Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 103 (12 Aug 2020)
Sequence version 1 (13 Sep 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Engulfment and cell motility protein 3

Gene

Elmo3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Phagocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Engulfment and cell motility protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Elmo3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19
  • UP000234681 Componentsi: Chromosome 19, Unassembled WGS sequence

Organism-specific databases

Rat genome database

More...
RGDi
1304734, Elmo3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003752231 – 720Engulfment and cell motility protein 3Add BLAST720

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q499U2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q499U2

PRoteomics IDEntifications database

More...
PRIDEi
Q499U2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000015800, Expressed in jejunum and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q499U2, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably interacts directly with the SH3-domain of DOCK1 via its SH3-binding site.

Part of a complex with DOCK1 and RAC1 (By similarity).

Interacts with ADGRB3 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000021362

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q499U2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini307 – 479ELMOPROSITE-ProRule annotationAdd BLAST173
Domaini541 – 663PHAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi699 – 706Poly-Pro8

Keywords - Domaini

SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2999, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159455

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023887_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q499U2

KEGG Orthology (KO)

More...
KOi
K19241

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEEYCLN

Database of Orthologous Groups

More...
OrthoDBi
234725at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q499U2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR024574, DUF3361
IPR030719, ELMO3
IPR006816, ELMO_dom
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR12771:SF16, PTHR12771:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11841, DUF3361, 1 hit
PF04727, ELMO_CED12, 1 hit
PF16457, PH_12, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51335, ELMO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q499U2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPRNVVKI AVQMSDAIPQ LIQLDQAKPL ATVLKEVCDT WSLTHPEHYA
60 70 80 90 100
LQFADGHRKY ITENNRSEIK NGSILCLSTA PDLKAQQLLS RLQNASREGC
110 120 130 140 150
CEVLRNLVPL ASDMTFAQEV ISRDGLQKLS TIIENGDDLG EMLALGLRAF
160 170 180 190 200
LELMEHGVVS WETLSISFVR KVVSYVNMNL MDASVQPLAL RLLESVTLSS
210 220 230 240 250
PTLGQLVKSE VPLDRLLVHL QVMNQQLQTK AMALLTALLQ GASPAERKDM
260 270 280 290 300
LDCLWKKNLR QFIYKNIIHS AAPMGDEMAH HLYVLQALTL GLLEPRMRTP
310 320 330 340 350
LDPYSQEQRE QLQALRQAAF EPDGESLGTG LSADRRRSLC VREFRKLGFS
360 370 380 390 400
NSSPAQDLER VPPGLLALDN MLYFSRHAPS AYSRFVLENS SREDKHECPF
410 420 430 440 450
ARSSIQLTVL LCELLHVGEP CSETAQDFSP MFFSQDHSFH ELFCVAIQLL
460 470 480 490 500
NKTWKEMRAT QEDFDKVMQV VREQLARTLA LKPTSLELFR TKVNALTYGE
510 520 530 540 550
VLRLRQTERL HQEGTLAPPI LELREKLKPE LMGLIRQQRL LRLCEGMLFR
560 570 580 590 600
KISSRRRQDK LWFCCLSPNH KVLQYGDVEE GANPPTLESL TEQLPVADIR
610 620 630 640 650
ALLMGKDCPH VREKGSGKQN KDLYELAFSI SYDHGEEEAY LNFIAPSKRD
660 670 680 690 700
FYLWTDGLSA LLGSTMGSEQ TRLDLEQLLT METKLRLLEL ENVPIPEHPP
710 720
PVPPPPTNFN FCYDYSMTEP
Length:720
Mass (Da):81,659
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F4230B0146340D4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH473972 Genomic DNA Translation: EDL92366.1
BC099761 mRNA Translation: AAH99761.1

NCBI Reference Sequences

More...
RefSeqi
NP_001025199.1, NM_001030028.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000021362; ENSRNOP00000021362; ENSRNOG00000015800

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
291962

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:291962

UCSC genome browser

More...
UCSCi
RGD:1304734, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473972 Genomic DNA Translation: EDL92366.1
BC099761 mRNA Translation: AAH99761.1
RefSeqiNP_001025199.1, NM_001030028.1

3D structure databases

SMRiQ499U2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021362

Proteomic databases

jPOSTiQ499U2
PaxDbiQ499U2
PRIDEiQ499U2

Genome annotation databases

EnsembliENSRNOT00000021362; ENSRNOP00000021362; ENSRNOG00000015800
GeneIDi291962
KEGGirno:291962
UCSCiRGD:1304734, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79767
RGDi1304734, Elmo3

Phylogenomic databases

eggNOGiKOG2999, Eukaryota
GeneTreeiENSGT00940000159455
HOGENOMiCLU_023887_0_0_1
InParanoidiQ499U2
KOiK19241
OMAiVEEYCLN
OrthoDBi234725at2759
PhylomeDBiQ499U2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q499U2

Gene expression databases

BgeeiENSRNOG00000015800, Expressed in jejunum and 20 other tissues
GenevisibleiQ499U2, RN

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR024574, DUF3361
IPR030719, ELMO3
IPR006816, ELMO_dom
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR12771:SF16, PTHR12771:SF16, 1 hit
PfamiView protein in Pfam
PF11841, DUF3361, 1 hit
PF04727, ELMO_CED12, 1 hit
PF16457, PH_12, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51335, ELMO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELMO3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q499U2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: September 13, 2005
Last modified: August 12, 2020
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again