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Entry version 126 (08 May 2019)
Sequence version 1 (13 Sep 2005)
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Protein

Synaptic vesicle glycoprotein 2C

Gene

SV2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.By similarity
(Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 (PubMed:27313224). Recognition by BoNT/A relies on both protein-protein and protein-N-glycosylation; glycosylation of Asn-559 increases its affinity for BoNT/A (PubMed:27313224). Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction (PubMed:29649119).5 Publications
(Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); note that type D does not usually infect humans.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5250955 Toxicity of botulinum toxin type D (BoNT/D)
R-HSA-5250968 Toxicity of botulinum toxin type A (BoNT/A)
R-HSA-5250981 Toxicity of botulinum toxin type F (BoNT/F)

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.22.6 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SV2C
Synonyms:KIAA1054
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30670 SV2C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610291 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q496J9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 154CytoplasmicSequence analysisAdd BLAST154
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 191ExtracellularSequence analysisAdd BLAST16
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 226CytoplasmicSequence analysisAdd BLAST14
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248ExtracellularSequence analysis1
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 280CytoplasmicSequence analysisAdd BLAST11
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 320ExtracellularSequence analysisAdd BLAST19
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 437CytoplasmicSequence analysisAdd BLAST96
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 578ExtracellularSequence analysis1 PublicationAdd BLAST120
Transmembranei579 – 599HelicalSequence analysisAdd BLAST21
Topological domaini600 – 609CytoplasmicSequence analysis10
Transmembranei610 – 630HelicalSequence analysisAdd BLAST21
Topological domaini631 – 636ExtracellularSequence analysis6
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Topological domaini658 – 669CytoplasmicSequence analysisAdd BLAST12
Transmembranei670 – 690HelicalSequence analysisAdd BLAST21
Topological domaini691 – 698ExtracellularSequence analysis8
Transmembranei699 – 719HelicalSequence analysisAdd BLAST21
Topological domaini720 – 727CytoplasmicSequence analysis8

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi559N → A: No change in interaction with C.botulinum neurotoxin type A heavy chain (botA, BoNT/A HC). Decreased molecular weight probably due to glycosylation loss, decreased interaction with BoNT/A HC. 3 Publications1
Mutagenesisi559N → Q: Decreased molecular weight probably due to glycosylation loss, decreased binding to BoNT/A HC. Greater reduction in weight; when associated with Q-565. 1 Publication1
Mutagenesisi561S → A: Decreased molecular weight probably due to glycosylation loss, decreased binding to BoNT/A HC. 1 Publication1
Mutagenesisi563F → A: No longer interacts with BoNT/A HC. 2 Publications1
Mutagenesisi565N → Q: Decreased molecular weight probably due to glycosylation loss, no change in binding to BoNT/A heavy chain. Greater reduction in weight; when associated with Q-559. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
22987

Open Targets

More...
OpenTargetsi
ENSG00000122012

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25005

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SV2C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
108860965

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002397711 – 727Synaptic vesicle glycoprotein 2CAdd BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75PhosphoserineBy similarity1
Modified residuei76PhosphoserineBy similarity1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei466PhosphotyrosineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi559N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi565N-linked (GlcNAc...) asparagineSequence analysis1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. Upon expression in a kidney cell line the most abundant glycan on Asn-534 is GlcNAc3Hex5, while on Asn-559 and Asn-565 the most abundant glycan is GlcNAc2Fuc1Man3GlcNAc3Gal3. Both Asn-559 and Asn-565 have a high degreee of glycan heterogeneity (PubMed:27313224).3 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q496J9

PeptideAtlas

More...
PeptideAtlasi
Q496J9

PRoteomics IDEntifications database

More...
PRIDEi
Q496J9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61995

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q496J9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q496J9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122012 Expressed in 116 organ(s), highest expression level in substantia nigra pars reticulata

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q496J9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q496J9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040722
HPA040770

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SYT1 in a calcium-dependent manner.By similarity
(Microbial infection) Interacts with C.botulinum neurotoxin type A1 and type A2 (BoNT/A, botA) (PubMed:29649119). Interaction is improved by glycosylation of SV2 (PubMed:29649119).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
botAP0DPI04EBI-16081469,EBI-8178893From Clostridium botulinum.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116636, 9 interactors

Database of interacting proteins

More...
DIPi
DIP-60687N

Protein interaction database and analysis system

More...
IntActi
Q496J9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000423541

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1727
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JRAX-ray2.30C/D456-574[»]
5JLVX-ray2.00C/D473-567[»]
5MOYX-ray2.30B456-574[»]
6ES1X-ray2.00B474-567[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q496J9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 57Interaction with SYT1By similarityAdd BLAST57
Regioni519 – 563(Microbial infection) C.botulinum neurotoxin type A-binding1 PublicationAdd BLAST45

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0255 Eukaryota
ENOG410YQME LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182940

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065727

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q496J9

KEGG Orthology (KO)

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KOi
K06258

Identification of Orthologs from Complete Genome Data

More...
OMAi
YDGEAND

Database of Orthologous Groups

More...
OrthoDBi
724235at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q496J9

TreeFam database of animal gene trees

More...
TreeFami
TF324824

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001646 5peptide_repeat
IPR011701 MFS
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
IPR022308 SV2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690 MFS_1, 1 hit
PF13599 Pentapeptide_4, 1 hit
PF00083 Sugar_tr, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF103473 SSF103473, 2 hits

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01299 synapt_SV2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q496J9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDSYKDRTS LMKGAKDIAR EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ
60 70 80 90 100
DEEDDDDYYP AGETYNGEAN DDEGSSEATE GHDEDDEIYE GEYQGIPSMN
110 120 130 140 150
QAKDSIVSVG QPKGDEYKDR RELESERRAD EEELAQQYEL IIQECGHGRF
160 170 180 190 200
QWALFFVLGM ALMADGVEVF VVGFVLPSAE TDLCIPNSGS GWLGSIVYLG
210 220 230 240 250
MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG YGFFLFCRLL
260 270 280 290 300
SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI
310 320 330 340 350
IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV
360 370 380 390 400
GKHDEAWMIL KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG
410 420 430 440 450
TWYRRCFVRI RTELYGIWLT FMRCFNYPVR DNTIKLTIVW FTLSFGYYGL
460 470 480 490 500
SVWFPDVIKP LQSDEYALLT RNVERDKYAN FTINFTMENQ IHTGMEYDNG
510 520 530 540 550
RFIGVKFKSV TFKDSVFKSC TFEDVTSVNT YFKNCTFIDT VFDNTDFEPY
560 570 580 590 600
KFIDSEFKNC SFFHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS
610 620 630 640 650
ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA
660 670 680 690 700
WNSLDVVTVE LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKSIP
710 720
ILLASTVLVC GGLVGLCLPD TRTQVLM
Length:727
Mass (Da):82,342
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0411B47057B3279C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KT41B3KT41_HUMAN
Synaptic vesicle glycoprotein 2C
SV2C
676Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti346F → S in AAI00825 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050303482T → S. Corresponds to variant dbSNP:rs2270927Ensembl.1
Natural variantiVAR_050304543D → N. Corresponds to variant dbSNP:rs31244Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC100824 mRNA Translation: AAI00825.1
BC100825 mRNA Translation: AAI00826.1
BC100826 mRNA Translation: AAI00827.1
BC100827 mRNA Translation: AAI00828.1
AB028977 mRNA Translation: BAA83006.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43331.1

NCBI Reference Sequences

More...
RefSeqi
NP_055794.3, NM_014979.3
XP_011541583.1, XM_011543281.2
XP_011541584.2, XM_011543282.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000502798; ENSP00000423541; ENSG00000122012

Database of genes from NCBI RefSeq genomes

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GeneIDi
22987

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22987

UCSC genome browser

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UCSCi
uc003kei.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100824 mRNA Translation: AAI00825.1
BC100825 mRNA Translation: AAI00826.1
BC100826 mRNA Translation: AAI00827.1
BC100827 mRNA Translation: AAI00828.1
AB028977 mRNA Translation: BAA83006.1
CCDSiCCDS43331.1
RefSeqiNP_055794.3, NM_014979.3
XP_011541583.1, XM_011543281.2
XP_011541584.2, XM_011543282.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JRAX-ray2.30C/D456-574[»]
5JLVX-ray2.00C/D473-567[»]
5MOYX-ray2.30B456-574[»]
6ES1X-ray2.00B474-567[»]
SMRiQ496J9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116636, 9 interactors
DIPiDIP-60687N
IntActiQ496J9, 1 interactor
STRINGi9606.ENSP00000423541

Protein family/group databases

TCDBi2.A.1.22.6 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ496J9
PhosphoSitePlusiQ496J9

Polymorphism and mutation databases

BioMutaiSV2C
DMDMi108860965

Proteomic databases

PaxDbiQ496J9
PeptideAtlasiQ496J9
PRIDEiQ496J9
ProteomicsDBi61995

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502798; ENSP00000423541; ENSG00000122012
GeneIDi22987
KEGGihsa:22987
UCSCiuc003kei.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22987
DisGeNETi22987

GeneCards: human genes, protein and diseases

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GeneCardsi
SV2C
HGNCiHGNC:30670 SV2C
HPAiHPA040722
HPA040770
MIMi610291 gene
neXtProtiNX_Q496J9
OpenTargetsiENSG00000122012
PharmGKBiPA25005

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
ENOG410YQME LUCA
GeneTreeiENSGT00950000182940
HOGENOMiHOG000065727
InParanoidiQ496J9
KOiK06258
OMAiYDGEAND
OrthoDBi724235at2759
PhylomeDBiQ496J9
TreeFamiTF324824

Enzyme and pathway databases

ReactomeiR-HSA-5250955 Toxicity of botulinum toxin type D (BoNT/D)
R-HSA-5250968 Toxicity of botulinum toxin type A (BoNT/A)
R-HSA-5250981 Toxicity of botulinum toxin type F (BoNT/F)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SV2C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22987

Protein Ontology

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PROi
PR:Q496J9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122012 Expressed in 116 organ(s), highest expression level in substantia nigra pars reticulata
ExpressionAtlasiQ496J9 baseline and differential
GenevisibleiQ496J9 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR001646 5peptide_repeat
IPR011701 MFS
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
IPR022308 SV2
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PF13599 Pentapeptide_4, 1 hit
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR01299 synapt_SV2, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSV2C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q496J9
Secondary accession number(s): Q496K1, Q9UPU8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: September 13, 2005
Last modified: May 8, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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