UniProtKB - Q496F6 (CLM2_HUMAN)
Protein
CMRF35-like molecule 2
Gene
CD300E
Organism
Homo sapiens (Human)
Status
Functioni
Probably acts as an activating receptor.1 Publication
GO - Molecular functioni
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- innate immune response Source: Reactome
- regulation of immune response Source: Reactome
Keywordsi
Molecular function | Receptor |
Biological process | Immunity |
Enzyme and pathway databases
PathwayCommonsi | Q496F6 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-2172127, DAP12 interactions |
Names & Taxonomyi
Protein namesi | Recommended name: CMRF35-like molecule 2Short name: CLM-2 Alternative name(s): CD300 antigen-like family member E CMRF35-A5 Immune receptor expressed on myeloid cells 2 Short name: IREM-2 Polymeric immunoglobulin receptor 2 Short name: PIgR-2 Short name: PIgR2 Short name: Poly-Ig receptor 2 CD_antigen: CD300e |
Gene namesi | Name:CD300E Synonyms:CD300LE, CLM2, CMRF35A5, IREM2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28874, CD300E |
MIMi | 609801, gene |
neXtProti | NX_Q496F6 |
VEuPathDBi | HostDB:ENSG00000186407.6 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 173 | ExtracellularSequence analysisAdd BLAST | 156 | |
Transmembranei | 174 – 194 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 195 – 205 | CytoplasmicSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 342510 |
OpenTargetsi | ENSG00000186407 |
PharmGKBi | PA142672152 |
Miscellaneous databases
Pharosi | Q496F6, Tbio |
Genetic variation databases
BioMutai | CD300E |
DMDMi | 296434454 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000320123 | 18 – 205 | CMRF35-like molecule 2Add BLAST | 188 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 104 | PROSITE-ProRule annotation | ||
Glycosylationi | 154 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q496F6 |
MassIVEi | Q496F6 |
PaxDbi | Q496F6 |
PeptideAtlasi | Q496F6 |
PRIDEi | Q496F6 |
ProteomicsDBi | 61989 |
PTM databases
GlyGeni | Q496F6, 2 sites, 2 O-linked glycans (1 site) |
iPTMneti | Q496F6 |
PhosphoSitePlusi | Q496F6 |
Expressioni
Tissue specificityi
Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000186407, Expressed in monocyte and 101 other tissues |
ExpressionAtlasi | Q496F6, baseline and differential |
Organism-specific databases
HPAi | ENSG00000186407, Tissue enhanced (blood, bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with TYROBP.
1 PublicationBinary interactionsi
Hide detailsQ496F6
With | #Exp. | IntAct |
---|---|---|
CTXN3 [Q4LDR2] | 3 | EBI-18010148,EBI-12019274 |
STX8 [Q9UNK0] | 3 | EBI-18010148,EBI-727240 |
TUSC5 [A5PKU2] | 3 | EBI-18010148,EBI-11988865 |
Protein-protein interaction databases
BioGRIDi | 131180, 11 interactors |
IntActi | Q496F6, 9 interactors |
STRINGi | 9606.ENSP00000376395 |
Miscellaneous databases
RNActi | Q496F6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 120 | Ig-like V-typeAdd BLAST | 103 |
Sequence similaritiesi
Belongs to the CD300 family.Curated
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SRT9, Eukaryota |
GeneTreei | ENSGT00940000162923 |
HOGENOMi | CLU_051023_3_0_1 |
InParanoidi | Q496F6 |
OMAi | WILDAWS |
OrthoDBi | 1494510at2759 |
PhylomeDBi | Q496F6 |
TreeFami | TF334441 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q496F6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWLLPALLLL CLSGCLSLKG PGSVTGTAGD SLTVWCQYES MYKGYNKYWC
60 70 80 90 100
RGQYDTSCES IVETKGEEKV ERNGRVSIRD HPEALAFTVT MQNLNEDDAG
110 120 130 140 150
SYWCKIQTVW VLDSWSRDPS DLVRVYVSPA ITTPRRTTHP ATPPIFLVVN
160 170 180 190 200
PGRNLSTGEV LTQNSGFRLS SPHFLLVVLL KLPLLLSMLG AVFWVNRPQW
APPGR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JDD2 | C9JDD2_HUMAN | CMRF35-like molecule 2 | CD300E | 121 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039129 | 19 | K → T1 PublicationCorresponds to variant dbSNP:rs581157Ensembl. | 1 | |
Natural variantiVAR_039130 | 27 | T → A in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1278044712Ensembl. | 1 | |
Natural variantiVAR_039131 | 158 | G → R2 PublicationsCorresponds to variant dbSNP:rs1878061Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF395839 mRNA Translation: AAP42154.1 AK298031 mRNA Translation: BAG60333.1 AC064805 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89176.1 BC100888 mRNA Translation: AAI00889.1 BC100889 mRNA Translation: AAI00890.1 BC100890 mRNA Translation: AAI00891.1 |
CCDSi | CCDS11702.1 |
RefSeqi | NP_852114.2, NM_181449.2 |
Genome annotation databases
Ensembli | ENST00000392619; ENSP00000376395; ENSG00000186407 |
GeneIDi | 342510 |
KEGGi | hsa:342510 |
UCSCi | uc002jlb.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF395839 mRNA Translation: AAP42154.1 AK298031 mRNA Translation: BAG60333.1 AC064805 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89176.1 BC100888 mRNA Translation: AAI00889.1 BC100889 mRNA Translation: AAI00890.1 BC100890 mRNA Translation: AAI00891.1 |
CCDSi | CCDS11702.1 |
RefSeqi | NP_852114.2, NM_181449.2 |
3D structure databases
SMRi | Q496F6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131180, 11 interactors |
IntActi | Q496F6, 9 interactors |
STRINGi | 9606.ENSP00000376395 |
PTM databases
GlyGeni | Q496F6, 2 sites, 2 O-linked glycans (1 site) |
iPTMneti | Q496F6 |
PhosphoSitePlusi | Q496F6 |
Genetic variation databases
BioMutai | CD300E |
DMDMi | 296434454 |
Proteomic databases
jPOSTi | Q496F6 |
MassIVEi | Q496F6 |
PaxDbi | Q496F6 |
PeptideAtlasi | Q496F6 |
PRIDEi | Q496F6 |
ProteomicsDBi | 61989 |
Protocols and materials databases
Antibodypediai | 2708, 300 antibodies |
Genome annotation databases
Ensembli | ENST00000392619; ENSP00000376395; ENSG00000186407 |
GeneIDi | 342510 |
KEGGi | hsa:342510 |
UCSCi | uc002jlb.3, human |
Organism-specific databases
CTDi | 342510 |
DisGeNETi | 342510 |
GeneCardsi | CD300E |
HGNCi | HGNC:28874, CD300E |
HPAi | ENSG00000186407, Tissue enhanced (blood, bone marrow, lymphoid tissue) |
MIMi | 609801, gene |
neXtProti | NX_Q496F6 |
OpenTargetsi | ENSG00000186407 |
PharmGKBi | PA142672152 |
VEuPathDBi | HostDB:ENSG00000186407.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SRT9, Eukaryota |
GeneTreei | ENSGT00940000162923 |
HOGENOMi | CLU_051023_3_0_1 |
InParanoidi | Q496F6 |
OMAi | WILDAWS |
OrthoDBi | 1494510at2759 |
PhylomeDBi | Q496F6 |
TreeFami | TF334441 |
Enzyme and pathway databases
PathwayCommonsi | Q496F6 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-2172127, DAP12 interactions |
Miscellaneous databases
BioGRID-ORCSi | 342510, 4 hits in 525 CRISPR screens |
GenomeRNAii | 342510 |
Pharosi | Q496F6, Tbio |
PROi | PR:Q496F6 |
RNActi | Q496F6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186407, Expressed in monocyte and 101 other tissues |
ExpressionAtlasi | Q496F6, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLM2_HUMAN | |
Accessioni | Q496F6Primary (citable) accession number: Q496F6 Secondary accession number(s): B4DNS1, Q7Z7I3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families