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Protein

DnaJ homolog subfamily C member 10

Gene

Dnajc10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 10 (EC:1.8.4.-)
Gene namesi
Name:Dnajc10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1307813 Dnajc10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000028148633 – 793DnaJ homolog subfamily C member 10Add BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi158 ↔ 161Redox-activePROSITE-ProRule annotation
Disulfide bondi480 ↔ 483Redox-activePROSITE-ProRule annotation
Glycosylationi530N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi588 ↔ 591Redox-activePROSITE-ProRule annotation
Disulfide bondi700 ↔ 703Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ498R3
PRIDEiQ498R3

PTM databases

iPTMnetiQ498R3
PhosphoSitePlusiQ498R3

Expressioni

Gene expression databases

BgeeiENSRNOG00000006803 Expressed in 9 organ(s), highest expression level in Ammon's horn
GenevisibleiQ498R3 RN

Interactioni

Subunit structurei

Interacts with HSPA5 (via its J domain). Interacts with EDEM1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi255075, 1 interactor
IntActiQ498R3, 5 interactors
STRINGi10116.ENSRNOP00000009839

Structurei

3D structure databases

ProteinModelPortaliQ498R3
SMRiQ498R3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 100JPROSITE-ProRule annotationAdd BLAST66
Domaini130 – 232Thioredoxin 1PROSITE-ProRule annotationAdd BLAST103
Domaini454 – 553Thioredoxin 2PROSITE-ProRule annotationAdd BLAST100
Domaini557 – 665Thioredoxin 3PROSITE-ProRule annotationAdd BLAST109
Domaini671 – 776Thioredoxin 4PROSITE-ProRule annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 350Trxb 1Add BLAST116
Regioni348 – 463Trxb 2Add BLAST116

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi790 – 793Prevents secretion from ERPROSITE-ProRule annotation4

Domaini

Thioredoxin domains 3 and 4 are the primary reductase domains.By similarity
The thioredoxin-like regions Trxb 1 and 2 lack a redox-active CXXC motif.By similarity

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IMZF Eukaryota
KOG0191 Eukaryota
COG0526 LUCA
COG2214 LUCA
GeneTreeiENSGT00860000133723
HOGENOMiHOG000231882
HOVERGENiHBG057048
InParanoidiQ498R3
KOiK09530
OMAiRAYPTVK
OrthoDBiEOG091G0BFU
PhylomeDBiQ498R3
TreeFamiTF105169

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd03004 PDI_a_ERdj5_C, 3 hits
cd03003 PDI_a_ERdj5_N, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR021170 ERdj5
IPR035674 ERdj5_TRX_C
IPR035673 ERdj5_TRX_N
IPR036869 J_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00085 Thioredoxin, 4 hits
PIRSFiPIRSF037293 DnaJ_homolog_subfam-C, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF52833 SSF52833, 6 hits
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 2 hits
PS51352 THIOREDOXIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q498R3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVWLNRDEF IRDVKRISLC LLVLYVVIVV GTDQNFYSLL GVSKTASSRE
60 70 80 90 100
IRQAFKKLAL KLHPDKNPNN PNAHGDFLKI NRAYEVLKDE DLRKKYDKYG
110 120 130 140 150
EKGLEDNQGG QYESWSYYRY DFGIYDDDPE IITLERREFD AAVNSGELWF
160 170 180 190 200
VNFYSPGCSH CHDLAPTWRE FAKEVDGLLR IGAVNCGDDR MLCRMKGVNS
210 220 230 240 250
YPSLFIFRSG MAAVKYNGDR SKESLVSFAM QHVRTTVTEL STGNFVNAIE
260 270 280 290 300
TAFAAGIGWL ITFCFKGEDC LTPQTRLRLS GMLDGLVNVG WVDCDTQDSL
310 320 330 340 350
CKSLDATAST TAYFPPGATL NNKEKSSVLF LNSLDAKEIY MEIIHNLPDF
360 370 380 390 400
ELLSANKLED RLAHHRWLVF FHFGKNENAN DPELKKLKTL LKNEHIQVGR
410 420 430 440 450
FDCSSAPGIC SDLYVFQSCL AVFKGQGTKE YEIHHGKKIL YDILAFAKES
460 470 480 490 500
VNSHVTTLGP QNFPASDKEP WLVDFFAPWC PPCRALLPEL RKASTLLYGQ
510 520 530 540 550
LKVGTLDCTI HEGLCNMYNI QAYPTTVVFN QSSVHEYEGH HSAEQILEFI
560 570 580 590 600
EDLRNPSVVS LTPTTFNELV KQRKHDEVWM VDFYSPWCHP CQVLMPEWKR
610 620 630 640 650
MARTLTGLIN VGSVDCQQYH SFCTQENVQR YPEIRFYPQK SSRAYQYHSY
660 670 680 690 700
NGWNRDAYSL RSWGLGFLPQ ASIDLTPQTF NEKVLQGKTH WVIDFYAPWC
710 720 730 740 750
GPCQNFAPEF ELLARMIKGK VKAGKVDCQA YPQTCQKAGI RAYPSVKLYL
760 770 780 790
YERAKKSIWE EQINSRDAKT IAALIYGKLE TFQSQVKRNK DEL
Length:793
Mass (Da):90,747
Last modified:March 20, 2007 - v2
Checksum:i9578A69C36C858C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03024291 Genomic DNA No translation available.
BC100105 mRNA Translation: AAI00106.1
RefSeqiNP_001099956.2, NM_001106486.2
UniGeneiRn.8642

Genome annotation databases

EnsembliENSRNOT00000009839; ENSRNOP00000009839; ENSRNOG00000006803
GeneIDi295690
KEGGirno:295690
UCSCiRGD:1307813 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03024291 Genomic DNA No translation available.
BC100105 mRNA Translation: AAI00106.1
RefSeqiNP_001099956.2, NM_001106486.2
UniGeneiRn.8642

3D structure databases

ProteinModelPortaliQ498R3
SMRiQ498R3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi255075, 1 interactor
IntActiQ498R3, 5 interactors
STRINGi10116.ENSRNOP00000009839

PTM databases

iPTMnetiQ498R3
PhosphoSitePlusiQ498R3

Proteomic databases

PaxDbiQ498R3
PRIDEiQ498R3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009839; ENSRNOP00000009839; ENSRNOG00000006803
GeneIDi295690
KEGGirno:295690
UCSCiRGD:1307813 rat

Organism-specific databases

CTDi54431
RGDi1307813 Dnajc10

Phylogenomic databases

eggNOGiENOG410IMZF Eukaryota
KOG0191 Eukaryota
COG0526 LUCA
COG2214 LUCA
GeneTreeiENSGT00860000133723
HOGENOMiHOG000231882
HOVERGENiHBG057048
InParanoidiQ498R3
KOiK09530
OMAiRAYPTVK
OrthoDBiEOG091G0BFU
PhylomeDBiQ498R3
TreeFamiTF105169

Miscellaneous databases

PROiPR:Q498R3

Gene expression databases

BgeeiENSRNOG00000006803 Expressed in 9 organ(s), highest expression level in Ammon's horn
GenevisibleiQ498R3 RN

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd03004 PDI_a_ERdj5_C, 3 hits
cd03003 PDI_a_ERdj5_N, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR021170 ERdj5
IPR035674 ERdj5_TRX_C
IPR035673 ERdj5_TRX_N
IPR036869 J_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00085 Thioredoxin, 4 hits
PIRSFiPIRSF037293 DnaJ_homolog_subfam-C, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF52833 SSF52833, 6 hits
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 2 hits
PS51352 THIOREDOXIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDJC10_RAT
AccessioniPrimary (citable) accession number: Q498R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: October 10, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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