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Protein
Submitted name:

Interferon-induced GTP-binding protein Mx2

Gene

Mx2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1169408 ISG15 antiviral mechanism

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon-induced GTP-binding protein Mx2Imported
Submitted name:
Myxovirus (Influenza virus) resistance 2Imported
Submitted name:
RCG53028Imported
Gene namesi
Name:Mx2Imported
ORF Names:rCG_53028Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi628821 Mx2

Expressioni

Gene expression databases

BgeeiENSRNOG00000001963 Expressed in 10 organ(s), highest expression level in lung

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 338Dynamin-type GInterPro annotationAdd BLAST274
Domaini571 – 659GEDInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOVERGENiHBG008788
KOiK14754
OMAiKATIPCL
OrthoDBiEOG091G080G
TreeFamiTF331484

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q499Q3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLSTEENRS VDLVNLPSVP LPDGEAGVGE NNKDSLNNLC SQYEEKVRPC
60 70 80 90 100
IDLIDSLRAL GVEQDLALPA IAVIGDQSSG KSSVLEALSG VALPRGSGIV
110 120 130 140 150
TRCPLVLKLK KLNQGEEWKG KVTYDDIEVE LSDPSEVEEA INTGQNHIAG
160 170 180 190 200
VGLGISDKLI SLDVSSPHVP DLTLIDLPGI TRVAVGNQPA DIGRQIKRLI
210 220 230 240 250
TNYIQKQETI NLVVVPSNVD IATTEALSMA QKVDPDGDRT IGILTKPDLV
260 270 280 290 300
DRGTEDKVVD VVRNLVCHLK KGYMIVKCRG QQDIQEQLSL AEALQKEQVF
310 320 330 340 350
FKEHPQFRAL LEDGKATVPC LAERLTMELI SHICKSLPLL ENQIKESHQS
360 370 380 390 400
TSEELQKYGA DIPEDENEKT LFLIEKINAF NQDITAIVEG EEIVREKECR
410 420 430 440 450
LFTKLRKEFF LWSEEIERNF QKGSDALYKE VYTFEMQYRG RELPGFVNYK
460 470 480 490 500
TFENIIRRQI KTLEEPAMEM LHKVTEIVRA AFTTVSEKNF SEFFNLHRTT
510 520 530 540 550
KSKLEDIRLE QETEAEKAIR LHFQMEQIIY CQDQIYRKAL QKVREEEAEE
560 570 580 590 600
EERKHGKSRS AQSPNLQTSS MDEIFQHLNA YRQEAHNCIS SHIPLIIQYF
610 620 630 640 650
ILKMFAEKLQ KGMLQLLQDK DSCSWLLKEK SDTSEKRRFL KERLARLAQA

QRRLAKFPG
Length:659
Mass (Da):74,949
Last modified:September 13, 2005 - v1
Checksum:i25330E74DC1C5BAE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P18589MX2_RAT
Interferon-induced GTP-binding prot...
Mx2
659Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072228 Genomic DNA No translation available.
AC133372 Genomic DNA No translation available.
BC099808 mRNA Translation: AAH99808.1
CH473967 Genomic DNA Translation: EDM10969.1
RefSeqiNP_599177.2, NM_134350.2
XP_006248212.1, XM_006248150.3
XP_008766790.1, XM_008768568.2
UniGeneiRn.10374

Genome annotation databases

EnsembliENSRNOT00000002695; ENSRNOP00000002695; ENSRNOG00000001963
ENSRNOT00000083067; ENSRNOP00000075302; ENSRNOG00000001963
ENSRNOT00000087603; ENSRNOP00000075496; ENSRNOG00000001963
GeneIDi286918
KEGGirno:286918

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072228 Genomic DNA No translation available.
AC133372 Genomic DNA No translation available.
BC099808 mRNA Translation: AAH99808.1
CH473967 Genomic DNA Translation: EDM10969.1
RefSeqiNP_599177.2, NM_134350.2
XP_006248212.1, XM_006248150.3
XP_008766790.1, XM_008768568.2
UniGeneiRn.10374

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002695; ENSRNOP00000002695; ENSRNOG00000001963
ENSRNOT00000083067; ENSRNOP00000075302; ENSRNOG00000001963
ENSRNOT00000087603; ENSRNOP00000075496; ENSRNOG00000001963
GeneIDi286918
KEGGirno:286918

Organism-specific databases

CTDi4600
RGDi628821 Mx2

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOVERGENiHBG008788
KOiK14754
OMAiKATIPCL
OrthoDBiEOG091G080G
TreeFamiTF331484

Enzyme and pathway databases

ReactomeiR-RNO-1169408 ISG15 antiviral mechanism

Gene expression databases

BgeeiENSRNOG00000001963 Expressed in 10 organ(s), highest expression level in lung

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ499Q3_RAT
AccessioniPrimary (citable) accession number: Q499Q3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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