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Entry version 43 (11 Dec 2019)
Sequence version 1 (13 Sep 2005)
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Protein

Exportin-4

Gene

xpo4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the nuclear export of proteins (cargos) with broad substrate specificity.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exportin-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:xpo4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-990879 xpo4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002376721 – 1150Exportin-4Add BLAST1150

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q499Y0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q499Y0

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

Database of Orthologous Groups

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OrthoDBi
106880at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q499Y0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAALGASEV IAQLESAAKV LMAPPSMVNN EQRQHAEHVF LSFRKSKSPF
60 70 80 90 100
AVCKHILETS KVDYVLFQAA TAIMEAVVRE WILLEKSSIE SLRTFLLTYV
110 120 130 140 150
LQRPNLQKYV REQILLAVAV IVKRGSLDKS IDCKSIFHEV SQLISSCNPT
160 170 180 190 200
MQTLACSILT ALLIEFSSSS KTSNIGLSME FHGSCKRVFQ DEDLRRIFML
210 220 230 240 250
TIEVLQEFSR RENLNAQMSS VFQRYLALAN QVLSWNFLPP NLGRHYIAMF
260 270 280 290 300
ESSQNVMLKP TESWRETLLN SRVMELFFTV HRKIREDSDM AQDSLQCLAQ
310 320 330 340 350
LASLHGPIFP DERSQVDYLA HFIEGLLSTI NGIEIEDSEA VGISNIISNL
360 370 380 390 400
ITVFPRNILT AIPSDLFSSF VNCLTHLTCS FGRSAALEEV LDKDDMVYME
410 420 430 440 450
AYDKLLESWL TLVQDDQHFH KGFFTQHAVQ VFNSYIQCHL AAPDGTRNLT
460 470 480 490 500
ANGVASREEE EINEIQEDDR DLFSDQLASV GMLGRIASDH CIPLLTSLLE
510 520 530 540 550
ERVTRLHGQL QRHQQQLLAS PGADSIDNKV LDDLYEDIHW LILVTGYLLA
560 570 580 590 600
DDTQGETPLI PSEIMEYSIK QSTEVDINTT LQILGSPGEK ASSIPGCNRT
610 620 630 640 650
DSVIRLVSAV LRASEVESRA TRADLTHLLS PQMGKDIVWF LKRWTKTYLL
660 670 680 690 700
VDEKLYDQIS LPFNTAFGAD TEGCHWIIGY LLEKVISNLS VWSSEQELAN
710 720 730 740 750
ETVQLLVTLV ERRERANLVI QCENWWNLAK QFAQRSPPLN FLSSSVQRTL
760 770 780 790 800
MKALVLGGFA HMDSDTKQQY WTEVLQPLQQ RFLNVINQEN FQQICQEEEV
810 820 830 840 850
KQEITATLEA LCGIAEATQI DNVAILFNFL MDFLTNCIGL MEVYKNNPET
860 870 880 890 900
VNLIIEVFVE VAHKQICYLG ESKAMNLYEA CLTLLQVYSK NNLGRKRIDV
910 920 930 940 950
TAEEDQYQDL LLIMELLTNL LSKEFIDFSD TDEVFRPHEP GQATNRPVSA
960 970 980 990 1000
ADVVLYGVNI VLPLMSQDLL KFPSLCNQYY KLITFICEIF PEKIPLLPED
1010 1020 1030 1040 1050
LFKSLMYSLE LGMTSMSSEV SQLCLEALTP LAEQCAKAQD TDSPLLAAMR
1060 1070 1080 1090 1100
HFLKLVFDML VLQKHNTEMT TAAGEAFYTL VCLNQAEYAE LVETLLSSQQ
1110 1120 1130 1140 1150
DPLIYQRLAD AFNKLTASST PPTLDRKQKM SFLKSLEEFM GNVGGLLCVK
Length:1,150
Mass (Da):130,095
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i080E2AD5D784D872
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC099668 mRNA Translation: AAH99668.1

NCBI Reference Sequences

More...
RefSeqi
NP_001089644.1, NM_001096175.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
734704

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:734704

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099668 mRNA Translation: AAH99668.1
RefSeqiNP_001089644.1, NM_001096175.1

3D structure databases

SMRiQ499Y0
ModBaseiSearch...

Proteomic databases

MaxQBiQ499Y0

Genome annotation databases

GeneIDi734704
KEGGixla:734704

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
734704
XenbaseiXB-GENE-990879 xpo4

Phylogenomic databases

OrthoDBi106880at2759

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPO4_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q499Y0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: September 13, 2005
Last modified: December 11, 2019
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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