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Protein

UPF0489 protein C5orf22

Gene

C5orf22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0489 protein C5orf22
Gene namesi
Name:C5orf22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000082213.17
HGNCiHGNC:25639 C5orf22
neXtProtiNX_Q49AR2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000082213
PharmGKBiPA144596503

Polymorphism and mutation databases

BioMutaiC5orf22

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050021 – 442UPF0489 protein C5orf22Add BLAST442

Proteomic databases

EPDiQ49AR2
MaxQBiQ49AR2
PaxDbiQ49AR2
PeptideAtlasiQ49AR2
PRIDEiQ49AR2
ProteomicsDBi62065
62066 [Q49AR2-2]
62067 [Q49AR2-3]

PTM databases

iPTMnetiQ49AR2
PhosphoSitePlusiQ49AR2

Miscellaneous databases

PMAP-CutDBiQ49AR2

Expressioni

Gene expression databases

BgeeiENSG00000082213 Expressed in 223 organ(s), highest expression level in secondary oocyte
CleanExiHS_C5orf22
ExpressionAtlasiQ49AR2 baseline and differential
GenevisibleiQ49AR2 HS

Organism-specific databases

HPAiHPA043062

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120603, 9 interactors
IntActiQ49AR2, 3 interactors
STRINGi9606.ENSP00000326879

Structurei

3D structure databases

ProteinModelPortaliQ49AR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0489 family.Curated

Phylogenomic databases

eggNOGiENOG410IGS7 Eukaryota
ENOG41109E9 LUCA
GeneTreeiENSGT00390000001801
HOGENOMiHOG000008429
HOVERGENiHBG057060
InParanoidiQ49AR2
OMAiNPFKEMF
OrthoDBiEOG091G0TRE
PhylomeDBiQ49AR2
TreeFamiTF324160

Family and domain databases

InterProiView protein in InterPro
IPR024131 UPF0489
PANTHERiPTHR13225 PTHR13225, 1 hit
PfamiView protein in Pfam
PF12640 UPF0489, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q49AR2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDSAGGRAG LRRYPKLPVW VVEDHQEVLP FIYRAIGSKH LPASNVSFLH
60 70 80 90 100
FDSHPDLLIP VNMPADTVFD KETLFGELSI ENWIMPAVYA GHFSHVIWFH
110 120 130 140 150
PTWAQQIREG RHHFLVGKDT STTTIRVTST DHYFLSDGLY VPEDQLENQK
160 170 180 190 200
PLQLDVIMVK PYKLCNNQEE NDAVSSAKKP KLALEDSENT ASTNCDSSSE
210 220 230 240 250
GLEKDTATQR SDQTCLEPSC SCSSENQECQ TAASTGEILE ILKKGKAFVL
260 270 280 290 300
DIDLDFFSVK NPFKEMFTQE EYKILQELYQ FKKPGTNLTE EDLVDIVDTR
310 320 330 340 350
IHQLEDLEAT FADLCDGDDE ETVQRWASNP GMESLVPLVQ SLKKRMEVPD
360 370 380 390 400
YEMVHQAGLT CDYSELPHHI STEQEIECLI QSVHYLLKNL PNPTLVTIAR
410 420 430 440
SSLDDYCPSD QVDTIQEKVL NMLRALYGNL DLQVYAAESP PS
Length:442
Mass (Da):49,967
Last modified:October 2, 2007 - v2
Checksum:iA79A014E358C7367
GO
Isoform 2 (identifier: Q49AR2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-265: Missing.

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):20,249
Checksum:i7703ABFA6BE14AA0
GO
Isoform 3 (identifier: Q49AR2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-279: Missing.
     280-353: QFKKPGTNLT...KRMEVPDYEM → MEVPDYEMFP...PVPKLLPHFQ

Note: No experimental confirmation available.
Show »
Length:163
Mass (Da):18,068
Checksum:iEC2BAF4545DD8097
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DR92B4DR92_HUMAN
UPF0489 protein C5orf22
C5orf22
136Annotation score:
E5RFG1E5RFG1_HUMAN
UPF0489 protein C5orf22
C5orf22
49Annotation score:
E5RHP8E5RHP8_HUMAN
UPF0489 protein C5orf22
C5orf22
156Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199S → P in BAA92060 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035149235T → P. Corresponds to variant dbSNP:rs17410000Ensembl.1
Natural variantiVAR_035150405D → E. Corresponds to variant dbSNP:rs16901277Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0281821 – 279Missing in isoform 3. 1 PublicationAdd BLAST279
Alternative sequenceiVSP_0281831 – 265Missing in isoform 2. 1 PublicationAdd BLAST265
Alternative sequenceiVSP_028184280 – 353QFKKP…PDYEM → MEVPDYEMFPASSSSPSETT SAWISLSMSLSAFWSKPFNK SLGSSKLSNISLPSSEPSKL FQPLPVPKLLPHFQ in isoform 3. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002055 mRNA Translation: BAA92060.1
AL834427 mRNA Translation: CAD39088.2
CH471118 Genomic DNA Translation: EAX10771.1
CH471118 Genomic DNA Translation: EAX10772.1
BC021215 mRNA Translation: AAH21215.1
BC032845 mRNA Translation: AAH32845.1
CCDSiCCDS3895.1 [Q49AR2-1]
RefSeqiNP_060826.2, NM_018356.2 [Q49AR2-1]
XP_006714543.1, XM_006714480.3 [Q49AR2-2]
XP_016865102.1, XM_017009613.1 [Q49AR2-2]
XP_016865103.1, XM_017009614.1 [Q49AR2-2]
XP_016865104.1, XM_017009615.1 [Q49AR2-2]
XP_016865105.1, XM_017009616.1 [Q49AR2-2]
UniGeneiHs.519246

Genome annotation databases

EnsembliENST00000325366; ENSP00000326879; ENSG00000082213 [Q49AR2-1]
GeneIDi55322
KEGGihsa:55322
UCSCiuc003jhj.4 human [Q49AR2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002055 mRNA Translation: BAA92060.1
AL834427 mRNA Translation: CAD39088.2
CH471118 Genomic DNA Translation: EAX10771.1
CH471118 Genomic DNA Translation: EAX10772.1
BC021215 mRNA Translation: AAH21215.1
BC032845 mRNA Translation: AAH32845.1
CCDSiCCDS3895.1 [Q49AR2-1]
RefSeqiNP_060826.2, NM_018356.2 [Q49AR2-1]
XP_006714543.1, XM_006714480.3 [Q49AR2-2]
XP_016865102.1, XM_017009613.1 [Q49AR2-2]
XP_016865103.1, XM_017009614.1 [Q49AR2-2]
XP_016865104.1, XM_017009615.1 [Q49AR2-2]
XP_016865105.1, XM_017009616.1 [Q49AR2-2]
UniGeneiHs.519246

3D structure databases

ProteinModelPortaliQ49AR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120603, 9 interactors
IntActiQ49AR2, 3 interactors
STRINGi9606.ENSP00000326879

PTM databases

iPTMnetiQ49AR2
PhosphoSitePlusiQ49AR2

Polymorphism and mutation databases

BioMutaiC5orf22

Proteomic databases

EPDiQ49AR2
MaxQBiQ49AR2
PaxDbiQ49AR2
PeptideAtlasiQ49AR2
PRIDEiQ49AR2
ProteomicsDBi62065
62066 [Q49AR2-2]
62067 [Q49AR2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325366; ENSP00000326879; ENSG00000082213 [Q49AR2-1]
GeneIDi55322
KEGGihsa:55322
UCSCiuc003jhj.4 human [Q49AR2-1]

Organism-specific databases

CTDi55322
EuPathDBiHostDB:ENSG00000082213.17
GeneCardsiC5orf22
H-InvDBiHIX0004781
HGNCiHGNC:25639 C5orf22
HPAiHPA043062
neXtProtiNX_Q49AR2
OpenTargetsiENSG00000082213
PharmGKBiPA144596503
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGS7 Eukaryota
ENOG41109E9 LUCA
GeneTreeiENSGT00390000001801
HOGENOMiHOG000008429
HOVERGENiHBG057060
InParanoidiQ49AR2
OMAiNPFKEMF
OrthoDBiEOG091G0TRE
PhylomeDBiQ49AR2
TreeFamiTF324160

Miscellaneous databases

GenomeRNAii55322
PMAP-CutDBiQ49AR2
PROiPR:Q49AR2

Gene expression databases

BgeeiENSG00000082213 Expressed in 223 organ(s), highest expression level in secondary oocyte
CleanExiHS_C5orf22
ExpressionAtlasiQ49AR2 baseline and differential
GenevisibleiQ49AR2 HS

Family and domain databases

InterProiView protein in InterPro
IPR024131 UPF0489
PANTHERiPTHR13225 PTHR13225, 1 hit
PfamiView protein in Pfam
PF12640 UPF0489, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCE022_HUMAN
AccessioniPrimary (citable) accession number: Q49AR2
Secondary accession number(s): Q8ND28, Q8WU61, Q9NUR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 12, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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