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UniProtKB - Q499N1 (Q499N1_RAT)
Protein
Submitted name:
Retinoic acid receptor, alpha
Gene
Rara
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- alpha-actinin binding Source: RGD
- chromatin binding Source: RGD
- chromatin DNA binding Source: RGD
- DNA binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- enzyme binding Source: RGD
- heterocyclic compound binding Source: RGD
- histone deacetylase binding Source: RGD
- mRNA 5'-UTR binding Source: RGD
- nuclear receptor activity Source: RGD
- phosphatidylinositol 3-kinase regulator activity Source: UniProtKB
- protein domain specific binding Source: RGD
- protein kinase A binding Source: RGD
- protein kinase B binding Source: RGD
- retinoic acid binding Source: RGD
- retinoic acid-responsive element binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- signaling receptor binding Source: RGD
- transcription cis-regulatory region binding Source: RGD
- translation repressor activity, mRNA regulatory element binding Source: RGD
- zinc ion binding Source: InterPro
GO - Biological processi
- apoptotic cell clearance Source: RGD
- bone development Source: RGD
- cell differentiation Source: GO_Central
- cellular response to estrogen stimulus Source: RGD
- cellular response to lipopolysaccharide Source: RGD
- chondroblast differentiation Source: RGD
- embryonic camera-type eye development Source: RGD
- face development Source: RGD
- female pregnancy Source: RGD
- germ cell development Source: RGD
- glandular epithelial cell development Source: RGD
- growth plate cartilage development Source: RGD
- hippocampus development Source: RGD
- hormone-mediated signaling pathway Source: GO_Central
- limb development Source: RGD
- liver development Source: RGD
- male gonad development Source: RGD
- multicellular organism growth Source: RGD
- negative regulation of cartilage development Source: RGD
- negative regulation of cell differentiation Source: RGD
- negative regulation of cell population proliferation Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of granulocyte differentiation Source: RGD
- negative regulation of interferon-gamma production Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- negative regulation of translation Source: RGD
- negative regulation of tumor necrosis factor production Source: RGD
- neural tube closure Source: RGD
- positive regulation of binding Source: RGD
- positive regulation of cell cycle Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of gene expression Source: RGD
- positive regulation of interleukin-13 production Source: RGD
- positive regulation of interleukin-4 production Source: RGD
- positive regulation of interleukin-5 production Source: RGD
- positive regulation of neuron differentiation Source: RGD
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of protein kinase B signaling Source: UniProtKB
- positive regulation of T-helper 2 cell differentiation Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- prostate gland development Source: RGD
- protein phosphorylation Source: RGD
- regulation of apoptotic process Source: RGD
- regulation of granulocyte differentiation Source: RGD
- regulation of myelination Source: RGD
- regulation of synaptic plasticity Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- response to cytokine Source: RGD
- response to estradiol Source: RGD
- response to ethanol Source: RGD
- response to retinoic acid Source: RGD
- response to vitamin A Source: RGD
- retinoic acid receptor signaling pathway Source: RGD
- Sertoli cell fate commitment Source: RGD
- signal transduction Source: RGD
- trachea cartilage development Source: RGD
- ureteric bud development Source: RGD
- ventricular cardiac muscle cell differentiation Source: RGD
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Retinoic acid receptor, alphaImportedSubmitted name: Retinoic acid receptor, alpha, isoform CRA_bImported |
Gene namesi | Name:RaraImported ORF Names:rCG_33521Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3534, Rara |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleus Source: RGD
Other locations
- chromatin Source: RGD
- cytoplasm Source: RGD
- dendrite Source: RGD
- neuron projection Source: RGD
- perinuclear region of cytoplasm Source: RGD
- protein-containing complex Source: RGD
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000009972, Expressed in testis and 20 other tissues |
Interactioni
GO - Molecular functioni
- alpha-actinin binding Source: RGD
- enzyme binding Source: RGD
- histone deacetylase binding Source: RGD
- protein domain specific binding Source: RGD
- protein kinase A binding Source: RGD
- protein kinase B binding Source: RGD
- signaling receptor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008659 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 82 – 157 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 180 – 414 | NR LBDInterPro annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 49 – 74 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 417 – 459 | DisorderedSequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 49 – 68 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 444 – 459 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000159997 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q499N1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYESVEVGGL APAPNPFLVV DFYNQNRACL LQEKGLPAPG PYSTPLRTPL
60 70 80 90 100
WNGSNHSIET QSSSSEEIVP SPPSPPPLPR IYKPCFVCQD KSSGYHYGVS
110 120 130 140 150
ACEGCKGFFR RSIQKNMVYT CHRDKNCIIN KVTRNRCQYC RLQKCFEVGM
160 170 180 190 200
SKESVRNDRN KKKKETPKPE CSESYTLTPE VGELIEKVRK AHQETFPALC
210 220 230 240 250
QLGKYTTNNS SEQRVSLDID LWDKFSELST KCIIKTVEFA KQLPGFTTLT
260 270 280 290 300
IADQITLLKA ACLDILILRI CTRYTPEQDT MTFSDGLTLN RTQMHNAGFG
310 320 330 340 350
PLTDLVFAFA NQLLPLEMDD AETGLLSAIC LICGDRQDLE QPDKVDMLQE
360 370 380 390 400
PLLEALKVYV RKRRPSRPHM FPKMLMKITD LRSISAKGAE RVITLKMEIP
410 420 430 440 450
GSMPPLIQEM LENSEGLDTL SGQSGGGTRD GGGLAPPPGS CSPSLSPSSH
RSSPATQSP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JW78 | A0A0G2JW78_RAT | Retinoic acid receptor, alpha | Rara rCG_33521 | 462 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC141969 Genomic DNA No translation available. BC099830 mRNA Translation: AAH99830.1 CH473948 Genomic DNA Translation: EDM05964.1 |
RefSeqi | NP_113716.2, NM_031528.2 |
Genome annotation databases
Ensembli | ENSRNOT00000008659; ENSRNOP00000008659; ENSRNOG00000009972 |
GeneIDi | 24705 |
KEGGi | rno:24705 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC141969 Genomic DNA No translation available. BC099830 mRNA Translation: AAH99830.1 CH473948 Genomic DNA Translation: EDM05964.1 |
RefSeqi | NP_113716.2, NM_031528.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008659 |
Chemistry databases
ChEMBLi | CHEMBL2269 |
Genome annotation databases
Ensembli | ENSRNOT00000008659; ENSRNOP00000008659; ENSRNOG00000009972 |
GeneIDi | 24705 |
KEGGi | rno:24705 |
Organism-specific databases
CTDi | 5914 |
RGDi | 3534, Rara |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000159997 |
Gene expression databases
Bgeei | ENSRNOG00000009972, Expressed in testis and 20 other tissues |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q499N1_RAT | |
Accessioni | Q499N1Primary (citable) accession number: Q499N1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 13, 2005 |
Last sequence update: | September 13, 2005 | |
Last modified: | January 19, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |