Stx1a

Functionⁱ

GO - Molecular functionⁱ

ATP-dependent protein binding Source: Ensembl
calcium-dependent protein binding Source: Ensembl
chloride channel inhibitor activity Source: Ensembl
ion channel binding Source: Ensembl
kinase binding Source: Ensembl
myosin head/neck binding Source: Ensembl
protein binding, bridging Source: Ensembl
protein domain specific binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein N-terminus binding Source: Ensembl
SNAP receptor activity Source: InterPro
SNARE binding Source: Ensembl

GO - Biological processⁱ

intracellular protein transport Source: InterPro
modulation of excitatory postsynaptic potential Source: Ensembl
positive regulation of calcium ion-dependent exocytosis Source: Ensembl
positive regulation of neurotransmitter secretion Source: Ensembl
positive regulation of norepinephrine secretion Source: Ensembl
protein localization to membrane Source: Ensembl
protein sumoylation Source: Ensembl
response to gravity Source: Ensembl
SNARE complex assembly Source: Ensembl
synaptic vesicle docking Source: Ensembl
synaptic vesicle endocytosis Source: Ensembl
synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Syntaxin 1A (Brain)Imported Submitted name: Syntaxin 1A (Brain), isoform CRA_aImported
Gene namesⁱ	Name:Stx1aImported ORF Names:mCG_16704Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:109355 Stx1a

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	266 – 287	HelicalSequence analysisAdd BLAST		22

Keywords - Cellular componentⁱ

Membrane

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000007207 Expressed in 231 organ(s), highest expression level in cerebral cortex

Bgeeⁱ

ENSMUSG00000007207 Expressed in 231 organ(s), highest expression level in cerebral cortex

Interactionⁱ

GO - Molecular functionⁱ

ATP-dependent protein binding Source: Ensembl
calcium-dependent protein binding Source: Ensembl
ion channel binding Source: Ensembl
kinase binding Source: Ensembl
myosin head/neck binding Source: Ensembl
protein binding, bridging Source: Ensembl
protein domain specific binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein N-terminus binding Source: Ensembl
SNAP receptor activity Source: InterPro
SNARE binding Source: Ensembl

Complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	192 – 254	T-SNARE coiled-coil homologyInterPro annotationAdd BLAST		63

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 20	DisorderedSequence analysisAdd BLAST		20

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	68 – 106	Sequence analysisAdd BLAST		39

Sequence similaritiesⁱ

Belongs to the syntaxin family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Coiled coilPROSITE-ProRule annotationSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0810 Eukaryota COG5074 LUCA
KEGG Orthology (KO) More...KOⁱ	K04560
OMAⁱ	FEEIDHI
Database of Orthologous Groups More...OrthoDBⁱ	1033833at2759

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00179 SynN, 1 hit
InterProⁱ	View protein in InterPro IPR010989 SNARE IPR028669 STX1 IPR006012 Syntaxin/epimorphin_CS IPR006011 Syntaxin_N IPR000727 T_SNARE_dom
PANTHERⁱ	PTHR19957:SF84 PTHR19957:SF84, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05739 SNARE, 1 hit PF00804 Syntaxin, 1 hit
SMARTⁱ	View protein in SMART SM00503 SynN, 1 hit SM00397 t_SNARE, 1 hit
SUPFAMⁱ	SSF47661 SSF47661, 1 hit
PROSITEⁱ	View protein in PROSITE PS00914 SYNTAXIN, 1 hit PS50192 T_SNARE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q497P1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKDRTQELRT AKDSDDDDDV TVTVDRDRFM DEFFEQVEEI RGFIDKIAEN 
        60         70         80         90        100
VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI 
       110        120        130        140        150
EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ 
       160        170        180        190        200
RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS 
       210        220        230        240        250
EIIKLETSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA VDYVERAVSD 
       260        270        280 
TKKAVKYQSK ARRKKIMIII CCVILGIIIA STIGGIFG

Length:288

Mass (Da):33,054

Last modified:September 13, 2005 - v1

Checksum:ⁱ8F8255F2EEF886CA

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC100446 mRNA Translation: AAI00447.1 CH466529 Genomic DNA Translation: EDL19394.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058081.2, NM_016801.4

Genome annotation databases

GeneIDⁱ	20907
KEGGⁱ	mmu:20907

Protein	Similar proteins		Species	Score	Length	Source
Q497P1	Syntaxin-1A		MOUSE		288	UniRef100_O35526
Stx1a protein (Fragment)		MOUSE		287

Protein	Similar proteins		Species	Score	Length	Source
Q497P1	Syntaxin-1A	)	RAT		288	UniRef90_P32851
Syntaxin-1A		BOVIN		288
Syntaxin-1A		MOUSE		288
Syntaxin-1A		PONAB		288
Uncharacterized protein		AOTNA		292
+122

Protein	Similar proteins		Species	Score	Length	Source
Q497P1	Syntaxin-1A	)	RAT		288	UniRef50_P32851
Syntaxin-1A		MOUSE		288
Syntaxin-1A		BOVIN		288
Syntaxin-1A		PONAB		288
Syntaxin-1B		SHEEP		288
+756

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC100446 mRNA Translation: AAI00447.1 CH466529 Genomic DNA Translation: EDL19394.1
RefSeqⁱ	NP_058081.2, NM_016801.4

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	20907
KEGGⁱ	mmu:20907

Organism-specific databases

CTDⁱ	6804
MGIⁱ	MGI:109355 Stx1a

Phylogenomic databases

eggNOGⁱ	KOG0810 Eukaryota COG5074 LUCA
KOⁱ	K04560
OMAⁱ	FEEIDHI
OrthoDBⁱ	1033833at2759

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000007207 Expressed in 231 organ(s), highest expression level in cerebral cortex

Bgeeⁱ

ENSMUSG00000007207 Expressed in 231 organ(s), highest expression level in cerebral cortex

Family and domain databases

CDDⁱ	cd00179 SynN, 1 hit
InterProⁱ	View protein in InterPro IPR010989 SNARE IPR028669 STX1 IPR006012 Syntaxin/epimorphin_CS IPR006011 Syntaxin_N IPR000727 T_SNARE_dom
PANTHERⁱ	PTHR19957:SF84 PTHR19957:SF84, 1 hit
Pfamⁱ	View protein in Pfam PF05739 SNARE, 1 hit PF00804 Syntaxin, 1 hit
SMARTⁱ	View protein in SMART SM00503 SynN, 1 hit SM00397 t_SNARE, 1 hit
SUPFAMⁱ	SSF47661 SSF47661, 1 hit
PROSITEⁱ	View protein in PROSITE PS00914 SYNTAXIN, 1 hit PS50192 T_SNARE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q497P1_MOUSE
Accessionⁱ	Q497P1Primary (citable) accession number: Q497P1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 13, 2005
	Last sequence update:	September 13, 2005
	Last modified:	June 5, 2019
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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Supporting data

UniProtKB - Q497P1 (Q497P1_MOUSE)

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Syntaxin 1A (Brain)

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Plasma Membrane

Other locations

Topology

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ