UniProtKB - Q49AI9 (Q49AI9_HUMAN)
Protein
Submitted name:
ABCA8 protein
Gene
ABCA8
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATPase-coupled transmembrane transporter activity Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: ABCA8 proteinImportedSubmitted name: ATP-binding cassette sub-family A member 8Imported |
Gene namesi | Name:ABCA8Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:38, ABCA8 |
VEuPathDBi | HostDB:ENSG00000141338.13 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 28 – 50 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000141338, Expressed in corpus callosum and 236 other tissues |
ExpressionAtlasi | Q49AI9, baseline and differential |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000162012 |
HOGENOMi | CLU_1685936_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR026082, ABCA IPR030372, ABCA8 |
PANTHERi | PTHR19229, PTHR19229, 1 hit PTHR19229:SF148, PTHR19229:SF148, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q49AI9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGMAQLLHL DYDLNSNAFP HPSDGSNLIV ATNFMLAFDT CLYLALAIYF
60 70 80 90 100
EKILPNEYGH RRPPLFFLKS SFWSQTQKTD HVALEDEMDA DPSFHDSFEQ
110 120 130 140 150
APPEFQGKEA IRIRNVTKEY KGKPDKIEAL KDLVFDIYEG QITAILVTVE
LESQHC
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO94911 | ABCA8_HUMAN | ABC-type organic anion transporter ... | ABCA8 KIAA0822 | 1,621 | Annotation score: | ||
A0A0A0MSU4 | A0A0A0MSU4_HUMAN | ATP-binding cassette sub-family A m... | ABCA8 | 1,616 | Annotation score: | ||
A0A075B774 | A0A075B774_HUMAN | ATP-binding cassette sub-family A m... | ABCA8 | 702 | Annotation score: | ||
K7ELK9 | K7ELK9_HUMAN | ATP-binding cassette sub-family A m... | ABCA8 | 115 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005922 Genomic DNA No translation available. AC015844 Genomic DNA No translation available. BC037309 mRNA Translation: AAH37309.1 |
Genome annotation databases
Ensembli | ENST00000615593; ENSP00000481467; ENSG00000141338 |
UCSCi | uc060jgc.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005922 Genomic DNA No translation available. AC015844 Genomic DNA No translation available. BC037309 mRNA Translation: AAH37309.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | Q49AI9 |
ProteomicsDBi | 62047 |
Protocols and materials databases
Antibodypediai | 31802, 130 antibodies |
Genome annotation databases
Ensembli | ENST00000615593; ENSP00000481467; ENSG00000141338 |
UCSCi | uc060jgc.1, human |
Organism-specific databases
HGNCi | HGNC:38, ABCA8 |
OpenTargetsi | ENSG00000141338 |
VEuPathDBi | HostDB:ENSG00000141338.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000162012 |
HOGENOMi | CLU_1685936_0_0_1 |
Miscellaneous databases
ChiTaRSi | ABCA8, human |
Gene expression databases
Bgeei | ENSG00000141338, Expressed in corpus callosum and 236 other tissues |
ExpressionAtlasi | Q49AI9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR026082, ABCA IPR030372, ABCA8 |
PANTHERi | PTHR19229, PTHR19229, 1 hit PTHR19229:SF148, PTHR19229:SF148, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q49AI9_HUMAN | |
Accessioni | Q49AI9Primary (citable) accession number: Q49AI9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 13, 2005 |
Last sequence update: | September 13, 2005 | |
Last modified: | February 10, 2021 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |