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Entry version 97 (13 Feb 2019)
Sequence version 2 (15 Jan 2008)
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Protein

Protein FAM135B

Gene

FAM135B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cellular lipid metabolic process Source: GO_Central

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

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ESTHERi
human-FAM135B Duf_676

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM135B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM135B
Synonyms:C8orfK32
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147724.11

Human Gene Nomenclature Database

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HGNCi
HGNC:28029 FAM135B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q49AJ0

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51059

Open Targets

More...
OpenTargetsi
ENSG00000147724

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162386277

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM135B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166233528

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003141711 – 1406Protein FAM135BAdd BLAST1406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei777PhosphoserineBy similarity1
Modified residuei778PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q49AJ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q49AJ0

PeptideAtlas

More...
PeptideAtlasi
Q49AJ0

PRoteomics IDEntifications database

More...
PRIDEi
Q49AJ0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
62048
62049 [Q49AJ0-2]
62050 [Q49AJ0-3]
62051 [Q49AJ0-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q49AJ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q49AJ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147724 Expressed in 77 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q49AJ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q49AJ0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023911
HPA023950
HPA024815

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119251, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q49AJ0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378710

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q49AJ0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM135 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2205 Eukaryota
ENOG410XQFK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156079

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082668

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107866

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q49AJ0

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLMALWT

Database of Orthologous Groups

More...
OrthoDBi
1132320at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q49AJ0

TreeFam database of animal gene trees

More...
TreeFami
TF314837

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR022122 DUF3657
IPR007751 DUF676_lipase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12394 DUF3657, 1 hit
PF05057 DUF676, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q49AJ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEIQGTVEF SVELHKFYNV DLFQRGYYQI RVTLKVSSRI PHRLSASIAG
60 70 80 90 100
QTESSSLHSA CVHDSTVHSR VFQILYRNEE VPINDAVVFR VHLLLGGERM
110 120 130 140 150
EDALSEVDFQ LKVDLHFTDS EQQLRDVAGA PMVSSRTLGL HFHPRNGLHH
160 170 180 190 200
QVPVMFDYFH LSVISVTVHA ALVALQQPLI SFTRPGRGSW LGKGGPDTGQ
210 220 230 240 250
EQSIISLENL VFGAGYCKPT SSEGSFYITS ENCMQHAHKW HRDLCLLLLH
260 270 280 290 300
AYRGLRLHFL VIMRDIPELP HTELEALAVE ETLSQLCSEL QMLNNPEKIA
310 320 330 340 350
EQISKDLAWL TSHMMTLWTQ FLDTVTLHSQ VTTYLTQEHH TLRVRRFSEA
360 370 380 390 400
FFYMEHQKLA VLTFQENLIQ THSQLSLDIR NSEYLTSMPP LPAECLDIDG
410 420 430 440 450
DWNTLPVIFE DRYVDCPATG HNLSVYPNFD VPVTSPTIMN LKDKEDNCMV
460 470 480 490 500
NSNLSFREDL VLSTIKPSQM DSDEEVIRCP EPGENVATQN HMDMCSESQV
510 520 530 540 550
YISIGEFQNK AGVPEDECWT GQTSDAGTYP VADVDTSRRS PGPEDGQAPV
560 570 580 590 600
LTYIDVKSSN KNPSRAEPLV AFNAQHESRS SRDKYGLDRT GLSKVVVGGS
610 620 630 640 650
HQNAISSDKT TLHELSTLGK GIDQEGKMVL LSLKLTPSEP CDPLSSTLRE
660 670 680 690 700
PLDIRSSLKD SHTEEQEELS VLSGVIKRSS SIISDSGIES EPSSVAWSEA
710 720 730 740 750
RSRALELPSD REVLHPFVRR HALHRNSLEG GHTESNTSLP SGIQASLTSI
760 770 780 790 800
SSLPFEEDER EVALTKLTKS VSAPHISSPE EAAEDADTKQ QDGGFAEPSD
810 820 830 840 850
MHSKSQGSPG SCSQLCGDSG TDAGADHPLV EIVLDADNQQ GPGYIDIPKG
860 870 880 890 900
KGKQFDAQGH CLPDGRTENT PGVETKGLNL KIPRVIALEN PRTRSLHRAL
910 920 930 940 950
EETPKGMPKD LNVGQQALSN SGISEVEGLS QHQVPELSCT SAADAINRNS
960 970 980 990 1000
TGQQSQSGSP CIMDDTAFNR GVNAFPEAKH KAGTVCPTVT HSVHSQVLKN
1010 1020 1030 1040 1050
QELKAGTSIM GSHLTSAETF TLDSLKAVEV VNLSVSCTAT CLPFSSVPKE
1060 1070 1080 1090 1100
TPARAGFSSK QTLFPITHQP LGSFGVVSTH SSTLDEEVSE RMFSFYQAKE
1110 1120 1130 1140 1150
KFKKELKIEG FLYSDLTVLA SDIPYFPPEE EEENLEDGIH LVVCVHGLDG
1160 1170 1180 1190 1200
NSADLRLVKT FIELGLPGGK LDFLMSEKNQ MDTFADFDTM TDRLLDEIIQ
1210 1220 1230 1240 1250
HIQLYNLSIS RISFIGHSLG NIIIRSVLTR PRFRYYLNKL HTFLSLSGPH
1260 1270 1280 1290 1300
LGTLYNNSTL VSTGLWLMQK LKKSGSLLQL TFRDNADLRK CFLYQLSQKT
1310 1320 1330 1340 1350
GLQYFKNVVL VASPQDRYVP FHSARIEMCK TALKDRHTGP VYAEMINNLL
1360 1370 1380 1390 1400
GPLVEAKDCT LIRHNVFHAL PNTANTLIGR AAHIAVLDSE LFLEKFFLVA

GLNYFK
Length:1,406
Mass (Da):155,770
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2C3831C53A6CA13
GO
Isoform 2 (identifier: Q49AJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.

Show »
Length:1,307
Mass (Da):144,486
Checksum:i9B78498264337737
GO
Isoform 3 (identifier: Q49AJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1094-1141: SFYQAKEKFK...EENLEDGIHL → RGRGRKFGRW...PWRKTGLPNV
     1142-1406: Missing.

Show »
Length:1,141
Mass (Da):125,562
Checksum:iAE306FE041CF6C5F
GO
Isoform 4 (identifier: Q49AJ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1213-1213: S → R
     1214-1406: Missing.

Note: No experimental confirmation available.
Show »
Length:1,213
Mass (Da):133,902
Checksum:iE04E7ED29303ECCE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBQ7H0YBQ7_HUMAN
Protein FAM135B
FAM135B
451Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSR3J3QSR3_HUMAN
Protein FAM135B
FAM135B
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH68E5RH68_HUMAN
Protein FAM135B
FAM135B
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFQ7E5RFQ7_HUMAN
Protein FAM135B
FAM135B
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti245C → W in AAH37288 (PubMed:15489334).Curated1
Sequence conflicti1020F → V in AAD20030 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053980477I → V1 PublicationCorresponds to variant dbSNP:rs7835830Ensembl.1
Natural variantiVAR_062218578S → N. Corresponds to variant dbSNP:rs57534956Ensembl.1
Natural variantiVAR_053981846D → N. Corresponds to variant dbSNP:rs2978180Ensembl.1
Natural variantiVAR_0622191142V → I. Corresponds to variant dbSNP:rs35765793Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0302321 – 99Missing in isoform 2. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_0302331094 – 1141SFYQA…DGIHL → RGRGRKFGRWNSPGCLCPWP GWEQCRPPAGKDFHRTGAPW RKTGLPNV in isoform 3. 3 PublicationsAdd BLAST48
Alternative sequenceiVSP_0302341142 – 1406Missing in isoform 3. 3 PublicationsAdd BLAST265
Alternative sequenceiVSP_0302351213S → R in isoform 4. 1 Publication1
Alternative sequenceiVSP_0302361214 – 1406Missing in isoform 4. 1 PublicationAdd BLAST193

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB196635 mRNA Translation: BAE53437.1
AC068467 Genomic DNA No translation available.
AC087711 Genomic DNA No translation available.
AC103777 Genomic DNA No translation available.
BC037288 mRNA Translation: AAH37288.1
BC106912 mRNA Translation: AAI06913.2
BC106913 mRNA Translation: AAI06914.2
AF131744 mRNA Translation: AAD20030.1
CR457147 mRNA Translation: CAG33428.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6375.2 [Q49AJ0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_056996.2, NM_015912.3 [Q49AJ0-1]
XP_011515366.1, XM_011517064.2 [Q49AJ0-1]
XP_011515370.1, XM_011517068.2 [Q49AJ0-2]
XP_016868959.1, XM_017013470.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.126024
Hs.662285

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276737; ENSP00000276737; ENSG00000147724 [Q49AJ0-3]
ENST00000395297; ENSP00000378710; ENSG00000147724 [Q49AJ0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51059

UCSC genome browser

More...
UCSCi
uc003yuy.3 human [Q49AJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196635 mRNA Translation: BAE53437.1
AC068467 Genomic DNA No translation available.
AC087711 Genomic DNA No translation available.
AC103777 Genomic DNA No translation available.
BC037288 mRNA Translation: AAH37288.1
BC106912 mRNA Translation: AAI06913.2
BC106913 mRNA Translation: AAI06914.2
AF131744 mRNA Translation: AAD20030.1
CR457147 mRNA Translation: CAG33428.1
CCDSiCCDS6375.2 [Q49AJ0-1]
RefSeqiNP_056996.2, NM_015912.3 [Q49AJ0-1]
XP_011515366.1, XM_011517064.2 [Q49AJ0-1]
XP_011515370.1, XM_011517068.2 [Q49AJ0-2]
XP_016868959.1, XM_017013470.1
UniGeneiHs.126024
Hs.662285

3D structure databases

ProteinModelPortaliQ49AJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119251, 2 interactors
IntActiQ49AJ0, 2 interactors
STRINGi9606.ENSP00000378710

Protein family/group databases

ESTHERihuman-FAM135B Duf_676

PTM databases

iPTMnetiQ49AJ0
PhosphoSitePlusiQ49AJ0

Polymorphism and mutation databases

BioMutaiFAM135B
DMDMi166233528

Proteomic databases

jPOSTiQ49AJ0
PaxDbiQ49AJ0
PeptideAtlasiQ49AJ0
PRIDEiQ49AJ0
ProteomicsDBi62048
62049 [Q49AJ0-2]
62050 [Q49AJ0-3]
62051 [Q49AJ0-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276737; ENSP00000276737; ENSG00000147724 [Q49AJ0-3]
ENST00000395297; ENSP00000378710; ENSG00000147724 [Q49AJ0-1]
GeneIDi51059
KEGGihsa:51059
UCSCiuc003yuy.3 human [Q49AJ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51059
DisGeNETi51059
EuPathDBiHostDB:ENSG00000147724.11

GeneCards: human genes, protein and diseases

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GeneCardsi
FAM135B
HGNCiHGNC:28029 FAM135B
HPAiHPA023911
HPA023950
HPA024815
neXtProtiNX_Q49AJ0
OpenTargetsiENSG00000147724
PharmGKBiPA162386277

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2205 Eukaryota
ENOG410XQFK LUCA
GeneTreeiENSGT00940000156079
HOGENOMiHOG000082668
HOVERGENiHBG107866
InParanoidiQ49AJ0
OMAiHLMALWT
OrthoDBi1132320at2759
PhylomeDBiQ49AJ0
TreeFamiTF314837

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FAM135B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51059

Protein Ontology

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PROi
PR:Q49AJ0

Gene expression databases

BgeeiENSG00000147724 Expressed in 77 organ(s), highest expression level in right testis
ExpressionAtlasiQ49AJ0 baseline and differential
GenevisibleiQ49AJ0 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR022122 DUF3657
IPR007751 DUF676_lipase-like
PfamiView protein in Pfam
PF12394 DUF3657, 1 hit
PF05057 DUF676, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF135B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q49AJ0
Secondary accession number(s): B5MDB3
, O95879, Q2WGJ7, Q3KP46
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 13, 2019
This is version 97 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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