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Protein

Protein FAM135B

Gene

FAM135B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cellular lipid metabolic process Source: GO_Central

Protein family/group databases

ESTHERihuman-FAM135B Duf_676

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM135B
Gene namesi
Name:FAM135B
Synonyms:C8orfK32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147724.11
HGNCiHGNC:28029 FAM135B
neXtProtiNX_Q49AJ0

Pathology & Biotechi

Organism-specific databases

DisGeNETi51059
OpenTargetsiENSG00000147724
PharmGKBiPA162386277

Polymorphism and mutation databases

BioMutaiFAM135B
DMDMi166233528

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141711 – 1406Protein FAM135BAdd BLAST1406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei777PhosphoserineBy similarity1
Modified residuei778PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ49AJ0
PeptideAtlasiQ49AJ0
PRIDEiQ49AJ0
ProteomicsDBi62048
62049 [Q49AJ0-2]
62050 [Q49AJ0-3]
62051 [Q49AJ0-4]

PTM databases

iPTMnetiQ49AJ0
PhosphoSitePlusiQ49AJ0

Expressioni

Gene expression databases

BgeeiENSG00000147724 Expressed in 77 organ(s), highest expression level in right testis
CleanExiHS_FAM135B
ExpressionAtlasiQ49AJ0 baseline and differential
GenevisibleiQ49AJ0 HS

Organism-specific databases

HPAiHPA023911
HPA023950
HPA024815

Interactioni

Protein-protein interaction databases

BioGridi119251, 2 interactors
IntActiQ49AJ0, 2 interactors
STRINGi9606.ENSP00000378710

Structurei

3D structure databases

ProteinModelPortaliQ49AJ0
SMRiQ49AJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM135 family.Curated

Phylogenomic databases

eggNOGiKOG2205 Eukaryota
ENOG410XQFK LUCA
GeneTreeiENSGT00390000007885
HOGENOMiHOG000082668
HOVERGENiHBG107866
InParanoidiQ49AJ0
OMAiHLMALWT
OrthoDBiEOG091G0KFW
PhylomeDBiQ49AJ0
TreeFamiTF314837

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR022122 DUF3657
IPR007751 DUF676_lipase-like
PfamiView protein in Pfam
PF12394 DUF3657, 1 hit
PF05057 DUF676, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q49AJ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEIQGTVEF SVELHKFYNV DLFQRGYYQI RVTLKVSSRI PHRLSASIAG
60 70 80 90 100
QTESSSLHSA CVHDSTVHSR VFQILYRNEE VPINDAVVFR VHLLLGGERM
110 120 130 140 150
EDALSEVDFQ LKVDLHFTDS EQQLRDVAGA PMVSSRTLGL HFHPRNGLHH
160 170 180 190 200
QVPVMFDYFH LSVISVTVHA ALVALQQPLI SFTRPGRGSW LGKGGPDTGQ
210 220 230 240 250
EQSIISLENL VFGAGYCKPT SSEGSFYITS ENCMQHAHKW HRDLCLLLLH
260 270 280 290 300
AYRGLRLHFL VIMRDIPELP HTELEALAVE ETLSQLCSEL QMLNNPEKIA
310 320 330 340 350
EQISKDLAWL TSHMMTLWTQ FLDTVTLHSQ VTTYLTQEHH TLRVRRFSEA
360 370 380 390 400
FFYMEHQKLA VLTFQENLIQ THSQLSLDIR NSEYLTSMPP LPAECLDIDG
410 420 430 440 450
DWNTLPVIFE DRYVDCPATG HNLSVYPNFD VPVTSPTIMN LKDKEDNCMV
460 470 480 490 500
NSNLSFREDL VLSTIKPSQM DSDEEVIRCP EPGENVATQN HMDMCSESQV
510 520 530 540 550
YISIGEFQNK AGVPEDECWT GQTSDAGTYP VADVDTSRRS PGPEDGQAPV
560 570 580 590 600
LTYIDVKSSN KNPSRAEPLV AFNAQHESRS SRDKYGLDRT GLSKVVVGGS
610 620 630 640 650
HQNAISSDKT TLHELSTLGK GIDQEGKMVL LSLKLTPSEP CDPLSSTLRE
660 670 680 690 700
PLDIRSSLKD SHTEEQEELS VLSGVIKRSS SIISDSGIES EPSSVAWSEA
710 720 730 740 750
RSRALELPSD REVLHPFVRR HALHRNSLEG GHTESNTSLP SGIQASLTSI
760 770 780 790 800
SSLPFEEDER EVALTKLTKS VSAPHISSPE EAAEDADTKQ QDGGFAEPSD
810 820 830 840 850
MHSKSQGSPG SCSQLCGDSG TDAGADHPLV EIVLDADNQQ GPGYIDIPKG
860 870 880 890 900
KGKQFDAQGH CLPDGRTENT PGVETKGLNL KIPRVIALEN PRTRSLHRAL
910 920 930 940 950
EETPKGMPKD LNVGQQALSN SGISEVEGLS QHQVPELSCT SAADAINRNS
960 970 980 990 1000
TGQQSQSGSP CIMDDTAFNR GVNAFPEAKH KAGTVCPTVT HSVHSQVLKN
1010 1020 1030 1040 1050
QELKAGTSIM GSHLTSAETF TLDSLKAVEV VNLSVSCTAT CLPFSSVPKE
1060 1070 1080 1090 1100
TPARAGFSSK QTLFPITHQP LGSFGVVSTH SSTLDEEVSE RMFSFYQAKE
1110 1120 1130 1140 1150
KFKKELKIEG FLYSDLTVLA SDIPYFPPEE EEENLEDGIH LVVCVHGLDG
1160 1170 1180 1190 1200
NSADLRLVKT FIELGLPGGK LDFLMSEKNQ MDTFADFDTM TDRLLDEIIQ
1210 1220 1230 1240 1250
HIQLYNLSIS RISFIGHSLG NIIIRSVLTR PRFRYYLNKL HTFLSLSGPH
1260 1270 1280 1290 1300
LGTLYNNSTL VSTGLWLMQK LKKSGSLLQL TFRDNADLRK CFLYQLSQKT
1310 1320 1330 1340 1350
GLQYFKNVVL VASPQDRYVP FHSARIEMCK TALKDRHTGP VYAEMINNLL
1360 1370 1380 1390 1400
GPLVEAKDCT LIRHNVFHAL PNTANTLIGR AAHIAVLDSE LFLEKFFLVA

GLNYFK
Length:1,406
Mass (Da):155,770
Last modified:January 15, 2008 - v2
Checksum:iE2C3831C53A6CA13
GO
Isoform 2 (identifier: Q49AJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.

Show »
Length:1,307
Mass (Da):144,486
Checksum:i9B78498264337737
GO
Isoform 3 (identifier: Q49AJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1094-1141: SFYQAKEKFK...EENLEDGIHL → RGRGRKFGRW...PWRKTGLPNV
     1142-1406: Missing.

Show »
Length:1,141
Mass (Da):125,562
Checksum:iAE306FE041CF6C5F
GO
Isoform 4 (identifier: Q49AJ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1213-1213: S → R
     1214-1406: Missing.

Note: No experimental confirmation available.
Show »
Length:1,213
Mass (Da):133,902
Checksum:iE04E7ED29303ECCE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QSR3J3QSR3_HUMAN
Protein FAM135B
FAM135B
153Annotation score:
H0YBQ7H0YBQ7_HUMAN
Protein FAM135B
FAM135B
451Annotation score:
E5RH68E5RH68_HUMAN
Protein FAM135B
FAM135B
43Annotation score:
E5RFQ7E5RFQ7_HUMAN
Protein FAM135B
FAM135B
68Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti245C → W in AAH37288 (PubMed:15489334).Curated1
Sequence conflicti1020F → V in AAD20030 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053980477I → V1 PublicationCorresponds to variant dbSNP:rs7835830Ensembl.1
Natural variantiVAR_062218578S → N. Corresponds to variant dbSNP:rs57534956Ensembl.1
Natural variantiVAR_053981846D → N. Corresponds to variant dbSNP:rs2978180Ensembl.1
Natural variantiVAR_0622191142V → I. Corresponds to variant dbSNP:rs35765793Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0302321 – 99Missing in isoform 2. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_0302331094 – 1141SFYQA…DGIHL → RGRGRKFGRWNSPGCLCPWP GWEQCRPPAGKDFHRTGAPW RKTGLPNV in isoform 3. 3 PublicationsAdd BLAST48
Alternative sequenceiVSP_0302341142 – 1406Missing in isoform 3. 3 PublicationsAdd BLAST265
Alternative sequenceiVSP_0302351213S → R in isoform 4. 1 Publication1
Alternative sequenceiVSP_0302361214 – 1406Missing in isoform 4. 1 PublicationAdd BLAST193

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196635 mRNA Translation: BAE53437.1
AC068467 Genomic DNA No translation available.
AC087711 Genomic DNA No translation available.
AC103777 Genomic DNA No translation available.
BC037288 mRNA Translation: AAH37288.1
BC106912 mRNA Translation: AAI06913.2
BC106913 mRNA Translation: AAI06914.2
AF131744 mRNA Translation: AAD20030.1
CR457147 mRNA Translation: CAG33428.1
CCDSiCCDS6375.2 [Q49AJ0-1]
RefSeqiNP_056996.2, NM_015912.3 [Q49AJ0-1]
XP_011515366.1, XM_011517064.2 [Q49AJ0-1]
XP_011515370.1, XM_011517068.2 [Q49AJ0-2]
XP_016868959.1, XM_017013470.1
UniGeneiHs.126024
Hs.662285

Genome annotation databases

EnsembliENST00000276737; ENSP00000276737; ENSG00000147724 [Q49AJ0-3]
ENST00000395297; ENSP00000378710; ENSG00000147724 [Q49AJ0-1]
GeneIDi51059
KEGGihsa:51059
UCSCiuc003yuy.3 human [Q49AJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196635 mRNA Translation: BAE53437.1
AC068467 Genomic DNA No translation available.
AC087711 Genomic DNA No translation available.
AC103777 Genomic DNA No translation available.
BC037288 mRNA Translation: AAH37288.1
BC106912 mRNA Translation: AAI06913.2
BC106913 mRNA Translation: AAI06914.2
AF131744 mRNA Translation: AAD20030.1
CR457147 mRNA Translation: CAG33428.1
CCDSiCCDS6375.2 [Q49AJ0-1]
RefSeqiNP_056996.2, NM_015912.3 [Q49AJ0-1]
XP_011515366.1, XM_011517064.2 [Q49AJ0-1]
XP_011515370.1, XM_011517068.2 [Q49AJ0-2]
XP_016868959.1, XM_017013470.1
UniGeneiHs.126024
Hs.662285

3D structure databases

ProteinModelPortaliQ49AJ0
SMRiQ49AJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119251, 2 interactors
IntActiQ49AJ0, 2 interactors
STRINGi9606.ENSP00000378710

Protein family/group databases

ESTHERihuman-FAM135B Duf_676

PTM databases

iPTMnetiQ49AJ0
PhosphoSitePlusiQ49AJ0

Polymorphism and mutation databases

BioMutaiFAM135B
DMDMi166233528

Proteomic databases

PaxDbiQ49AJ0
PeptideAtlasiQ49AJ0
PRIDEiQ49AJ0
ProteomicsDBi62048
62049 [Q49AJ0-2]
62050 [Q49AJ0-3]
62051 [Q49AJ0-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276737; ENSP00000276737; ENSG00000147724 [Q49AJ0-3]
ENST00000395297; ENSP00000378710; ENSG00000147724 [Q49AJ0-1]
GeneIDi51059
KEGGihsa:51059
UCSCiuc003yuy.3 human [Q49AJ0-1]

Organism-specific databases

CTDi51059
DisGeNETi51059
EuPathDBiHostDB:ENSG00000147724.11
GeneCardsiFAM135B
HGNCiHGNC:28029 FAM135B
HPAiHPA023911
HPA023950
HPA024815
neXtProtiNX_Q49AJ0
OpenTargetsiENSG00000147724
PharmGKBiPA162386277
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2205 Eukaryota
ENOG410XQFK LUCA
GeneTreeiENSGT00390000007885
HOGENOMiHOG000082668
HOVERGENiHBG107866
InParanoidiQ49AJ0
OMAiHLMALWT
OrthoDBiEOG091G0KFW
PhylomeDBiQ49AJ0
TreeFamiTF314837

Miscellaneous databases

GeneWikiiFAM135B
GenomeRNAii51059
PROiPR:Q49AJ0

Gene expression databases

BgeeiENSG00000147724 Expressed in 77 organ(s), highest expression level in right testis
CleanExiHS_FAM135B
ExpressionAtlasiQ49AJ0 baseline and differential
GenevisibleiQ49AJ0 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR022122 DUF3657
IPR007751 DUF676_lipase-like
PfamiView protein in Pfam
PF12394 DUF3657, 1 hit
PF05057 DUF676, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF135B_HUMAN
AccessioniPrimary (citable) accession number: Q49AJ0
Secondary accession number(s): B5MDB3
, O95879, Q2WGJ7, Q3KP46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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