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Protein

Zinc finger CCHC domain-containing protein 2

Gene

Zcchc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1121 – 1138CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 2
Gene namesi
Name:Zcchc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1310626 Zcchc2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003294141 – 1168Zinc finger CCHC domain-containing protein 2Add BLAST1168

Proteomic databases

PaxDbiQ498S6
PRIDEiQ498S6

PTM databases

iPTMnetiQ498S6
PhosphoSitePlusiQ498S6

Expressioni

Gene expression databases

BgeeiENSRNOG00000002882 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiQ498S6 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003870

Structurei

3D structure databases

ProteinModelPortaliQ498S6
SMRiQ498S6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 74Pro-richAdd BLAST68

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1121 – 1138CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3791 Eukaryota
KOG4400 Eukaryota
ENOG4111U3M LUCA
GeneTreeiENSGT00520000055637
HOGENOMiHOG000155766
HOVERGENiHBG108762
InParanoidiQ498S6
KOiK22700
OrthoDBiEOG091G01BF
PhylomeDBiQ498S6
TreeFamiTF335574

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR036871 PX_dom_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF57756 SSF57756, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q498S6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRMKLPPKS THPSEPPPDA EEPEADARPG AKAPPRRRRD CRPPPPPPTG
60 70 80 90 100
LPRGPPPPPP SPPRGLEPPV ASGPTAGAGM PGGGGHAAAL REQERVYEWF
110 120 130 140 150
GLVLGSAQRL EFLCGLLDLC NPLELRFLGS CLEDLARKDY HYLRDSEAKA
160 170 180 190 200
NGLSDPGSLA DFREPAVRSR LIVYLALLGS ENREAAGRLH RLLPQVDAVL
210 220 230 240 250
RSLRATRVEG SRGSVEDEPG GDDEQDAEKD GPGPEGGGCA KLGTGGGLGF
260 270 280 290 300
RAQEELLLLF TMASLHPAFS FHQRVTLREH LERLRSALRV EPEDAEVEPS
310 320 330 340 350
NFAGSRAQND SACGDYIQSN ETGLVEQAQI PQDGLTVAPH RAQREAVHIE
360 370 380 390 400
KIMLKGVQRR RADKYWEYTF KVNWSDLSVT TVTKTHQELQ EFLLKLPKEF
410 420 430 440 450
SSESFDKTIL KALNQGSLRR EERRHPDLEP ILRQLFSTSP QAFLQSHKVR
460 470 480 490 500
SFFRSISSES QHSFNNLQSS LKTSKILEHL KEDSSEASSQ EEDVLQHTII
510 520 530 540 550
HKKHAGKSPA GNVATSCALL EGLTMQYAEQ NGVVDWRNQG CAAIQHSEHC
560 570 580 590 600
VSSADQLSAE KRSLSSVNKK KGKPQVEKEK IKKTENRLSS RINGIRLSAP
610 620 630 640 650
QHAHGSTVKD MNLDVGSGHD TCGETSSESY SSPSSPRHDG RESLESEEEK
660 670 680 690 700
DRDTDSNSED SGNPSSARFA GHGSVTQTVS VQPPADTVSL GTENGNLLEA
710 720 730 740 750
PLTSHKYPHI PFMPTLPCVM HNGAQKSEVV IPSPKSADGK AVGVLVPNPV
760 770 780 790 800
AISTMMESTN AAPVGILGPA ASGESEKHLE LLASPLPIPS PFLPHSSAPA
810 820 830 840 850
LQLTLQSLKL QPPQGASENC PVNIPQQAAT RLSIGSPNTA LIPVHNPGAF
860 870 880 890 900
PGSPVAATDP ITKSASQVVG LNQMVPQIEG NTGTVPQPNN VKVVLPAAGL
910 920 930 940 950
SAAQPPASYT FPGSPLAASV LPTQNSTVLN TATSAQPAST GISPAQSTVP
960 970 980 990 1000
PAVPTHTPGP APSPSPALTH STAQSDSTSY ISAVGNTNAN STIVPPQPLG
1010 1020 1030 1040 1050
PCGSCGRRCS CGTNGNLQLN SYYYPNPMPG PMYRLPSFFT LPSICNGSYL
1060 1070 1080 1090 1100
NQAHQSNGNQ LPFFLPQTPY ANGLVHDPVM GSQASYGMQQ MAGFGRLYPV
1110 1120 1130 1140 1150
YPAPNVVANT SGSGPKKNGS VSCYNCGVSG HYAQDCKQSS MEANQQGTYR
1160
LRYAPPLPPS NDTLDSAD
Length:1,168
Mass (Da):124,732
Last modified:April 8, 2008 - v2
Checksum:i2073BF76D9403922
GO
Isoform 2 (identifier: Q498S6-2) [UniParc]FASTAAdd to basket
Also known as: Tnfrsf11a

The sequence of this isoform differs from the canonical sequence as follows:
     466-493: Missing.
     512-512: N → K
     513-1168: Missing.

Note: No experimental confirmation available.
Show »
Length:484
Mass (Da):53,400
Checksum:i8B302500D92BC090
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UHB2A0A0H2UHB2_RAT
Zinc finger CCHC domain-containing ...
Zcchc2
1,169Annotation score:

Sequence cautioni

The sequence AAI00091 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032981466 – 493Missing in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_032982512N → K in isoform 2. 1 Publication1
Alternative sequenceiVSP_032983513 – 1168Missing in isoform 2. 1 PublicationAdd BLAST656

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03084820 Genomic DNA No translation available.
BC100090 mRNA Translation: AAI00091.1 Different initiation.
RefSeqiNP_001257971.1, NM_001271042.1 [Q498S6-2]
XP_006249687.1, XM_006249625.3 [Q498S6-1]
XP_006249688.1, XM_006249626.3 [Q498S6-1]
UniGeneiRn.76723

Genome annotation databases

EnsembliENSRNOT00000061814; ENSRNOP00000058528; ENSRNOG00000002882 [Q498S6-2]
ENSRNOT00000086167; ENSRNOP00000075165; ENSRNOG00000002882 [Q498S6-1]
GeneIDi304695
KEGGirno:304695
UCSCiRGD:1310626 rat [Q498S6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03084820 Genomic DNA No translation available.
BC100090 mRNA Translation: AAI00091.1 Different initiation.
RefSeqiNP_001257971.1, NM_001271042.1 [Q498S6-2]
XP_006249687.1, XM_006249625.3 [Q498S6-1]
XP_006249688.1, XM_006249626.3 [Q498S6-1]
UniGeneiRn.76723

3D structure databases

ProteinModelPortaliQ498S6
SMRiQ498S6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003870

PTM databases

iPTMnetiQ498S6
PhosphoSitePlusiQ498S6

Proteomic databases

PaxDbiQ498S6
PRIDEiQ498S6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000061814; ENSRNOP00000058528; ENSRNOG00000002882 [Q498S6-2]
ENSRNOT00000086167; ENSRNOP00000075165; ENSRNOG00000002882 [Q498S6-1]
GeneIDi304695
KEGGirno:304695
UCSCiRGD:1310626 rat [Q498S6-1]

Organism-specific databases

CTDi54877
RGDi1310626 Zcchc2

Phylogenomic databases

eggNOGiKOG3791 Eukaryota
KOG4400 Eukaryota
ENOG4111U3M LUCA
GeneTreeiENSGT00520000055637
HOGENOMiHOG000155766
HOVERGENiHBG108762
InParanoidiQ498S6
KOiK22700
OrthoDBiEOG091G01BF
PhylomeDBiQ498S6
TreeFamiTF335574

Miscellaneous databases

PROiPR:Q498S6

Gene expression databases

BgeeiENSRNOG00000002882 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiQ498S6 baseline and differential

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR036871 PX_dom_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF57756 SSF57756, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZCHC2_RAT
AccessioniPrimary (citable) accession number: Q498S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 12, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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