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UniProtKB - Q498B9 (Q498B9_HUMAN)
Protein
Submitted name:
ASXL1 protein
Gene
ASXL1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Biological process | TranscriptionARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: ASXL1 proteinImportedSubmitted name: Polycomb group protein ASXL1Imported |
Gene namesi | Name:ASXL1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18318, ASXL1 |
VEuPathDBi | HostDB:ENSG00000171456 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171456, Expressed in stomach and 237 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 85 | HTH HARE-typeInterPro annotationAdd BLAST | 75 |
Phylogenomic databases
GeneTreei | ENSGT00520000055578 |
OrthoDBi | 53757at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR024811, ASX/ASX-like IPR024815, ASXL1 IPR007759, Asxl_HARE-HTH |
PANTHERi | PTHR13578, PTHR13578, 1 hit PTHR13578:SF19, PTHR13578:SF19, 1 hit |
Pfami | View protein in Pfam PF05066, HARE-HTH, 1 hit |
PROSITEi | View protein in PROSITE PS51913, HTH_HARE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
Q498B9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDKQKKKKE RTWAEAARLV LENYSDAPMT PKQILQVIEA EGLKEMRSGT
60 70 80
SPLACLNAML HSNSRGGEGL FYKLPGRISL FTLKV
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8IXJ9 | ASXL1_HUMAN | Polycomb group protein ASXL1 | ASXL1 KIAA0978 | 1,541 | Annotation score: | ||
Q76L82 | Q76L82_HUMAN | Additional sex combs like 1 (Drosop... | ASXL1 ASXH1, hCG_38816 | 1,536 | Annotation score: | ||
A0A2R8Y5U1 | A0A2R8Y5U1_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 1,480 | Annotation score: | ||
A0A494C1R1 | A0A494C1R1_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 625 | Annotation score: | ||
A0A2R8Y627 | A0A2R8Y627_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 135 | Annotation score: | ||
Q5JWS8 | Q5JWS8_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 81 | Annotation score: | ||
H0YJC9 | H0YJC9_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 75 | Annotation score: | ||
A0A2R8Y6V0 | A0A2R8Y6V0_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 78 | Annotation score: | ||
A0A2R8Y4U9 | A0A2R8Y4U9_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 85 | Annotation score: | ||
A0A2R8Y6F0 | A0A2R8Y6F0_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 75 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL034550 Genomic DNA No translation available. AL121583 Genomic DNA No translation available. KF495689 Genomic DNA No translation available. BC100280 mRNA Translation: AAI00281.1 |
RefSeqi | NP_001158075.1, NM_001164603.1 |
Genome annotation databases
Ensembli | ENST00000542461; ENSP00000438654; ENSG00000171456 ENST00000646367; ENSP00000493987; ENSG00000171456 |
GeneIDi | 171023 |
UCSCi | uc061weh.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL034550 Genomic DNA No translation available. AL121583 Genomic DNA No translation available. KF495689 Genomic DNA No translation available. BC100280 mRNA Translation: AAI00281.1 |
RefSeqi | NP_001158075.1, NM_001164603.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q498B9, 1 interactor |
Proteomic databases
ProteomicsDBi | 62004 |
Protocols and materials databases
Antibodypediai | 10384, 111 antibodies from 25 providers |
DNASUi | 171023 |
Genome annotation databases
Ensembli | ENST00000542461; ENSP00000438654; ENSG00000171456 ENST00000646367; ENSP00000493987; ENSG00000171456 |
GeneIDi | 171023 |
UCSCi | uc061weh.1, human |
Organism-specific databases
CTDi | 171023 |
HGNCi | HGNC:18318, ASXL1 |
OpenTargetsi | ENSG00000171456 |
PharmGKBi | PA25078 |
VEuPathDBi | HostDB:ENSG00000171456 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00520000055578 |
OrthoDBi | 53757at2759 |
Miscellaneous databases
BioGRID-ORCSi | 171023, 19 hits in 1058 CRISPR screens |
ChiTaRSi | ASXL1, human |
GenomeRNAii | 171023 |
Gene expression databases
Bgeei | ENSG00000171456, Expressed in stomach and 237 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR024811, ASX/ASX-like IPR024815, ASXL1 IPR007759, Asxl_HARE-HTH |
PANTHERi | PTHR13578, PTHR13578, 1 hit PTHR13578:SF19, PTHR13578:SF19, 1 hit |
Pfami | View protein in Pfam PF05066, HARE-HTH, 1 hit |
PROSITEi | View protein in PROSITE PS51913, HTH_HARE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q498B9_HUMAN | |
Accessioni | Q498B9Primary (citable) accession number: Q498B9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 13, 2005 |
Last sequence update: | September 13, 2005 | |
Last modified: | January 19, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |