 (13 Sep 2005)
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Protein
Submitted name:

ANKS1A protein

Gene

ANKS1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ANKS1A proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKS1AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q49AR9

PRoteomics IDEntifications database

More...
PRIDEi
Q49AR9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q49AR9
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-11954519,EBI-11096309
ALDOC [P09972]3EBI-11954519,EBI-2952751
ANKRD55 [Q3KP44]3EBI-11954519,EBI-14493093
BCAR1 [P56945]3EBI-11954519,EBI-702093
BLZF1 [Q9H2G9]3EBI-11954519,EBI-2548012
C17orf50 [Q8WW18]3EBI-11954519,EBI-12877892
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-11954519,EBI-11976299
C22orf39 [Q6P5X5]3EBI-11954519,EBI-7317823
C3orf36 [Q3SXR2]3EBI-11954519,EBI-18036948
C9orf152 [Q5JTZ5]3EBI-11954519,EBI-18560658
CADPS [A2RRN7]3EBI-11954519,EBI-10179719
CCDC184 [Q52MB2]3EBI-11954519,EBI-10179526
CHCHD3 [Q9NX63]3EBI-11954519,EBI-743375
CYSRT1 [A8MQ03]3EBI-11954519,EBI-3867333
DAB2IP - isoform 5 [Q5VWQ8-5]3EBI-11954519,EBI-12196395
DOK3 - isoform 3 [Q7L591-3]3EBI-11954519,EBI-10694655
ESM1 [Q9NQ30]3EBI-11954519,EBI-12260294
FAM217B [Q9NTX9]3EBI-11954519,EBI-19153639
FAM221A [A4D161]3EBI-11954519,EBI-11960181
FAM22F [B7ZLH0]3EBI-11954519,EBI-10220102
FAM86C1P - isoform 2 [Q9NVL1-2]3EBI-11954519,EBI-12845222
FCHSD2 - isoform 3 [O94868-3]3EBI-11954519,EBI-11958845
FHL5 [Q5TD97]3EBI-11954519,EBI-750641
GOLGA2 [Q08379]3EBI-11954519,EBI-618309
HOXA1 [P49639]3EBI-11954519,EBI-740785
HOXC8 [P31273]3EBI-11954519,EBI-1752118
ID3 [Q02535]3EBI-11954519,EBI-1387094
IKZF3 [Q9UKT9]5EBI-11954519,EBI-747204
ISCA2 [Q86U28]3EBI-11954519,EBI-10258659
ITIH6 [Q6UXX5]3EBI-11954519,EBI-11028396
KCTD9 [Q7L273]3EBI-11954519,EBI-4397613
KEAP1 [Q14145]3EBI-11954519,EBI-751001
KIAA1328 [Q86T90]3EBI-11954519,EBI-3437878
KLHL26 [Q53HC5]3EBI-11954519,EBI-724915
KPRP [Q5T749]3EBI-11954519,EBI-10981970
KRT31 [Q15323]3EBI-11954519,EBI-948001
KRT34 [O76011]3EBI-11954519,EBI-1047093
KRT39 [Q6A163]3EBI-11954519,EBI-11958242
KRT75 [O95678]3EBI-11954519,EBI-2949715
KRT83 [P78385]3EBI-11954519,EBI-10221390
KRTAP10-11 [P60412]3EBI-11954519,EBI-10217483
KRTAP10-8 [P60410]5EBI-11954519,EBI-10171774
KRTAP10-9 [P60411]3EBI-11954519,EBI-10172052
KRTAP11-1 [Q8IUC1]3EBI-11954519,EBI-1052037
KRTAP19-7 [Q3SYF9]3EBI-11954519,EBI-10241353
KRTAP4-2 [Q9BYR5]3EBI-11954519,EBI-10172511
KRTAP6-2 [Q3LI66]3EBI-11954519,EBI-11962084
KRTAP9-3 [Q9BYQ3]3EBI-11954519,EBI-1043191
LASP1 - isoform 2 [Q14847-2]3EBI-11954519,EBI-9088686
LHX2 [P50458]3EBI-11954519,EBI-12179869
LNX1 [Q8TBB1]3EBI-11954519,EBI-739832
MBD3L1 [Q8WWY6]3EBI-11954519,EBI-12516603
MED20 [Q9H944]3EBI-11954519,EBI-394644
MEOX2 [Q6FHY5]3EBI-11954519,EBI-16439278
MID2 - isoform 2 [Q9UJV3-2]3EBI-11954519,EBI-10172526
MTUS2 - isoform 2 [Q5JR59-3]3EBI-11954519,EBI-11522433
NADSYN1 [Q6IA69]3EBI-11954519,EBI-748610
NEDD9 - isoform 2 [Q14511-2]6EBI-11954519,EBI-11746523
NOTCH2NLC [P0DPK4]3EBI-11954519,EBI-22310682
PRDM6 [Q9NQX0]3EBI-11954519,EBI-11320284
PRKAR1B [P31321]3EBI-11954519,EBI-2805516
RIN1 [Q13671]3EBI-11954519,EBI-366017
RORB - isoform 1 [Q92753-1]3EBI-11954519,EBI-18560266
RUSC1 [Q9BVN2]3EBI-11954519,EBI-6257312
SCN5A - isoform 3 [Q14524-3]3EBI-11954519,EBI-14276801
SH3KBP1 [Q96B97]3EBI-11954519,EBI-346595
SHISA6 [Q6ZSJ9]3EBI-11954519,EBI-12037847
SLC15A2 [Q16348]3EBI-11954519,EBI-12806032
SORBS3 [O60504]3EBI-11954519,EBI-741237
SPATA12 [Q7Z6I5]3EBI-11954519,EBI-10696971
SPRED1 [Q7Z699]3EBI-11954519,EBI-5235340
TOX2 - isoform 3 [Q96NM4-3]3EBI-11954519,EBI-12815137
TP53BP1 [Q12888]3EBI-11954519,EBI-396540
TRIM29 [Q14134]3EBI-11954519,EBI-702370
USP54 - isoform 6 [Q70EL1-9]3EBI-11954519,EBI-11975223
USP7 [Q93009]3EBI-11954519,EBI-302474
ZBTB32 [A0A0C4DGF1]3EBI-11954519,EBI-10188476
ZBTB42 [B2RXF5]3EBI-11954519,EBI-12287587
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-11954519,EBI-14104088
ZNF135 [P52742]3EBI-11954519,EBI-7101455

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q49AR9, 80 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 88SAMInterPro annotationAdd BLAST64
Domaini96 – 155SAMInterPro annotationAdd BLAST60
Domaini268 – 394PIDInterPro annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni184 – 222DisorderedSequence analysisAdd BLAST39
Regioni406 – 425DisorderedSequence analysisAdd BLAST20
Regioni464 – 490DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi204 – 222PolyampholyteSequence analysisAdd BLAST19

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09499, SAM_AIDA1AB-like_repeat1, 1 hit
cd09500, SAM_AIDA1AB-like_repeat2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 2 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033637, ANKS1A
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR041880, SAM_ANKS1_repeat1
IPR041882, SAM_ANKS1_repeat2

The PANTHER Classification System

More...
PANTHERi
PTHR24174:SF4, PTHR24174:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00640, PID, 1 hit
PF00536, SAM_1, 1 hit
PF07647, SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462, PTB, 1 hit
SM00454, SAM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01179, PID, 1 hit
PS50105, SAM_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q49AR9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSIGEGIDF SQERQKISGS RTLEQSVGEW LESIGLQQYE SKLLLNGFDD
60 70 80 90 100
VHFLGSNVME EQDLRDIGIS DPQHRRKLLQ AARSLPKVKA LGYDGNSPPS
110 120 130 140 150
VPSWLDSLGL QDYVHSFLSS GYSSIDTVKN LWELELVNVL KVQLLGHRKR
160 170 180 190 200
IIASLADRPY EEPPQKPPRF SQLRCQDLLS QTSSQLSQND SCTGRSADLL
210 220 230 240 250
LPPGDTGRRR HDSLHDPAAP SRAERFRIQE EHREAKLTLR PPSLAAPYAP
260 270 280 290 300
VQSWQHQPEK LIFESCGYEA NYLGSMLIKD LRGTESTQDA CAKMRKSTEH
310 320 330 340 350
MKKIPTIILS ITYKGVKFID ASNKNVIAEH EIRNISCAAQ DPEDLCTFAY
360 370 380 390 400
ITKDLQTSHH YCHVFSTVDV NLTYEIILTL GQAFEVAYQL ALQAQKSRAT
410 420 430 440 450
GASAAEMIET KSSKPVPKPR VGVRKSAVPL PPDSRCCYCH TCTTHRPSYL
460 470 480 490 500
PLPSVSPGVK LEPPDMDQDA QSHASVSWVV DPKPDSKRSL STNHTRLELV
510 520 530 540 550
CCSQPENELV STISGDKPKS FLEPLLFVMP TTAYNHNCPE WRSQKDGGCS
560 570
TSECPHHLCL EKPGVLSLER
Length:570
Mass (Da):63,580
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA141CEF1650953A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC031934 mRNA Translation: AAH31934.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031934 mRNA Translation: AAH31934.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ49AR9, 80 interactors

Proteomic databases

PeptideAtlasiQ49AR9
PRIDEiQ49AR9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ANKS1A, human

Family and domain databases

CDDicd09499, SAM_AIDA1AB-like_repeat1, 1 hit
cd09500, SAM_AIDA1AB-like_repeat2, 1 hit
Gene3Di1.10.150.50, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR033637, ANKS1A
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR041880, SAM_ANKS1_repeat1
IPR041882, SAM_ANKS1_repeat2
PANTHERiPTHR24174:SF4, PTHR24174:SF4, 1 hit
PfamiView protein in Pfam
PF00640, PID, 1 hit
PF00536, SAM_1, 1 hit
PF07647, SAM_2, 1 hit
SMARTiView protein in SMART
SM00462, PTB, 1 hit
SM00454, SAM, 2 hits
SUPFAMiSSF47769, SSF47769, 2 hits
PROSITEiView protein in PROSITE
PS01179, PID, 1 hit
PS50105, SAM_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ49AR9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q49AR9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 7, 2021
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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