UniProtKB - Q498D1 (FOXP1_RAT)
Protein
Forkhead box protein P1
Gene
Foxp1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18. Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 340 – 365 | C2H2-typeAdd BLAST | 26 | |
DNA bindingi | 499 – 589 | Fork-headPROSITE-ProRule annotationAdd BLAST | 91 |
GO - Molecular functioni
- androgen receptor binding Source: RGD
- chromatin binding Source: RGD
- core promoter sequence-specific DNA binding Source: RGD
- DNA binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- identical protein binding Source: RGD
- metal ion binding Source: UniProtKB-KW
- protein self-association Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- transcription factor binding Source: RGD
- transcription regulatory region sequence-specific DNA binding Source: RGD
GO - Biological processi
- cardiac muscle cell differentiation Source: RGD
- cellular response to DNA damage stimulus Source: RGD
- cellular response to ionomycin Source: RGD
- cellular response to tumor necrosis factor Source: RGD
- circulatory system development Source: RGD
- endothelial cell activation Source: RGD
- forebrain development Source: RGD
- heart development Source: RGD
- immunoglobulin V(D)J recombination Source: RGD
- innate vocalization behavior Source: RGD
- interleukin-21 production Source: RGD
- in utero embryonic development Source: RGD
- lung development Source: RGD
- lung secretory cell differentiation Source: RGD
- macrophage activation Source: RGD
- monocyte activation Source: RGD
- motor neuron axon guidance Source: RGD
- negative regulation of androgen receptor signaling pathway Source: RGD
- negative regulation of B cell apoptotic process Source: RGD
- negative regulation of cell growth involved in cardiac muscle cell development Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of lung goblet cell differentiation Source: RGD
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: RGD
- osteoclast development Source: RGD
- osteoclast differentiation Source: RGD
- positive regulation of B cell receptor signaling pathway Source: RGD
- positive regulation of endothelial cell migration Source: RGD
- positive regulation of epithelial cell proliferation Source: RGD
- positive regulation of hydrogen peroxide-induced cell death Source: RGD
- positive regulation of immunoglobulin production Source: RGD
- positive regulation of mesenchymal cell proliferation Source: RGD
- positive regulation of smooth muscle cell proliferation Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- pre-B cell differentiation Source: RGD
- regulation of action potential Source: RGD
- regulation of cardiac muscle cell proliferation Source: RGD
- regulation of chemokine (C-X-C motif) ligand 2 production Source: RGD
- regulation of defense response to bacterium Source: RGD
- regulation of endothelial tube morphogenesis Source: RGD
- regulation of gene expression Source: RGD
- regulation of inflammatory response Source: RGD
- regulation of interleukin-12 production Source: RGD
- regulation of interleukin-1 beta production Source: RGD
- regulation of lung goblet cell differentiation Source: RGD
- regulation of macrophage colony-stimulating factor production Source: RGD
- regulation of monocyte differentiation Source: RGD
- regulation of tumor necrosis factor production Source: RGD
- response to lipopolysaccharide Source: RGD
- response to testosterone Source: RGD
- sarcomere organization Source: RGD
- skeletal muscle tissue development Source: RGD
- smooth muscle tissue development Source: RGD
- striatum development Source: RGD
- T follicular helper cell differentiation Source: RGD
- ventral spinal cord development Source: RGD
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein P1 |
Gene namesi | Name:Foxp1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1308669, Foxp1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Note: Not found in the nucleolus.By similarity
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000294519 | 1 – 711 | Forkhead box protein P1Add BLAST | 711 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 115 | PhosphoserineBy similarity | 1 | |
Cross-linki | 321 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 406 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 411 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 476 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 687 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 692 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q498D1 |
PRIDEi | Q498D1 |
PTM databases
iPTMneti | Q498D1 |
PhosphoSitePlusi | Q498D1 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000009184, Expressed in spleen and 21 other tissues |
Genevisiblei | Q498D1, RN |
Interactioni
Subunit structurei
Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Self-associates.
Interacts with CTBP1.
Interacts with NCOR2 and AR.
Interacts with FOXP2 (By similarity).
Interacts with TBR1 (By similarity).
Interacts with AURKA; this interaction facilitates the phosphorylation of FOXP1, which suppresses the expression of FBXL7 (By similarity).
By similarityGO - Molecular functioni
- androgen receptor binding Source: RGD
- identical protein binding Source: RGD
- protein self-association Source: UniProtKB
- transcription factor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000013271 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 382 – 403 | Leucine-zipperAdd BLAST | 22 | |
Regioni | 416 – 420 | CTBP1-bindingBy similarity | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 55 – 264 | Gln-richAdd BLAST | 210 |
Domaini
The leucine-zipper is required for dimerization and transcriptional repression.By similarity
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 340 – 365 | C2H2-typeAdd BLAST | 26 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4385, Eukaryota |
GeneTreei | ENSGT00940000159892 |
HOGENOMi | CLU_019502_3_1_1 |
InParanoidi | Q498D1 |
OMAi | GHAYCTP |
OrthoDBi | 836427at2759 |
PhylomeDBi | Q498D1 |
TreeFami | TF326978 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q498D1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMQESGSEAK SNGSTIQNGS SGGNHLLECG TLRDTRSNGE APAVDLGAAD
60 70 80 90 100
LAHVQQQQQQ ALQVARQLLL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ
110 120 130 140 150
QQQQQQQQQV SGLKSPKRND KQPALQVPVS VAMMTPQVIT PQQMQQILQQ
160 170 180 190 200
QVLSPQQLQV LLQQQQALML QQQQLQEFYK KQQEQLQLQL LQQQHAGKQP
210 220 230 240 250
KEQQQQQVAT QQLAFQQQLL QMQQLQQQHL LSLQRQGLLT IQPGQPALPL
260 270 280 290 300
QPLAQGMIPT ELQQLWKEVT SAHTAEETTG SNHSSLDLTS TCVSSSAPSK
310 320 330 340 350
TSLIMNPHAS TNGQLSVHTP KRESLSHEEH PHSHPLYGHG VCKWPGCEAV
360 370 380 390 400
CDDFPAFLKH LNSEHALDDR STAQCRVQMQ VVQQLELQLA KDKERLQAMM
410 420 430 440 450
THLHVKSTEP KAAPQPLNLV SSVTLSKSAS EASPQSLPHT PTTPTAPLTP
460 470 480 490 500
VTQGPSVITT TSMHTVGPIR RRYSDKYNVP ISSADIAQNQ EFYKNAEVRP
510 520 530 540 550
PFTYASLIRQ AILESPEKQL TLNEIYNWFT RMFAYFRRNA ATWKNAVRHN
560 570 580 590 600
LSLHKCFVRV ENVKGAVWTV DEVEFQKRRP QKISGNPSLI KNMQSGHAYC
610 620 630 640 650
TPLNAALQAS MAENSIPLYT TASMGNPTLG SLASAIREEL NGAMEHTNSN
660 670 680 690 700
ESDSSPGRSP MQAVHPIHVK EEPLDPEEAE GPLSLVTTAN HSPDFDHDRD
710
YEDEPVNEDM E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC100267 mRNA Translation: AAI00268.1 |
RefSeqi | NP_001029303.1, NM_001034131.1 XP_008761370.1, XM_008763148.1 XP_008761371.1, XM_008763149.2 XP_008761372.1, XM_008763150.2 XP_008761374.1, XM_008763152.2 XP_008761375.1, XM_008763153.2 |
Genome annotation databases
Ensembli | ENSRNOT00000013271; ENSRNOP00000013271; ENSRNOG00000009184 |
GeneIDi | 297480 |
KEGGi | rno:297480 |
UCSCi | RGD:1308669, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC100267 mRNA Translation: AAI00268.1 |
RefSeqi | NP_001029303.1, NM_001034131.1 XP_008761370.1, XM_008763148.1 XP_008761371.1, XM_008763149.2 XP_008761372.1, XM_008763150.2 XP_008761374.1, XM_008763152.2 XP_008761375.1, XM_008763153.2 |
3D structure databases
SMRi | Q498D1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000013271 |
PTM databases
iPTMneti | Q498D1 |
PhosphoSitePlusi | Q498D1 |
Proteomic databases
PaxDbi | Q498D1 |
PRIDEi | Q498D1 |
Genome annotation databases
Ensembli | ENSRNOT00000013271; ENSRNOP00000013271; ENSRNOG00000009184 |
GeneIDi | 297480 |
KEGGi | rno:297480 |
UCSCi | RGD:1308669, rat |
Organism-specific databases
CTDi | 27086 |
RGDi | 1308669, Foxp1 |
Phylogenomic databases
eggNOGi | KOG4385, Eukaryota |
GeneTreei | ENSGT00940000159892 |
HOGENOMi | CLU_019502_3_1_1 |
InParanoidi | Q498D1 |
OMAi | GHAYCTP |
OrthoDBi | 836427at2759 |
PhylomeDBi | Q498D1 |
TreeFami | TF326978 |
Miscellaneous databases
PROi | PR:Q498D1 |
Gene expression databases
Bgeei | ENSRNOG00000009184, Expressed in spleen and 21 other tissues |
Genevisiblei | Q498D1, RN |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FOXP1_RAT | |
Accessioni | Q498D1Primary (citable) accession number: Q498D1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | September 13, 2005 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |