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Protein
Submitted name:

FGD4 protein

Gene

FGD4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri311 – 371FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
FGD4 proteinImported
Gene namesi
Name:FGD4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiQ49A55
PRIDEiQ49A55

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ49A55, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ49A55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 145DHInterPro annotationAdd BLAST145
Domaini174 – 273PHInterPro annotationAdd BLAST100
Domaini311 – 371FYVE-typeInterPro annotationAdd BLAST61

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri311 – 371FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4424 Eukaryota
ENOG410XRXV LUCA
HOGENOMiHOG000220866
HOVERGENiHBG007506

Family and domain databases

CDDicd15791 PH1_FDG4, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR037742 FDG4_N_PH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequencei

Sequence statusi: Complete.

Q49A55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNKIFSNIS SINAFHSKFL LPELEKRMQE WETTPRIGDI LQKLAPFLKM
60 70 80 90 100
YGEYVKGFDN AMELVKNMTE RIPQFKSVVE EIQKQKICGS LTLQHHMLEP
110 120 130 140 150
VQRIPRYEML LKDYLRKLPP DSLDWNDAKK SLEIISTAAS HSNSAIRKME
160 170 180 190 200
NLKKLLEIYE MLGEEEDIVN PSNELIKEGQ ILKLAARNTS ARERYLFLFN
210 220 230 240 250
NMLLYCVPKF SLVGSKFTVR TRVGIDGMKI VETQNEEYPH TFQVSGKERT
260 270 280 290 300
LELQASSAQD KEEWIKALQE TIDAFHQRHE TFRNAIAKDN DIHSEVSTAE
310 320 330 340 350
LGKRAPRWIR DNEVTMCMKC KEPFNALTRR RHHCRACGYV VCWKCSDYKA
360 370 380 390 400
QLEYDGGKLS KVCKDCYQII SGFTDSEEKK RKGILEIESA EVSGNSVVCS
410 420 430 440 450
FLQYMEKSKP WQKAWCVIPK QDPLVLYMYG APQVSKPHLS EGTDALGGKG
460 470
KRVDSGLKIC RTRVQAVSLF H
Length:471
Mass (Da):54,252
Last modified:September 13, 2005 - v1
Checksum:i7225FD8BDDCA85DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045552 mRNA Translation: AAH45552.1
RefSeqiNP_001291412.1, NM_001304483.1
UniGeneiHs.117835

Genome annotation databases

GeneIDi121512

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045552 mRNA Translation: AAH45552.1
RefSeqiNP_001291412.1, NM_001304483.1
UniGeneiHs.117835

3D structure databases

ProteinModelPortaliQ49A55
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ49A55, 1 interactor

Proteomic databases

PeptideAtlasiQ49A55
PRIDEiQ49A55

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi121512

Organism-specific databases

CTDi121512

Phylogenomic databases

eggNOGiKOG4424 Eukaryota
ENOG410XRXV LUCA
HOGENOMiHOG000220866
HOVERGENiHBG007506

Miscellaneous databases

ChiTaRSiFGD4 human
GenomeRNAii121512

Family and domain databases

CDDicd15791 PH1_FDG4, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR037742 FDG4_N_PH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ49A55_HUMAN
AccessioniPrimary (citable) accession number: Q49A55
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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