UniProtKB - Q497P1 (Q497P1_MOUSE)
Protein
Submitted name:
Syntaxin 1A (Brain)
Gene
Stx1a
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- ATP-dependent protein binding Source: Ensembl
- calcium-dependent protein binding Source: Ensembl
- chloride channel inhibitor activity Source: Ensembl
- identical protein binding Source: Ensembl
- ion channel binding Source: Ensembl
- kinase binding Source: Ensembl
- myosin head/neck binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- protein N-terminus binding Source: Ensembl
- SNAP receptor activity Source: InterPro
- SNARE binding Source: Ensembl
GO - Biological processi
- intracellular protein transport Source: InterPro
- modulation of excitatory postsynaptic potential Source: Ensembl
- positive regulation of calcium ion-dependent exocytosis Source: Ensembl
- positive regulation of neurotransmitter secretion Source: Ensembl
- positive regulation of norepinephrine secretion Source: Ensembl
- protein localization to membrane Source: Ensembl
- protein sumoylation Source: Ensembl
- response to gravity Source: Ensembl
- SNARE complex assembly Source: Ensembl
- synaptic vesicle docking Source: Ensembl
- synaptic vesicle endocytosis Source: Ensembl
- synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
Keywordsi
Biological process | Neurotransmitter transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Syntaxin 1A (Brain)Imported |
Gene namesi | Name:Stx1aImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:109355, Stx1a |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type IV membrane protein ARBA annotation
Cytoskeleton
- actomyosin Source: Ensembl
Plasma Membrane
- integral component of presynaptic membrane Source: Ensembl
- presynaptic active zone membrane Source: Ensembl
- voltage-gated potassium channel complex Source: Ensembl
Other locations
- glutamatergic synapse Source: Ensembl
- integral component of synaptic vesicle membrane Source: Ensembl
- neuron projection Source: Ensembl
- postsynaptic density Source: Ensembl
- secretory granule Source: Ensembl
- synaptobrevin 2-SNAP-25-syntaxin-1a complex Source: Ensembl
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex Source: Ensembl
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex Source: Ensembl
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000007207, Expressed in cerebral cortex and 254 other tissues |
Interactioni
GO - Molecular functioni
- ATP-dependent protein binding Source: Ensembl
- calcium-dependent protein binding Source: Ensembl
- identical protein binding Source: Ensembl
- ion channel binding Source: Ensembl
- kinase binding Source: Ensembl
- myosin head/neck binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- protein N-terminus binding Source: Ensembl
- SNARE binding Source: Ensembl
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Coiled coilARBA annotation, Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
HOGENOMi | CLU_042423_2_2_1 |
OMAi | GQIRKQQ |
OrthoDBi | 1033833at2759 |
Family and domain databases
CDDi | cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR028669, STX1 IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957:SF84, PTHR19957:SF84, 1 hit |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q497P1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDRTQELRT AKDSDDDDDV TVTVDRDRFM DEFFEQVEEI RGFIDKIAEN
60 70 80 90 100
VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI
110 120 130 140 150
EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ
160 170 180 190 200
RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS
210 220 230 240 250
EIIKLETSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA VDYVERAVSD
260 270 280
TKKAVKYQSK ARRKKIMIII CCVILGIIIA STIGGIFG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC100446 mRNA Translation: AAI00447.1 |
RefSeqi | NP_058081.2, NM_016801.4 |
Genome annotation databases
GeneIDi | 20907 |
KEGGi | mmu:20907 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC100446 mRNA Translation: AAI00447.1 |
RefSeqi | NP_058081.2, NM_016801.4 |
3D structure databases
SMRi | Q497P1 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q497P1 |
Protocols and materials databases
Antibodypediai | 3644, 672 antibodies |
Genome annotation databases
GeneIDi | 20907 |
KEGGi | mmu:20907 |
Organism-specific databases
CTDi | 6804 |
MGIi | MGI:109355, Stx1a |
Phylogenomic databases
HOGENOMi | CLU_042423_2_2_1 |
OMAi | GQIRKQQ |
OrthoDBi | 1033833at2759 |
Miscellaneous databases
BioGRID-ORCSi | 20907, 0 hits in 17 CRISPR screens |
ChiTaRSi | Stx1a, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000007207, Expressed in cerebral cortex and 254 other tissues |
Family and domain databases
CDDi | cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR028669, STX1 IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957:SF84, PTHR19957:SF84, 1 hit |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q497P1_MOUSE | |
Accessioni | Q497P1Primary (citable) accession number: Q497P1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 13, 2005 |
Last sequence update: | September 13, 2005 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |