Retinoic acid receptor, alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• drug binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 19100254
• histone deacetylase binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 21383775
• mRNA 5'-UTR binding Source: RGDInferred from direct assayⁱ
  • 19073915
• nuclear receptor transcription coactivator activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• phosphatidylinositol 3-kinase regulator activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 19531492
• retinoic acid receptor activity Source: RGDInferred from direct assayⁱ
  • 19100254
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• signaling receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• steroid hormone receptor activity Source: InterPro
• transcription factor binding Source: RGDInferred from physical interactionⁱ
  • 19292987
  • 21383775
• transcription regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• translation repressor activity, mRNA regulatory element binding Source: RGDInferred from direct assayⁱ
  • 19073915
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• bone morphogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cellular response to retinoic acid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• epithelium development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• female pregnancy Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 18342837
• gland development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• hippocampus development Source: RGDInferred from expression patternⁱ
  • 18619947
• hormone-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• liver development Source: RGDInferred from expression patternⁱ
  • 15388488
• male gonad development Source: RGDInferred from direct assayⁱ
  • 14613895
• multicellular organism development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of cell proliferation Source: RGDInferred from direct assayⁱ
  • 12704731
• negative regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of translation Source: RGDInferred from direct assayⁱ
  • 19073915
• positive regulation of ERK1 and ERK2 cascade Source: UniProtKBInferred from mutant phenotypeⁱ
  • 19531492
• positive regulation of neuron differentiation Source: RGDInferred from direct assayⁱ
  • 19100254
• positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKBInferred from mutant phenotypeⁱ
  • 19531492
• positive regulation of protein kinase B signaling Source: UniProtKBInferred from mutant phenotypeⁱ
  • 19531492
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• prostate gland development Source: RGDInferred from expression patternⁱ
  • 12193579
• regulation of apoptotic process Source: RGDInferred from direct assayⁱ
  • 12186877
• regulation of myelination Source: RGDInferred from direct assayⁱ
  • 20648638
• regulation of synaptic plasticity Source: RGDInferred from direct assayⁱ
  • 18957222
• response to cytokine Source: RGDInferred from expression patternⁱ
  • 17078027
• response to estradiol Source: RGDInferred from expression patternⁱ
  • 12193579
• response to ethanol Source: RGDInferred from direct assayⁱ
  • 12954654
• response to lipid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to retinoic acid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to vitamin A Source: RGDInferred from expression patternⁱ
  • 18384703
• retinoic acid receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • 19100254
• transcription, DNA-templated Source: UniProtKB-UniRule

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• histone deacetylase binding Source: RGDInferred from physical interactionⁱ
  • 21383775
• transcription factor binding Source: RGDInferred from physical interactionⁱ
  • 19292987
  • 21383775

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MYESVEVGGL APAPNPFLVV DFYNQNRACL LQEKGLPAPG PYSTPLRTPL 
        60         70         80         90        100
WNGSNHSIET QSSSSEEIVP SPPSPPPLPR IYKPCFVCQD KSSGYHYGVS 
       110        120        130        140        150
ACEGCKGFFR RSIQKNMVYT CHRDKNCIIN KVTRNRCQYC RLQKCFEVGM 
       160        170        180        190        200
SKESVRNDRN KKKKETPKPE CSESYTLTPE VGELIEKVRK AHQETFPALC 
       210        220        230        240        250
QLGKYTTNNS SEQRVSLDID LWDKFSELST KCIIKTVEFA KQLPGFTTLT 
       260        270        280        290        300
IADQITLLKA ACLDILILRI CTRYTPEQDT MTFSDGLTLN RTQMHNAGFG 
       310        320        330        340        350
PLTDLVFAFA NQLLPLEMDD AETGLLSAIC LICGDRQDLE QPDKVDMLQE 
       360        370        380        390        400
PLLEALKVYV RKRRPSRPHM FPKMLMKITD LRSISAKGAE RVITLKMEIP 
       410        420        430        440        450
GSMPPLIQEM LENSEGLDTL SGQSGGGTRD GGGLAPPPGS CSPSLSPSSH 

RSSPATQSP                                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ