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Entry version 85 (11 Dec 2019)
Sequence version 1 (13 Sep 2005)
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Protein
Submitted name:

Tln1 protein

Gene

Tln1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tln1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tln1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q498D4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini413 – 529VBSInterPro annotationAdd BLAST117
Domaini1028 – 1152VBSInterPro annotationAdd BLAST125

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili203 – 223Sequence analysisAdd BLAST21
Coiled coili229 – 256Sequence analysisAdd BLAST28
Coiled coili331 – 351Sequence analysisAdd BLAST21
Coiled coili972 – 992Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4261 Eukaryota
ENOG410XQ0V LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006734

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q498D4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12150 talin-RS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR035964 I/LWEQ_dom_sf
IPR037438 Talin1/2-RS
IPR015009 Vinculin-bd_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08913 VBS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109885 SSF109885, 2 hits
SSF47220 SSF47220, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q498D4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRQARILAQ ATSDLVNAIK ADAEGESDLE NSRKLLSAAK ILADATAKMV
60 70 80 90 100
EAAKGAAAHP DSEEQQQRLR EAAEGLRMAT NAAAQNAIKK KLVQRLEHAA
110 120 130 140 150
KQAAASATQT IAAAQHAASA PKASAGPQPL LVQSCKAVAE QIPLLVQGVR
160 170 180 190 200
GSQAQPDSPS AQLALIAASQ SFLQPGGKMV AAAKASVPTI QDQASAMQLS
210 220 230 240 250
QCAKNLGTAL AELRTAAQKA QEACGPLEMD SALSVVQNLE KDLQEIKAAA
260 270 280 290 300
REGKLKPLPG ETMEKCTQDL GNSTKAVSSA IAKLLGEIAQ GNENYAGIAA
310 320 330 340 350
RDVAGGLRSL AQAARGVAAL TTDPAVQAIV LDTASDALDK ASSLIEEAKK
360 370 380 390 400
ASGHPGDPES QQRLAQVAKA VTQALNRCVS CLPGQRDVDN ALRAVGDASK
410 420 430 440 450
RLLSDSLPPS TGTFQEAQSR LNEAAAGLNQ AATELVQASR GTPQDLARAS
460 470 480 490 500
GRFGQDFSTF LEAGVEMAGQ APSQEDRAQV VSNLKGISMS SSKLLLAAKA
510 520 530 540 550
LSTDPAAPNL KSQLAAAARA VTDSINQLIT MCTQQAPGQK ECDNALRQLE
560 570 580 590 600
TVRELLENPV QPINDMSYFG CLDSVMENSK VLGEAMTGIS QNAKNGNLPE
610 620 630 640 650
FGDAIATASK ALCGFTEAAA QAAYLVGVSD PNSQAGQQGL VEPTQFARAN
660 670 680 690 700
QAIQMACQSL GEPGCTQAQV LSAATIVAKH TSALCNSCRL ASARTANPTA
710 720 730 740 750
KRQFVQSAKE VANSTANLVK TIKALDGAFT EENRAQCRAA TAPLLEAVDN
760 770 780 790 800
LSAFASNPEF SSVPAQISPE GRAAMEPIVI SAKTMLESAG GLIQTARALA
810 820 830 840 850
VNPRDPPRWS VLAGHSRTVS DSIKKLITSM RDKAPGQLEC ETAIAALNSC
860 870 880 890 900
LRDLDQASLA AVSQQLAPRE GISQEALHTQ MLTAVQEISH LIEPLASAAR
910 920 930 940 950
AEASQLGHKV SQMAQYFEPL TLAAVGAASK TLSHPQQMAL LDQTKTLAES
960 970 980 990 1000
ALQLLYTAKE AGGNPKQAAH TQEALEEAVQ MMTEAVEDLT TTLNEAASAA
1010 1020 1030 1040 1050
GVVGGMVDSI TQAINQLDEG PMGEPEGSFV DYQTTMVRTA KAIAVTVQEM
1060 1070 1080 1090 1100
VTKSNTSPEE LGPLANQLTS DYGRLASQAK PAAVAAENEE IGAHIKHRVQ
1110 1120 1130 1140 1150
ELGHGCSALV TKAGALQCSP SDVYTKKELI ECARRVSEKV SHVLAALQAG
1160 1170 1180 1190 1200
NRGTQACITA ASAVSGIIAD LDTTIMFATA GTLNREGAET FADHREGILK
1210 1220 1230 1240 1250
TAKVLVEDTK VLVQNAAGSQ EKLAQAAQSS VATITRLADV VKLGAASLGA
1260 1270 1280 1290 1300
EDPETQVVLI NAVKDVAKAL GDLISATKAA AGKVGDDPAV WQLKNSAKVM
1310 1320 1330 1340 1350
VTNVTSLLKT VKAVEDEATK GTRALEATTE HIRQELAVFC SPEPPAKTST
1360 1370 1380 1390 1400
PEDFIRMTKG ITMATAKAVA AGNSCRQEDV IATANLSRRA IADMLRACKE
1410 1420 1430 1440 1450
AAFHPEVAPD VRLRALHFGR ECANGYLELL DHVLLTLQKP NPELKQQLTG
1460 1470 1480 1490 1500
HSKRVAGSVT ELIQAAEAMK GTEWVDPEDP TVIAENELLG AAAAIEAAAK
1510 1520 1530 1540 1550
KLEQLKPRAK PKVRAAPSLS PVTGPRGLHL CPFSLCLPHS PPLCNLLPTG

GR
Length:1,552
Mass (Da):161,978
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D74ED0CB22B1C28
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC100262 mRNA Translation: AAI00263.1

Genome annotation databases

UCSC genome browser

More...
UCSCi
RGD:1306247 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100262 mRNA Translation: AAI00263.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ498D4

Genome annotation databases

UCSCiRGD:1306247 rat

Phylogenomic databases

eggNOGiKOG4261 Eukaryota
ENOG410XQ0V LUCA
HOGENOMiHOG000006734
PhylomeDBiQ498D4

Family and domain databases

CDDicd12150 talin-RS, 1 hit
InterProiView protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR035964 I/LWEQ_dom_sf
IPR037438 Talin1/2-RS
IPR015009 Vinculin-bd_dom
PfamiView protein in Pfam
PF08913 VBS, 2 hits
SUPFAMiSSF109885 SSF109885, 2 hits
SSF47220 SSF47220, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ498D4_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q498D4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: December 11, 2019
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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