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Protein

Zinc finger protein ZFP69

Gene

ZFP69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 293C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFP69
Alternative name(s):
Zinc finger protein 642
Gene namesi
Name:ZFP69
Synonyms:ZNF642
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000187815.9
HGNCiHGNC:24708 ZFP69
MIMi617939 gene
neXtProtiNX_Q49AA0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi339559
OpenTargetsiENSG00000187815
PharmGKBiPA134917508

Polymorphism and mutation databases

BioMutaiZFP69
DMDMi115502934

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002521611 – 526Zinc finger protein ZFP69Add BLAST526

Proteomic databases

MaxQBiQ49AA0
PaxDbiQ49AA0
PeptideAtlasiQ49AA0
PRIDEiQ49AA0
ProteomicsDBi62038

PTM databases

iPTMnetiQ49AA0
PhosphoSitePlusiQ49AA0

Expressioni

Gene expression databases

BgeeiENSG00000187815
CleanExiHS_ZNF642
GenevisibleiQ49AA0 HS

Organism-specific databases

HPAiHPA027808
HPA054942

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361790

Structurei

3D structure databases

ProteinModelPortaliQ49AA0
SMRiQ49AA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 39SCAN boxAdd BLAST39
Domaini76 – 147KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 293C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144215
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ49AA0
KOiK09228
OMAiSEHIRIH
OrthoDBiEOG091G02KC
PhylomeDBiQ49AA0
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequencei

Sequence statusi: Complete.

Q49AA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQQLLITLP TEASTWVKLQ HPKKAVEGAP LWEDVTKMFE GEALLSQDAE
60 70 80 90 100
DVKTQRESLE DEVTPGLPTA ESQELLTFKD ISIDFTQEEW GQLAPAHQNL
110 120 130 140 150
YREVMLENYS NLVSVGYQLS KPSVISQLEK GEEPWMAEKE GPGDPSSDLK
160 170 180 190 200
SKIETIESTA KSTISQERLY HGIMMESFMR DDIIYSTLRK VSTYDDVLER
210 220 230 240 250
HQETCMRDVR QAILTHKKRV QETNKFGENI IVHSNVIIEQ RHHKYDTPTK
260 270 280 290 300
RNTYKLDLIN HPTSYIRTKT YECNICEKIF KQPIHLTEHM RIHTGEKPFR
310 320 330 340 350
CKECGRAFSQ SASLSTHQRI HTGEKPFECE ECGKAFRHRS SLNQHHRTHT
360 370 380 390 400
GEKPYVCDKC QKAFSQNISL VQHLRTHSGE KPFTCNECGK TFRQIRHLSE
410 420 430 440 450
HIRIHTGEKP YACTACCKTF SHRAYLTHHQ RIHTGERPYK CKECGKAFRQ
460 470 480 490 500
RIHLSNHKTV HTGVKAYECN RCGKAYRHDS SFKKHQRHHT GEKPYECNEC
510 520
GKAFSYNSSL SRHHEIHRRN AFRNKV
Length:526
Mass (Da):61,181
Last modified:October 3, 2006 - v2
Checksum:iF0B624CF36BF4F36
GO

Sequence cautioni

The sequence BAC85492 differs from that shown. Reason: Erroneous termination at position 506. Translated as Tyr.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159T → A in AAH41873 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033583113V → L. Corresponds to variant dbSNP:rs34752670Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122618 mRNA Translation: BAC85492.1 Sequence problems.
AL603839 Genomic DNA No translation available.
BC041873 mRNA Translation: AAH41873.1
CCDSiCCDS30686.1
RefSeqiNP_001307107.1, NM_001320178.1
NP_001307108.1, NM_001320179.1
NP_940896.2, NM_198494.2
XP_006710669.1, XM_006710606.3
UniGeneiHs.434385

Genome annotation databases

EnsembliENST00000372705; ENSP00000361790; ENSG00000187815
ENST00000372706; ENSP00000361791; ENSG00000187815
GeneIDi339559
KEGGihsa:339559
UCSCiuc001cfo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZFP69_HUMAN
AccessioniPrimary (citable) accession number: Q49AA0
Secondary accession number(s): Q5SWM5, Q6ZWK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 20, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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