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Protein
Submitted name:

ASXL1 protein

Gene

ASXL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
ASXL1 proteinImported
Submitted name:
Putative Polycomb group protein ASXL1Imported
Gene namesi
Name:ASXL1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000171456.16
HGNCiHGNC:18318 ASXL1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171456
PharmGKBiPA25078

Expressioni

Gene expression databases

BgeeiENSG00000171456 Expressed in 227 organ(s), highest expression level in left lobe of thyroid gland

Interactioni

Protein-protein interaction databases

IntActiQ498B9, 1 interactor
Q498B9, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 82HARE-HTHInterPro annotationAdd BLAST72

Phylogenomic databases

eggNOGiENOG410IGAP Eukaryota
ENOG410YF2J LUCA
GeneTreeiENSGT00520000055578
HOVERGENiHBG062365

Family and domain databases

InterProiView protein in InterPro
IPR024811 ASX/ASX-like
IPR024815 ASXL1
IPR007759 HB1/Asxl_HTH
PANTHERiPTHR13578 PTHR13578, 1 hit
PTHR13578:SF19 PTHR13578:SF19, 1 hit
PfamiView protein in Pfam
PF05066 HARE-HTH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

Q498B9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDKQKKKKE RTWAEAARLV LENYSDAPMT PKQILQVIEA EGLKEMRSGT
60 70 80
SPLACLNAML HSNSRGGEGL FYKLPGRISL FTLKV
Length:85
Mass (Da):9,550
Last modified:September 13, 2005 - v1
Checksum:i8AF0F72066DC1F4B
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IXJ9ASXL1_HUMAN
Putative Polycomb group protein ASX...
ASXL1 KIAA0978
1,541Annotation score:
Q76L82Q76L82_HUMAN
Additional sex combs like 1 (Drosop...
ASXL1 ASXH1, hCG_38816
1,536Annotation score:
A0A2R8Y5U1A0A2R8Y5U1_HUMAN
Putative Polycomb group protein ASX...
ASXL1
1,480Annotation score:
Q5JWS8Q5JWS8_HUMAN
Putative Polycomb group protein ASX...
ASXL1
81Annotation score:
H0YJC9H0YJC9_HUMAN
Putative Polycomb group protein ASX...
ASXL1
75Annotation score:
A0A087WWN0A0A087WWN0_HUMAN
Putative Polycomb group protein ASX...
ASXL1
57Annotation score:
Q6P1M8Q6P1M8_HUMAN
ASXL1 protein
ASXL1
84Annotation score:
A0A2R8Y627A0A2R8Y627_HUMAN
Putative Polycomb group protein ASX...
ASXL1
135Annotation score:
A0A2R8Y6V0A0A2R8Y6V0_HUMAN
Putative Polycomb group protein ASX...
ASXL1
78Annotation score:
A0A2R8Y4U9A0A2R8Y4U9_HUMAN
Putative Polycomb group protein ASX...
ASXL1
85Annotation score:
There is more potential isoformShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034550 Genomic DNA No translation available.
AL121583 Genomic DNA No translation available.
KF495689 Genomic DNA No translation available.
BC100280 mRNA Translation: AAI00281.1
RefSeqiNP_001158075.1, NM_001164603.1
UniGeneiHs.374043

Genome annotation databases

EnsembliENST00000542461; ENSP00000438654; ENSG00000171456
ENST00000646367; ENSP00000493987; ENSG00000171456
GeneIDi171023
UCSCiuc061weh.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034550 Genomic DNA No translation available.
AL121583 Genomic DNA No translation available.
KF495689 Genomic DNA No translation available.
BC100280 mRNA Translation: AAI00281.1
RefSeqiNP_001158075.1, NM_001164603.1
UniGeneiHs.374043

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ498B9, 1 interactor
Q498B9, 1 interactor

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000542461; ENSP00000438654; ENSG00000171456
ENST00000646367; ENSP00000493987; ENSG00000171456
GeneIDi171023
UCSCiuc061weh.1 human

Organism-specific databases

CTDi171023
EuPathDBiHostDB:ENSG00000171456.16
HGNCiHGNC:18318 ASXL1
OpenTargetsiENSG00000171456
PharmGKBiPA25078
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGAP Eukaryota
ENOG410YF2J LUCA
GeneTreeiENSGT00520000055578
HOVERGENiHBG062365

Miscellaneous databases

ChiTaRSiASXL1 human
GenomeRNAii171023

Gene expression databases

BgeeiENSG00000171456 Expressed in 227 organ(s), highest expression level in left lobe of thyroid gland

Family and domain databases

InterProiView protein in InterPro
IPR024811 ASX/ASX-like
IPR024815 ASXL1
IPR007759 HB1/Asxl_HTH
PANTHERiPTHR13578 PTHR13578, 1 hit
PTHR13578:SF19 PTHR13578:SF19, 1 hit
PfamiView protein in Pfam
PF05066 HARE-HTH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ498B9_HUMAN
AccessioniPrimary (citable) accession number: Q498B9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 7, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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